JPH042983Y2 - - Google Patents
Info
- Publication number
- JPH042983Y2 JPH042983Y2 JP1983048939U JP4893983U JPH042983Y2 JP H042983 Y2 JPH042983 Y2 JP H042983Y2 JP 1983048939 U JP1983048939 U JP 1983048939U JP 4893983 U JP4893983 U JP 4893983U JP H042983 Y2 JPH042983 Y2 JP H042983Y2
- Authority
- JP
- Japan
- Prior art keywords
- fiber
- water
- nitroglycerin
- absorbing
- fibers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000835 fiber Substances 0.000 claims description 48
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 18
- 239000000006 Nitroglycerin Substances 0.000 claims description 18
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 18
- 239000010410 layer Substances 0.000 claims description 14
- 239000012790 adhesive layer Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 239000002250 absorbent Substances 0.000 claims description 8
- -1 polyethylene Polymers 0.000 claims description 7
- 230000002745 absorbent Effects 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 229920000297 Rayon Polymers 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 239000002964 rayon Substances 0.000 claims description 4
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 239000011888 foil Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229920003002 synthetic resin Polymers 0.000 description 5
- 239000000057 synthetic resin Substances 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000002759 woven fabric Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000037374 absorbed through the skin Effects 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本案は狭心症、心不全、その他の心蔵疾患の治
療、予防等に使用する医療用貼付剤に関する。
従来ニトログリセリンは冠状血管拡張剤として
狭心症の発作其の他の心蔵疾患の治療や予防等に
用いられ、静脈注射、舌下錠、軟膏等として適時
に投与されているが、前二者は効果持続時間が短
い上静脈注射は有資格者でなければ施術できず、
又後者は使用上に多くの面倒がある等の欠点を有
する。皮膚等に貼付して経皮的に投与するものも
知られているが、一般に構造が複雑であつて、満
足の行くものが少い。
上記に鑑み考案者等は種々研究の結果、ニトロ
グリセリンの担持体として吸水性繊維と非吸水性
繊維で構成された繊維層がニトログリセリンの放
出速度を調節し得る性質を有することを発見し、
本案に到達したもので、本案は吸水性繊維と非吸
水性繊維との混合繊維で構成された繊維層を基材
の粘着剤塗布面に設け、これにニトログリセリン
の所要量を含浸させたもので、上記繊維層を構成
する吸水性繊維と非吸水性繊維の含有比率を変え
ることによつて、ニトログリセリンの効果持続時
間が適度に調節できて長時間の有効な使用ができ
ると共に必要時簡易に利用できるものである。
以下実施例について説明すると、合成樹脂フイ
ルム、金属箔積層合成樹脂フイルム等の材料で適
宜形状に形成された基材１の上面所要部にゴム
系、アクリル系、シリコーン系その他の粘着剤層
２を形成し、該基材の粘着剤層の在る面に、その
周面に前記粘着剤層を存して、吸水性繊維３１と
非吸水性繊維３２で構成された特殊組識の繊維層
３を設け、該繊維層には所定量のニトログリセリ
ン含有溶液４の所要量を含浸保持させている。こ
のニトログリセリン含有繊維層の上面には、前記
粘着剤層に対し剥離性を合成樹脂フイルム、金属
箔積層合成樹脂フイルム等の不透過性な被覆５
を、その周縁部を前記基材１の周面に露出してい
る粘着剤層に被着させて、ニトログリセリン含浸
繊維層を密封状に包被している。
繊維層を構成する吸水性繊維には、例えばビス
コースレーヨン、銅アンモニアレーヨン、ポリビ
ニルアルコール繊維、綿その他があり、又非吸水
性繊維には、例えばポリエステル系、ポリエチレ
ン系、ポリプロピレン系等の合成繊維がある。こ
れら両繊維の割合（重量）は吸水性繊維：非吸水
性繊維＝１：10〜10：１で、特に好ましくは１：
10〜12：10である。これら混合繊維は適宜形状の
不織布、織布、其の他の布帛、フリース、スライ
バー其の他に形成して使用できる。又吸水性繊維
と非吸水繊維で形成された不織布、織布その他の
布帛、フリース、スライバー等を前記の割合にな
るように組合せて形成してもよく、織布等は前記
別々に紡糸された糸を前記割合になるように組合
せて織成したものでもよい。
第１図に示した貼付剤６は、アルミニウム箔の
両面にポリエチレンフイルムを積層した直径約50
mmの基材１の周縁部に巾約５mmの環状のゴム系粘
着剤層２を形成し、その内側にポリエステル繊維
80％（重量）とレーヨン20％（重量）で構成され
た厚さ約0.5mm、径約40mmの不織布（重量約160
ｇ／m2）を置き、これにニトログリセリン２％含
有ポリエチレングリコール溶液0.5ｇを含浸させ、
アルミニウム箔積層ポリエチレンフイルムの被覆
５を前記基材の周縁部の粘着剤層に接着して密封
しニトログリセリン10mgを含有するものである。
この貼付剤は１箇若しくは２箇以上の適宜数
を、アルミニウム箔、アルミニウム箔積層ポリエ
チレンフイルム、合成樹脂フイルム等で形成され
た袋内に密封して市販に供することができる。な
お上記の貼付剤を体重約７Kgの雑犬に剪毛して貼
付し、該雑犬の血液中ニトログリセリンの濃度を
経時的に測定した結果は次表の如くであつた。
This application relates to a medical patch used for the treatment and prevention of angina, heart failure, and other cardiac diseases. Conventionally, nitroglycerin has been used as a coronary vasodilator for the treatment and prevention of angina pectoris attacks and other cardiac diseases, and has been administered in a timely manner as intravenous injections, sublingual tablets, ointments, etc. Supervenous injections, which have a short duration of effect, can only be performed by a qualified person.
Furthermore, the latter has drawbacks such as being troublesome in use. Some drugs are known that can be applied transdermally by applying them to the skin, but they generally have complex structures and are rarely satisfactory. In view of the above, the inventors conducted various studies and discovered that a fiber layer composed of water-absorbing fibers and non-water-absorbing fibers as a carrier for nitroglycerin has the property of being able to adjust the release rate of nitroglycerin.
The present idea is to provide a fiber layer composed of a mixed fiber of water-absorbent fibers and non-water-absorbent fibers on the adhesive-coated surface of the base material, and to impregnate this with the required amount of nitroglycerin. By changing the content ratio of water-absorbing fibers and non-water-absorbing fibers that make up the above-mentioned fiber layer, the duration of the effect of nitroglycerin can be appropriately adjusted, making it possible to use it effectively for a long time, and to easily use it when needed. It can be used for In the following, an example will be described. A rubber-based, acrylic-based, silicone-based, or other adhesive layer 2 is applied to a required portion of the upper surface of a base material 1 formed into an appropriate shape using a material such as a synthetic resin film or a metal foil laminated synthetic resin film. A fiber layer 3 having a special structure composed of water-absorbing fibers 31 and non-water-absorbing fibers 32, with the adhesive layer on the peripheral surface of the surface of the base material where the adhesive layer is present. is provided, and the fiber layer is impregnated with a required amount of a predetermined amount of nitroglycerin-containing solution 4. The upper surface of this nitroglycerin-containing fiber layer is coated with an impermeable coating 5 such as a synthetic resin film, a metal foil laminated synthetic resin film, etc., which has releasability to the adhesive layer.
The peripheral edge portion of the adhesive layer is adhered to the adhesive layer exposed on the circumferential surface of the base material 1, and the nitroglycerin-impregnated fiber layer is hermetically covered. Water absorbent fibers constituting the fiber layer include, for example, viscose rayon, copper ammonia rayon, polyvinyl alcohol fiber, cotton, etc., and non-water absorbent fibers include synthetic fibers such as polyester, polyethylene, and polypropylene. There is. The ratio (weight) of both these fibers is water absorbent fiber: non-water absorbent fiber = 1:10 to 10:1, particularly preferably 1:
10-12:10. These mixed fibers can be used in the form of nonwoven fabrics, woven fabrics, other fabrics, fleeces, slivers, and other forms of suitable shapes. Alternatively, non-woven fabrics, woven fabrics, other fabrics, fleeces, slivers, etc. made of water-absorbing fibers and non-water-absorbing fibers may be combined in the above-mentioned proportions, and woven fabrics, etc. may be formed by combining the above-mentioned separately spun fabrics, etc. It may be woven by combining threads in the above proportions. The patch 6 shown in Fig. 1 is made of aluminum foil with polyethylene film laminated on both sides and has a diameter of about 50 mm.
An annular rubber adhesive layer 2 with a width of about 5 mm is formed on the periphery of a base material 1 with a diameter of
Non-woven fabric approximately 0.5 mm thick and approximately 40 mm in diameter (weight approximately 160 mm) composed of 80% (by weight) and 20% (by weight) rayon.
g/m 2 ) and impregnated with 0.5 g of polyethylene glycol solution containing 2% nitroglycerin.
A coating 5 of aluminum foil laminated polyethylene film was adhered and sealed to the adhesive layer on the periphery of the base material, and contained 10 mg of nitroglycerin. One or more appropriate numbers of these patches can be sold commercially by sealing them in a bag made of aluminum foil, aluminum foil laminated polyethylene film, synthetic resin film, or the like. The above patch was applied to a mongrel dog weighing about 7 kg after shearing, and the concentration of nitroglycerin in the blood of the mongrel dog was measured over time. The results are shown in the following table.
【表】
本案は以上のような構成で、ニトログリセリン
を含浸させた繊維層の、吸水性繊維の含有比率を
高くして行くとニトログリセリンに対する保持作
用が高まつて、単位時間当りの放出量が少くな
り、放出時間が長くなるが、逆に非吸水性繊維の
含有比率を高くして行くとニトログリセリンに対
する保持作用が低くなつて、単位時間当りの放出
量が多くなり、放出時間が短くなるから、この吸
水性繊維と非吸水性繊維の含有比率を変化させる
ことによつて、ニトログリセリンの保持量、単位
時間当りの放出量及びその放出時間が容易に調節
でき、剥離性被覆をはがすだけで簡易に施用でき
ることと相俟つて適量のニトログリセリンを能率
よく皮膚から吸収させて症状発生に速応して治療
が迅速にできる。又施用中、頭痛等の副作用によ
り中断しなければならない場合には、皮膚から剥
がせば簡単に防止できるもので、狭心症等の心蔵
疾患の治療、予防に極めて有効なものである。[Table] The present invention has the above structure, and as the content ratio of water-absorbing fibers in the fiber layer impregnated with nitroglycerin increases, the retention effect on nitroglycerin increases, and the amount released per unit time increases. On the other hand, as the content ratio of non-water-absorbing fibers increases, the retention effect on nitroglycerin decreases, resulting in a larger release amount per unit time and a shorter release time. Therefore, by changing the content ratio of water-absorbing fibers and non-water-absorbing fibers, the amount of nitroglycerin retained, the amount released per unit time, and the release time can be easily adjusted, and the releasable coating can be peeled off. Coupled with the fact that it can be easily applied by itself, an appropriate amount of nitroglycerin can be efficiently absorbed through the skin, allowing prompt treatment in response to the onset of symptoms. In addition, if during application, it is necessary to discontinue use due to side effects such as headaches, this can be easily prevented by peeling it off the skin, making it extremely effective for the treatment and prevention of cardiac diseases such as angina pectoris.
図面は本案の実施例を示し、第１図は平面図、
第２図は第１図の−線拡大断面図、第３図は
変形例を示す平面図である。
１は基材、２は粘着剤層、３は繊維層、３１は
吸水性繊維、３２は非吸水性繊維、４はニトログ
リセリン含有液、５は剥離性被覆、６は医療用貼
付剤である。
The drawings show an embodiment of the present invention, and FIG. 1 is a plan view;
FIG. 2 is an enlarged sectional view taken along the line -- in FIG. 1, and FIG. 3 is a plan view showing a modification. 1 is a base material, 2 is an adhesive layer, 3 is a fiber layer, 31 is a water-absorbing fiber, 32 is a non-water-absorbing fiber, 4 is a nitroglycerin-containing liquid, 5 is a peelable coating, and 6 is a medical patch. .
Claims (1)
面部に粘着剤層を形成し、その上に繊維層を設
け、該繊維層にニトログリセリンを含浸させ、
この繊維層は上記ニトログリセリンの保持量及
び放出量を調節し得るよう吸水性繊維と非吸水
性繊維を１：10〜10：１の割合で含有してお
り、上記繊維層の上から剥離性フイルムの被覆
を覆着した医療用貼付剤。 ２ 上記吸水性繊維がレーヨンである実用新案登
録請求の範囲第１項に記載の医療用貼付剤。 ３ 上記非吸水性繊維がポリエステル系繊維、ポ
リエチレン繊維若しくはポリプロピレン繊維で
ある実用新案登録請求の範囲第１項に記載の医
療用貼付剤。 ４ 上記繊維層は吸水性繊維としてレーヨンを、
非吸水性繊維としてポリエステル繊維を１：４
の割合で含有している実用新案登録請求の範囲
第１項に記載の医療用貼付剤。[Claims for Utility Model Registration] 1. A product having a base material, an adhesive layer formed on at least the peripheral surface of the upper surface of the base material, a fiber layer provided thereon, and the fiber layer impregnated with nitroglycerin. let me,
This fiber layer contains water-absorbing fibers and non-water-absorbing fibers in a ratio of 1:10 to 10:1 in order to adjust the amount of nitroglycerin retained and released. A medical patch covered with a film coating. 2. The medical patch according to claim 1, wherein the water-absorbing fiber is rayon. 3. The medical patch according to claim 1, wherein the non-water-absorbing fiber is polyester fiber, polyethylene fiber, or polypropylene fiber. 4 The above fiber layer uses rayon as a water absorbent fiber,
1:4 polyester fiber as non-water absorbent fiber
The medical patch according to claim 1 of the utility model registration claim, which contains the following:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4893983U JPS59157431U (en) | 1983-04-04 | 1983-04-04 | medical patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4893983U JPS59157431U (en) | 1983-04-04 | 1983-04-04 | medical patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59157431U JPS59157431U (en) | 1984-10-22 |
| JPH042983Y2 true JPH042983Y2 (en) | 1992-01-31 |
Family
ID=30179457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4893983U Granted JPS59157431U (en) | 1983-04-04 | 1983-04-04 | medical patch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59157431U (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1272922A (en) * | 1986-06-03 | 1990-08-21 | Peter William Berry | Drug delivery device, its preparation and use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56100716A (en) * | 1980-01-16 | 1981-08-12 | Nitto Electric Ind Co Ltd | Drug administration member |
-
1983
- 1983-04-04 JP JP4893983U patent/JPS59157431U/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56100716A (en) * | 1980-01-16 | 1981-08-12 | Nitto Electric Ind Co Ltd | Drug administration member |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59157431U (en) | 1984-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5008110A (en) | Storage-stable transdermal patch | |
| EP0593746B1 (en) | Transdermal drug delivery system | |
| EP0451202B1 (en) | Application system for drug containing microemulsions | |
| US5846559A (en) | Skin patch for use in contact immunotherapy | |
| JP2585600B2 (en) | Drug release device, its manufacture and use | |
| KR950005865B1 (en) | Plaster | |
| FI79467B (en) | NYTT BANDAGE FOER ADMINISTRERING AV ETT CEILINGS. | |
| JP2004521085A (en) | Transdermal delivery system capable of titration | |
| JPH10511353A (en) | Transdermal delivery system using adhesive overlay and peelable seal disk | |
| EP0052660A1 (en) | Bandage containing attachment post | |
| NZ202758A (en) | Adhesive bandage:v-shaped recess in release sheet facilitates blister rupture | |
| SK278995B6 (en) | Method for producing transdermal therapeutic plaster | |
| US6086912A (en) | Topical drug delivery system | |
| US20070073210A1 (en) | Wound dressing and adhesive wound dressing comprising a vasoconstrictive ingredient, and processes for the production thereof | |
| JP3002772B2 (en) | Patch and its manufacturing method | |
| JPH042983Y2 (en) | ||
| JP2837337B2 (en) | Patch | |
| JPH06501857A (en) | double layer dressing | |
| US20010051182A1 (en) | Skin patch for use in contact immunotherapy | |
| JPH0248407Y2 (en) | ||
| JP2781016B2 (en) | Transdermal formulation | |
| JPH042984Y2 (en) | ||
| JP2540861B2 (en) | Poultice | |
| JP2511772Y2 (en) | Combination patch | |
| JPH0477419A (en) | Formulation for patching |