JPH04169528A - Spray-dried biotin medicine and preparation thereof - Google Patents
Spray-dried biotin medicine and preparation thereofInfo
- Publication number
- JPH04169528A JPH04169528A JP29786390A JP29786390A JPH04169528A JP H04169528 A JPH04169528 A JP H04169528A JP 29786390 A JP29786390 A JP 29786390A JP 29786390 A JP29786390 A JP 29786390A JP H04169528 A JPH04169528 A JP H04169528A
- Authority
- JP
- Japan
- Prior art keywords
- biotin
- lactose
- spray
- preparation
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title claims abstract description 110
- 229960002685 biotin Drugs 0.000 title claims abstract description 55
- 235000020958 biotin Nutrition 0.000 title claims abstract description 55
- 239000011616 biotin Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 239000003814 drug Substances 0.000 title abstract description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 21
- 239000008101 lactose Substances 0.000 claims abstract description 21
- -1 amino acid salt Chemical class 0.000 claims abstract description 9
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 4
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims abstract description 4
- 150000001413 amino acids Chemical class 0.000 claims abstract description 4
- 238000001694 spray drying Methods 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 7
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 5
- 150000001340 alkali metals Chemical class 0.000 claims description 4
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 4
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 20
- 150000001615 biotins Chemical class 0.000 abstract description 5
- 230000001747 exhibiting effect Effects 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 3
- 239000003513 alkali Substances 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 4
- 238000004455 differential thermal analysis Methods 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 235000019766 L-Lysine Nutrition 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- 239000000347 magnesium hydroxide Substances 0.000 description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 150000008545 L-lysines Chemical class 0.000 description 1
- 241001417527 Pempheridae Species 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
Abstract
Description
【発明の詳細な説明】 （産業上の利用分野） 本発明は、水溶性ビオチン製剤及びその製法に関する。[Detailed description of the invention] (Industrial application field) The present invention relates to a water-soluble biotin preparation and a method for producing the same.
（従来の技術）
ビオチンは、家畜、養殖魚類などの飼料添加物、あるい
は皮膚疾患の予防・治療薬として使用されているが、水
に難溶性であるため、水溶液としての添加・投与が困難
であった。このため、ビオチンの水溶性を増強させるた
め、例えば、ビオチンと乳糖とアンモニアを含有する水
溶液を噴霧乾燥して水溶性のビオチン製剤を得る方法が
知られている（特公昭６１−２５６８８号）。(Prior art) Biotin is used as a feed additive for livestock and farmed fish, and as a prophylactic/therapeutic agent for skin diseases, but it is difficult to add or administer as an aqueous solution because it is poorly soluble in water. there were. Therefore, in order to enhance the water solubility of biotin, a method is known in which, for example, an aqueous solution containing biotin, lactose, and ammonia is spray-dried to obtain a water-soluble biotin preparation (Japanese Patent Publication No. 25688/1988).
しかしながら、この方法で得た製剤中のビオチンは、水
に対する溶解度が４鵬ｇ／鵠ｌ以下と低く、水溶性に難
点があるとともに、この方法によれば、温度の上昇に伴
ってアンモニアが気化するため、噴霧乾燥を常に低温で
実施しなければならず、多量の製剤を短時間では製造し
難い難点もあった。However, the biotin in the preparation obtained by this method has a low water solubility of less than 4 g/l, and this method has problems with water solubility. Therefore, spray drying must always be carried out at low temperatures, making it difficult to produce large quantities of formulations in a short period of time.
（発明が解決しようとする課Ｈ）
本発明の目的は、上記従来公知のビオチン製剤に較べ水
溶性の高いビオチン製剤を提供するものであり、さらに
他の目的はかかる水溶性の高いビオチン製剤を効率よく
製造する工業的に優れた製法を提供するものである。(Problem H to be Solved by the Invention) An object of the present invention is to provide a biotin preparation with higher water solubility than the above-mentioned conventionally known biotin preparations, and another object is to provide a biotin preparation with high water solubility. This provides an industrially superior manufacturing method that produces efficiently.
（課題を解決するための手段）
本発明は、ビオチンのアルカリ金属、アルカリ土類金属
もしくは塩基性アミノ酸塩と乳糖を含有してなるビオチ
ン噴霧乾燥製剤に関する。(Means for Solving the Problems) The present invention relates to a biotin spray-dried preparation containing an alkali metal, alkaline earth metal or basic amino acid salt of biotin and lactose.
本発明のビオチン噴霧乾燥製剤は、上記従来公知のビオ
チン製剤に較べ、約３倍優れた水溶性を示し、かつ優れ
た流動性、湿度安定性を示すという種々の特長を有する
。The biotin spray-dried preparation of the present invention has various features such as exhibiting approximately three times better water solubility than the above-mentioned conventionally known biotin preparations, and exhibiting excellent fluidity and humidity stability.
本発明のかかるビオチン噴霧乾燥製剤の具体例としては
、ビオチンをナトリウム塩、カリウム塩等のアルカリ金
属塩、マグネシウム塩、カルシウム塩等のアルカリ土類
金属塩またはＬ−リジン塩、アルギニン塩、ヒスチジン
塩等の塩基性アミノ酸塩として含有するものがあげられ
る。Specific examples of the biotin spray-dried preparation of the present invention include biotin with alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts and calcium salts, or L-lysine salts, arginine salts, and histidine salts. Examples include those contained as basic amino acid salts such as.
また、上記ビオチンの塩と乳糖との量的比率に特に制約
はないが、通常は製剤中に含まれるビオチン塩を遊離の
ビオチンに換算した場合、乳糖とのモル比が１：３０〜
７０、とりわけ１：３０〜４０であるのが好ましい。Furthermore, although there are no particular restrictions on the quantitative ratio of the biotin salt to lactose, when the biotin salt contained in the preparation is converted to free biotin, the molar ratio to lactose is usually 1:30 to 1:30.
70, especially preferably 1:30 to 40.
本発明によれば、ビオチン噴霧乾燥製剤は、ビオチンを
水酸化アルカリ金属、水酸化アルカリ土類金属もしくは
塩基性アミノ酸で中和後、乳糖とともに噴霧乾燥し、要
すれば、更に結晶化して製造することができる。According to the present invention, the biotin spray-dried preparation is prepared by neutralizing biotin with an alkali metal hydroxide, an alkaline earth metal hydroxide, or a basic amino acid, then spray-drying it with lactose, and if necessary, further crystallizing it. be able to.
ビオチンの中和は常法により実施することができる。中
和は必ずしもｐＨ７となるよう厳密に実施する必要はな
く、概ね液性がｐＨ６〜８となるよう水酸化アルカリ金
属、水酸化アルカリ土類金属または塩基性アミノ酸の量
を調整して実施すればよい。Neutralization of biotin can be carried out by conventional methods. Neutralization does not necessarily have to be carried out strictly to achieve a pH of 7, but can be carried out by adjusting the amount of alkali metal hydroxide, alkaline earth metal hydroxide or basic amino acid so that the pH of the solution is approximately 6 to 8. good.
またこの際ビオチンは塩として例えば水などの溶媒に溶
解しているのが望ましく、所望とあれば、中和は加温下
に実施することもできる。In this case, biotin is preferably dissolved as a salt in a solvent such as water, and if desired, neutralization can be carried out under heating.
乳糖は噴霧乾燥前であれば、いつ添加してもよく、例え
ばビオチン及び乳糖をまず水などの溶媒に分散させ、つ
いで中和操作を実施してもよく、或いはビオチンを中和
後、この溶液に乳糖を溶解させてもよい。Lactose may be added at any time before spray drying; for example, biotin and lactose may be first dispersed in a solvent such as water, and then a neutralization operation may be performed, or the biotin may be neutralized and then this solution may be added. Lactose may be dissolved in.
噴霧乾燥は、ビオチンの塩と乳糖を含有する溶液を噴霧
し、熱風と接触させることにより実施することができる
。かかる操作は、通常の噴霧乾燥装置を用いて実施する
ことができる。さらにエアースィーパ−及び／または二
次冷風装置を有する噴霧乾燥装置を用いればより好適に
実施することができる。当該噴霧乾燥は８０〜２００°
Ｃ１とりわけ１５０〜２００°Ｃで実施するのが好まし
い。Spray drying can be carried out by spraying a solution containing a salt of biotin and lactose and contacting it with hot air. Such operations can be carried out using conventional spray drying equipment. Furthermore, it is possible to carry out the process more preferably by using a spray drying device having an air sweeper and/or a secondary cooling air device. The spray drying temperature is 80~200°
C1 is preferably carried out at 150 to 200°C.
かかる操作により、ビオチンのアルカリ金属、アルカリ
土類金属もしくは塩基性アミノ酸塩が乳糖中に均一に分
散・含有されると共に、微粒化されて大きな表面積をも
つ球型に近い細粒状のビオチン製剤として得ることがで
き、噴霧乾燥条件を適宜選択すれば、球径を概ね０．２
ｍｍ以下に調節することもできる。Through this operation, the alkali metal, alkaline earth metal, or basic amino acid salt of biotin is uniformly dispersed and contained in the lactose, and the biotin preparation is atomized and has a nearly spherical shape with a large surface area. If the spray drying conditions are selected appropriately, the sphere diameter can be reduced to approximately 0.2
It can also be adjusted to less than mm.
さらにかくして得たビオチン製剤は、所望により結晶化
させることができる。結晶化は、上記製剤を加湿下かく
はんするか、またはこれに適量の水を滴下または噴霧し
ながらかくはんすることにより容易に実施することがで
きる。例えば、加湿下に実施する場合は相対湿度が約２
０〜１００％で、また水を滴下又は噴霧して行う場合は
、ビオチン製剤に対する水量が約２〜１０重量％となる
ようにするのが好ましい。また、かくはんは、室温〜加
温下、剪断力に優れたかくはん機を用いて実施すること
により、好結果を得ることができる。かかるかくはん機
としては、円錐型スクリュー（遊星型）混合機、万能混
合機等を好適に使用することができる。かかる操作によ
り、乳糖及びビオチン塩が結晶化し、湿度に対し優れた
安定性を示す噴霧乾燥製剤として得られる。Furthermore, the biotin preparation thus obtained can be crystallized if desired. Crystallization can be easily carried out by stirring the above-mentioned preparation under humidification, or by stirring while dropping or spraying an appropriate amount of water thereon. For example, when performing under humidified conditions, the relative humidity is approximately 2
The amount of water is preferably 0 to 100%, and when water is added dropwise or sprayed, the amount of water relative to the biotin preparation is preferably about 2 to 10% by weight. Further, good results can be obtained by stirring at room temperature or under heating using a stirrer with excellent shearing force. As such a stirrer, a conical screw (planetary type) mixer, a universal mixer, etc. can be suitably used. By this operation, the lactose and biotin salts are crystallized and obtained as a spray-dried preparation that exhibits excellent stability against humidity.
（作用）
本発明により得られるビオチン乾燥噴霧製剤の水溶性を
下記表に示す。(Effect) The water solubility of the biotin dry spray preparation obtained by the present invention is shown in the table below.
なお、水溶性の測定は室温で行い、ビオチンの定量は高
速液体クロマトグラフ法で行った。Note that water solubility was measured at room temperature, and biotin was quantified by high performance liquid chromatography.
＊）：参考例２：特公昭６１−２５６８８号記載のデー
タ（実施例）
実施例１
ビオチン５０ｇ及び乳１！２４５０ｇを水１０ｆに分散
させ、５０°Ｃに加熱し、水酸化ナトリウムを加え、ｐ
Ｈ７，０に調整して溶解させる。この溶液を噴霧乾燥（
条件：水溶液供給量：１１．４４ｋｇ／ｈ、入口温度１
５０℃、出口温度６０°Ｃ、ディスク回転数１４．１０
１００ｒｐしてビオチン製剤２３７５ｇを得る。*): Reference Example 2: Data described in Japanese Patent Publication No. 61-25688 (Example) Example 1 50 g of biotin and 1.2450 g of milk were dispersed in 10 f of water, heated to 50°C, and sodium hydroxide was added. p
Adjust to H7.0 and dissolve. Spray dry this solution (
Conditions: Aqueous solution supply rate: 11.44 kg/h, inlet temperature 1
50℃, outlet temperature 60℃, disc rotation speed 14.10
100 rpm to obtain 2375 g of biotin preparation.
実施例２
水酸化ナトリウムに代えて水酸化マグネシウムを用いる
こと以外は実施例１と同様にして水酸化マグネシウムを
含有するビオチン製剤を得る。Example 2 A biotin preparation containing magnesium hydroxide is obtained in the same manner as in Example 1 except that magnesium hydroxide is used in place of sodium hydroxide.
実施例３
水酸化ナトリウムに代えて水酸化カルシウムを用いるこ
と以外は実施例１と同様にして水酸化カルシウムを含有
するビオチン製剤を得る。Example 3 A biotin preparation containing calcium hydroxide is obtained in the same manner as in Example 1 except that calcium hydroxide is used in place of sodium hydroxide.
実施例４
水酸化ナトリウムに代えてＬ−リジンを用いること以外
は実施例１と同様にしてＬ−リジンを含有するビオチン
製剤を得る。Example 4 A biotin preparation containing L-lysine is obtained in the same manner as in Example 1 except that L-lysine is used in place of sodium hydroxide.
実施例５
実施例１で得たビオチン製剤２０００ｇを１０！反応釜
に入れ、相対湿度１００％に調湿した空気（温度３５°
Ｃ）を、流量２０ｆ／ｍｉｎで吹き込みながら、６０ｒ
ｐｍの速度で５時間撹拌することにより、ビオチン製剤
２０３０ｇを得る。Example 5 2000g of the biotin preparation obtained in Example 1 was added to 10! Air placed in the reaction vessel and conditioned to 100% relative humidity (temperature 35°)
C) at a flow rate of 20 f/min at 60 r.
By stirring for 5 hours at a speed of pm, 2030 g of biotin preparation is obtained.
示差熱分析（ＤＴＡ）結果：第一図
直径：０．０４〜０．０６ＩＩ１１
参考例１
ビオチン０．５ｇ及び乳糖２４．５ｇを水１００ｄに分
散させ、２４％アンモニア水溶液０． ３ｇを添加し、
６０〜７０°Ｃに加熱して溶解させる。この溶液を噴霧
乾燥（ヤマト科学製ミニスプレードライヤー、条件：チ
ャンバー温度１９０〜２００°Ｃ１チヤンバーバキユー
ム３０１１１８２０ 、アトマイズ圧力２ 、 ５ Ｋ
ｇ／ｃｍｚ） Ｌ／てビオチン製剤を得る。Differential thermal analysis (DTA) results: Figure 1 Diameter: 0.04-0.06II11 Reference Example 1 0.5 g of biotin and 24.5 g of lactose were dispersed in 100 d of water, and 0.5 g of 24% ammonia aqueous solution was added. Add 3g,
Heat to 60-70°C to dissolve. This solution was spray-dried (Yamato Scientific mini spray dryer, conditions: chamber temperature 190-200°C, chamber vacuum 30111820, atomization pressure 2, 5K).
g/cmz) to obtain a biotin preparation.
（発明の効果）
本発明の噴霧乾燥製剤は、表記数の通り、特公昭６１−
２５６８８号記載のビオチン製剤と比較して、約３倍優
れた水溶性を示すため、飼料添加物あるいは皮膚疾患の
予防・治療薬として使用するに際し、高濃度の水溶液と
して添加ないし投与しうるという優れた特性を有する。(Effects of the Invention) The spray-dried preparation of the present invention is as indicated in the number,
Compared to the biotin preparation described in No. 25688, it exhibits about three times better water solubility, so it has the advantage of being able to be added or administered as a highly concentrated aqueous solution when used as a feed additive or as a preventive/therapeutic drug for skin diseases. It has the following characteristics.
また、本発明の噴霧乾燥製剤は、乳糖の粒子中にビオチ
ンが均一に分散・含有され、かつ球状として得られるの
で、流動性にも優れ、飼料等への均一な混合が容易であ
るとともに、湿度に対しても安定であるという優れた特
長を有する。In addition, the spray-dried preparation of the present invention has biotin uniformly dispersed and contained in the lactose particles and is obtained in a spherical shape, so it has excellent fluidity and can be uniformly mixed into feed etc. It has the excellent feature of being stable against humidity.
さらには、上記公知方法では、アンモニアを使用するた
め、１５０°Ｃ以上の高温では噴霧乾燥し難いという難
点があったが、本発明の製法によれば、アンモニアを使
用しないため、この様な難点がなく、むしろ高温で噴霧
乾燥することによって水など溶媒の蒸発速度を高め、単
位時間当たりの噴霧乾燥製剤の生産量を増すことができ
るので、生産能力を顕著に向上させることが可能になる
という工業的に優れた利点が得られる。Furthermore, since the above-mentioned known method uses ammonia, it has the disadvantage that spray drying is difficult at high temperatures of 150°C or higher; however, the production method of the present invention does not use ammonia, and therefore does not have such disadvantages. Rather, spray drying at high temperatures increases the evaporation rate of solvents such as water and increases the amount of spray-dried preparation produced per unit time, making it possible to significantly improve production capacity. Industrial advantages can be obtained.
第一図は、実施例５で得られたビオチン製剤の示差熱分
析（ＤＴＡ）結果を表したものである。
手続補正書（方式）
平成３年２月２１日
１、事件の表示
平成２年特許願第２９７８６３号
２、発明の名称
ビオチン噴霧乾燥製剤及びその製法
３、補正をする者
事件との関係 特許出願人
郵便番号 ５４１
大阪府大阪市中央区道修町３丁目２番１０号（２９５）
田辺製薬株式会社
代表者 千 畑 一部
４、代理人
郵便番号 ５３２
大阪府大阪市淀川区加島３丁目１６番８９号（置 ０６
−３００−２７２３又は２７２４特許センター）５、補
正命令の日付（特許庁発送臼）
平成３年２月１２日
６、補正の対象
図面
７、補正の内容
別紙の通り
第一図
Ｔｉｍｅ （ｍｉｎ） 〜−一−−→FIG. 1 shows the results of differential thermal analysis (DTA) of the biotin preparation obtained in Example 5. Procedural amendment (method) February 21, 1991 1. Indication of the case 1990 Patent Application No. 297863 2. Name of the invention Biotin spray-dried preparation and its manufacturing method 3. Person making the amendment Relationship with the case Patent application Postal code 541 3-2-10 Doshomachi, Chuo-ku, Osaka-shi, Osaka (295)
Tanabe Pharmaceutical Co., Ltd. Representative Chibata Part 4 Agent postal code 532 3-16-89 Kashima, Yodogawa-ku, Osaka-shi, Osaka (location 06)
-300-2723 or 2724 Patent Center) 5. Date of amendment order (Japan Patent Office dispatch) February 12, 1991 6. Drawing subject to amendment 7. Contents of amendment As shown in the attached sheet, the first drawing Time (min) ~ −1−−→
Claims (1)
は塩基性アミノ酸塩と乳糖を含有してなるビオチン噴霧
乾燥製剤。 ２）ビオチンのアルカリ金属、アルカリ土類金属もしく
は塩基性アミノ酸塩に含まれるビオチン１モルに対し、
乳糖を３０〜７０モル含有してなる請求項１）記載のビ
オチン噴霧乾燥製剤。 ３）ビオチンを水酸化アルカリ金属、水酸化アルカリ土
類金属もしくは塩基性アミノ酸で中和後、乳糖とともに
噴霧乾燥し、要すれば、更に結晶化することを特徴とす
るビオチン噴霧乾燥製剤の製法。 ４）ビオチン１モルに対し、乳糖３０〜７０モル配合す
ることを特徴とする請求項３）記載のビオチン噴霧乾燥
製剤の製法。[Scope of Claims] 1) A biotin spray-dried preparation containing an alkali metal, alkaline earth metal or basic amino acid salt of biotin and lactose. 2) For 1 mole of biotin contained in an alkali metal, alkaline earth metal or basic amino acid salt of biotin,
The biotin spray-dried preparation according to claim 1, which contains 30 to 70 moles of lactose. 3) A method for producing a biotin spray-dried preparation, which comprises neutralizing biotin with an alkali metal hydroxide, an alkaline earth metal hydroxide, or a basic amino acid, and then spray-drying it together with lactose, and if necessary, further crystallizing it. 4) The method for producing a biotin spray-dried preparation according to claim 3), wherein 30 to 70 moles of lactose are blended per mole of biotin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29786390A JPH04169528A (en) | 1990-11-01 | 1990-11-01 | Spray-dried biotin medicine and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29786390A JPH04169528A (en) | 1990-11-01 | 1990-11-01 | Spray-dried biotin medicine and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04169528A true JPH04169528A (en) | 1992-06-17 |
Family
ID=17852117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29786390A Pending JPH04169528A (en) | 1990-11-01 | 1990-11-01 | Spray-dried biotin medicine and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04169528A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5814650A (en) * | 1992-09-28 | 1998-09-29 | Lifegroup S.P.A. | Biotin amides able to control glucidic metabolisms under dysmetabolic conditions and relative therapeutical compositions |
| WO2001047519A1 (en) * | 1999-12-24 | 2001-07-05 | Sumitomo Chemical Company, Limited | Powdery biotin preparations |
| JP2019526638A (en) * | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | Magnesium biotinate composition and method of use |
| WO2022202982A1 (en) * | 2021-03-25 | 2022-09-29 | 株式会社トクヤマ | Method for preparing biotin, l-lysine salt of biotin, and method for preparing same |
| US11622571B2 (en) | 2019-12-16 | 2023-04-11 | Nutrition21, LLC | Methods of production of arginine-silicate complexes |
| US11850219B2 (en) | 2015-11-12 | 2023-12-26 | Nutrition21, LLC | Inositol-stabilized arginine-silicate for hair growth and thickening |
-
1990
- 1990-11-01 JP JP29786390A patent/JPH04169528A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5814650A (en) * | 1992-09-28 | 1998-09-29 | Lifegroup S.P.A. | Biotin amides able to control glucidic metabolisms under dysmetabolic conditions and relative therapeutical compositions |
| WO2001047519A1 (en) * | 1999-12-24 | 2001-07-05 | Sumitomo Chemical Company, Limited | Powdery biotin preparations |
| US11850219B2 (en) | 2015-11-12 | 2023-12-26 | Nutrition21, LLC | Inositol-stabilized arginine-silicate for hair growth and thickening |
| JP2019526638A (en) * | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | Magnesium biotinate composition and method of use |
| US20210100776A1 (en) * | 2016-09-01 | 2021-04-08 | Jds Therapeutics, Llc | Magnesium biotinate compositions and methods of use |
| JP2022023868A (en) * | 2016-09-01 | 2022-02-08 | ニュートリション・２１，エルエルシー | Magnesium biotinate compositions and methods of use |
| AU2017318672B2 (en) * | 2016-09-01 | 2022-03-10 | Nutrition 21, Llc | Magnesium biotinate compositions and methods of use |
| US11931342B2 (en) | 2016-09-01 | 2024-03-19 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
| US11938117B2 (en) | 2016-09-01 | 2024-03-26 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
| US11622571B2 (en) | 2019-12-16 | 2023-04-11 | Nutrition21, LLC | Methods of production of arginine-silicate complexes |
| WO2022202982A1 (en) * | 2021-03-25 | 2022-09-29 | 株式会社トクヤマ | Method for preparing biotin, l-lysine salt of biotin, and method for preparing same |
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