JPH04124127A - Microcapsule type sustained releasable preparation and its production - Google Patents

Microcapsule type sustained releasable preparation and its production

Info

Publication number
JPH04124127A
JPH04124127A JP24278390A JP24278390A JPH04124127A JP H04124127 A JPH04124127 A JP H04124127A JP 24278390 A JP24278390 A JP 24278390A JP 24278390 A JP24278390 A JP 24278390A JP H04124127 A JPH04124127 A JP H04124127A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
substance
microcapsule
lt
particle diameter
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP24278390A
Inventor
Masayuki Arakawa
Yasushi Sato
Takashi Uchio
Original Assignee
Chugai Pharmaceut Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

PURPOSE:To obtain a microcapsule type sustained releasable preparation gradually releasable in vivo for many hours, having fine and uniform particle diameter, containing a physiologically active substance and a polymer substance compatible with living body. CONSTITUTION:0.01-50wt.% physiologically active substance such as protein, polypeptide or a derivative thereof is contained as an inner substance of microcapsule. 20-99wt.% polymer substance compatible with living body (e.g. polylactic acid glycolic acid copolymer) to be a shell substance of microcapsule is contained. An aqueous solution of the physiologically active substance and a solution of said polymer substance in an organic solvent are adjusted to W/O type emulsion, which is secondarily emulsified with an aqueous solution of a water-soluble polymer substance. In the operation, a salt substance having 0.1M to saturated concentration is made to exist in the outer water layer to prepare a W/O/W type emulsion. The objective substance having <=150mum maximum particle diameter, <=5-100mum average particle diameter and <=50% coefficient of variation is obtained and is directly used as an injection as it is without especially carrying out classifying and adjusting operation of particles.
JP24278390A 1990-09-14 1990-09-14 Microcapsule type sustained releasable preparation and its production Pending JPH04124127A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP24278390A JPH04124127A (en) 1990-09-14 1990-09-14 Microcapsule type sustained releasable preparation and its production

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24278390A JPH04124127A (en) 1990-09-14 1990-09-14 Microcapsule type sustained releasable preparation and its production
JP25712791A JP3372558B2 (en) 1990-09-14 1991-09-10 Microencapsulated sustained release preparation and their preparation
PCT/JP1991/001224 WO1992004891A1 (en) 1990-09-14 1991-09-13 Microencapsulated sustained-release preparation and production
KR930070774A KR100202073B1 (en) 1990-09-14 1993-03-13 Microencapsulated sustained-release preparation and manufacturing method thereof

Publications (1)

Publication Number Publication Date
JPH04124127A true true JPH04124127A (en) 1992-04-24

Family

ID=17094224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP24278390A Pending JPH04124127A (en) 1990-09-14 1990-09-14 Microcapsule type sustained releasable preparation and its production

Country Status (3)

Country Link
JP (1) JPH04124127A (en)
KR (1) KR100202073B1 (en)
WO (1) WO1992004891A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0955331A2 (en) * 1998-04-23 1999-11-10 Dainippon Ink And Chemicals, Inc. Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07507806A (en) * 1992-06-11 1995-08-31
ES2110573T3 (en) * 1992-08-07 1998-02-16 Takeda Chemical Industries Ltd Production of microcapsules water soluble drugs.
US5599583A (en) * 1994-05-27 1997-02-04 Micro Flo Company Encapsulation with water soluble polymer
JP2008184468A (en) * 1995-03-10 2008-08-14 Roche Diagnostics Gmbh Polypeptide-containing pharmaceutical form of administration in the form of microparticle
GB9617732D0 (en) * 1996-08-23 1996-10-02 Int Centre Genetic Eng & Bio Sustained-release preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4933738B1 (en) * 1969-01-16 1974-09-09
JPS5619324B2 (en) * 1972-05-18 1981-05-07
JPS5094112A (en) * 1973-12-06 1975-07-26
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPH0720859B2 (en) * 1985-02-07 1995-03-08 武田薬品工業株式会社 Microcapsule production method
JP2526589B2 (en) * 1986-08-08 1996-08-21 武田薬品工業株式会社 Peptide-containing microcapsules and their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0955331A2 (en) * 1998-04-23 1999-11-10 Dainippon Ink And Chemicals, Inc. Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof
EP0955331A3 (en) * 1998-04-23 2001-07-18 Dainippon Ink And Chemicals, Inc. Self-water dispersible particle made of biodegradable polyester and process for the preparation thereof

Also Published As

Publication number Publication date Type
WO1992004891A1 (en) 1992-04-02 application
KR100202073B1 (en) 1999-06-15 grant

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