JPH04321627A - Method for preparing iodine-containing complex and iodine-containing complex - Google Patents

Abstract

PURPOSE:To provide the iodine-containing complex prevented in the dissipation of an iodine agent consisting main of iodine as an active ingredient in the atmosphere and improved in the handling property. CONSTITUTION:The preparation of the complex of iodine with a collagen is characterized by mixing an alkali triiodide solution with a collagen solution or by treating the collagen with an alkali triiodide solution.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing an iodine-containing composite which is particularly effective as a wound disinfectant, and to an iodine-containing composite.

0002

BACKGROUND OF THE INVENTION Iodine has an excellent bactericidal effect and is widely used as a bactericidal agent.

0003

[Problems to be Solved by the Invention] When using iodine as a disinfectant, solid iodine itself has too strong an effect and is difficult to handle. It is used as a liquid iodine agent such as potash solution). Typical examples are iodine tincture and Lugol's solution. Such iodine preparations are inconvenient to handle because they are in liquid form. In addition, by impregnating gauze etc., it becomes easy to handle and can be used as a wound covering or therapeutic agent, but since iodine has a high sublimation property, it dissipates into the air in a short period of time, so the specificity of the effect is limited. Moreover, it is necessary to soak gauze etc. with liquid iodine preparation each time. The present invention aims to solve the problems of the prior art described above and to provide an iodine agent with good sustainability and ease of handling.

0004

[Means for Solving the Problems] In order to achieve the above object, in the present invention, a collagen solution and an alkaline triiodide solution are mixed, or collagens are treated with an alkaline triiodide solution. An iodine-containing composite is produced by the method, and the iodine-containing composite containing collagen and alkali triiodide is used as an iodine agent.

Next, the present invention will be explained in more detail. Collagens refer to collagen, collagen derivatives (eg, gelatin), and thermally denatured products thereof (eg, thermally denatured collagen). What is alkali triiodide?KI3
It refers to a triiodide represented by the general formula MI3 (M is an alkali metal), and can be suitably produced by dissolving iodine in an aqueous solution of an alkali metal salt of hydrogen iodide such as an alkali iodide. . The alkaline triiodide solution contains iodine (I2) and MI in 100 ml.
0.001-200g and 0.001-100g respectively
, preferably. It is appropriate to use one containing 0.1 to 3 g, or 0.1 to 3 g.

[0006] If the concentration is too low, the iodine content in the obtained composite will be small and the effect will likely be insufficient.
Also, if the concentration is too high, the coloring will be strong and it will be difficult to handle.

[0007] As a solution of collagen, an aqueous solution using water as a solvent is suitable, but acetic acid,
More preferably, a dilute solution of an organic or mineral acid such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid is used. The concentration is 0.0
A suitable range is 0.01 to 10M, preferably 0.05 to 0.5M. In addition, the concentration of collagen is 0.01~
A suitable amount is 100 g/l, preferably 1 to 10 g/l.

In the method according to claim 1, the iodine-containing composite is produced by mixing a collagen solution and an alkaline triiodide solution. There is no particular limitation on the mixing method, and the alkali triiodide solution may be added while stirring the collagen solution, or the collagen solution may be added while stirring the alkali triiodide solution. Further, the collagen solution and the alkaline triiodide solution may be supplied to the mixing tank at the same time, or these solutions may be jetted from a nozzle and mixed.

By mixing the collagen solution and the alkaline triiodide solution in this way, the iodine-containing composite according to claim 3 can be obtained. Although the microstructure of the iodine-containing complex is not certain, it is presumed from the following experiments that iodine is strongly bound to collagen in some way to form a complex.

FIG. 1 is a graph showing changes over time in the absorption spectrum of a saturated solution of iodine (1×10 −3 M) measured with a spectrophotometer. In Figure 1, 220nm and 460n
The absorption seen near m is due to I2,
The absorption observed near 289 nm and 350 nm is due to I3- generated by hydrolysis of a part of I2. It can be seen that these absorptions decrease rapidly with time.

FIG. 2 is a graph showing the results of a similar experiment conducted using a solution in which collagen was dissolved at a rate of 0.5 g/l in the iodine aqueous solution used in the experiment of FIG. A comparison between FIG. 1 and FIG. 2 reveals that the rate of decrease in the absorption spectrum over time is significantly reduced by adding collagen.

In addition, in FIG. 2, 289 nm and 350 nm
It turns out that there is a very large I3-induced absorption in the vicinity of nm, and that the decrease in this absorption over time is extremely slow. Again I
The absorption spectrum due to I2 is lower than that in Figure 1, and by adding collagen,
It can be seen that has changed to I3-. From the above experiments, it is estimated that some kind of complex is formed between collagen and I3-, and the formation of this complex can significantly reduce the sublimation and dissipation of iodine. The effect of retaining iodine by collagen is particularly large when collagen is treated with alkali triiodide, and the complex obtained by the above method has a high iodine content and is extremely effective as a disinfectant for wounds. It turned out that.

The composite obtained by this method is in the form of agar, but if desired it can be rolled into a sheet and dried to be used as a wound dressing, or it can be used in the form of a dry powder. You can also do that. This powder can also be used as an iodine source that supplies iodine little by little. Although the above explanation was made with respect to collagen, it has been found that similar effects can be obtained by using collagen derivatives such as gelatin or heat-changeable products thereof.

In the second aspect of the invention, the iodine-containing composite is obtained by treating solid collagen with an alkaline triiodide solution. Solid collagen can be suitably produced by casting the collagen solution described above onto a substrate such as styrene shear. When using this method, a collagen film of uniform thickness can be obtained. It goes without saying that the substrate is not limited to a styrene petri dish. By treating the film with an alkali triiodide solution by pouring the solution or the like, an iodine-containing composite having the same effect as the invention described in claim 1 can be obtained. Since this composite is in the form of a film, it can be used as it is as a wound covering material after drying.

[0015]

[Operation] By mixing a collagen solution and an alkali triiodide solution, or by treating collagen with an alkali triiodide solution, an iodine-containing complex with high iodine retention is obtained.

[0016]

[Example] 0.00ml containing collagen at a rate of 5g/l.
A 1M acetic acid solution was cast into a styrene shear plate to produce a collagen film with a thickness of 6 μm. On this film, 25.4g/l and 16.0g of I2 and KI were added, respectively.
Pour a solution of potassium triiodide containing in the proportion of /l,
The mixture was left at room temperature for 5 minutes, washed, and dried to obtain a film-like iodine-containing composite. Even when this composite was left at room temperature for one week, the iodine content hardly changed and it could be suitably used as a wound dressing.

[0017]

[Effects of the Invention] Good iodine retention and handling properties.

[0018]

[Brief explanation of the drawing]

FIG. 1 is a graph showing changes over time in the absorption spectrum of iodine.

FIG. 2 is a graph showing changes over time in the absorption spectrum of iodine.

Claims (3)

[Claims] 1. A method for producing an iodine-containing composite, which comprises mixing a collagen solution and an alkaline triiodide solution. 2. A method for producing an iodine-containing composite, which comprises treating collagen with an alkaline triiodide solution. 3. An iodine-containing composite comprising collagen and alkali triiodide.