CN110934819A - Special nano-silver sol for gel and preparation method thereof - Google Patents
Special nano-silver sol for gel and preparation method thereof Download PDFInfo
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- CN110934819A CN110934819A CN202010029491.8A CN202010029491A CN110934819A CN 110934819 A CN110934819 A CN 110934819A CN 202010029491 A CN202010029491 A CN 202010029491A CN 110934819 A CN110934819 A CN 110934819A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The invention discloses a special nano-silver sol for gel and a preparation method thereof, wherein the special nano-silver sol for gel is prepared by the following steps: dissolving carbomer in deionized water, adding a proper amount of alkaline solution, and adjusting the pH value to be neutral to obtain a neutral carbomer solution with the mass concentration of 0.01-2 g/l; dissolving silver salt in deionized water to obtain silver salt water solution with mass concentration of 0.001-10 g/l; dissolving sodium borohydride in deionized water to obtain a sodium borohydride aqueous solution with the mass concentration of 0.001-1 g/l; and (3) mixing the neutral carbomer solution and the silver salt aqueous solution, uniformly stirring, and dripping the sodium borohydride aqueous solution until silver ions are completely reduced into nano silver particles under continuous stirring to obtain the nano silver sol special for gel. The nano-silver sol system has good stability, can be directly added into carbomer gel, and is convenient to popularize and apply in nano-silver antibacterial gel.
Description
Technical Field
The invention relates to the field of nano-silver sol, in particular to nano-silver sol special for gel and a preparation method thereof.
Background
The nano silver has strong bacteriostasis and sterilization effects and broad-spectrum antibacterial activity, and has incomparable antibacterial effect compared with the traditional inorganic antibacterial agent due to quantum effect, small-size effect and extremely large specific surface area. The nano silver antibacterial gel is widely applied to the clinical treatment of gynecological diseases and burn wounds. The nano silver antibacterial gel is generally prepared by adding a nano silver solution into a carbomer aqueous solution, and then adjusting the pH value to be neutral to obtain the antibacterial gel. The nano silver solution in the market is usually stable in respective stable systems due to the adoption of unique stable systems, but when the nano silver solution is added into carbomer gel, the stable system is changed or damaged, so that the nano silver particles are agglomerated, discolored and the like, and the stable and uniform nano silver antibacterial gel is not obtained easily. Therefore, aiming at the defects of compatibility and stability of the existing nano silver sol and carbomer gel, a gel special nano silver sol with good carbomer compatibility and a preparation method thereof need to be found so as to meet the processing requirement of nano silver antibacterial gel.
Disclosure of Invention
The invention mainly solves the technical problem of a special nano silver sol for gel and a preparation method thereof, improves the compatibility with carbomer gel, and increases the dispersion effect and stability.
In order to solve the technical problems, the invention adopts a technical scheme that: the special preparation method of the nano-silver sol special for the gel comprises the following steps:
(1) dissolving carbomer in deionized water, adding a proper amount of alkaline solution, and adjusting the pH value to be neutral to obtain a neutral carbomer solution with the mass concentration of 0.01-2 g/l;
(2) dissolving silver salt in deionized water to obtain silver salt water solution with mass concentration of 0.001-10 g/l; dissolving sodium borohydride in deionized water to obtain a sodium borohydride aqueous solution with the mass concentration of 0.001-1 g/l;
(3) and (3) mixing the neutral carbomer solution and the silver salt aqueous solution, uniformly stirring, and dripping the sodium borohydride aqueous solution until silver ions are completely reduced into nano silver particles under continuous stirring to obtain the nano silver sol special for gel.
In a preferred embodiment of the invention, the silver salt component is one or a mixture of silver nitrate and silver acetate.
In a preferred embodiment of the present invention, the alkaline solution is an ammonia solution, a diethanolamine solution or a triethanolamine solution.
In order to solve the technical problem, the invention adopts another technical scheme that: provides a special nano silver sol for gel, which is prepared by the preparation method of the special nano silver sol for gel.
The invention has the beneficial effects that: the nano silver sol special for gel and the preparation method thereof completely use carbomer as a dispersing agent, do not add any auxiliary dispersing agent, have good system stability, can be directly added into carbomer gel, and are convenient to popularize and apply in nano silver antibacterial gel.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
(1) weighing 0.1 carbomer, dissolving in 1l of deionized water, adding a proper amount of triethanolamine solution, and adjusting the pH value to be neutral to obtain a neutral carbomer solution with the mass concentration of 0.g/l;
(2) weighing 3.13g of silver nitrate and dissolving the silver nitrate in 1l of deionized water to obtain silver salt aqueous solution with the mass concentration of 3.13 g/l; dissolving sodium borohydride in deionized water to obtain a sodium borohydride aqueous solution with the mass concentration of 0.13 g/l;
(3) neutral carbomer solution and aqueous silver salt solution 1: 1, uniformly stirring, and dripping sodium borohydride aqueous solution until silver ions are completely reduced into nano silver particles under continuous stirring to obtain the special gel nano silver sol with the silver content of about 1000 mg/kg.
Mixing the nano-silver antibacterial gel with a mixture of 1: 5 percent of the silver-containing antibacterial carbomer gel is added into the carbomer gel with the solid content of 0.2 percent, so that the silver-containing antibacterial carbomer gel which is stable and uniformly dispersed can be obtained.
Example 2:
(1) weighing 0.1 carbomer, dissolving in 1l of deionized water, adding a proper amount of diethanolamine solution, and adjusting the pH value to be neutral to obtain a neutral carbomer solution with the mass concentration of 0.g/l;
(2) weighing 3.09g of silver acetate and dissolving the silver acetate in 1l of deionized water to obtain silver salt aqueous solution with the mass concentration of 3.09 g/l; dissolving sodium borohydride in deionized water to obtain a sodium borohydride aqueous solution with the mass concentration of 0.13 g/l;
(3) neutral carbomer solution and aqueous silver salt solution 1: 1, uniformly stirring, and dripping sodium borohydride aqueous solution until silver ions are completely reduced into nano silver particles under continuous stirring to obtain the special gel nano silver sol with the silver content of about 1000 mg/kg.
Mixing the nano-silver antibacterial gel with a mixture of 1: 5 percent of the silver-containing antibacterial carbomer gel is added into the carbomer gel with the solid content of 0.2 percent, so that the silver-containing antibacterial carbomer gel which is stable and uniformly dispersed can be obtained.
Claims (4)
1. The special nano silver sol for gel and the preparation method thereof are characterized by comprising the following steps:
(1) dissolving carbomer in deionized water, adding a proper amount of alkaline solution, and adjusting the pH value to be neutral to obtain a neutral carbomer solution with the mass concentration of 0.01-2 g/l;
(2) dissolving silver salt in deionized water to obtain silver salt water solution with mass concentration of 0.001-10 g/l;
(3) dissolving sodium borohydride in deionized water to obtain a sodium borohydride aqueous solution with the mass concentration of 0.001-1 g/l;
(4) mixing the neutral carbomer solution and the silver salt aqueous solution, and uniformly stirring;
(5) and (3) under the condition of continuously stirring, dropwise adding a sodium borohydride aqueous solution until silver ions are completely reduced into nano silver particles, thus obtaining the special nano silver sol for gel.
2. The nano silver sol special for gel and the preparation method thereof according to claim 1 are characterized in that: the silver salt component is one or a mixture of silver nitrate and silver acetate.
3. The nano silver sol special for gel and the preparation method thereof according to claim 1 are characterized in that: the alkaline solution is ammonia, diethanolamine or triethanolamine solution.
4. The special nano-silver sol for gel is characterized by being prepared by the preparation method of the special nano-silver sol for gel according to any one of claims 1 to 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019103152121 | 2019-04-18 | ||
| CN201910315212.1A CN109820817A (en) | 2019-04-18 | 2019-04-18 | A kind of gel special-purpose nanometer silver sol and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110934819A true CN110934819A (en) | 2020-03-31 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910315212.1A Withdrawn CN109820817A (en) | 2019-04-18 | 2019-04-18 | A kind of gel special-purpose nanometer silver sol and preparation method thereof |
| CN202010029491.8A Withdrawn CN110934819A (en) | 2019-04-18 | 2020-01-13 | Special nano-silver sol for gel and preparation method thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910315212.1A Withdrawn CN109820817A (en) | 2019-04-18 | 2019-04-18 | A kind of gel special-purpose nanometer silver sol and preparation method thereof |
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| CN (2) | CN109820817A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110625130B (en) * | 2019-10-11 | 2022-03-18 | 深圳埃米迦医药生物科技有限公司 | Eimeria silver, external gel of Eimeria silver, preparation method and application |
| CN114309581B (en) * | 2021-12-30 | 2022-08-30 | 山东大学 | Silver ion modified silver sol, preparation method thereof and application thereof in surface enhanced Raman spectroscopy quantitative detection of arsenic |
| CN115317513A (en) * | 2022-08-01 | 2022-11-11 | 宁波博雅格致健康科技有限公司 | Sterilization repair gel and preparation method and application thereof |
-
2019
- 2019-04-18 CN CN201910315212.1A patent/CN109820817A/en not_active Withdrawn
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2020
- 2020-01-13 CN CN202010029491.8A patent/CN110934819A/en not_active Withdrawn
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| CN109820817A (en) | 2019-05-31 |
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Application publication date: 20200331 |