JP5527885B2 - Medical adhesive tape - Google Patents

Description

  The present invention relates to a medical adhesive tape. More specifically, the present invention relates to a medical pressure-sensitive adhesive tape that is excellent in operability and can be attached to the surface of a living body without generation of wrinkles.

  Medical adhesive tapes are widely used for the purpose of protecting affected parts of a living body surface (for example, skin), fixing gauze to a living body surface, medical instruments (for example, a catheter), etc., and transdermal absorption of drugs. Usually, such a medical adhesive tape is provided with a release liner, and is applied to the surface of a living body after the release liner is released. Since the medical adhesive tape after the release liner is peeled is thin and flexible, wrinkles are likely to occur. The purpose of the medical adhesive tape attached with wrinkles is that the adhesiveness is insufficient, the problem of floating or peeling due to wrinkles becomes a bacterial infection route, and the percutaneous absorption of drugs. In this case, there is a problem that a desired drug absorption amount cannot be obtained. In addition, if it is attempted to be applied while preventing the generation of wrinkles, the working efficiency is deteriorated. Therefore, there is a need for a medical adhesive tape that can be applied with good operability.

Japanese Utility Model Publication No. 58-124123 JP 2008-295568 A JP 2009-136557 A

  The present invention has been made to solve the above-described conventional problems, and an object of the present invention is to provide a medical pressure-sensitive adhesive tape that is excellent in operability and can be attached to the surface of a living body without generation of wrinkles. There is.

The medical pressure-sensitive adhesive tape of the present invention is provided with a film base, a first pressure-sensitive adhesive layer, and a release liner that covers the first pressure-sensitive adhesive layer and is peeled and laminated in this order. The release liner is divided into a first divided piece and a second divided piece, and the first divided piece covers the part of the first pressure-sensitive adhesive layer so as to cover the first pressure-sensitive adhesive layer. It arrange | positions at the width direction edge part of one side of 1 adhesive layer, and this 2nd division | segmentation piece covers the part which is not covered with the 1st division | segmentation piece of this 1st adhesive layer. It is arrange | positioned and this 2nd division | segmentation piece has the folding | returning part extended toward the width direction edge part.
In another embodiment, the medical pressure-sensitive adhesive tape of the present invention comprises a film substrate, a first pressure-sensitive adhesive layer, and a release liner that is releasably laminated so as to cover the first pressure-sensitive adhesive layer. A medical pressure-sensitive adhesive tape provided in order, wherein the release liner is divided into a first divided piece, a second divided piece, and a third divided piece, wherein the second divided piece is the first adhesive piece. A part of the first pressure-sensitive adhesive layer is disposed on one side of the first pressure-sensitive adhesive layer so as to cover a part of the pressure-sensitive adhesive layer, and the third divided piece covers a part of the first pressure-sensitive adhesive layer. The first pressure-sensitive adhesive layer is disposed at the other end in the width direction so as to cover the first pressure-sensitive adhesive layer, the second pressure-sensitive adhesive layer and the second pressure-sensitive adhesive layer. It is arranged between the second divided piece and the third divided piece in the width direction so as to cover a portion not covered with the three divided pieces, and the second divided piece and the The third divided piece has a folded portion extending toward the end in the width direction.
In a preferred embodiment, the folded portion of the second divided piece has an extended portion of the second divided piece extending to the outside from the film base material.
In a preferred embodiment, the folded portion of the third divided piece has an extended portion of the third divided piece that extends outward from the film base material.
In a preferred embodiment, the first divided piece covers at least a part of the second divided piece.
In a preferred embodiment, the first divided piece covers at least a part of the third divided piece.
In preferable embodiment, the said 1st division | segmentation piece has the extension part of the 1st division | segmentation piece extended to the outer side from the said film base material in at least one of the width direction.
In a preferred embodiment, the extending portion of the first divided piece extends to the outside of the second divided piece and the third divided piece.
In a preferred embodiment, the film further includes a support and a second pressure-sensitive adhesive layer, and the support is disposed on the opposite side of the film base from the first pressure-sensitive adhesive layer, and the second pressure-sensitive adhesive is provided. A layer is disposed between the support and the film substrate.
In preferable embodiment, the said support body has a window part.
In preferable embodiment, the medical adhesive tape of this invention is further equipped with the support body which has a window part, and a 2nd adhesive layer, and the support body which has this window part is the said film base material and the said 1st film. It arrange | positions between adhesive layers and this 2nd adhesive layer is arrange | positioned between the support body which has the said film base material and this window part.
According to another situation of this invention, the film dressing produced using the said medical adhesive tape is provided.
According to another situation of this invention, the adhesive bandage produced using the said medical adhesive tape is provided.
According to another situation of this invention, the transdermal absorption tape formulation produced using the said medical adhesive tape is provided.

  ADVANTAGE OF THE INVENTION According to this invention, by providing the release liner divided | segmented into the specific shape, it is excellent in operativity and can provide the medical adhesive tape which can be affixed on the biological body surface without generation | occurrence | production of a wrinkle. Specifically, a part of the divided release liner is first peeled off, and a part of the pressure-sensitive adhesive surface (adhesive layer) of the medical pressure-sensitive adhesive tape body is attached to the surface of the living body, whereby the medical pressure-sensitive adhesive tape body After deciding the attachment position, the remaining release liner can be peeled off and the entire adhesive surface of the medical adhesive tape body can be attached, so the medical adhesive tape body does not wrinkle, And it can affix on the biological body surface with sufficient operativity. Also, these operations can be performed without the operator touching the adhesive surface.

(A) is a schematic plan view of the medical adhesive tape by preferable embodiment of this invention, (b) is a schematic sectional drawing by the Ib-Ib line of the medical adhesive tape of (a). (A) is a schematic top view of the medical adhesive tape by another preferable embodiment of this invention, (b) is a schematic sectional drawing by the IIb-IIb line | wire of the medical adhesive tape of FIG. 2 (a). is there. It is a schematic sectional drawing of the medical adhesive tape by another preferable embodiment of this invention. It is a schematic sectional drawing of the medical adhesive tape by another preferable embodiment of this invention. (A) is a schematic plan view of the medical adhesive tape by another preferable embodiment of this invention, (b) is a schematic sectional drawing by the Vb-Vb line | wire of the medical adhesive tape of (a). (A) is a schematic top view of the medical adhesive tape by another preferable embodiment of this invention, (b) is a schematic sectional drawing by the VIb-VIb line | wire of the medical adhesive tape of (a). (A) is a schematic top view of the medical adhesive tape by another preferable embodiment of this invention, (b) is a schematic sectional drawing by the VIIb-VIIb line | wire of the medical adhesive tape of (a). (A) is a schematic plan view of the medical adhesive tape by further another preferable embodiment of this invention, (b) is a schematic sectional drawing by the VIIIb-VIIIb line | wire of the medical adhesive tape of (a). It is a disassembled perspective view explaining the medical adhesive tape by another preferable embodiment of this invention. It is the schematic for demonstrating the specific affixing procedure of the medical adhesive tape of this invention. It is the schematic for demonstrating the specific affixing procedure of the medical adhesive tape of this invention.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings, but the present invention is not limited to these specific embodiments.

A. 1A is a schematic plan view of a medical pressure-sensitive adhesive tape according to a preferred embodiment of the present invention, and FIG. 1B is a diagram of the medical pressure-sensitive adhesive tape of FIG. It is a schematic sectional drawing by the Ib-Ib line. It should be noted that for the sake of easy understanding, the ratio of the vertical, horizontal, and thickness of each layer and each part in the illustrated example is different from the actual ratio. The medical adhesive tape 100 includes a film base 110, a first adhesive layer 120, and a release liner 130 that covers the first adhesive layer 120 and is detachably laminated. FIG. 1A is a schematic plan view of the medical adhesive tape 100 as viewed from the release liner 130 side. Further, in the present specification, the laminate excluding the release liner (in FIG. 1, the laminate of the film base 110 and the first adhesive layer 120) may be collectively referred to as a medical adhesive tape body. is there. The shape of the medical pressure-sensitive adhesive tape in plan view is not limited to the illustrated example, and it is needless to say that any appropriate shape (for example, a circle, a square, a rectangle, or a trapezoid) can be adopted depending on the purpose. When a square or a rectangle is adopted as the planar view shape, the medical adhesive tape is wound in the length direction (that is, the vertical direction of the paper surface of FIG. 1A and the vertical direction of the paper surface of FIG. 1B). Can be provided in the form of a rolled roll, and can be cut into any length as required.

  The release liner 130 is divided into a first divided piece 131 and a second divided piece 132. The entire first pressure-sensitive adhesive layer 120 is covered with the first divided piece 131 and the second divided piece 132. The first divided piece 131 covers a part of the first pressure-sensitive adhesive layer 120 so as to cover one side of the first pressure-sensitive adhesive layer 120 in the width direction (that is, FIG. 1 (a) and ( b) on the right side of the paper surface). The 2nd division piece 132 is arrange | positioned so that the part which is not covered with the 1st division piece 131 of the 1st adhesive layer 120 may be covered. If the release liner 130 is divided in this way, the first divided piece 131 is first peeled off, and the portion corresponding to the first divided piece 131 of the first adhesive layer 120 is removed from the surface of the living body (for example, The second adhesive piece 120 is peeled off, and the portion corresponding to the second adhesive segment 120 of the first adhesive layer 120 is removed from the living body. Since it can be affixed to the surface, it is possible to complete the affixing of the medical adhesive tape main body at a desired position with good operability and without occurrence of wrinkles. In addition, the medical adhesive tape 100 of the present invention can be attached by holding the second divided piece 132 when the portion corresponding to the first divided piece 131 is attached. Since the part corresponding to the 1st division | segmentation piece 131 has adhered to the biological body surface when peeling, it can affix without touching the 1st adhesive layer 120. FIG.

  The width of the first pressure-sensitive adhesive layer 120 covered by the first divided piece 131 (that is, the width of the portion where the first pressure-sensitive adhesive layer 120 directly contacts the first divided piece 131) is the first pressure-sensitive adhesive. The total width of the layer 120 is preferably 10% to 80%, more preferably 20% to 60%, and particularly preferably 20% to 40%.

  The 2nd division | segmentation piece 132 has the folding | turning part 132a extended toward the edge part in the width direction. Preferably, the folded portion 132a of the first divided piece has an extended portion 132b of the first divided piece extending to the outside from the film base 110. By adopting such a configuration, the operability of peeling the second divided piece 132 from the temporarily placed medical adhesive tape main body can be remarkably improved. As a result, the medical pressure-sensitive adhesive tape main body can be satisfactorily adhered to the living body surface by a simple operation.

  The first divided piece 131 preferably has a fold or a perforation (not shown) substantially parallel to the side of the width direction end. If the 1st division | segmentation piece 131 has a crease | fold or a perforation, the operativity of peeling of a 1st division | segmentation piece will improve. Further, at the time of temporary fitting, the first divided piece 131 is folded back from the crease or perforation, and a part of the first divided piece 131 is peeled off from the first pressure-sensitive adhesive layer 120 to expose the first pressure-sensitive adhesive layer. After affixing 120 on the living body surface, the entire first divided piece 131 can be peeled off. Therefore, if the first divided piece 131 has a crease or a perforation, the first divided piece 131 can be peeled in stages, so that the first divided piece is peeled off and the medical adhesive tape. The operability when temporarily fitting the main body is improved.

  FIG. 2A is a schematic plan view of a medical pressure-sensitive adhesive tape according to another preferred embodiment of the present invention, and FIG. 2B is a line IIb-IIb of the medical pressure-sensitive adhesive tape of FIG. It is a schematic sectional drawing. The release liner 230 of the medical adhesive tape 200 is divided into a first divided piece 231, a second divided piece 232, and a third divided piece 233. The entire first adhesive layer 220 is covered with the first divided piece 231, the second divided piece 232, and the third divided piece 233. The second divided piece 232 covers a part of the first pressure-sensitive adhesive layer 220 so as to cover an end in the width direction on one side of the first pressure-sensitive adhesive layer 220 (that is, FIG. (b) the left end of the paper surface). The third divided piece 233 covers a part of the first pressure-sensitive adhesive layer 220 so as to cover the other side of the first pressure-sensitive adhesive layer 220 in the width direction (that is, FIG. b) on the right side of the paper surface). The first divided piece 231 covers the portion of the first pressure-sensitive adhesive layer 220 that is not covered with the second divided piece 232 and the third divided piece 233, and in the width direction, the second divided piece 231 232 and the third divided piece 233. If the release liner 230 is divided in this way, the first divided piece 231 is first peeled off, and the portion corresponding to the first divided piece 231 of the first adhesive layer 220 is removed from the surface of the living body (for example, The second adhesive strip 220 is peeled off after the medical adhesive tape body is temporarily attached to the skin, and then the second adhesive strip 220 is separated. Since the part corresponding to 232 and the 3rd division | segmentation piece 233 can be affixed on the biological body surface, affixing of the medical adhesive tape main body to a desired position with good operativity and without generating wrinkles Can be completed. In addition, the medical adhesive tape 200 of the present invention can be attached by holding the second divided piece 232 and / or the third divided piece 233 when a portion corresponding to the first divided piece 231 is attached. In addition, when the second divided piece 232 and the third divided piece 233 are peeled off, the portion corresponding to the first divided piece 231 is attached to the surface of the living body. Can be pasted without touching.

  The widths of the first divided piece 231, the second divided piece 232, and the third divided piece 233 can be set to any appropriate length. The width of the first pressure-sensitive adhesive layer 220 covered by the first divided piece 231 (that is, the width of the portion where the first pressure-sensitive adhesive layer 220 is in direct contact with the first divided piece 231) is the first pressure-sensitive adhesive. It is preferably 10% to 80%, more preferably 20% to 60%, and particularly preferably 20% to 40% with respect to the entire width of the layer 220. Further, the width of the first pressure-sensitive adhesive layer 220 covered by the second divided piece 232 and the width of the first pressure-sensitive adhesive layer 220 covered by the third divided piece 233 may be the same or different. It may be.

  The 2nd division piece 232 and the 3rd division piece 233 have the folding | returning part 232a, 233a extended toward the width direction edge part. Preferably, the folded portion 232a of the second divided piece has an extended portion 232b of the second divided piece extending to the outside of the film base 210, and the folded portion 233a of the third divided piece is the film base. It has the extended part 233b of the 3rd division piece extended to 210 outside. By adopting such a configuration, the operability of peeling off the second divided piece 232 and the third divided piece 233 from the temporarily tacked medical adhesive tape body can be significantly improved. As a result, the medical adhesive tape can be satisfactorily adhered to the living body surface by a simple operation.

  FIG. 3 is a schematic cross-sectional view of a medical pressure-sensitive adhesive tape according to still another preferred embodiment of the present invention. FIG. 3 shows a medical adhesive tape 300 in which the first divided piece in FIG. 1 is arranged so as to cover at least a part of the second divided piece. In this medical adhesive tape 300, the first divided piece 331 covers a portion of the first adhesive layer 320 that is not covered by the second divided piece and at least a part of the second divided piece 332. Thus, the first pressure-sensitive adhesive layer 320 is disposed on the opposite side of the base film 310 and the second divided piece 332 on the opposite side of the first pressure-sensitive adhesive layer 320. If it is such a structure, the operativity of peeling of the 1st division | segmentation piece 331 from a medical adhesive tape main body can improve.

  Preferably, the first divided piece 331 has an extended portion 331b of the first divided piece extending outward in the width direction from the film base material 310. More preferably, the extension part 331b of the first divided piece extends to the outside of the second divided piece 332. Therefore, most preferably, as shown in FIG. 3, the second divided piece 332 is provided with a folded portion 332a and an extending portion 332b, and the extended portion 331b of the first divided piece is the second divided piece. The extending portion 332b extends to the outside. With such a configuration, since the extension part 331b of the first divided piece that is first peeled off when the medical adhesive tape is applied extends to the outermost side, the extension part 331b of the first divided piece. Therefore, the operability of peeling the first divided piece 331 from the medical adhesive tape main body can be remarkably improved. Moreover, although not shown in figure, the 1st division | segmentation piece 331 may have the extension part in the width direction both sides (Namely, you may have an extension part further on the left side of the paper surface of FIG. 3). .

  FIG. 4 is a schematic cross-sectional view of a medical pressure-sensitive adhesive tape according to still another preferred embodiment of the present invention. FIG. 4 shows a medical adhesive tape 400 in which the first divided piece in FIG. 2 is further arranged to cover at least a part of the second divided piece and / or at least a part of the third divided piece. . In the medical adhesive tape 400, the first divided piece 431 is a portion of the first adhesive layer 420 that is not covered with the second divided piece 432 and the third divided piece 433, and the second divided piece. The side of the first pressure-sensitive adhesive layer 420 opposite to the base film 410 and the second divided piece 432 and / or so as to cover at least a part of 432 and / or at least a part of the third divided piece 433. The third divided piece 433 is disposed on the opposite side to the first pressure-sensitive adhesive layer 420. If it is such a structure, the operativity of peeling of the 1st division | segmentation piece 431 from a medical adhesive tape main body can improve.

  Preferably, the first divided piece 431 includes first divided piece extending portions 431 b and 431 b ′ extending outward in the width direction from the film substrate 410. More preferably, the extending portions 431 b and 431 b ′ of the first divided piece extend to the outside of the second divided piece 432 and / or the third divided piece 433. Therefore, most preferably, the second divided piece 432 and the third divided piece 433 are provided with folded portions 432a and 433a and extending portions 432b and 433b, respectively, and the extended portion 431b of the first divided piece. , 431b ′ extend to the outside from the extension part 432b of the second split piece and / or the extension part 433b of the third split piece. With such a configuration, since the extended portions 431b and 431b ′ of the first divided piece that are first peeled off when the medical adhesive tape is applied extend to the outermost side, the extension of the first divided piece is extended. The protruding portions 431b and 431b ′ can function more effectively as gripping margins, and the operability of peeling the first divided piece 431 from the medical adhesive tape main body can be remarkably improved.

  FIG. 5 (a) is a schematic plan view of a medical adhesive tape according to still another preferred embodiment of the present invention as seen from the side opposite to the release liner side, and FIG. 5 (b) is a plan view of FIG. 5 (a). It is a schematic sectional drawing by the Vb-Vb line | wire of the medical adhesive tape of this. This medical adhesive tape 500 further includes a support 540 in addition to the configuration shown in FIG. The support 540 is disposed on the opposite side of the base film 510 from the first pressure-sensitive adhesive layer 520 with the second pressure-sensitive adhesive layer 550 interposed therebetween. If the medical pressure-sensitive adhesive tape 500 includes the support 540, the medical pressure-sensitive adhesive tape main body can be given rigidity and shape retention, and handleability can be improved. Preferably, the support 540 is provided with a window 560. If the support body 540 has the window part 560, when the medical adhesive tape covers the affected part on the surface of the living body, the puncture part of the medical instrument, etc., while observing the affected part or the puncture part, Adhesive tape can be attached.

  6 (a) is a schematic plan view of a medical adhesive tape according to still another preferred embodiment of the present invention as viewed from the side opposite to the release liner side, and FIG. 6 (b) is a plan view of FIG. 6 (a). It is a schematic sectional drawing by the VIb-VIb line | wire of the medical adhesive tape of FIG. In the medical pressure-sensitive adhesive tape 600, the support 640 is disposed between the film base 610 and the first pressure-sensitive adhesive layer 620. The second pressure-sensitive adhesive layer 650 is disposed between the film base 610 and the support 640.

  Fig.7 (a) is the schematic plan view seen from the opposite side to the release liner side of the medical adhesive tape by another preferable embodiment of this invention, FIG.7 (b) is FIG.7 (a). It is a schematic sectional drawing by the VIIb-VIIb line | wire of the medical adhesive tape of FIG. The medical adhesive tape 700 further includes a support 740 in addition to the configuration shown in FIG. The support 740 is disposed on the opposite side of the base film 710 from the first pressure-sensitive adhesive layer 720 with the second pressure-sensitive adhesive layer 750 interposed therebetween. Preferably, the support 740 is provided with a window portion 760.

  FIG. 8 (a) is a schematic plan view of a medical adhesive tape according to still another preferred embodiment of the present invention as seen from the side opposite to the release liner side, and FIG. 8 (b) is a plan view of FIG. 8 (a). It is a schematic sectional drawing by the VIIIb-VIIIb line | wire of the medical adhesive tape of FIG. . In the medical pressure-sensitive adhesive tape 800, the support 840 is disposed between the film base 810 and the first pressure-sensitive adhesive layer 820. The second pressure-sensitive adhesive layer 850 is disposed between the film base 810 and the support 840.

  FIG. 9 is an exploded perspective view illustrating a medical pressure-sensitive adhesive tape according to still another preferred embodiment of the present invention. FIG. 9 shows a medical pressure-sensitive adhesive tape 900 in which the first divided piece in FIG. 5 further covers the second divided piece and has an extending portion extending to the outside from the first divided piece. As for this medical adhesive tape 900, the support body 940 has the window part 960, and the 2nd division | segmentation piece has the window part 932c. In FIG. 9, the film substrate, the first pressure-sensitive adhesive layer, and the second pressure-sensitive adhesive layer are not shown for easy understanding. In the medical adhesive tape 900, the window portion 932c of the second divided piece 932 is provided at a position corresponding to the window portion 960 of the support, and the second divided piece 932 is the window portion 960 of the first adhesive layer. Do not cover the part corresponding to. That is, in the embodiment, the second divided piece 932 is disposed so as to cover only a portion corresponding to the frame portion of the support 940 of the first pressure-sensitive adhesive layer. Further, the folded portion 932a of the second divided piece 932 does not cover the portion corresponding to the window portion 960 of the first adhesive layer. According to such embodiment, the 1st division | segmentation piece 931 is arrange | positioned so that the part which is not covered with the 2nd division | segmentation piece of the 1st adhesive layer may be covered at least. When the release liner is divided into three parts, a first divided piece, a second divided piece, and a third divided piece, the second divided piece and the third divided piece (and their folded portions) Are arranged so as not to cover a portion corresponding to the window portion of the first pressure-sensitive adhesive layer, and the first divided piece is at least the second divided piece and the third piece of the first pressure-sensitive adhesive layer. It may be arranged so as to cover a portion not covered with the divided pieces. By setting it as such a structure, when a medical adhesive tape covers the affected part on the surface of a biological body, a medical adhesive tape can be affixed, observing an affected part. In addition, when the medical adhesive tape covers the puncture portion of the medical instrument, the positioning of the medical adhesive tape and the peeling operation of the second divided piece are facilitated, and the medical adhesive tape is observed while observing the puncture portion. Can be pasted. Furthermore, the balance between rigidity and flexibility in a state where the first divided piece is peeled off is excellent, and the medical adhesive tape main body can be easily attached to an uneven biological surface.

  The medical adhesive tape of the present invention can be appropriately combined with the embodiments described above as long as the effects of the present invention are obtained.

B. Explanation of each component B-1. Film Base Any suitable film can be adopted as the film base as long as it can be used for a medical pressure-sensitive adhesive tape. Typically, a film that has flexibility and does not damage the surface of a living body such as skin may be employed. Specific examples of such film materials include acrylic polymers, polyethylene, ethylene-vinyl acetate copolymers, polyurethanes, polyether polyesters, and polyamide derivatives. Acrylic polymers, polyurethanes, polyether polyesters and polyamide derivatives are preferred. Since the film has excellent water vapor permeability, it can hardly prevent breathing of the covered skin, can suppress the whitening phenomenon of the skin, and has excellent transparency. (For example, when fixing a punctured catheter, it can be affixed while observing the catheter insertion portion).

  As the thickness of the film substrate, any appropriate thickness can be adopted depending on the purpose and application. The thickness of the film substrate is preferably 1 μm to 150 μm, more preferably 5 μm to 75 μm, and particularly preferably 10 μm to 50 μm. If it is such thickness, it is excellent in the followability to the unevenness | corrugation of the biological body surface, and can function favorably as a base material of a medical adhesive tape. Moreover, even if the film base material is very thin, the medical pressure-sensitive adhesive tape of the present invention can be attached to the surface of a living body with good operability and without generating wrinkles.

B-2. Adhesive Layer As the adhesive constituting the first adhesive layer, any suitable adhesive can be adopted as long as it can be used by being attached to the surface of a living body. Specific examples of such pressure-sensitive adhesives include pressure sensitive pressure-sensitive adhesives such as natural rubber, synthetic rubber, acrylic, silicone, and hot melt. Acrylic pressure sensitive adhesive is preferred. This is because the transparency of the medical pressure-sensitive adhesive tape can be further increased and the irritation to the skin can be further suppressed. Among acrylic pressure-sensitive adhesives, an oily gel-like acrylic pressure-sensitive adhesive is particularly preferable. This is because it is hypoallergenic to scars and suture wounds as well as to skin with photosensitivity and photoallergy. Details of the oily gel-like acrylic pressure-sensitive adhesive are described in, for example, JP-A-6-319793, the description of which is incorporated herein by reference.

  The first pressure-sensitive adhesive layer may contain any appropriate transdermally absorbable drug as necessary. The medical pressure-sensitive adhesive tape in which the first pressure-sensitive adhesive layer contains a transdermally absorbable drug can be suitably used as a transdermally absorbable tape preparation. Examples of such transdermally absorbable drugs include corticosteroids, analgesics / anti-inflammatory agents, hypnotic sedatives, tranquilizers, antihypertensive agents, antihypertensive diuretics, antibiotics, anesthetics, antibacterial agents, antifungal agents, vitamins Drugs, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improving agents, antiemetics, antitumor agents, biopharmaceuticals, and the like, which can be absorbed through the skin. These transdermally absorbable drugs may be used alone or in combination of two or more.

  The content of the transdermally absorbable drug can be set to any appropriate content as required (for example, depending on the type of transdermally absorbable drug and the purpose of administration). The content of the transdermally absorbable drug is preferably 1% to 40% by weight, more preferably 3% to 30% by weight in the pressure-sensitive adhesive layer. Within such a range, the medical pressure-sensitive adhesive tape of the present invention can release a sufficient amount of drug effective for treatment.

  As the thickness of the first pressure-sensitive adhesive layer, any appropriate thickness can be adopted depending on the purpose and application. The thickness of the first pressure-sensitive adhesive layer is preferably 5 μm to 400 μm, more preferably 10 μm to 300 μm, and particularly preferably 30 μm to 200 μm. If the thickness of the said adhesive layer is such a range, since it is excellent in the adhesiveness to the biological body surface, the sticking and peeling of the affixed medical adhesive tape can be prevented favorably. Further, the end of the medical adhesive tape when the medical adhesive tape is applied for a long period of time can be prevented well.

  As the pressure-sensitive adhesive constituting the second pressure-sensitive adhesive layer, the same pressure-sensitive adhesive as the pressure-sensitive adhesive constituting the first pressure-sensitive adhesive layer can be used.

  As the thickness of the second pressure-sensitive adhesive layer, any appropriate thickness can be adopted depending on the purpose and application. The thickness of the first pressure-sensitive adhesive layer is preferably 5 μm to 100 μm, more preferably 10 μm to 70 μm, and particularly preferably 30 μm to 70 μm.

  Any appropriate method can be adopted as a method of providing the first pressure-sensitive adhesive layer and the second pressure-sensitive adhesive layer. Specific examples include a method of applying and drying the pressure-sensitive adhesive composition on the pressure-sensitive adhesive layer arrangement surface, and a method of transferring and laminating the pressure-sensitive adhesive layer formed into a predetermined shape on the pressure-sensitive adhesive layer arrangement surface. It is done.

B-3. Release liner Any appropriate release liner can be adopted as the release liner as long as it can be satisfactorily released from the pressure-sensitive adhesive layer used in the present invention. Typically, the release liner has a substrate and a release treatment layer formed on the surface of the substrate. Specific examples of the substrate include plastic films (for example, polyethylene, polypropylene, polyester, or laminated composites thereof) and paper (for example, fine paper, kraft paper, etc.). The release treatment layer can be formed by subjecting the substrate surface to a silicone resin treatment, a fluorine resin treatment, or the like. In the present invention, the release treatment layer is preferably formed on both surfaces of the substrate.

  The thickness of the release liner can be appropriately set according to the purpose. The thickness of the release liner is preferably 50 μm to 250 μm, more preferably 75 μm to 200 μm.

B-4. Support As the support, any appropriate material can be used as long as the effects of the present invention can be obtained. Specific examples of the material for the support include cotton, rayon, nylon, urethane, polyethylene, polypropylene, polyester, and pulp. With such a material, since it has moderate strength and flexibility, it is possible to obtain a medical pressure-sensitive adhesive tape having good shape retention and excellent followability to unevenness on the surface of a living body. More specific forms of the support include, for example, spunlace nonwoven fabric, spunbond nonwoven fabric, melt blown nonwoven fabric, urethane nonwoven fabric, urethane foam sheet, polyethylene foam sheet, polypropylene foam sheet, and mixed nonwoven fabric of pulp and acrylic ester. Can be mentioned. The support may have a single layer structure or a laminated structure of two or more layers. In the case of a laminated structure, each layer may be the same or different.

  The thickness of the support can be set to any appropriate thickness depending on the purpose. The thickness of the support is preferably 100 μm to 500 μm, more preferably 200 μm to 400 μm. If the thickness of the support is within such a range, a medical pressure-sensitive adhesive tape having an excellent balance between strength and flexibility, good shape retention, and excellent conformability to the surface of a living body. Can get

  The support preferably has a window portion, for example, as shown in FIG. If the said support body has a window part, it can affix, observing the fixed position of medical instruments, such as a catheter. As the shape and size of the window portion, any appropriate shape and size can be adopted as long as the fixing position of a medical instrument such as a catheter can be observed.

C. Specific Procedure for Affixing Medical Adhesive Tape FIG. 10 is a schematic diagram for explaining a specific application procedure for the medical adhesive tape 400 of the embodiment shown in FIG. 4. FIG. 11 is a schematic diagram for explaining a specific attaching procedure of the medical adhesive tape 900 of the embodiment shown in FIG. 9. The procedure for applying the medical adhesive of the present invention will be specifically described with these embodiments as representatives.

  In affixing the medical adhesive tape 400 of the present invention, (a) First, the first divided piece 431 of the release liner is peeled from the medical adhesive tape main body. At this time, if the first divided piece 431 has an extending portion, the first divided piece 431 can be used as a margin for grasping the extending portion (in the illustrated example, by grasping the extending portion 431b). It peels in the width direction (namely, the right direction of the paper surface of FIG. 10) of the adhesive tape 400 for use. Next, (b) a part of the first pressure-sensitive adhesive layer 420 exposed by peeling off the first divided piece 431 is attached to the living body surface 1. Thereafter, (c) the second divided piece 432 and the third divided piece 433 of the release liner are peeled from the medical adhesive tape main body. At this time, the second divided piece 432 and the third divided piece 433 of the release liner are folded portions 432a and 433a (in the case where an extended portion is provided in the folded portion as shown in FIG. 2, the extended portion). 432b and 433b) are peeled off in the width direction of the medical adhesive tape 400 (that is, the left and right direction of the paper surface of FIG. 10). (D) The adhesive layer 420 exposed by peeling the second divided piece 432 and the third divided piece 433 in this way is attached to the living body surface 1, and the medical pressure-sensitive adhesive tape main body (the film base material 410 and Attachment of the first pressure-sensitive adhesive layer 420 laminate is completed. Since the medical pressure-sensitive adhesive tape of the present invention can be applied to the medical pressure-sensitive adhesive tape body in a stepwise manner as described above, it is excellent in operability and can be applied to the surface of a living body without generating wrinkles.

  In affixing the medical adhesive tape 900 of the present invention, (a) First, the first divided piece 931 of the release liner is peeled from the medical adhesive tape main body. At this time, if the first divided piece 931 has an extending portion, the first divided piece 931 can use the extending portion to grasp the width direction of the medical adhesive tape 900 (that is, the paper surface of FIG. 11). To the right). Next, (b) a part of the first pressure-sensitive adhesive layer exposed by peeling off the first divided piece 931 (that is, a portion corresponding to the window portion 960 of the first pressure-sensitive adhesive layer, a second The portion not covered with the divided piece 932) is attached to the living body surface 1. Thereafter, (c) the second divided piece 932 of the release liner is peeled from the medical adhesive tape main body. At this time, the second divided piece 932 of the release liner has a folded portion 932a (or an extended portion when the folded portion is provided with an extended portion) as a margin for gripping the medical adhesive tape 900 in the width direction ( That is, it peels in the right direction of the paper surface of FIG. (D) The pressure-sensitive adhesive layer thus exposed by peeling off the second divided piece 932 (that is, the pressure-sensitive adhesive layer corresponding to the frame portion of the support 940 covered by the second divided piece 932) is a living body. Affixing to the surface 1 completes the affixing of the medical adhesive tape body. Although not shown, a part of the first divided piece 931 is peeled off from the medical pressure-sensitive adhesive tape body in the operation (a), and the first pressure-sensitive adhesive layer exposed in the operation (b) is removed from the living body surface. After being attached to 1, the entire first divided piece 931 and the second divided piece 932 may be peeled off in the operation (c).

D. Use The medical adhesive tape of this invention can be used for a film dressing, adhesive bandage, a transdermal absorption tape formulation, etc., for example.

  The medical pressure-sensitive adhesive tape of the present invention can be used as a bandage by providing a pad for protecting a wound portion on the surface of a living body on a part or all of the surface of the first pressure-sensitive adhesive layer on the release liner side. . As a material used for the pad, a material exhibiting liquid absorbency is preferable. Specific examples of the material used for the pad include gauze, liquid absorbent foam, cotton cloth, non-woven fabric, composite product of absorbent cotton and nonwoven fabric, composite product of absorbent cotton and knitted net, and the like.

  The medical pressure-sensitive adhesive tape of the present invention can be used as a percutaneous absorption tape agent by containing the first pressure-sensitive adhesive layer. Examples of the transdermally absorbable drug include the drugs described in Section B-2.

[Example 1]
1. Lamination of film base material and first pressure-sensitive adhesive layer A polyurethane film having a thickness of 30 μm was used as the film base material.
A pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer) made of an acrylic pressure-sensitive adhesive is provided on the surface of the film base so as to have a thickness of 30 μm to obtain a laminate 1 of the film base and the first pressure-sensitive adhesive layer. It was. The size of the laminate 1 was 80 mm × 80 mm.
2. Lamination of Support and Second Adhesive Layer A spunlace nonwoven fabric having a thickness of 300 μm was used as the support. The support was provided with 60 mm (width direction) × 70 mm (length direction) window portions at positions 10 mm from both ends in the width direction and 5 mm from both ends in the length direction, using a spring blade. A pressure-sensitive adhesive layer (second pressure-sensitive adhesive layer) made of an acrylic pressure-sensitive adhesive was provided on the surface of the support so as to have a thickness of 50 μm to obtain a laminate 2 of the support and the second pressure-sensitive adhesive layer. The size of the laminate 2 was 80 mm × 80 mm.
3. Laminate 1, Laminate 2 and Release Liner Bonding One side of a paper having a thickness of 100 μm was treated with a silicone resin to obtain a release liner. The obtained release liner was divided into a first divided piece and a second divided piece.
The size of the second divided piece was 150 mm (width direction) × 80 mm (length direction). The 2nd division | segmentation piece was affixed on the laminated body 1 so that one width direction edge part 70mm width | variety of the 1st adhesive layer of the said laminated body 1 might be covered, and the 80 mm folding | returning part was provided in the width direction ( That is, the extension part is 10 mm). At this time, the second divided piece was provided with a window portion so that the second divided piece did not cover the portion corresponding to the window portion of the first adhesive layer.
The size of the first divided piece was 100 mm (width direction) × 80 mm (length direction). The first divided piece covers a portion of the first pressure-sensitive adhesive layer that is not covered by the second divided piece (the other width direction end portion of the first pressure-sensitive adhesive layer having a width of 10 mm). Then, it was affixed to the laminate 1 and further provided with a 90 mm extension in the width direction. The extension portion was disposed so as to cover a portion corresponding to the second divided piece and the window portion of the first pressure-sensitive adhesive layer. At this time, the extension part of the 1st division piece extended 10 mm from the outside of the extension part of the 2nd division piece. In addition, the 1st division | segmentation piece was provided with the perforation in the position of 25 mm from the other width direction edge part of the 1st adhesive layer substantially parallel to the edge | side of the width direction edge part.
Next, the base film of the laminate 1 on which the release liner was attached as described above and the second pressure-sensitive adhesive layer of the laminate 2 were bonded together.
Thus, the medical adhesive tape which has a support body, a 2nd adhesive layer, a base film, a 1st adhesive layer, and a release liner (a 1st division piece, a 2nd division piece) in this order. Obtained.

[Example 2]
1. Lamination of film base material and pressure-sensitive adhesive layer A polyurethane film having a thickness of 30 μm was used as the film base material.
A pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer) made of an acrylic pressure-sensitive adhesive is provided on the surface of the film base so as to have a thickness of 30 μm to obtain a laminate 3 of the film base and the first pressure-sensitive adhesive layer. It was. The size of the laminate 3 was 80 mm × 80 mm.
2. Lamination of laminate 3 and release liner A silicone resin treatment was applied to one side of a 100 μm thick paper to obtain a release liner. The obtained release liner was divided into a first divided piece, a second divided piece, and a third divided piece.
The size of the second and third divided pieces was 50 mm (width direction) × 80 mm (length direction). The second divided piece was attached to the laminate 3 so as to cover one width direction end portion 25 mm of the pressure-sensitive adhesive layer of the laminate 3 and provided with a 25 mm folded portion in the width direction (that is, extended) No part was established). The third divided piece was affixed to the laminate 3 so as to cover the other widthwise end 25 mm of the pressure-sensitive adhesive layer of the laminate 3 and provided with a folded portion of 25 mm in the width direction (that is, extended) There was no exit.)
The size of the first divided piece was 30 mm (width direction) × 80 mm (length direction). The 1st division piece was affixed on the laminated body 3 so that the part which is not covered with the said 2nd division piece and 3rd division piece of an adhesive layer might be covered.
Thus, the medical adhesive tape provided with a film base material, an adhesive layer, and a release liner (a 1st division piece, a 2nd division piece, a 3rd division piece) in this order was obtained.

[Example 3]
The size of the second divided piece and the third divided piece is 55 mm (width direction) × 80 mm (length direction), and the folded portions of the second divided piece and the third divided piece are each 30 mm (ie, extended) A medical pressure-sensitive adhesive tape was obtained in the same manner as in Example 2 except that the part was 5 mm.

[Example 4]
The size of the second divided piece and the third divided piece is 55 mm (width direction) × 80 mm (length direction), and the folded portions of the second divided piece and the third divided piece are each 30 mm (that is, the extended portion) 5 mm), and the size of the first divided piece is 90 mm (width direction) × 80 mm (length direction), and an extension part having a width of 30 mm is provided on both sides in the width direction of the first divided piece. In the same manner as in Example 1, a medical pressure-sensitive adhesive tape was obtained. At this time, the extension part of the 1st division piece did not extend outside the extension part of the 2nd division piece and the 3rd division piece.

[Example 5]
The size of the second divided piece and the third divided piece is 55 mm (width direction) × 80 mm (length direction), and the folded portions of the second divided piece and the third divided piece are each 30 mm (that is, the extended portion) 5 mm), and the size of the first divided piece is 100 mm (width direction) × 80 mm (length direction), and an extension portion having a width of 35 mm is provided on both sides of the first divided piece in the width direction. In the same manner as in Example 1, a medical pressure-sensitive adhesive tape was obtained. At this time, the extending portion of the first divided piece extended outward by 5 mm from the extending portions of the second divided piece and the third divided piece.

[Comparative Example 1]
1. Lamination of film base material and pressure-sensitive adhesive layer A polyurethane film having a thickness of 30 μm was used as the film base material.
A pressure-sensitive adhesive layer made of an acrylic pressure-sensitive adhesive was provided on the surface of the film base so as to have a thickness of 30 μm to obtain a laminate 4 of the film base and the pressure-sensitive adhesive layer.
2. Lamination of laminate 4 and release liner A silicone resin treatment was applied to one side of a 100 μm thick paper to obtain a release liner. The release liner was bonded so as to cover the entire pressure-sensitive adhesive layer of the laminate 4 to obtain a medical pressure-sensitive adhesive tape of 80 mm (width direction) × 80 mm (length direction).

[Comparative Example 2]
Comparative Example, except that the release liner was divided into a first divided piece (40 mm (width direction) × 80 mm (length direction)) and a second divided piece (40 mm (width direction) × 80 mm (length direction)) In the same manner as in Example 1, a medical adhesive tape was obtained.

[Comparative Example 3]
The release liner is divided into a first divided piece (30 mm (width direction) × 80 mm (length direction)), a second divided piece (25 mm (width direction) × 80 mm (length direction)), and a third divided piece (25 mm). A medical pressure-sensitive adhesive tape was obtained in the same manner as in Comparative Example 1 except that (width direction) × 80 mm (length direction)).

<Evaluation method>
For the medical adhesive tape obtained above, Example 1 and Comparative Example 2 were in accordance with the procedure shown in FIG. 11, and Examples 2 to 5 and Comparative Example 3 were in accordance with the procedure shown in FIG. Is attached to a cylindrical plastic tube with a diameter of 76mm x length of 300mm by the procedure of attaching the medical adhesive tape body after peeling the release liner. It evaluated as follows. The evaluation results are shown in Table 1.
(1) Operability (i) At the time of peeling of the first divided pieces of Examples 1 to 5 and Comparative Examples 2 to 3 and at the time of peeling of the release liner of Comparative Example 1 (of (a) in FIGS. 10 and 11) Operation), (ii) after the first divided piece is peeled off, when the medical adhesive tape main body is temporarily folded (operation (b) in FIGS. 10 and 11), and (iii) the second divided piece and the third piece. The operability at the time of peeling of the divided pieces (operation (c) in FIGS. 10 and 11) was evaluated according to the following criteria.
◎: Good operability ○: No problem operability △: Slightly difficult to operate ×: Difficult to operate (2) Wrinkles and floats The condition after application of the medical adhesive tape was visually checked for the presence or absence of wrinkles and floats.

  When the second divided piece and the third divided piece have an extending portion (Examples 1 and 3 to 5), since the operation can be performed by grasping the extending portion, temporary fitting (ii) from the start of the pasting operation The series of operations up to were successfully performed.

  As shown in Examples 1 to 5, the medical adhesive tape of the present invention has a release liner peeling that is divided into three or two, and the second divided piece and the third divided piece have folded portions ( i) After the first divided piece is peeled off, (ii) a medical adhesive tape is applied to the surface of the living body, and then (iii) the second divided piece and the third divided piece are peeled off. The adhesive tape main body can be affixed to the surface of the living body, and as a result, the operations (i) to (iii) can be performed with good operability. Moreover, the medical adhesive tape of this invention can be affixed in the state in which wrinkles and floating were suppressed.

  The first divided piece is peeled off particularly well when the extending portion of the first divided piece extends to the outside of the second divided piece and the third divided piece (Examples 1 and 5). be able to.

  The peeling of the second divided piece and the third divided piece is performed when the extending portions of the second divided piece and the third divided piece extend to the outside of the base film (Examples 1 and 3 to 5). Can be performed particularly well.

  The medical pressure-sensitive adhesive tape of the present invention can be particularly suitably used for film dressing and bandages for protecting wounds on the surface of living bodies, film dressing for fixing medical devices such as catheters, and transdermal absorption tape preparations.

110, 210 Film base material 120, 220 First adhesive layer 130 Release liner 131, 231 First divided piece 132, 232 Second divided piece 233 Third divided piece 132a, 232a, 233a Folded portion 132b, 232b 233b, 331b, 332b Extension part 540, 640 Support body 550, 650 Second adhesive layer 560, 660 Window part

Claims (12)

A medical pressure-sensitive adhesive tape comprising a film substrate, a first pressure-sensitive adhesive layer, and a release liner that covers the first pressure-sensitive adhesive layer and is peeled and laminated in this order,
The release liner is divided into a first segment and a second segment;
The first divided piece is disposed at an end in the width direction on one side of the first pressure-sensitive adhesive layer so as to cover a part of the first pressure-sensitive adhesive layer,
The first divided piece has an extended portion of the first divided piece extending to the outside from the film base material in at least one of the width directions;
The second divided piece is arranged so as to cover a portion of the first pressure-sensitive adhesive layer that is not covered by the first divided piece,
Said second split pieces, have a folded portion extending toward the widthwise end portions,
The extending portion of the first divided piece extends to the outside from both ends in the width direction of the second divided piece.
Medical adhesive tape. A medical pressure-sensitive adhesive tape comprising a film substrate, a first pressure-sensitive adhesive layer, and a release liner that covers the first pressure-sensitive adhesive layer and is peeled and laminated in this order,
The release liner is divided into a first divided piece, a second divided piece, and a third divided piece,
The second divided piece is disposed at an end in the width direction on one side of the first pressure-sensitive adhesive layer so as to cover a part of the first pressure-sensitive adhesive layer,
The third divided piece is disposed at the widthwise end of the other side of the first pressure-sensitive adhesive layer so as to cover a part of the first pressure-sensitive adhesive layer,
The first divided piece covers the second divided piece and the third divided piece in the width direction so as to cover the second divided piece and the third divided piece of the first pressure-sensitive adhesive layer. Arranged between the third divided piece,
The first divided piece has an extended portion of the first divided piece extending to the outside from the film base material in at least one of the width directions,
Divided piece and the third divided piece of the said second, have a folded portion extending toward the widthwise end portions,
The extending part of the first divided piece extends to the outside in the width direction both ends of the second divided piece and / or the widthwise both ends of the third divided piece,
Medical adhesive tape. The medical pressure-sensitive adhesive tape according to claim 2, wherein the first divided piece further covers at least a part of the third divided piece. The medical adhesive tape according to any one of claims 1 to 3 , wherein the folded portion of the second divided piece has an extended portion of the second divided piece extending to the outside from the film base material.   The medical pressure-sensitive adhesive tape according to claim 2, wherein the folded portion of the third divided piece has an extended portion of the third divided piece extending to the outside from the film base material. The medical pressure-sensitive adhesive tape according to any one of claims 1 to 5, wherein the first divided piece further covers at least a part of the second divided piece. Further comprising a support and a second pressure-sensitive adhesive layer,
The support is disposed on the opposite side of the film substrate from the first pressure-sensitive adhesive layer;
The second pressure-sensitive adhesive layer is disposed between the support and the film substrate;
The medical adhesive tape in any one of Claim 1 to 6 . The medical adhesive tape according to claim 7 , wherein the support has a window portion. A support having a window and a second pressure-sensitive adhesive layer;
A support having the window is disposed between the film substrate and the first pressure-sensitive adhesive layer;
The second pressure-sensitive adhesive layer is disposed between the film substrate and the support having the window,
The medical adhesive tape in any one of Claim 1 to 6 . The film dressing produced using the medical adhesive tape in any one of Claim 1 to 9 . A bandage made using the medical adhesive tape according to any one of claims 1 to 9 . With medical adhesive tape according to any one of claims 1 to 9 were prepared, transdermal absorption tape preparation.

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