JPH0421621A - Beautifying cosmetic - Google Patents
Beautifying cosmeticInfo
- Publication number
- JPH0421621A JPH0421621A JP12777590A JP12777590A JPH0421621A JP H0421621 A JPH0421621 A JP H0421621A JP 12777590 A JP12777590 A JP 12777590A JP 12777590 A JP12777590 A JP 12777590A JP H0421621 A JPH0421621 A JP H0421621A
- Authority
- JP
- Japan
- Prior art keywords
- cosmetic
- acid
- present
- blended
- squaric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 15
- 239000002253 acid Substances 0.000 claims description 13
- 230000002087 whitening effect Effects 0.000 claims description 10
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 6
- 239000000049 pigment Substances 0.000 abstract description 5
- PWEBUXCTKOWPCW-UHFFFAOYSA-N squaric acid Chemical compound OC1=C(O)C(=O)C1=O PWEBUXCTKOWPCW-UHFFFAOYSA-N 0.000 abstract description 4
- 229960005070 ascorbic acid Drugs 0.000 abstract description 3
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 230000003405 preventing effect Effects 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 239000002211 L-ascorbic acid Substances 0.000 abstract description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 235000006708 antioxidants Nutrition 0.000 abstract description 2
- -1 antiseptic Substances 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000000975 dye Substances 0.000 abstract 2
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 102000003425 Tyrosinase Human genes 0.000 description 5
- 108060008724 Tyrosinase Proteins 0.000 description 5
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 2
- 229960004705 kojic acid Drugs 0.000 description 2
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、スクワリン酸を配合してなる皮膚安全性に優
れ、皮膚の色素沈着を予防する効果或いは治療する効果
を有する美白化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a whitening cosmetic containing squarinic acid, which is excellent in skin safety and has an effect of preventing or treating skin pigmentation.
〔従来の技術及び発明が解決しようとする課題〕日焼は
等にみられる皮膚の色素沈着は、皮膚内に存在するチロ
シンがチロシナーゼの作用によりメラニン色素となり、
このメラニンが過剰に生成することに起因するとされて
いる。この色素沈着を予防或いは治療することを目的と
し従来よりし一アスコルビン酸又はその誘導体、コウジ
酸又はその誘導体、ハイドロキノン等を配合してなる美
白化粧料が提案されている。[Prior art and problems to be solved by the invention] Skin pigmentation, which is seen in sunburns, is caused by tyrosine present in the skin becoming melanin pigment due to the action of tyrosinase.
It is believed that this is caused by excessive production of melanin. For the purpose of preventing or treating this pigmentation, whitening cosmetics containing monoascorbic acid or its derivatives, kojic acid or its derivatives, hydroquinone, etc. have been proposed.
しかしながら、Ｌ〜アスコルビン酸誘導体、コウジ酸又
はその誘導体等は保存安定性が不充分であるか、或いは
美白効果が充分に認められないものであったり、ハイド
ロキノンのように皮膚安全性上に問題が生しるものであ
って、全てを十分満足し得る美白化粧料を得ることは困
難であった。However, L~ascorbic acid derivatives, kojic acid, and its derivatives, etc., have insufficient storage stability, or do not have sufficient whitening effects, and like hydroquinone, have skin safety problems. It has been difficult to obtain a whitening cosmetic that satisfies all of the above requirements.
本発明者らは、上述の事情に鑑み鋭意研究した結果、ス
クワリン酸を配合してなる美白化粧料が、上記の目的を
達成することを見出だし、本発明を完成するに至った。As a result of intensive research in view of the above-mentioned circumstances, the present inventors have discovered that a whitening cosmetic containing squarinic acid achieves the above-mentioned object, and have completed the present invention.
即ち、本発明は、スクワリン酸を配合してなることを特
徴とする美白化粧料を提供するものである。That is, the present invention provides a whitening cosmetic characterized by containing squarinic acid.
本発明に用いられるスクワリン酸は公知の物質であって
、四員環構造を有する有機二塩基酸の非常に興味深い化
合物で、オキソカーボンと称する一連の化合物であり、
熱、光に対し安定である。Squaric acid used in the present invention is a known substance, and is a very interesting organic dibasic acid compound with a four-membered ring structure, and is a series of compounds called oxocarbons.
Stable against heat and light.
スクワリン酸に関する化学的性質等は下記の通りである
。The chemical properties of squarinic acid are as follows.
（１） 構造式：
％式％：
）ニ
スクワリン酸（Ｓｑｕａｒｉｃ ａｃｉｄ）（４）分子
式： Ｃ，Ｈ２Ｏ。(1) Structural formula: %Formula%: ) Nisqualic acid (4) Molecular formula: C, H2O.
（５）分子量： １１４．０６
（６）融点＝３００℃〈
本発明の化粧料中の上記スクワリン酸の配合量は０．０
００１〜１０．０重量％（以下、−ｔ％と略記する）が
好ましく、更に好ましくは０．００１〜３．０−１％で
ある。(5) Molecular weight: 114.06 (6) Melting point = 300°C <The amount of squarinic acid blended in the cosmetic of the present invention is 0.0
It is preferably from 0.001 to 10.0% by weight (hereinafter abbreviated as -t%), and more preferably from 0.001 to 3.0-1%.
本発明の美白化粧料の剤型は特に限定されるものではな
く、例えば、ローション状、乳液状、クリーム状、パウ
ダー状等々、任意の剤型を使用することができる。The dosage form of the whitening cosmetic of the present invention is not particularly limited, and any dosage form such as lotion, milky lotion, cream, powder, etc. can be used.
尚、本発明の美白化粧料にはスクワリン酸の他に、従来
の化粧料に用いられている色素、香料、防ｇ荊、界面活
性剤、顔料、抗酸化剤等を本発明の目的を達成する範囲
内で適宜配合することができる。In addition to squarinic acid, the whitening cosmetic of the present invention contains pigments, fragrances, anti-inflammatory agents, surfactants, pigments, antioxidants, etc. used in conventional cosmetics to achieve the purpose of the present invention. It can be blended as appropriate within the range.
次に、実験例により本発明の詳細な説明する。 Next, the present invention will be explained in detail using experimental examples.
実験例１（チロシナーゼ活性抑制試験）酵素チロシナー
ゼを使用し、チロシンより生成されるドーパ−クローム
による褐変化を肉眼観察することによりチロシナーゼ活
性抑制効果を判断した。Experimental Example 1 (Tyrosinase Activity Inhibition Test) Using the enzyme tyrosinase, the inhibitory effect on tyrosinase activity was determined by visually observing the browning caused by dopachrome produced from tyrosine.
試料０．９ｄ （本発明試料として３０■スクワリン酸
含有のもの、対照試料として３０■Ｌ−アスコルビン酸
含有のもの）を採取し、Ｌ−千ロシンｉ液（０，３■／
ｄ）１ｍ、マツクルへイン氏の緩衝’ａ （ｐＨ６，８
） ｌ−をそれぞれ加え、３７°Ｃ恒温槽水中で１０分
間予備保温した後、これらにチロシナーゼ溶液（１■／
、ｄ）を０．１１加えてよく撹拌し、３７°Ｃに保って
１５分間インキユヘートした後、褐変化を肉眼観察した
。A sample of 0.9 d (containing 30 μl of squarinic acid as a sample of the present invention, and a sample containing 30 μl of L-ascorbic acid as a control sample) was taken, and L-1000 rosine i solution (0.3 μl/ml) was collected.
d) 1 m, Matsukuruhan's buffer'a (pH 6,8
) was added to each, and after pre-incubation for 10 minutes in a 37°C constant temperature bath water, a tyrosinase solution (1 /
, d) was added in an amount of 0.11, stirred well, kept at 37°C, and incubated for 15 minutes, and then browning was observed with the naked eye.
その結果、スクワリン酸を使用したものについては、ド
ーパクロームによる褐変化は認められず、し−アスコル
ビン酸より強いメラニン色素形成抑制効果を示した。As a result, no browning caused by dopachrome was observed in the product using squarinic acid, and it showed a stronger melanin pigment formation inhibiting effect than ascorbic acid.
以下、実施例にて本発明を更に詳細に説明するが、本発
明はこれらの実施例に限定されるものではない。EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples.
実施例１ 下記処方により美白クリームを調製した。Example 1 A whitening cream was prepared according to the following formulation.
Ａ相：
モノステアリン酸グリセリル ５．０スクワラン
８．０
トリオクタン酸グリセリル ８．０セタノール
５．５
１．０
０．２
０．１
圓ｔχ
パラフィンワックス
メチルポリシロキサン
プロピルパラヘン
Ｂ相：
メチルパラヘン
■、３−ブチレングリコール
精製水
Ｃ相ニ
スクワリン酸
精製水
０．１
６．０
５４．０
０．１
１Ｏ１０
−Ｌχ
−ｔχ
上記Ａ相及びＢ相をそれぞれ８０’Ｃまで加温した後、
Ａ相にＢ相を加え乳化した。次いで放冷し、５０°Ｃ以
下でＣ相を加え、クリームを調製した。Phase A: Glyceryl monostearate 5.0 Squalane 8.0 Glyceryl trioctanoate 8.0 Setanol 5.5 1.0 0.2 0.1 Paraffin wax Methyl polysiloxane propyl parahen Phase B: Methyl parahen ■, 3 -Butylene glycol purified water Phase C Nisqualic acid purified water 0.1 6.0 54.0 0.1 1O10 -Lχ -tχ After heating the above A phase and B phase to 80'C, respectively,
Phase B was added to phase A and emulsified. Next, the mixture was allowed to cool, and phase C was added at a temperature below 50°C to prepare a cream.
Claims (1)
化粧料。1. A whitening cosmetic characterized by containing squarinic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12777590A JPH0421621A (en) | 1990-05-16 | 1990-05-16 | Beautifying cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12777590A JPH0421621A (en) | 1990-05-16 | 1990-05-16 | Beautifying cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0421621A true JPH0421621A (en) | 1992-01-24 |
Family
ID=14968386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12777590A Pending JPH0421621A (en) | 1990-05-16 | 1990-05-16 | Beautifying cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0421621A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012236995A (en) * | 2011-04-28 | 2012-12-06 | Kyushu Univ | Hydrogelling agent |
-
1990
- 1990-05-16 JP JP12777590A patent/JPH0421621A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012236995A (en) * | 2011-04-28 | 2012-12-06 | Kyushu Univ | Hydrogelling agent |
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