JPH04138366A - Analyser possible in self-evaluation - Google Patents

Abstract

PURPOSE:To automatically perform the self-evaluation of analytical capacity by measuring a group of samples twice by changing a measuring order and calculating autocorrelation with respect to the measured result. CONSTITUTION:In the first measurement, (N) samples arranged to a sample holding part 2 are successively measured from the first sample by an analyzing part 4 and the measured results are stored in a memory part 8 corresponding to sample numbers. In the second measurement, for example, random numbers are generated in a sample selecting part 6 so as to defer the order of the samples and the measuring order of the samples is differentiated to measure the samples in the same way to store the measured results in the memory part 8. After the second measurement, an operation part 10 calculates a regres sion equation by the regression analysis based on the measured values to calcu late autocorrelation. Then, the state of the analytical capacity of the apparatus is judged on the basis of the preset reference value of autocorrelation and the evaluating measurement thereof is automatically carried out. By this constitu tion, the reliability of the apparatus is confirmed for a long period of time to be kept.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to an analyzer such as an electrolyte analyzer for clinical testing.

(Prior Art) In electrolyte analyzers, the analytical performance is mainly measured and evaluated by the manufacturer, and the customer only evaluates the reproducibility, which requires simple operations.

Generally, analyzers are not equipped with programs for self-evaluation of analytical performance.

(Problems to be Solved by the Invention) When trying to evaluate the accuracy of analytical performance under actual analytical conditions, it is not possible to develop some kind of evaluation method and manually execute it. There is a risk that differences may occur in the evaluation results.

An object of the present invention is to provide an analyzer having a function of automatically self-evaluating analytical performance under actual analytical conditions.

(Means for solving problems) The invention is illustrated in FIG.

2 is a sample holder that holds multiple samples and can position any sample to the sample collection section; 4 is an analysis section that collects the sample at the sample collection position of sample holder 2 for quantitative analysis; and 6 is for a group of samples. A sample selection section controls the operation of the sample holding section 2 so as to perform two measurements with different measurement orders; 8 is a storage section that stores the results of instrument analysis by the analysis section in association with sample numbers; 10 is a storage section; This is a calculation unit that calls the analysis results from the unit 8 and calculates the autocorrelation for the two measurement results.

(Function) Regarding the N samples arranged in the sample holding section 2, in one measurement at a time, the samples 111 to N are determined in that order in the analysis section 4, and the measurement results are transferred to the sample. The information is stored in the storage unit 8 in correspondence with the number.

Next, when performing the second measurement, the measurement order is changed. For example, the sample selection section 6 is provided with a section that generates random numbers, and the 6111 fixed order of 2 times ['' is determined according to the random numbers. A second measurement is performed in the determined order, and the measurement results by the analysis section 4 are also stored in the storage section 8 in association with the sample number.

Let the first measurement value be X] (i=1 to N), and the second measurement value 11 be y] (i=1 to N). 1 is the sample number. The arithmetic unit 10 calculates the regression equation: 3 Y i = +i +b X 1 from the two measured values. The calculation results are displayed.

(Example) FIG. 2 represents one embodiment.

Reference numeral 12 denotes a turntable of a sample holding section, and a plurality of sample containers 14 are arranged along the circumference of the turntable. 16 is a motor that rotates the turntable 12. A position detector 18 is provided close to the turntable 12 to detect the rotational position of the turntable 2. Position detector 1
8, the computer 20 determines the number of the sample at the sample collection position.

A sample injection nozzle 22 for collecting a sample is provided on the sample side of the sample collection position. Inject into 28. 24 is a motor that moves the nozzle 22 by 15μ. The motors 16 and 24 are connected to the computer 20
Motor control by the signal from! It is controlled by a control circuit 26.

Reference numeral 28 denotes an analysis section, which is equipped with an electrode as a sensor in the electrolyte analyzer. The regular analysis results by the analysis section 28 are taken into the computer 20 via an analog circuit such as an amplifier circuit and a Δ/D converter 30. 32 is a display device such as a CRT or a printer.

Sample selection section 6, storage section 8 and calculation section 10 in FIG.
is realized by the computer 20.

Next, the operation of one embodiment will be explained with reference to FIG.

When the start of measurement is instructed, the measurement sample number is set to 1, the turntable 12 is rotated, and the sample numbered 1 is positioned at the sample collection position. The sample is collected and analyzed in the analysis department 2.
Measured at 8. The 1llll determination result is converted into a digital signal and taken into the computer 20, where the sample number and measurement value are stored.

Next, 1 is added to the S constant sample number, and the sample with the next number is positioned at the sample collection position and measured in the same manner.
The measured values are also stored in the computer 20 along with the sample number.

Thereafter, chemical constants are similarly proceeded in the order of sample numbers, and when one measurement for all samples is completed, the process proceeds to the second measurement.

In the second 411 measurement, for example, a random number sequence is generated in order to change the sample dl determination order, and the second measurement order is determined by the random number sequence. Then, the samples are measured according to the determined measurement order, and the measured values are also stored in the computer 2° along with the sample number.

Once the second measurement is completed for all samples, calculations are performed.

In the calculation, the regression equation is determined by the above-mentioned equation (1) through regression analysis, and the autocorrelation Sy.X is determined by the equation (2). The calculation results are displayed on a CRT and printed on a printer.

When displaying the calculation results, - The base Q10 value of autocorrelation 5y-x is predetermined by the manufacturer or set by the user as an evaluation standard for analytical performance, and the calculated autocorrelation result is used as the evaluation standard. If the condition is not satisfied, a warning may be displayed indicating that the analysis performance of the analyzer has decreased.

(Effects of the Invention) In the present invention, since the evaluation measurement of analytical performance is automatically performed, the operator does not have to worry about confirming and maintaining the reliability of the analytical device over a long period of time. It becomes possible to perform stable analysis performance evaluation by eliminating variations in evaluation operations.

[Brief explanation of drawings]

FIG. 1 is a block diagram showing the present invention, FIG. 2 is a block diagram showing one embodiment, and FIG. 3 is a flowchart showing the operation of one embodiment. 2...Sample holding section, 4...Analysis section, 6...
Sample selection unit, 8... Storage unit, 10... Calculation unit, 12... Turntable, 14... Sample container, 20 Computer, 28... Analysis unit. Patent applicant: Shimadzu Corporation

Claims (1)

[Claims] (1) A sample holding part that holds multiple samples and can position any sample to the sample collection part, an analysis part that collects the sample at the sample collection position of the sample holding part and performs quantitative analysis, and a measurement order for a group of samples. a sample selection section that controls the operation of the sample holding section so as to perform two measurements with different values; a storage section that stores quantitative analysis results by the analysis section in association with sample numbers;
An analysis device comprising: a calculation unit that retrieves analysis results from a storage unit and calculates an autocorrelation for two measurement results.