JPH0432806B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an aqueous composition containing octacosanol, and more particularly to an emulsifying or solubilizing composition of octacosanol that is extremely stable even under acidic conditions.

Octacosanol is a white solid with a melting point of 83°C that is found in trace amounts in wheat germ oil, apple peel, alpha alpha, etc. Octacosanol is a useful physiologically active substance that improves stamina and endurance, and is said to have a positive effect on the thyroid, sex hormones, muscles, heart, etc., and is used to effectively obtain kinetic energy during intense exercise and labor. It is used for purposes such as increasing physical strength and recovering from fatigue.

Octacosanol has been developed in a capsule form to make it easier for humans to ingest. It has long been desired to apply octacosanol as an emulsified or soluble product, but octacosanol has an extremely high melting point and is difficult to dissolve in most substances, making it difficult to obtain a stable emulsified or soluble product. It was hot.

The present inventors have conducted extensive research on methods for emulsifying and solubilizing octacosanol in order to make it easier to handle, and have discovered a method for obtaining an aqueous composition containing octacosanol that has extremely high emulsification and solubilization stability even under acidic conditions. I found it.

That is, the present invention is an octacosanol-containing aqueous composition characterized by emulsifying or solubilizing octacosanol in the presence of a polyglycerin fatty acid ester.

The octacosanol used in the present invention may be extracted from natural products such as wheat germ oil, sugarcane wax, beeswax, candelilla wax, carnauba wax, montan wax, or rice wax, or may be synthetically obtained. good. Whether the purity of octacosanol is high or low, there is no problem in its use. The content of octacosanol in the emulsified or solubilized product is preferably 40% by weight or less, and if it exceeds 40% by weight, it becomes pasty.

The fatty acid ester of polyglycerin is preferably a fatty acid ester of polyglycerin having an average degree of polymerization of 6 or more, and is used in an amount of 0.5 to 30% by weight. Average degree of polymerization 6
The fatty acids used in the above polyglycerin fatty acid esters include caprylic acid, capric acid, lauric acid, myristic acid, stearic acid, oleic acid,
Saturated and unsaturated fatty acids having 8 to 22 carbon atoms such as behenic acid are preferred. Polyglycerin fatty acid esters include mono, di, tri, tetra, penta,
Hexa, hepta, octa, and deca fatty acid esters are preferred.

In the emulsifying or solubilizing composition of the present invention, food emulsifiers such as lecithin, glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, etc. may be used alone or in combination of two or more. can. Further, as a stabilizer for the emulsified or solubilized composition, saponins such as Quillaja saponin, gum arabic, xanthan gum, tragacanth gum, guar gum, locust bean gum, etc. may be used alone or in combination of two or more. Furthermore, as a solubilizer for octacosanol, vegetable oils such as olive oil, soybean oil, rice bran oil, palm oil, safflower oil, and sesame oil, tocopherols, and the like may be used. The aqueous composition containing octacosanol obtained by the present invention has extremely high emulsification or solubilization, and is stably emulsified or solubilized even under acidic conditions of PH3. Furthermore, even when the octacosanol-containing aqueous composition obtained by the present invention is used in beverages, aqueous emulsified pharmaceuticals, etc., it is characterized by extremely high emulsification or solubilization stability.

Next, the present invention will be explained with reference to examples.

Example 1 A mixture of 1 g of octacosanol (Octacosanol-12: manufactured by Taiyo Kagaku Co., Ltd.) with a purity of 12% and 5 g of tocopherol with a purity of 90% heated to 80°C and uniformly dissolved was mixed with decaglycerin monolaurate 2
The mixture was added to 92 g of an aqueous solution containing g, and stirred and mixed in a homomixer at 80°C to obtain a homogeneous emulsion.

When this was diluted 100 and 500 times with water at pH 3.2, it was a stable emulsifying or solubilizing liquid.

Example 2 10 g of octacosanol with a purity of 15% [Octacosanol-15: manufactured by Taiyo Kagaku Co., Ltd.] and 10 g of safflower oil
The mixture was heated to 80°C and uniformly dissolved, and the mixture was added to 68g of an aqueous solution containing 12g of triacontaglycerin monopaltimate, and the mixture was stirred and mixed in a homomixer at 80°C to obtain a uniform emulsion.

When this was diluted 10,000 or 2,000 times with water at pH 3.5, it was a stable emulsifying or solubilizing liquid.

Example 3 2 g of octacosanol with a purity of 12% was heated to 85°C, and decaglycerin monomyristic acid ester 2
g, and 1 g of sucrose fatty acid ester (HLB=16) were added to 95 g of an aqueous solution containing 1 g of sucrose fatty acid ester (HLB=16), and stirred and mixed with a homomixer at 85° C. to obtain a homogeneous emulsion.

When this was diluted 100 or 500 times with water at pH 6.0, it was a stable emulsifying or solubilizing liquid.

Example 4 A mixture of 5 g of 12% pure octacosanol and 3 g of olive oil heated to 80°C and uniformly dissolved was mixed with 5 g of Quillaja saponin, 2 g of decaglycerin monolaurate, and 1 g of monocapric acid glyceride.
The mixture was added to 84 g of an aqueous solution containing the following, and stirred and mixed in a homomixer at 80°C to obtain a homogeneous emulsion.

When this was diluted 1,000 or 2,000 times with water at pH 5, it was a stable emulsifying or solubilizing liquid.

Comparative Example 1 A mixture of 1 g of octacosanol with a purity of 12% and 5 g of tocopherol with a purity of 90% heated to 80°C and uniformly dissolved was mixed with sucrose fatty acid ester (HLB=
16) It was added to 92 g of an aqueous solution containing 2 g and stirred and mixed in a homomixer at 80°C to obtain a homogeneous emulsion.

When this was diluted 100 or 500 times with water with a pH of 3.5, the emulsification broke immediately and a precipitate was formed.

Comparative Example 2 A mixture of 1 g of octacosanol with a purity of 12% and 5 g of tocopherol with a purity of 90% heated to 80°C and uniformly dissolved was added to 92 g of an aqueous solution containing 2 g of sorbitan monooleate and 0.g of gum arabic, and the mixture was heated at 80°C. The mixture was stirred and mixed using a homomixer to obtain a homogeneous emulsion.

When this was diluted 100 to 500 times with water at pH 3.5, the emulsification was partially broken and an oil film was formed on the upper layer.

Claims (1)

[Claims] 1. An octacosanol-containing aqueous composition characterized by emulsifying or solubilizing octacosanol in the presence of a polyglycerol fatty acid ester.