JPH042984Y2 - - Google Patents

Description

[Detailed explanation of the invention] This invention is for the treatment of muscle pain, leumatis, neuralgia, etc.
Related to medical patches used for prevention, etc.

This project involves dissolving indomethacin, which is effective for muscle pain, etc., in a mixed solution of ethanol and polyethylene glycol and supporting it on the fiber layer, thereby gradually administering indomethacin transdermally and prolonging the duration of its medicinal effects. The aim is to enable effective administration.

To explain the embodiment of the present invention, the base material 1 is made of non-woven fabric, woven fabric, plastic film, aluminum foil laminated film, or other material and is formed into an appropriate shape. A patch layer 2 made of a rubber-based, vinyl ether-based, silicone-based or other adhesive is provided, and a fibrous layer 3 of woven fabric, non-woven fabric, fleece, sliver, or other material is formed in the central zone.
is provided with the patch layer on its periphery, and the fibrous layer is impregnated and supported with an indomethacin solution 4 of an appropriate concentration obtained by dissolving indomethacin in a mixed solvent of ethanol and polyethylene glycol, and this drug solution-containing A releasable coating 5 is provided on the upper surface of the fibrous layer with respect to the patch layer, and its peripheral portion is applied to the patch layer exposed to the outside of the fibrous layer.

The fibers constituting the above fiber layer include cotton, rayon, polyvinyl alcohol, polyester, and other fibers, but rayon and other water-absorbing fibers are suitable because of their excellent ability to retain drug solutions, and they are suitable for use with non-water-absorbing fibers such as synthetic fibers. By mixing, the release properties of the drug can be appropriately adjusted.

In this example, an adhesive layer is used as the patch layer outside the fiber layer, which is formed so that the releasable coating 5 can be stably attached temporarily and the patch can be stably held on the skin. In addition, as the base material, plastic films with appropriate flexibility and stretchability, plastic films laminated with aluminum foil, other films, nonwoven fabrics and other fabrics, processed paper, etc. can be used as appropriate, and peelable The coating 5 can also be made of the same material as the base material.

The illustrated patch 6 has a patch layer made of an acrylic adhesive with a thickness of about 40 μm formed on the top surface of a circular polypropylene film base material 1 with a diameter of about 50 mm, and a fiber layer 3 with a diameter of about 40 μm in the center. Approximately 40mm, thickness approximately 0.5
A rayon nonwoven fabric of 5 mm in diameter was placed on it, impregnated with 41 g of a 1% solution of indomethacin (a mixed solvent solution of polyethylene glycol 400 and ethanol in a ratio of 80:19), and a polyester film 5 was placed thereon. This patch was applied to the shaved back of a rabbit, and the concentration of indomethacin in the blood was measured over time. The results are as follows, indicating that the drug is appropriately absorbed through the skin.

Time elapsed after application Amount of drug in plasma 2 hours 400μg/ml 4 hours 300 〃 12 hours 100 〃 The patch formed as above is sold in an appropriate number, such as one or several, sealed with an impermeable material. It can be provided to

According to this proposal, the ethanol in which indomethacin is dissolved is located in a dispersed state between polyethylene glycol, which is difficult to dissolve compared to ethanol.
The solution in which indomethacin is dissolved does not volatilize from the fiber layer, and is stably retained in the fiber layer due to the appropriate viscosity of polyethylene glycol.

When this patch is applied to the skin, indomethacin is dissolved in ethanol and absorbed through the skin along with the ethanol, but this ethanol becomes dispersed between polyethylene glycol as described above. The transdermal dose of this ethanol is moderately regulated by polyethylene glycol, and it is gradually passed through the skin, so indomethacin can be administered in appropriate doses over a long period of time, maintaining its medicinal efficacy. It is possible,
It is extremely effective in the treatment and prevention of muscle pain, leumatis, neuralgia and other diseases. If the mixing ratio of ethanol and polyethylene glycol is changed, the degree of regulation of the above-mentioned dosage by polyethylene glycol will change, so the dosage per unit time, transdermal absorption rate, administration duration, etc. of indomethacin will be changed. can be done.

[Brief explanation of the drawing]

The drawings show an embodiment of the present invention, and FIG. 1 is a plan view;
FIG. 2 is a sectional view taken along the line -- in FIG. 1, and FIG. 3 is a plan view showing a modification. 1 is a substrate, 2 is a patch layer, 3 is a fiber layer, 4 is a drug solution, and 5 is a peelable coating.

Claims (1)

[Claims for Utility Model Registration] 1. Having a base material, forming an adhesive layer on at least the peripheral surface of the upper surface of the base material, and providing a fiber layer thereon,
A medical patch comprising: the fiber layer impregnated with a solution of indomethacin dissolved in a mixed solvent of polyethylene glycol and ethanol, and a peelable film covering applied over the fiber layer. 2 Polyethylene glycol 400 and ethanol
The medical patch according to claim 1, wherein the fiber layer is impregnated with a 1% solution of indomethacin made from a solvent mixed at a ratio of 80:19. 3. The medical patch according to claim 1 or 2, wherein the fiber layer is formed of a nonwoven fabric. 4 The above-mentioned fiber layer is formed by a mixture of water-absorbing fibers and non-water-absorbing fibers Utility model registration item 1~
The medical patch according to any of paragraph 3.