JPH04309356A - Method for sterilizing aluminum cap or container - Google Patents
Method for sterilizing aluminum cap or containerInfo
- Publication number
- JPH04309356A JPH04309356A JP3103294A JP10329491A JPH04309356A JP H04309356 A JPH04309356 A JP H04309356A JP 3103294 A JP3103294 A JP 3103294A JP 10329491 A JP10329491 A JP 10329491A JP H04309356 A JPH04309356 A JP H04309356A
- Authority
- JP
- Japan
- Prior art keywords
- sterilization
- aluminum
- electron beam
- containers
- caps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 54
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229910052782 aluminium Inorganic materials 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000010894 electron beam technology Methods 0.000 claims abstract description 41
- 230000001678 irradiating effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 46
- 230000001133 acceleration Effects 0.000 abstract description 5
- 239000011096 corrugated fiberboard Substances 0.000 abstract 2
- 238000012360 testing method Methods 0.000 description 21
- 230000000694 effects Effects 0.000 description 8
- 239000007789 gas Substances 0.000 description 6
- 238000012790 confirmation Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 239000003566 sealing material Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 238000005273 aeration Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000002845 discoloration Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000004388 gamma ray sterilization Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000194103 Bacillus pumilus Species 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- GFEGEDUIIYDMOX-YHARCJFQSA-N Thiamine disulfide Chemical compound C=1N=C(C)N=C(N)C=1CN(C=O)C(/C)=C(CCO)/SSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N GFEGEDUIIYDMOX-YHARCJFQSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 239000002901 radioactive waste Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
【０００１】0001
【産業上の利用分野】本発明は、医薬品、飲料、食品等
に使用されるアルミニウム製蓋又は容器の滅菌方法に関
するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for sterilizing aluminum lids or containers used for pharmaceuticals, beverages, foods, etc.
【０００２】0002
【従来の技術及びその課題】従来、医薬品、飲料、食品
等に使用されるアルミニウム製蓋又は容器の滅菌方法に
は、エチレンオキサイドガス（以下「ＥＯＧ」と称する
）滅菌又はオゾン滅菌等のガス滅菌や、γ線滅菌、消毒
液浸漬滅菌及びオ−トクレ−ブ滅菌などがあった。[Prior art and its problems] Conventionally, methods for sterilizing aluminum lids or containers used for pharmaceuticals, beverages, foods, etc. include gas sterilization such as ethylene oxide gas (hereinafter referred to as "EOG") sterilization or ozone sterilization. There were other methods such as gamma ray sterilization, disinfectant immersion sterilization, and autoclave sterilization.
【０００３】上記従来のＥＯＧ滅菌やオゾン滅菌では、
用いたガスがアルミニウム製蓋又は容器内に僅かなりと
も残留することがあり、その毒性を回避することができ
ない点に課題があった。また、γ線滅菌に関しては、放
射線源の管理・維持が面倒であり、又線源の追加や廃棄
が必要であり、コスト高になる点等に課題があった。さ
らに、上記消毒液浸漬滅菌及びオ−トクレ−ブ滅菌では
、アルミニウム製蓋又は容器に変色・変質が生じる恐れ
があり、また、アルミニウム製蓋では通常シ−ル材が一
体となっているものが多いので該シ−ル材も変質する点
に課題があった。[0003] In the conventional EOG sterilization and ozone sterilization,
There is a problem in that the gas used may remain in the aluminum lid or container, even if only in a small amount, and its toxicity cannot be avoided. Furthermore, with respect to γ-ray sterilization, there are problems in that it is troublesome to manage and maintain the radiation source, and it is necessary to add and dispose of the radiation source, resulting in high costs. Furthermore, the above-mentioned disinfectant immersion sterilization and autoclave sterilization may cause discoloration or deterioration of the aluminum lid or container, and aluminum lids usually have an integrated sealing material. There was a problem in that the quality of the sealing material also deteriorated because of the large amount of oxidation.
【０００４】本発明は、上記従来技術の滅菌方法におけ
る上記の課題に鑑み、これを解消するためになされたも
のであり、確実に滅菌でき、また、内容成分に及ぼす影
響を防止乃至抑制すると共に、迅速に且つ低コストで滅
菌できるアルミニウム製蓋又は容器の滅菌方法を提供す
ることにある。The present invention has been made in view of the above-mentioned problems in the conventional sterilization methods, and has been made to solve these problems.It enables reliable sterilization, prevents or suppresses the influence on the contents, and An object of the present invention is to provide a method for sterilizing aluminum lids or containers that can be sterilized quickly and at low cost.
【０００５】[0005]
【課題を解決するための手段及び作用】本発明によれば
、アルミニウム製蓋又は容器に電子線を照射することを
特徴とする、アルミニウム製蓋又は容器の滅菌方法によ
り、上記の課題が解決されると共に、上記の目的が達成
される。すなわち、本発明方法を利用すればアルミニウ
ム製蓋又は容器に場合により付着している雑菌、微生物
等は電子線の照射により死滅し、照射された電子線は残
留せず、且つアルミニウム製蓋又は容器自体の物性面に
与える影響は少ないのである。[Means and effects for solving the problems] According to the present invention, the above problems are solved by a method for sterilizing an aluminum lid or container, which is characterized by irradiating the aluminum lid or container with an electron beam. At the same time, the above objectives are achieved. In other words, by using the method of the present invention, germs, microorganisms, etc. that may adhere to aluminum lids or containers are killed by electron beam irradiation, and the irradiated electron beams do not remain. It has little effect on its physical properties.
【０００６】本発明において用いるアルミニウム製蓋と
しては、例えば、ＰＰ（Ｐｉｌｆｅｒ Ｐｒｏｏｆ）キ
ャップと略称されるものが使用でき、該ＰＰキャップは
、その厚みが０．２０〜０．２６ｍｍであり、口径が２
２ｍｍ， ２８ｍｍ， ２９．３ｍｍとなっている。上
記ＰＰキャップ以外のアルミニウム製蓋でも、電子線の
照射線量及び照射時間を適宣調整することにより、その
種類・構造を問わず使用できるものである。また、上記
アルミニウム製蓋には、通常、密封性を向上させるため
に合成樹脂又は合成ゴム製等のシ−ル材が施されている
が、該シ−ル材が施されたアルミニウム製蓋であっても
よい。[0006] As the aluminum lid used in the present invention, for example, what is abbreviated as a PP (Pilfer Proof) cap can be used, and the PP cap has a thickness of 0.20 to 0.26 mm and a diameter of 2
They are 2mm, 28mm, and 29.3mm. Aluminum lids other than the above-mentioned PP caps can be used regardless of their type and structure by appropriately adjusting the electron beam irradiation dose and irradiation time. In addition, the aluminum lid mentioned above is usually coated with a sealing material made of synthetic resin or synthetic rubber to improve sealing performance. There may be.
【０００７】また、本発明において用いるアルミニウム
製容器としては、電子線の照射線量及び照射時間を適宣
調整することにより、その種類・構造を問わず使用でき
るものであり、例えば、スコア缶等に使用される上面開
放形の容器が使用でき、該容器は、通常、厚みが０．２
〜０．５ｍｍ、直径４０〜６５ｍｍ、高さ７０〜１６５
ｍｍとなっている。Furthermore, the aluminum container used in the present invention can be used regardless of its type or structure by appropriately adjusting the electron beam irradiation dose and irradiation time. For example, it can be used as a score can, etc. An open-top container can be used, which typically has a thickness of 0.2
~0.5mm, diameter 40-65mm, height 70-165
mm.
【０００８】本発明における電子線の照射は、電子線加
速装置によって行われる。該電子線加速装置としては、
高エネルギーの電子線をもたらすものであれば特に限定
されず、例えば、住友重機械工業（株）製のダイナミト
ロン（標章）が使用される。該電子線加速装置は、０．
５ＭｅＶ〜５ＭｅＶまで無段階に加速エネルギーを設定
でき、カートコンベアで搬送されてくる被処理物に対し
て上記エネルギーの電子線を照射するようになされてい
るものである。また、アルミニウム製蓋又は容器の滅菌
に最適な電子線の照射線量としては、５ｋＧｙ〜７５ｋ
Ｇｙが好ましい。７５ｋＧｙ以上を照射するとアルミニ
ウム表面のコーテイング材、塗料、シール材等に変化が
起こるので好ましくない。また、アルミニウム製蓋又は
容器に付着する雑菌、微生物等が少ない場合には、１ｋ
Ｇｙの照射でも滅菌が可能であるが、実際上は５ｋＧｙ
以上照射する必要があった。[0008] The electron beam irradiation in the present invention is performed by an electron beam accelerator. As the electron beam accelerator,
There is no particular limitation as long as it provides a high-energy electron beam, and for example, Dynamitron (trade mark) manufactured by Sumitomo Heavy Industries, Ltd. is used. The electron beam accelerator has an acceleration of 0.
The acceleration energy can be set steplessly from 5 MeV to 5 MeV, and the workpiece being transported by a cart conveyor is irradiated with an electron beam having the above energy. In addition, the optimum electron beam irradiation dose for sterilizing aluminum lids or containers is 5kGy to 75kGy.
Gy is preferred. Irradiation of 75 kGy or more is not preferable because it causes changes in the coating material, paint, sealing material, etc. on the aluminum surface. In addition, if there are few bacteria or microorganisms adhering to the aluminum lid or container, 1k
Sterilization is possible with Gy irradiation, but in practice 5kGy
It was necessary to irradiate more than that.
【０００９】[0009]
【実施例】次に、比較試験例としての実施例により本発
明を更に詳細に説明する。
比較試験例１
本発明による電子線滅菌アルミニウム製蓋と従来技術に
よるＥＯＧ滅菌アルミニウム製蓋とを使用して蓋の性能
及び内容成分に与える影響について試験した。[Example] Next, the present invention will be explained in more detail with reference to an example as a comparative test example. Comparative Test Example 1 An electron beam sterilized aluminum lid according to the present invention and an EOG sterilized aluminum lid according to the prior art were used to test the performance of the lid and the effect on contents.
【００１０】（１） 滅菌方法
■電子線滅菌
アルミニウム製蓋（ＰＰキャップ、口径２９．３ｍｍ，
厚み０．２６ｍｍ×１，４７０個）をダンボール箱に詰
め、電子線加速装置（ダイナミトロン−標章）で、電子
線の加速エネルギーを５ＭｅＶ×１０ｍＡに且つカート
コンベアの速度を１６ｍ／ｍｉｎに設定してダンボール
箱の外側から該箱内のＰＰキャツプに電子線を照射した
（先ず正置状態で１回パスさせ、次いで裏置状態になし
て１回パスさせた）。電子線の照射線量はダンボール箱
内の辺部のＰＰキャツプでは１１ｋＧｙであり、また、
ダンボール箱中心部のＰＰキャツプでは１８ｋＧｙであ
った。
■ＥＯＧ滅菌
ＥＯＧ２０％及び炭酸ガス８０％の混合ガスを調製し、
０．３５ｋｇ／ｃｍ２の圧力条件下に温度３５〜５０℃
で４．５〜５．０時間曝気してアルミニウム製蓋（ＰＰ
キャップ）を滅菌し、次いで、エアレーションを１５〜
２０分間に亘り３回行った。(1) Sterilization method ■ Electron beam sterilization aluminum lid (PP cap, diameter 29.3 mm,
Packed in a cardboard box (0.26 mm thick x 1,470 pieces), and set the electron beam acceleration energy to 5 MeV x 10 mA and the speed of the cart conveyor to 16 m/min using an electron beam accelerator (Dynamitron - mark). Then, an electron beam was irradiated from the outside of the cardboard box to the PP cap inside the box (first, one pass was made in the upright position, and then one pass was made in the upside down position). The electron beam irradiation dose was 11 kGy at the PP cap on the side of the cardboard box, and
The PP cap in the center of the cardboard box was 18 kGy. ■ EOG sterilization Prepare a gas mixture of 20% EOG and 80% carbon dioxide,
Temperature 35~50℃ under pressure condition of 0.35kg/cm2
After aeration for 4.5 to 5.0 hours, the aluminum lid (PP
sterilize the cap) and then aerate for 15~
This was done three times for 20 minutes.
【００１１】（２） 試験方法
上記夫々の滅菌方法における滅菌状態を確認するため下
記に記載の滅菌状態確認試験を行うと共に、上記滅菌方
法により得た電子線滅菌ＰＰキャップとＥＯＧ滅菌ＰＰ
キャップとを使用して下記に記載の内容成分試験及びＰ
Ｐキャップ性能試験を行った。(2) Test method In order to confirm the sterilization status in each of the above sterilization methods, the following sterilization status confirmation test was conducted, and the electron beam sterilized PP cap and EOG sterilized PP cap obtained by the above sterilization method were
The content component test and P
A P-cap performance test was conducted.
【００１２】■滅菌状態確認試験
ａ）電子線滅菌
ダンボ−ル箱内の辺部及び中心部のＰＰキャップにＢＩ
テストピ−ス（バチルス プミルス ”Ｂ．ｐｕｍ
ｉｌｕｓ” ＡＴＣＣ２７１４２， １０５ ｓｐ
ｏｒｅｓ／枚）をセットし上記電子線滅菌方法により滅
菌処理した後、培養テスト（ＢＩテストピ−スを試験管
に移し、恒温器内で７日間培養）した結果、すべて陰性
（無菌）であることを確認した。
ｂ）ＥＯＧ滅菌
上記ＥＯＧ滅菌方法により得たＥＯＧＰＰキャップをラ
ンダムに抜取り、無菌水にて洗浄した後、その洗浄水に
ついて日本薬局方・無菌試験法によりテストしたところ
、陰性（無菌）であることを確認した。■Sterilization status confirmation test a) BI on the PP caps on the sides and center of the electron beam sterilized cardboard box
Test piece (Bacillus pumilus “B. pum”)
illus” ATCC27142, 105 sp
ores/piece) and sterilized using the electron beam sterilization method described above, the results of a culture test (transferring the BI test piece to a test tube and culturing it in a thermostatic chamber for 7 days) must be negative (sterile). It was confirmed. b) EOG sterilization EOGPP caps obtained by the above EOG sterilization method were randomly extracted and washed with sterile water, and the washed water was tested according to the Japanese Pharmacopoeia sterility test method, and it was found to be negative (sterile). confirmed.
【００１３】■内容成分試験及びＰＰキャップ性能試験
上記夫々の滅菌方法により得た電子線滅菌キャップ及び
ＥＯＧ滅菌キャップを使用して夫々薬液（滋養強壮剤）
入りガラス瓶を製造した。即ち、薬液（レバンコンク）
をガラス瓶にボトリング後、上記夫々の滅菌ＰＰキャッ
プをガラス瓶に取り付けてパストライザ−処理（９７℃
、３５分）して滅菌した。次いで、上記夫々の薬液の内
容成分であるＴＤＳ、リボフラビン、塩酸ピリドキシン
、シアノコバラミン、総窒素、ｐＨ、外観性状について
調べると共に、当該夫々のＰＰキャップの開栓トルク圧
、液漏れ及び変色状態について調べた。結果は下記表１
に示されるとおりであった。■Content component test and PP cap performance test Using electron beam sterilized caps and EOG sterilized caps obtained by the above sterilization methods, medicinal solutions (nutrient tonics) were prepared.
A glass bottle was manufactured. Namely, drug solution (Levanconc)
After bottling into glass bottles, each of the above sterilized PP caps was attached to the glass bottles and pasteurized (97°C).
, 35 minutes) and sterilized. Next, the contents of each of the above medicinal solutions, such as TDS, riboflavin, pyridoxine hydrochloride, cyanocobalamin, total nitrogen, pH, and appearance properties were investigated, as well as the opening torque pressure, liquid leakage, and discoloration of each of the PP caps. . The results are shown in Table 1 below.
It was as shown in
【００１４】[0014]
【表１】[Table 1]
【００１５】■内容成分試験及び性能試験に関する考察
上記表１の結果から明らかなように、本発明による電子
線滅菌ＰＰキャップと従来技術によるＥＯＧ滅菌ＰＰキ
ャップとでは、両者とも内容成分において変化は見られ
ず、性能試験の液漏れテストでは本発明による電子線滅
菌ＰＰキャップの方が良い結果を示した。従って、本発
明によるアルミニウム製蓋の電子線滅菌方法は従来技術
によるＥＯＧ滅菌方法と同等以上の滅菌効果を有するこ
とが判明した。■Considerations regarding content component test and performance test As is clear from the results in Table 1 above, there was no change in the content components of both the electron beam sterilized PP cap according to the present invention and the EOG sterilized PP cap according to the prior art. However, the electron beam sterilized PP cap according to the present invention showed better results in the liquid leakage test of the performance test. Therefore, it has been found that the electron beam sterilization method for aluminum lids according to the present invention has a sterilization effect equal to or higher than that of the EOG sterilization method according to the prior art.
【００１６】比較試験例２
本発明による電子線滅菌アルミニウム製容器と従来技術
によるＥＯＧ滅菌アルミニウム製容器を使用して容器の
滅菌状態を確認する試験を行った。Comparative Test Example 2 A test was conducted to confirm the sterilization state of the containers using an electron beam sterilized aluminum container according to the present invention and an EOG sterilized aluminum container according to the prior art.
【００１７】（１） 滅菌方法
■電子線滅菌アルミニウム製容器
アルミニウム製容器（厚さ０．５ｍｍ、直径６５ｍｍ、
高さ１６５ｍｍ）をダンボール箱に詰め、電子線加速装
置（ダイナミトロン−標章）で、電子線の加速エネルギ
ーを５ＭｅＶ×１０ｍＡに且つカートコンベアの速度を
１１ｍ／ｍｉｎに設定してダンボール箱の外側から該箱
内のアルミニウム製容器に電子線を照射した（表裏各１
回パス）。電子線の照射線量は、ダンボール箱内の辺部
のアルミニウム製容器では２７．０ｋＧｙであり、また
、ダンボール箱中心部のアルミニウム製容器では１２．
０ｋＧｙであった。
■ＥＯＧ滅菌アルミニウム製容器
ＥＯＧ２０％及び炭酸ガス８０％の混合ガスを調製し、
０．３５ｋｇ／ｃｍ２の圧力条件下、温度３５〜５０℃
で４．５〜５．０時間曝気してアルミニウム製容器を滅
菌し、次いで、エアレーションを１５〜２０分間に亘り
３回行った。(1) Sterilization method ■ Electron beam sterilization aluminum container Aluminum container (thickness 0.5 mm, diameter 65 mm,
165 mm in height) in a cardboard box, and using an electron beam accelerator (Dynamitron - mark), set the acceleration energy of the electron beam to 5 MeV x 10 mA and the speed of the cart conveyor to 11 m/min, and set the outside of the cardboard box. An electron beam was irradiated onto the aluminum container inside the box (one each on the front and back).
times). The electron beam irradiation dose was 27.0 kGy for the aluminum container at the side of the cardboard box, and 12.0 kGy for the aluminum container at the center of the cardboard box.
It was 0kGy. ■ EOG sterilized aluminum container Prepare a mixed gas of 20% EOG and 80% carbon dioxide,
Under pressure condition of 0.35kg/cm2, temperature 35-50℃
The aluminum container was sterilized by aeration for 4.5 to 5.0 hours, and then aeration was performed three times for 15 to 20 minutes.
【００１８】（２） 試験方法
上記夫々の滅菌方法における滅菌状態を確認するため下
記に記載の滅菌状態確認試験を行った。
■滅菌状態確認試験
ａ） 電子線滅菌
ダンボ−ル箱を２箱用意し、各箱内の辺部及び中心部の
アルミニウム製容器にＢＩテストピ−ス（バチルス
プミルス ”Ｂ．ｐｕｍｉｌｕｓ” ＡＴＣＣ２７１
４２，１０５ ｓｐｏｒｅｓ／枚）をセットし上記電
子線滅菌方法により処理した後、該アルミニウム製容器
を培養テストした結果、下記表２に示すとおり、すべて
陰性（無菌）であることを確認した。
ｂ） ＥＯＧ滅菌
上記ＥＯＧ滅菌方法によりＥＯＧ滅菌したＥＯＧアルミ
ニウム製容器をランダムに抜取り、無菌水にて洗浄した
後、その洗浄水について日本薬局方・無菌試験法により
テストした結果、表２に示すとおり、すべて陰性（無菌
）であることを確認した。(2) Test method In order to confirm the sterilization state in each of the above-mentioned sterilization methods, the following sterilization state confirmation test was conducted. ■Sterilization status confirmation test a) Prepare two electron beam sterilized cardboard boxes, and place BI test pieces (Bacillus
Pumilus "B. pumilus" ATCC271
After setting 42,105 spores/piece and treating them by the above-mentioned electron beam sterilization method, the aluminum containers were subjected to a culture test, and as shown in Table 2 below, all were confirmed to be negative (sterile). b) EOG sterilization EOG aluminum containers that had been EOG sterilized using the above EOG sterilization method were randomly sampled, washed with sterile water, and the washed water was tested according to the Japanese Pharmacopoeia sterility test method, as shown in Table 2. All tests were confirmed to be negative (sterile).
【００１９】[0019]
【表２】[Table 2]
【００２０】■滅菌状態確認試験総合評価上記表２の結
果から明らかなように本発明によるアルミニウム製容器
の電子線滅菌方法は従来技術によるＥＯＧ滅菌方法と同
等の滅菌効果を有することが判明した。① Sterility Confirmation Test Comprehensive Evaluation As is clear from the results in Table 2 above, it was found that the electron beam sterilization method for aluminum containers according to the present invention has a sterilization effect equivalent to that of the EOG sterilization method according to the prior art.
【００２１】[0021]
【発明の効果】本発明方法によれば下記に記載の効果が
もたらされる。
（１） 本発明方法により電子線滅菌したアルミニウム
製蓋又は容器を用いた場合、放射線は残留しないので、
製品を高品質に維持できる。
（２） 本発明方法によれば、従来のＥＯＧ滅菌及びオ
ゾンガスによる滅菌方法と異なり残留物の毒性に関する
問題は生じない。
（３） 従来の加熱、薬液、アルコ−ル等による滅菌方
法では、アルミニウム製蓋又は容器に変色・変質が生じ
る恐れがあるが、本発明方法ではこれらを有効に回避す
ることができる。
（４） 本発明方法は、滅菌作用をもたらす本体である
電子線は電圧・電流の値を設定することにより管理でき
るため滅菌管理が容易であり、所要時間も従来のγ線滅
菌と比較しても遥かに短く、又γ線照射の場合には照射
域を設定するためのシ−ルド、線源の管理、放射性廃棄
物の処理等の種々の問題があるが、本発明が採用する電
子線照射の場合には照射域の安全管理だけで充分であり
、この点と短時間での大量処理を考え併せるとコスト的
にも有利となる。Effects of the Invention The method of the present invention provides the following effects. (1) When using an aluminum lid or container that has been sterilized with electron beams using the method of the present invention, no radiation remains;
Able to maintain high quality products. (2) According to the method of the present invention, unlike conventional EOG sterilization and ozone gas sterilization methods, problems regarding the toxicity of residues do not occur. (3) Conventional sterilization methods using heat, chemicals, alcohol, etc. may cause discoloration or deterioration of the aluminum lid or container, but the method of the present invention can effectively avoid these problems. (4) In the method of the present invention, sterilization is easy because the electron beam, which is the main body that brings about the sterilization effect, can be controlled by setting the voltage and current values, and the time required is also shorter than that of conventional gamma ray sterilization. In addition, in the case of gamma ray irradiation, there are various problems such as shielding for setting the irradiation area, management of the radiation source, and disposal of radioactive waste, but the electron beam adopted by the present invention In the case of irradiation, safety management of the irradiation area is sufficient, and when this point is combined with the ability to process a large amount in a short time, it becomes advantageous in terms of cost.
Claims (1)
照射することを特徴とする、アルミニウム製蓋又は容器
の滅菌方法。1. A method for sterilizing an aluminum lid or container, which comprises irradiating the aluminum lid or container with an electron beam.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3103294A JP2582002B2 (en) | 1991-04-09 | 1991-04-09 | Sterilization method of aluminum lid or container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3103294A JP2582002B2 (en) | 1991-04-09 | 1991-04-09 | Sterilization method of aluminum lid or container |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04309356A true JPH04309356A (en) | 1992-10-30 |
| JP2582002B2 JP2582002B2 (en) | 1997-02-19 |
Family
ID=14350261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3103294A Expired - Lifetime JP2582002B2 (en) | 1991-04-09 | 1991-04-09 | Sterilization method of aluminum lid or container |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2582002B2 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5915027A (en) * | 1982-07-05 | 1984-01-26 | 東洋製罐株式会社 | Method of sterilizing can vessel |
| JPS61226050A (en) * | 1985-03-29 | 1986-10-07 | エナジー・サイエンシーズ，インコーポレーテツド | Electron beam irradiation sterilizing method |
| JPS6365865A (en) * | 1986-09-05 | 1988-03-24 | エルソルプロダクツ株式会社 | Sterilization treatment of cosmetics |
| JPH0329662A (en) * | 1989-06-27 | 1991-02-07 | Osaka Prefecture | Sterilization method for feeding diet of experimental animals by high energy electron beam irradiation |
-
1991
- 1991-04-09 JP JP3103294A patent/JP2582002B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5915027A (en) * | 1982-07-05 | 1984-01-26 | 東洋製罐株式会社 | Method of sterilizing can vessel |
| JPS61226050A (en) * | 1985-03-29 | 1986-10-07 | エナジー・サイエンシーズ，インコーポレーテツド | Electron beam irradiation sterilizing method |
| JPS6365865A (en) * | 1986-09-05 | 1988-03-24 | エルソルプロダクツ株式会社 | Sterilization treatment of cosmetics |
| JPH0329662A (en) * | 1989-06-27 | 1991-02-07 | Osaka Prefecture | Sterilization method for feeding diet of experimental animals by high energy electron beam irradiation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2582002B2 (en) | 1997-02-19 |
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