JPH04164839A - Treatment of inner surface of glass tube bottle - Google Patents

Abstract

PURPOSE:To easily decrease the dissolution of alkali at a low cost without causing the problems of the clouding of a glass tube bottle and the environmental pollution by heating and forming a glass tube in the form of a tube bottle, pouring distilled water into the bottle and slowly cooling the bottle. CONSTITUTION:A tube bottle is formed by heating a glass tube and slowly cooled after pouring distilled water into the bottle. The thermal forming temperature of a glass tube to a tube bottle is generally >=1200 deg.C. Distilled water of normal temperature can be used in the case of pouring the water to a glass tube bottle cooled to <=300 deg.C. When the temperature of the glass tube bottle is >=300 deg.C, the bottle may be broken by the thermal shock by the pouring of distilled water of normal temperature. Accordingly, it is necessary to use hot water of >=30 deg.C in the above case. The use of distilled water as the treating liquid prevents the clouding of the glass tube bottle and the undesirable effect on human body and environment.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention particularly relates to a method for treating the inner surface of a glass tube bottle used as a glass container for pharmaceuticals.

[Prior art and its problems] Tube bottles used as glass containers for pharmaceuticals are usually made of a glass tube made of a glass material with a small amount of alkali elution and excellent water resistance. After forming into a tube bottle by heating, 600~7
Although it is produced by slow cooling at a temperature of 00°C, alkaline components volatilize from the surface of the glass, which becomes hot during heating with a burner, and are likely to burn onto the glass tube bottle during slow cooling. - Once alkaline components are baked onto the surface of a glass tube bottle, it is difficult to remove them even if ultrasonic cleaning or jet cleaning is performed using pure water in the subsequent process. If this happens, there is a risk that alkaline components baked into the inner surface of the glass tube bottle will elute into the drug solution and cause deterioration.

Under these circumstances, various methods have been used to suppress the elution of alkaline components from glass tube bottles, such as a method of dealkalizing the inner surface of the glass tube bottle after slow cooling using a sulfur compound. There is. This is a method of extracting and removing alkaline components from the surface layer by reacting a sulfur compound with a tube heated to a temperature near the glass transition point. According to this method, the amount of alkali eluted from the inner surface of the tube is small. However, on the other hand, the reaction products generate cloudiness and the problem of environmental pollution due to exhaust gas tends to occur.

Furthermore, JP-A-2-175G30 discloses a method for preventing the elution of alkaline components by treating the inner surface of medical glass products with metal oxide to form a silica film. Manufacturing costs are high,
In addition, in order to form a stable silica film, the tube bottle must be in an extremely clean state before the film is applied, so care must be taken to prevent it from becoming contaminated during production and storage.

[Object of the Invention] The object of the present invention is to easily reduce the amount of alkaline components eluted at low cost without causing cloudiness in the glass tube bottle or causing environmental pollution. An object of the present invention is to provide a method for treating the inner surface of a glass tube bottle.

[Structure of the Invention] The method for treating the inner surface of a glass tube bottle according to the present invention is characterized by forming a glass tube into a tube bottle by heating, and then injecting distilled water into the tube and then slowly cooling the tube. do.

In general, the temperature when heating and forming a glass tube into a tube bottle is
If the temperature is 1,200°C or higher and you pour distilled water after the temperature of the glass tube has fallen to 300°C or lower, room temperature water can be used, but if the temperature of the glass tube is 300°C or higher, If you pour room-temperature distilled water inside, the glass tube bottle will be easily damaged by thermal shock, so please
It is necessary to use high temperature water of 0°C or higher.

When the method of the present invention is applied to industrial production, it is sufficient to provide a device for injecting distilled water into each glass tube while it is being transferred from the tube bottle forming machine to the slow cooling furnace.

Further, in the present invention, since distilled water is used as the treatment liquid, no cloudiness is generated in the glass tube bottle, and there is no adverse effect on the human body or the environment.

[Function] In the present invention, since distilled water is injected into the glass tube bottle produced by thermoforming before it is slowly cooled, even if alkaline components volatilize on the inner surface,
The alkali is dissolved in distilled water, and during slow cooling during heating at 600 to 700°C, the alkali component (1) tends to evaporate out of the bottle together with the distilled water, reducing the amount of alkali eluted from the glass tube.

[Example] Hereinafter, the method for treating the inner surface of a glass tube bottle of the present invention will be described in detail based on Examples.

The following table shows Examples of the present invention (Sample Nos. 1 to 4) and Comparative Examples (Sample Nos. 5 and G).

In the margin table below, each sample No. 1 to 4 which is an example is S10°73%, B2031O%, Al2037 in weight percentage.
%, Ca01%, Ba02%, Na2O6%, K2O1
A glass tube with a composition of 1200% using a burner
Groove capacity 2.7 mJ or 1 by heating at ℃
After forming into a 3.0 ml tube bottle, 1 m7 or 2 ml of 30°C distilled water was poured into the bottle without much time, and then slowly cooled to 650°C.

On the other hand, sample No. 5, which is a comparative example, is a tube bottle with a groove capacity of 2.7 mj, which is the same as in the example, and is slowly cooled at a temperature of 650°C without any treatment. , the same tube bottle with a groove capacity of 13.0 + nj was not treated at all, and 6
It was slowly cooled at a temperature of 50°C.

Each sample thus prepared was tested according to the Japanese Pharmacopoeia 11th revision, General Test Method 27, Glass Container Test Method for Injectables (3) (ii).
An alkali elution test was conducted based on the second method.

As is clear from the table, the groove capacity without any treatment 2.
Sample No. 5 of 7m7 has alkali elution amount of 0.85m
? On the other hand, the amount of alkaline elution for samples No. 1 and 2 with a groove volume of 2.7 ml whose inner surfaces were treated with distilled water was:
They were 0.6 Omj and 0.55 m7, respectively, which were improvements.

In addition, sample N with a groove capacity of 13.0 mj was not treated.
o, the alkali elution amount of Ili is 0.27 rivers! In contrast, the groove capacity when the inner surface was treated with distilled water was 13.0 rn.
Sample No.

The alkali elution amounts of Nos. 3 and 4 were O, 19m7.0.
17 rivers! These were also improved.

In addition, no cloudiness was observed on the surface of each sample.

[Effects of the Invention] As described above, according to the method for treating the inner surface of a glass tube bottle of the present invention, there is no clouding in the glass tube bottle, there is no problem of environmental pollution, and there is no problem during slow cooling. Since it is possible to reduce the alkaline components volatilized on the inner surface of the glass tube bottle, it is possible to easily produce a glass tube bottle with a small amount of alkali elution at low cost, especially on the inner surface of pharmaceutical glass containers. This is suitable as a method for treating.

Claims (1)

[Claims] (1) A method for treating the inner surface of a glass tube bottle, which comprises heating the glass tube to form it into a tube bottle, then pouring distilled water into the tube and then slowly cooling the tube.