JPH0421602A - Sustained-release pheromone drug - Google Patents
Sustained-release pheromone drugInfo
- Publication number
- JPH0421602A JPH0421602A JP2123861A JP12386190A JPH0421602A JP H0421602 A JPH0421602 A JP H0421602A JP 2123861 A JP2123861 A JP 2123861A JP 12386190 A JP12386190 A JP 12386190A JP H0421602 A JPH0421602 A JP H0421602A
- Authority
- JP
- Japan
- Prior art keywords
- pheromone
- tio2
- release
- substance
- sustained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003016 pheromone Substances 0.000 title claims abstract description 41
- 238000013268 sustained release Methods 0.000 title claims description 15
- 239000012730 sustained-release form Substances 0.000 title claims description 15
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000126 substance Substances 0.000 claims abstract description 20
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims abstract description 9
- 239000005038 ethylene vinyl acetate Substances 0.000 claims abstract description 6
- 239000004698 Polyethylene Substances 0.000 claims abstract description 5
- 239000004408 titanium dioxide Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 abstract description 10
- 230000007423 decrease Effects 0.000 abstract description 9
- 238000007789 sealing Methods 0.000 abstract description 7
- 239000000843 powder Substances 0.000 abstract description 3
- 238000001125 extrusion Methods 0.000 abstract description 2
- 239000000314 lubricant Substances 0.000 abstract description 2
- -1 polyethylene Polymers 0.000 abstract 2
- 229920000573 polyethylene Polymers 0.000 abstract 2
- 238000012856 packing Methods 0.000 abstract 1
- 239000011369 resultant mixture Substances 0.000 abstract 1
- 239000003405 delayed action preparation Substances 0.000 description 5
- 210000005239 tubule Anatomy 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000002861 polymer material Substances 0.000 description 4
- YJINQJFQLQIYHX-PLNGDYQASA-N 11Z-Tetradecenyl acetate Chemical compound CC\C=C/CCCCCCCCCCOC(C)=O YJINQJFQLQIYHX-PLNGDYQASA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- AEPMMTRERWOSHG-HULFFUFUSA-N (1E,3E)-dodeca-1,3-dien-1-ol Chemical compound CCCCCCCC\C=C\C=C\O AEPMMTRERWOSHG-HULFFUFUSA-N 0.000 description 1
- CSWBSLXBXRFNST-MQQKCMAXSA-N (8e,10e)-dodeca-8,10-dien-1-ol Chemical compound C\C=C\C=C\CCCCCCCO CSWBSLXBXRFNST-MQQKCMAXSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000000877 Sex Attractant Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 239000010954 inorganic particle Substances 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、徐放性フェロモン製剤、とくには害虫の防除
に使用されるフェロモン物質を長期間−定の速度で徐々
に放出し得るフェロモン製剤に関するものである。Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a sustained-release pheromone preparation, particularly a pheromone preparation that can gradually release pheromone substances at a constant rate for a long period of time and is used for controlling pests. It is related to.
（従来の技術）
従来から徐放性製剤の内蔵するフェロモン物質を経時的
に安定に放出させる工夫が進められ、例えば昆虫の性フ
エロモンについては、その気化放出をコントロールした
容器中に一定量のフェロモン物質を封入した製剤が既に
実用化されている。(Prior art) Efforts have been made to stably release pheromone substances contained in sustained-release preparations over time. For example, for insect sex pheromones, a certain amount of pheromone is stored in a container whose vaporization and release are controlled. Preparations encapsulating substances have already been put into practical use.
本出願人は、高分子材料製の細管にフェロモン物質を内
蔵させた、この範ちゅうに属する管状の蒸気徐放体につ
いて、これまでに数多くの提案を行ってきた。（特開昭
５６−１４２２０２号、５７−９７０５号、＃−５０９
０１号、ｌｌ−７２９０４号、＃−１５６４０３号、５
９−２１６８０２号、６Ｏ−２１５Ｇ６７号、６ｌ−２
（１２６，４３号、 ６２−１９５３０３号、”−２２
３１０１号および＃−２５１１３０１号の各公報参照）
（発明が解決しようとする課題）
しかし、これらの管状の徐放性製剤において放出が進ん
で内蔵しているフェロモン量が減少することは、その構
造上管内に残るフェロモン部分の長さの減少、すなわち
放出に関与する部分の減少となることから放出速度が経
時的に漸減するという欠点があった。The present applicant has so far made numerous proposals regarding tubular sustained vapor release bodies belonging to this category, in which a pheromone substance is housed in a thin tube made of a polymeric material. (JP-A-56-142202, 57-9705, #-509
No. 01, No. ll-72904, No. #-156403, 5
9-216802, 6O-215G67, 6l-2
(No. 126, 43, No. 62-195303, “-22
3101 and #-2511301)
(Problem to be Solved by the Invention) However, the decrease in the amount of pheromone contained in these tubular sustained-release preparations due to the progress of release is due to the decrease in the length of the pheromone portion remaining in the tube due to their structure. That is, there is a drawback that the release rate gradually decreases over time because the portion involved in release decreases.
そこで、本出願人は高分子管内に糸を入れて放出が進ん
でもフェロモンの接触する部分の長さが変化しないよう
にした管状の徐放体（実開昭５７−５１５３３号公報）
や、高分子細管に隔壁を設けて幾つかの小部屋に分割し
、これらにフェロモンを充填することにより長平方向へ
のフェロモンの拡散を利用して放出に関与する部分が減
少するのを抑制した徐放体（特開昭６４−７５４０２号
公報）などの改良を行った。しかし、これらの徐放体は
製造に多くの手間を要するという問題があった。Therefore, the present applicant developed a tubular sustained-release body (Utility Model Application Publication No. 57-51533) in which a thread is inserted into a polymer tube so that the length of the part in contact with the pheromone does not change even as the release progresses.
Alternatively, a partition wall was installed in the polymer tubule to divide it into several small chambers, and by filling these with pheromone, the diffusion of the pheromone in the longitudinal direction was used to suppress the reduction of the part involved in release. Improvements were made to sustained-release products (Japanese Patent Application Laid-Open No. 64-75402). However, these sustained-release products have a problem in that they require a lot of effort to manufacture.
したがって、本発明の目的は、内蔵するフェロモン物質
を長期間一定の速度で徐々に放出することができると共
に、構造が簡単で生産性を阻害することのない管状の徐
放性フェロモン製剤を提供するにある。Therefore, an object of the present invention is to provide a tubular sustained-release pheromone preparation that is capable of gradually releasing internal pheromone substances at a constant rate over a long period of time, has a simple structure, and does not impede productivity. It is in.
（ＩＩ！題を解決するための手段）
本発明者等は、フェロモン透過性の高分子材料からなる
管状の徐放性フェロモン製剤において。(II! Means for Solving the Problem) The present inventors provide a tubular sustained-release pheromone preparation made of a pheromone-permeable polymer material.
フェロモン透過性の高分子材料中に無機粒子を配合する
と高分子鎖の絡み合いが緩みフェロモンに対する高分子
材料の透過性が改善されるのではないかと考えて、各種
無機質粉体の添加効果について鋭意研究を進めた結果、
二酸化チタンを０．１〜５重量％配合すれば、フェロモ
ンの放出速度の漸減が少なくなって長期間安定に維持さ
れること、また徐放体製造のための高分子細管の加工の
際に。We believe that adding inorganic particles to a pheromone-permeable polymer material loosens the entanglement of the polymer chains and improves the permeability of the polymer material to pheromones, so we conducted extensive research on the effects of adding various inorganic powders. As a result of proceeding with
If 0.1 to 5% by weight of titanium dioxide is added, the gradual decrease in the rate of pheromone release will be reduced and it will be maintained stably for a long period of time, and also during the processing of polymer tubules for producing sustained release products.
二酸化チタンが滑剤として働いて高分子鎖の動きを滑ら
かにするため従来と比べて加工性が著しく向上すること
を見出し、本発明を完成するに至ったものである。They discovered that titanium dioxide acts as a lubricant and smoothes the movement of polymer chains, resulting in significantly improved processability compared to conventional methods, leading to the completion of the present invention.
すなわち１本発明による徐放性フェロモン製剤は、０．
１〜５重量％の二酸化チタンを配合した、フェロモン物
質に対して不溶かつ透過性の高分子材料からなる管状容
器内に、フェロモン物質を充填してなるものとしたこと
を要旨とするものである５
二の徐放性フェロモン製剤はまた、高分子材料がポリエ
チレンまたはエチレン−酢酸ビニル共重合体であること
を好適とする。That is, the sustained release pheromone preparation according to the present invention has a 0.
The gist is that the pheromone substance is filled in a tubular container made of a polymeric material that is insoluble and permeable to the pheromone substance and contains 1 to 5% by weight of titanium dioxide. In the second sustained release pheromone preparation, it is also preferable that the polymeric material is polyethylene or ethylene-vinyl acetate copolymer.
以下１本発明の詳細な説明する。The present invention will be explained in detail below.
本発明において、高分子材料内に配合される二酸化チタ
ンはプラスチック、ゴム等の着色用顔料として一般によ
く知られている白色粉末状のものである。この二酸化チ
タンは無機顔料で、有機系の顔料や染料と異なり極性を
持つことがないので、フェロモンが高分子材料の壁を透
過する際に、フェロモンとの間で相互作用を起こして、
その放出速度を妨げたり、管状物の成形性に影響を及ぼ
す恐れがない。In the present invention, the titanium dioxide blended into the polymeric material is a white powder that is generally well known as a pigment for coloring plastics, rubber, etc. This titanium dioxide is an inorganic pigment, and unlike organic pigments and dyes, it does not have polarity, so it interacts with pheromones when they pass through the walls of polymeric materials.
There is no risk of interfering with the release rate or affecting the formability of the tubular article.
高分子材料内に配合される二酸化チタンの量は０．１〜
５重量％であることが好ましい。これが０．１重量％未
満ではその添加量が少なすぎて高分子鎖の絡み合いを充
分に弛緩させられないので放出速度の漸減の抑制が充分
でなく、また５重量％を超えると、却って高分子鎖の間
を目止めすることになって同様に放出速度の漸減を回避
できない。The amount of titanium dioxide blended into the polymer material is 0.1~
Preferably it is 5% by weight. If it is less than 0.1% by weight, the amount added is too small and the entanglement of polymer chains cannot be sufficiently relaxed, so that the gradual decrease in the release rate cannot be suppressed sufficiently, and if it exceeds 5% by weight, the polymer Similarly, a gradual decrease in the release rate cannot be avoided due to the sealing between the chains.
本発明に用いられる細管はポリエチレンあるいはエチレ
ン−酢酸ビニル共重合体であることが好ましく、安定剤
、可塑剤などと共に、必要量の二酸化チタンを混合し、
通常知られている押出成形法により管状に加工される。The thin tube used in the present invention is preferably made of polyethylene or ethylene-vinyl acetate copolymer, and a necessary amount of titanium dioxide is mixed with the stabilizer, plasticizer, etc.
It is processed into a tubular shape by a commonly known extrusion method.
この細管の大きさは徐放体が長期にわたる徐放性を確保
するように、細管が適度の放出表面積を確保し、かつ適
度のフェロモン物質の内蔵量となるようにするのが好ま
しく、平均内径は０．３〜ｌＯＩ、細管の肉厚は０．１
〜３ｍのものが用いられる。The size of this tubule is preferably such that the tubule has an appropriate release surface area and an appropriate amount of pheromone substance to ensure long-term sustained release properties, and the average inner diameter is 0.3 to lOI, and the wall thickness of the tubule is 0.1
A length of ~3m is used.
内径がこの範囲より細いものは細管の製造が著しく困難
であるほか、内部にフェロモン物質を充填しにくくなる
ため、実用性に乏しいものとなる。If the inner diameter is smaller than this range, it is extremely difficult to manufacture a thin tube, and it becomes difficult to fill the inside with a pheromone substance, making it impractical.
また、内径がこの範囲より大きいものは、通常フェロモ
ン物質の要求される気中濃度から考えて一年分以上のフ
ェロモンを収納できるが、対象とする作物の耕作期間等
を考慮すると、それほどの容量を必要としないし、また
コスト高となるので好ましくない。Also, those with an inner diameter larger than this range can normally store more than one year's worth of pheromone considering the required atmospheric concentration of pheromone substances, but considering the cultivation period of the target crop, etc. This is not desirable since it is not necessary and the cost is high.
肉厚はフェロモン物質の蒸発速度に大きく影響するので
、適切な肉厚のものが選ばれるが、一般には０．１閣よ
り薄いと成形が困難なため好ましくなく、３Ｉよりも厚
いものは経済的に無駄を招き実用的でない。The wall thickness has a large effect on the evaporation rate of the pheromone substance, so an appropriate wall thickness is selected, but in general, a wall thickness of less than 0.1 mm is undesirable because it is difficult to mold, and a wall thickness of 3 I or thicker is not economical. This results in waste and is not practical.
本発明に使用されるフェロモン物質は１種または２種以
上の混合物として使用されるが、必要に応じ酸化防止剤
、着色剤等を添加してもよい。The pheromone substances used in the present invention may be used alone or as a mixture of two or more, and antioxidants, colorants, etc. may be added as necessary.
（実施例）
以下、本発明の具体的態様を実施例および比較例により
説明するが、本発明はこの実施例に限定されるものでは
ない。(Examples) Hereinafter, specific aspects of the present invention will be explained using Examples and Comparative Examples, but the present invention is not limited to these Examples.
実施例 １゜
内径０ 、９＋＊ｍ、外径１ 、６ｍｍ、長さ２００ｍ
ｍの二酸化チタンが３％配合された高密度ポリエチレン
チューブに、７５ｍｇのＺ−１１−テトラデセニルアセ
テートを封入したデイスペンサーを、３０℃、０．５ｍ
／ｓｅｅの空気流速中に懸吊し、Ｚ−１１−テトラデセ
ニルアセテートの放出速度を測定したところ、第１図に
実線で示す結果が得られた。Example 1゜Inner diameter 0, 9+*m, Outer diameter 1, 6mm, Length 200m
A dispenser containing 75 mg of Z-11-tetradecenyl acetate was placed in a high-density polyethylene tube containing 3% titanium dioxide at 30°C for 0.5 m.
The release rate of Z-11-tetradecenyl acetate was measured by suspending the sample in an air flow rate of /see, and the results shown by the solid line in FIG. 1 were obtained.
比較例 １゜
前例で用いたのと同じ寸法で二酸化チタンが含有されて
いないチューブに、７５ＨのＺ−１１−テトラデセニル
アセテートを封入し、前例と同様に放出速度を測定した
結果を、第１図に点線で示した。Comparative Example 1゜75H Z-11-tetradecenyl acetate was sealed in a tube with the same dimensions as used in the previous example but did not contain titanium dioxide, and the release rate was measured in the same manner as in the previous example. It is shown in FIG. 1 by a dotted line.
これとの比較より、前例におけるデイスペンサーの放出
速度がより均一に制御されていることがわかる。A comparison with this shows that the release rate of the dispenser in the previous example is more uniformly controlled.
実施例 ２゜
内径０ 、６ｍｎ＋、外径１ 、３ｍｍの二酸化チタン
を４．５％含有するエチレン−酢酸ビニル共重合体製の
チューブに、Ｅ、Ｅ−８，１０−ドデカジエノールを注
入した後、５０ｍ間隔で公知のシール機を用いてシール
し、その部分を切断することにより、連続的に長さ５０
１ｍの徐放体を製造した。この徐放体１００個を４０℃
で一昼夜放置した後、シール部よりのＥ、Ｅ−８，１０
−ドデカジエノールの洩れを調べたところ、一つも洩れ
がなく、公知のシール機で連続的に生産できることがわ
かった。Example 2 E,E-8,10-dodecadienol was injected into a tube made of ethylene-vinyl acetate copolymer containing 4.5% titanium dioxide and having an inner diameter of 0.6 mm+ and an outer diameter of 1.3 mm. After that, sealing is performed using a known sealing machine at intervals of 50 m, and the parts are cut to continuously form 50 m long pieces.
A 1 m sustained release body was manufactured. 40°C
After leaving it for a day and night, E, E-8, 10 from the seal part
- When the leakage of dodecadienol was investigated, it was found that there was no leakage, and that it could be continuously produced using a known sealing machine.
比較例 ２゜
実施例２と同じ寸法で二酸化チタンを含有しないエチレ
ン−酢酸ビニル共重合体製のチューブを用いて実施例２
と同様の試験を行った。その結果１００個中１ｚ個の製
剤に フェロモンの洩れが認められ、前例に比較して大
きく劣る結果となった。Comparative Example 2゜Example 2 was prepared using a tube made of ethylene-vinyl acetate copolymer that had the same dimensions as Example 2 and did not contain titanium dioxide.
A similar test was conducted. As a result, pheromone leakage was observed in 1z preparations out of 100, which was significantly inferior to the previous results.
（発明の効果）
本発明による徐放性製剤は、従来の管状徐放体と比べて
放出速度の漸減が緩やかで、より長期にわたって安定的
な放出が行われる。また徐放性製剤へのフェロモン物質
の封入に際して、一般に広く用いられているヒートシー
ル、インパルスシール等が利用でき、その加工性も従来
の管状徐放体に比へて著しく向上する。(Effects of the Invention) The sustained-release preparation according to the present invention has a slower gradual decrease in release rate and stable release over a longer period of time than conventional tubular sustained-release preparations. In addition, when encapsulating the pheromone substance in a sustained release preparation, widely used heat seals, impulse seals, etc. can be used, and the processability thereof is significantly improved compared to conventional tubular sustained release materials.
第１図は実施例１（実線）および比較例１（点線）にお
けるデイスペンサーの特性を、残存フェロモン量（＋ａ
ｇ、横軸）と放出速度（ｍｇ ／日、縦軸）との関係で
示したグラフである。
第
目
図
（ｍ９／日）
○
ケ友イ引フェロモレ量（ｍｇ）Figure 1 shows the characteristics of the dispenser in Example 1 (solid line) and Comparative Example 1 (dotted line), and the residual pheromone amount (+a
This is a graph showing the relationship between the release rate (mg, horizontal axis) and the release rate (mg/day, vertical axis). Table of Contents (m9/day) ○ Amount of ferro-mole (mg)
Claims (1)
ロモン物質に対して不溶かつ透過性の高分子材料からな
る管状容器内に、フェロモン物質を充填してなる徐放性
フェロモン製剤。 ２、高分子材料が、ポリエチレンまたはエチレン−酢酸
ビニル共重合体からなる請求項１記載の徐放性フェロモ
ン製剤。1. A sustained-release pheromone preparation comprising a pheromone substance filled in a tubular container made of a polymeric material insoluble and permeable to the pheromone substance and containing 0.1 to 5% by weight of titanium dioxide. 2. The sustained release pheromone preparation according to claim 1, wherein the polymeric material comprises polyethylene or ethylene-vinyl acetate copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2123861A JPH0421602A (en) | 1990-05-14 | 1990-05-14 | Sustained-release pheromone drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2123861A JPH0421602A (en) | 1990-05-14 | 1990-05-14 | Sustained-release pheromone drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0421602A true JPH0421602A (en) | 1992-01-24 |
Family
ID=14871206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2123861A Pending JPH0421602A (en) | 1990-05-14 | 1990-05-14 | Sustained-release pheromone drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0421602A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007129769A1 (en) | 2006-05-09 | 2007-11-15 | Mitsubishi Gas Chemical Company, Inc. | Process for hydrogen peroxide production including step for regeneration of working solution |
| EP2042235A1 (en) | 2007-07-11 | 2009-04-01 | Mitsubishi Gas Chemical Company, Inc. | Method for producing regeneration catalyst for working solution usable for hydrogen peroxide production |
| JP2011225483A (en) * | 2010-04-20 | 2011-11-10 | Shin-Etsu Chemical Co Ltd | Sustained release sex pheromone preparation using sex pheromone derivative and insect pest repelling method |
-
1990
- 1990-05-14 JP JP2123861A patent/JPH0421602A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007129769A1 (en) | 2006-05-09 | 2007-11-15 | Mitsubishi Gas Chemical Company, Inc. | Process for hydrogen peroxide production including step for regeneration of working solution |
| EP2042235A1 (en) | 2007-07-11 | 2009-04-01 | Mitsubishi Gas Chemical Company, Inc. | Method for producing regeneration catalyst for working solution usable for hydrogen peroxide production |
| JP2011225483A (en) * | 2010-04-20 | 2011-11-10 | Shin-Etsu Chemical Co Ltd | Sustained release sex pheromone preparation using sex pheromone derivative and insect pest repelling method |
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