JPH04360834A - Keratotic reproduction inhibitor - Google Patents

Abstract

PURPOSE:To obtain a keratotic reproduction inhibitor capable of delaying production of keratotic plugs in contracted skin pores after removing the keratotic plugs, keeping also the reproduced keratotic plugs small and thereby making the skin pores inconspicuous. CONSTITUTION:A keratotic reproduction inhibitor is obtained by including 0.01-10wt.%, especially 0.1-5wt.% one or more compounds selected from tannic acid, zinc oxide, zinc sulfate, zinc chloride, potassium aluminum sulfate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum or allantoin dihydroxyaluminum as an active ingredient. The aforementioned inhibitor is capable of suppressing reproducition of keratotic plugs in temporarily contracted skin pores after removing the keratotic plugs and making the skin pores inconspicuous. Furthermore, the keratotic plugs can effectively be removed by employing a keratoric removing agent containing a polymeric compound having salt-forming groups such as carboxyl group, sulfonate group, sulfate group, phosphate residue, nitrate residue, amino group or ammonium group.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a keratotic plug regeneration inhibitor that inhibits the regeneration of keratotic plugs after removal of keratotic plugs from pores.

0002

[Prior Art and Problems to be Solved by the Invention] One of the most common skin concerns faced by women these days is the visibility of pores. This is largely due to the keratotic plugs that form in the pores. A keratin plug contains sebum and dirt, turns into a keratin, and becomes clogged in the pores, and if left untreated, it not only makes the pores more noticeable, but also causes various skin problems. Therefore, it is preferable to remove the keratotic plug from the viewpoint of beauty and skin health.

[0003] However, removing the keratotic plug only once is not sufficient. In other words, the pores after removing the keratin plug are
The size of the keratin plug temporarily decreases within 1 to 2 days after removal, but within 10 days to 2 weeks, the keratin plug regenerates and the pore returns to its original size.

[0004] On the other hand, lotions are available on the market that tighten pores and make them less noticeable, but they have almost no effect on preventing the regeneration of keratin plugs. Therefore, there has been a desire for an inhibitor of keratotic plug regeneration that can effectively suppress the regeneration of keratotic plugs.

[0005]

[Means for Solving the Problems] In view of the above-mentioned circumstances, the present inventor conducted intensive research and found that a keratotic plug regeneration inhibitor containing a certain amount of tannic acid etc. temporarily contracted after removal of the keratotic plug. The present invention was completed by discovering that the re-generation of keratin plugs in pores can be suppressed and the pores can be made less conspicuous.

[0006] That is, the present invention includes one or more selected from tannic acid, zinc oxide, zinc sulfate, zinc chloride, potassium aluminum sulfate, aluminum chlorohydroxy, aluminum allantoin chlorohydroxy, and aluminum aluminum allantoin dihydroxy. The present invention provides a characteristic keratotic plug regeneration inhibitor.

[0007] Tannic acid as used herein means m-galloyl gallic acid, which is obtained by hydrolysis of tannins extracted from plants. As such tannic acid, purified tannic acid may be used, but tannin hydrolyzate may also be used as it is. The amount of tannic acid etc. contained in the keratotic plug regeneration inhibitor of the present invention is 0.01 to 10% by weight.
(hereinafter simply indicated as "%"), but in particular 0.1 to
It is preferable to set it to 5%. If it is less than 0.01%, the effect of suppressing the regeneration of keratotic plugs will not be sufficient, and if it is used in excess of 10%, there will not be much difference in the effect, which is not preferable.

[0008] In addition to the above-mentioned essential ingredients, the keratotic plug regeneration inhibitor of the present invention may optionally contain ingredients used in ordinary cosmetics. These ingredients include water, ethanol,
Polyhydric alcohols, water-soluble polymers, salts, bases, acids, fragrances,
Pigments, preservatives, ultraviolet absorbers, metal chelating agents, oils,
Examples include surfactants, vitamins, skin-beautifying ingredients, bactericides, anti-inflammatory agents, viscosity modifiers, solubilizers, and the like.

The keratotic plug regeneration inhibitor of the present invention is produced by a conventional method, and its dosage form is not particularly limited, and may be liquid, paste, or
It can be in the form of powder, granules, solid, etc., but from the viewpoint of handling, it is preferably in the form of liquid or paste.

[0010] To use the keratotic plug regeneration inhibitor of the present invention,
First, you need to remove the keratin plugs that are clogging your pores. The means for removing keratotic plugs is not particularly limited, but they can be effectively removed by using a keratotic plug removing agent characterized by containing a polymer compound having a salt-forming group as described below. The salt-forming group of the polymer compound used here is not particularly limited as long as it forms a salt in the presence of an acid or base, and may be any anionic, cationic, or amphoteric group. good. Specific examples of such salt-forming groups include carboxyl groups, sulfonic acid residues, sulfuric acid residues, phosphoric acid residues, nitric acid residues, amino groups, and ammonium groups. Two or more types of these groups may be contained in one compound.

[0011]Although it is preferable for aesthetics that these polymer compounds be water-soluble, they may be cloudy.

Specific examples of such polymer compounds, natural or semi-synthetic, include mucopolysaccharides hyaluronic acid, sodium hyaluronate, and sodium chondroitin sulfate;
Hemicelluloses alginic acid, sodium alginate,
Examples include ammonium alginate, carboxymethylcellulose Na salt, and carboxymethylamylose.
Synthetic ones are more preferable, and examples of synthetic ones include those obtained by polymerizing one or more of the following monomers, or a combination of these monomers and other vinyl monomers such as (meth)acrylic acid ester and styrene. Examples include copolymers with common monomers and mixtures of these polymers.

Anionic: unsaturated carboxylic acid monomers such as acrylic acid (AA), methacrylic acid (MA), maleic acid, itaconic acid, or their anhydrides or salts thereof;
Unsaturated sulfonic acid monomers or salts thereof such as styrene sulfonic acid and 2-acrylamido-2-methylpropanesulfonic acid (AMPS); unsaturated phosphoric acid monomers such as vinylphosphonic acid and acid phosphoxyethyl (meth)acrylate.

Cationic: dimethylaminoethyl acrylate (DMAEA), dimethylaminoethyl methacrylate (DMAEMA), acrylamidepropyltrimethylammonium chloride (DMAPAAm)
(meth)acrylic acid esters or (meth)acrylamides having a dialkylamino group such as; styrenes having a dialkylamino group such as dimethylaminostyrene (DMASt) and dimethylaminomethylstyrene (DMAMSt); 4-vinylpyridine, 2 - Vinylpyridines such as vinylpyridine; or those quaternized using known quaternizing agents such as alkyl halides, benzyl halides, alkyl or arylsulfonic acids, or dialkyl sulfates.

Zwitterionic: N-(3-sulfopropyl)
-N-acryloyloxyethyl-N,N-dimethylammonium betaine, N-(3-sulfopropyl)-N
-methacryloylamidopropyl-N,N-dimethylammonium betaine, N-(3-carboxymethyl)-
N-methacryloylamidopropyl-N,N-dimethylammonium betaine, N-(3-sulfopropyl)-
N-methacryloyloxyethyl-N,N-dimethylammonium betaine, N-carboxymethyl-N-methacryloyloxyethyl-N,N-dimethylammonium betaine.

[0016] If the salt-forming groups of these polymer compounds are not ionized, existing acids such as hydrochloric acid,
Inorganic salts such as sulfuric acid; organic acids such as acetic acid, propionic acid, lactic acid, succinic acid, and glycolic acid; or bases, such as tertiary amines such as trimethylamine and triethylamine; neutralized with ammonia, sodium hydroxide, etc., and ionized. It is preferable to do so.

[0017] Furthermore, the molecular weight of these polymer compounds is
Those in the range of 10,000 to 1,500,000 are preferred, particularly 100,000 to 1,500,000.
One million is preferred. If the molecular weight is less than 10,000, the strength of the formed film will be insufficient, the tension on the skin will be weak, and it will be easy to tear when peeled off, while on the other hand, it will be difficult to produce a film with a molecular weight of more than 1,500,000.

The amount of the above-mentioned polymer compound used in this keratotic plug remover is preferably 0.01 to 70%, particularly 5 to 40%.

The above-mentioned synthetic polymer compound is used after being dissolved in a solvent, but the solvent is not particularly limited as long as it can stably dissolve the polymer compound and is safe for the skin, such as Examples include water, ethanol, isopropyl alcohol (IPA), and the like. The blending amount of this solvent may be appropriately determined depending on the polymer compound, optional components, and dosage form, but it is generally 30 to 99.99%, particularly 60 to 99.99%.
95% is preferred.

[0020] In addition to the pack agent, the dosage form of the keratotic plug remover is
It may be applied to cotton cloth, soft cloth, woven cloth such as Tetoron, nylon, or plastic sheet, and used as a poultice.

[0021] This keratotic plug remover can be produced in accordance with the manufacturing method of ordinary packs and poultices. Furthermore, the method for removing keratotic plugs using this keratotic plug remover may be the same as the method for using ordinary packs and poultices. That is, for example, in the case of a pack agent, it may be applied to the skin, dried and then peeled off.

[0022]

[Effects of the Invention] By using the keratotic plug regeneration inhibitor of the present invention, it is possible to delay the regeneration of keratotic plugs in the pores after removal of the keratotic plugs, and it is also possible to keep the regenerated keratotic plugs small. Therefore, pores can be made less noticeable.

[0023]

[Examples] The present invention will be explained in more detail below with reference to Examples, but the present invention is not limited thereto. Example 1 0.1 ml of a 20% aqueous solution of sodium p-styrene sulfonate/methacrylic acid (1/1) copolymer was applied almost uniformly to both sides of the nose of a total of six panelists, three men and three women, and dried. After exfoliation, the keratotic plug was removed. Next, 0.1 ml of a 1% aqueous tannic acid solution was applied to one side of each nose, and the other side was left blank. Tannic acid was applied twice a day, in the morning and at night, for 3 days.

[0024] Immediately after the removal of the keratotic plug and 3 days later, the area of the pore was measured using the following measuring method. The results are shown in Table 1. Measurement method for keratin plug formation rate: Determine the pore to be observed by comparing it with a clinical photograph taken in advance to measure the same pore, paste a 2 mm square frame, and measure the DSA at 200x magnification.
(Direct Skin Analyzer: manufactured by Kao Corporation). By image analysis of this DSA image, the number of pores from which keratin plugs have come out immediately after the keratin plug removal treatment and the number of pores where keratin plugs have regenerated after 3 days are measured, and the keratin plug generation rate is calculated using the following formula (1). I asked for In addition, 30 pores were measured on each side of each person, and the average value was taken for each individual and is shown in Table 1.

[0025]

[Math 1]

[0026]

[Table 1]

Example 2 Care agent after removal of keratotic plug (liquid type):

(%) Tannic acid

1.5 Sorbit

2.0 Glycerin

3
．． 0 Polyoxyethylene oleyl ether (20E
．． O. ) 1.0
ethanol

15.0 Fragrance

0.2
purified water

balance amount

Example 3
Care agent after removing keratotic plug (cream type):

Claims (1)

[Claims] [Claim 1] Containing one or more selected from tannic acid, zinc oxide, zinc sulfate, zinc chloride, potassium aluminum sulfate, aluminum chlorohydroxy, aluminum allantoin chlorhydroxy, and aluminum dihydroxy allantoin. Keratin plug regeneration inhibitor.