JPH04124127A - Microcapsule type sustained releasable preparation and its production - Google Patents
Microcapsule type sustained releasable preparation and its productionInfo
- Publication number
- JPH04124127A JPH04124127A JP24278390A JP24278390A JPH04124127A JP H04124127 A JPH04124127 A JP H04124127A JP 24278390 A JP24278390 A JP 24278390A JP 24278390 A JP24278390 A JP 24278390A JP H04124127 A JPH04124127 A JP H04124127A
- Authority
- JP
- Grant status
- Application
- Patent type
- Prior art keywords
- substance
- microcapsule
- type
- polymer
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Abstract
PURPOSE:To obtain a microcapsule type sustained releasable preparation gradually releasable in vivo for many hours, having fine and uniform particle diameter, containing a physiologically active substance and a polymer substance compatible with living body. CONSTITUTION:0.01-50wt.% physiologically active substance such as protein, polypeptide or a derivative thereof is contained as an inner substance of microcapsule. 20-99wt.% polymer substance compatible with living body (e.g. polylactic acid glycolic acid copolymer) to be a shell substance of microcapsule is contained. An aqueous solution of the physiologically active substance and a solution of said polymer substance in an organic solvent are adjusted to W/O type emulsion, which is secondarily emulsified with an aqueous solution of a water-soluble polymer substance. In the operation, a salt substance having 0.1M to saturated concentration is made to exist in the outer water layer to prepare a W/O/W type emulsion. The objective substance having <=150mum maximum particle diameter, <=5-100mum average particle diameter and <=50% coefficient of variation is obtained and is directly used as an injection as it is without especially carrying out classifying and adjusting operation of particles.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24278390A JPH04124127A (en) | 1990-09-14 | 1990-09-14 | Microcapsule type sustained releasable preparation and its production |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24278390A JPH04124127A (en) | 1990-09-14 | 1990-09-14 | Microcapsule type sustained releasable preparation and its production |
JP25712791A JP3372558B2 (en) | 1990-09-14 | 1991-09-10 | Microencapsulated sustained release preparation and their preparation |
PCT/JP1991/001224 WO1992004891A1 (en) | 1990-09-14 | 1991-09-13 | Microencapsulated sustained-release preparation and production |
KR930070774A KR100202073B1 (en) | 1990-09-14 | 1993-03-13 | Microencapsulated sustained-release preparation and manufacturing method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH04124127A true true JPH04124127A (en) | 1992-04-24 |
Family
ID=17094224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP24278390A Pending JPH04124127A (en) | 1990-09-14 | 1990-09-14 | Microcapsule type sustained releasable preparation and its production |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPH04124127A (en) |
KR (1) | KR100202073B1 (en) |
WO (1) | WO1992004891A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0955331A2 (en) * | 1998-04-23 | 1999-11-10 | Dainippon Ink And Chemicals, Inc. | Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07507806A (en) * | 1992-06-11 | 1995-08-31 | ||
ES2110573T3 (en) * | 1992-08-07 | 1998-02-16 | Takeda Chemical Industries Ltd | Production of microcapsules water soluble drugs. |
US5599583A (en) * | 1994-05-27 | 1997-02-04 | Micro Flo Company | Encapsulation with water soluble polymer |
JP2008184468A (en) * | 1995-03-10 | 2008-08-14 | Roche Diagnostics Gmbh | Polypeptide-containing pharmaceutical form of administration in the form of microparticle |
GB9617732D0 (en) * | 1996-08-23 | 1996-10-02 | Int Centre Genetic Eng & Bio | Sustained-release preparation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4933738B1 (en) * | 1969-01-16 | 1974-09-09 | ||
JPS5619324B2 (en) * | 1972-05-18 | 1981-05-07 | ||
JPS5094112A (en) * | 1973-12-06 | 1975-07-26 | ||
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
JPH0720859B2 (en) * | 1985-02-07 | 1995-03-08 | 武田薬品工業株式会社 | Microcapsule production method |
JP2526589B2 (en) * | 1986-08-08 | 1996-08-21 | 武田薬品工業株式会社 | Peptide-containing microcapsules and their preparation |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0955331A2 (en) * | 1998-04-23 | 1999-11-10 | Dainippon Ink And Chemicals, Inc. | Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof |
EP0955331A3 (en) * | 1998-04-23 | 2001-07-18 | Dainippon Ink And Chemicals, Inc. | Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof |
Also Published As
Publication number | Publication date | Type |
---|---|---|
WO1992004891A1 (en) | 1992-04-02 | application |
KR100202073B1 (en) | 1999-06-15 | grant |
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