JPH0436233A - Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body - Google Patents

Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body

Info

Publication number
JPH0436233A
JPH0436233A JP13889990A JP13889990A JPH0436233A JP H0436233 A JPH0436233 A JP H0436233A JP 13889990 A JP13889990 A JP 13889990A JP 13889990 A JP13889990 A JP 13889990A JP H0436233 A JPH0436233 A JP H0436233A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
drying
absorbable
living body
active substance
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13889990A
Inventor
Jiyoukiyuu Gen
Original Assignee
Biomaterial Universe Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: To obtain the subject drug preparation having high uptake ratio and loading ratio of drug, exhibiting suppressed burst at the initial stage of release and capable of slowly releasing the drug over a long period by including a physiologically active substance into a small sphere of a water-soluble polymer and coating the sphere with a polymer decomposable and absorbable in living body.
CONSTITUTION: A small sphere having particle size of 0.01-200μm is produced from an aqueous solution of a water-soluble polymeric substance (e.g. sodium polyacrylate, PVA, CMC, gelatin and carrageenan) containing a physiologically active substance by spray-drying, coacervation, fluidized bed process, drying in liquid, freeze-drying, etc. The small sphere is encapsulated with a polymer decomposable and absorbable in living body (e.g. polyglycolic acid, polylactic acid and polyamino acid) by drying in liquid or spray-drying to obtain the objective sustained release preparation having particle size of 0.01-300μm.
COPYRIGHT: (C)1992,JPO&Japio
JP13889990A 1990-05-29 1990-05-29 Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body Pending JPH0436233A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13889990A JPH0436233A (en) 1990-05-29 1990-05-29 Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13889990A JPH0436233A (en) 1990-05-29 1990-05-29 Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body

Publications (1)

Publication Number Publication Date
JPH0436233A true true JPH0436233A (en) 1992-02-06

Family

ID=15232727

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13889990A Pending JPH0436233A (en) 1990-05-29 1990-05-29 Sustained release preparation containing physiologically active substance and decomposable and absorbable in living body

Country Status (1)

Country Link
JP (1) JPH0436233A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036059A3 (en) * 1997-12-30 1999-09-16 Cosmeticos Natural Ind Com Microcapsules; process for preparing microcapsules containing a biologically active compound and liquid solution
WO2004094595A2 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals Inc. MODIFIED iRNA AGENTS
WO2004094345A2 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals Inc. Protected monomers
JP2006257080A (en) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd Method for reducing or avoiding adverse effect of steroid compound
JP2007537288A (en) * 2004-05-12 2007-12-20 チルドレンズ ホスピタル オブ ピッツバーグ Oligonucleotides containing microspheres, for the manufacture of a medicament for the treatment of type 1 diabetes, using the
JP2007537284A (en) * 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド The nucleic acid microspheres, the generation and delivery
EP2216407A2 (en) 2003-03-07 2010-08-11 Alnylam Pharmaceuticals, Inc. Therapeutic Compositions
JP4754067B2 (en) * 1997-12-02 2011-08-24 アルキメデス ディヴェロプメント リミテッド Nasal administration compositions
JP2014501252A (en) * 2010-12-24 2014-01-20 サムヤン バイオファーマシューティカルズ コーポレイション Fine particles and a manufacturing method thereof containing a physiologically active peptide, and pharmaceutical composition containing them
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
EP3141265A1 (en) 2007-12-04 2017-03-15 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4754067B2 (en) * 1997-12-02 2011-08-24 アルキメデス ディヴェロプメント リミテッド Nasal administration compositions
WO1999036059A3 (en) * 1997-12-30 1999-09-16 Cosmeticos Natural Ind Com Microcapsules; process for preparing microcapsules containing a biologically active compound and liquid solution
EP2239329A1 (en) 2003-03-07 2010-10-13 Alnylam Pharmaceuticals, Inc. Therapeutic compositions
EP2216407A2 (en) 2003-03-07 2010-08-11 Alnylam Pharmaceuticals, Inc. Therapeutic Compositions
EP2669377A2 (en) 2003-04-17 2013-12-04 Alnylam Pharmaceuticals Inc. Modified iRNA agents
EP2666858A1 (en) 2003-04-17 2013-11-27 Alnylam Pharmaceuticals Inc. Modified iRNA agents
EP2664672A1 (en) 2003-04-17 2013-11-20 Alnylam Pharmaceuticals Inc. Modified iRNA agents
WO2004094595A2 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals Inc. MODIFIED iRNA AGENTS
WO2004094345A2 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals Inc. Protected monomers
EP2660322A2 (en) 2003-04-17 2013-11-06 Alnylam Pharmaceuticals Inc. Modified iRNA agents
JP2007537284A (en) * 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド The nucleic acid microspheres, the generation and delivery
JP2007537288A (en) * 2004-05-12 2007-12-20 チルドレンズ ホスピタル オブ ピッツバーグ Oligonucleotides containing microspheres, for the manufacture of a medicament for the treatment of type 1 diabetes, using the
JP2006257080A (en) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd Method for reducing or avoiding adverse effect of steroid compound
EP3141265A1 (en) 2007-12-04 2017-03-15 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
JP2014501252A (en) * 2010-12-24 2014-01-20 サムヤン バイオファーマシューティカルズ コーポレイション Fine particles and a manufacturing method thereof containing a physiologically active peptide, and pharmaceutical composition containing them
US9931411B2 (en) 2010-12-24 2018-04-03 Samyang Biopharmaceuticals Corporation Microparticles containing physiologically active peptide, method for preparing the same, and pharmaceutical composition comprising the same
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide

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