JPH0394777A - Medical treatment device - Google Patents

Abstract

PURPOSE:To surely execute the medical treatment even if a shape of the affected part is complicated, and also, to simultaneously execute the medical treatment of the affected part of a wide area by providing a balloon consisting of an expandable/ contractable transparent member on an inserting part inserted into a living body, providing a semiconductor substance having an optical catalytic effect on its outside surface, and providing a light guiding means for executing light irradiation to the balloon on the inserting part. CONSTITUTION:When air is fed by an air feed syringe 7, air is fed to a balloon 4 through man air feed duct line 3, the balloon 4 expands, and a semiconductor electrode 10 stuck to the outside surface comes into contact with a cancer organization 12. In this state, when a light guiding fiber 8 of the air feed duct line 3 of an inserting part 2 is inserted, and a light beam emitted from a light source unit 9 is guided to the inside peripheral surface, an illuminating light transmits through a peripheral wall of the balloon 4 being a transparent member and reaches the semiconductor electrode 10. When the illuminating light hits against the semiconductor electrode 10, an oxidation reaction occurs on the semiconductor electrode 10, and the cancer organization 12 can be allowed to perish by an optical catalyst effect. In this case, the medical treatment extending over a wide area is executed simultaneously, and also, even if a shape of the affected part is complicated, the medical treatment is executed.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a treatment device that is inserted into a living body to treat an affected part of the living body.

[Prior Art J] Recently, photoelectrochemical therapy has been known as a method for treating malignant tumors such as cancer. This is an application of the strong reactivity of the photo-excited semiconductor surface to the killing effect on cancer cells, and experiments have shown that it has a remarkable effect on killing cancer cells.

Here, to explain the principle of photochemical reaction of semiconductor particles, as shown in Figure 10, when some types of semiconductors are exposed to light, electrons in the valence band are excited into the conductor by photoexcitation, and the electrons in the valence band are excited. A hole is created. If these electrons and holes do not recombine, they can be used for redox reactions. In other words, electrons excited in a conductor have higher energy than electrons in the valence band by the amount of the band gap, so they have a stronger reducing power, and holes in the valence band have a higher electron affinity than empty levels in the conductor by the amount of the band gap. Because it is large, it has oxidizing ability. Titanium oxide (hereinafter referred to as
TLO2) is known, and when platinum (hereinafter referred to as Pt) is supported on semiconductor fine particles of this Tie, TLO2 is known.
It is also known that the photocatalytic ability of i02 is significantly increased. In a photocatalytic system in which TiO2 powder containing pt is suspended in a solution, various reactions proceed as a semiconductor is photoexcited, similar to a photochemical cell. Is this optical excitation at a wavelength corresponding to the semiconductor bandgap? Rimo short wavelength (
This occurs when light of 415 nm (in the case of T i 02) is irradiated, and the photoexcited TiO2 surface has a very strong oxidizing power and can oxidize and decompose various compounds.

In addition, the smaller the particle size of the semiconductor fine particles, the higher the reaction activity (in the case of TiO2, the maximum reaction activity is 0.2 μm or less), and the larger the number of semiconductor fine particles and the greater the amount of light. Great effect.

For example, the technology for sterilizing and killing malignant tumors by utilizing the reaction caused by photoexcitation of semiconductors was developed in Japanese Patent Application Laid-open No. 62
Publication No. 87526, JP-A-63-1. 7 7 8
49, particularly the latter, a therapeutic probe is introduced into a living body through an insertion channel of an endoscope, a semiconductor electrode and a platinum electrode having a photocatalytic effect are punctured into a cancer site, and the therapeutic probe is introduced into a living body through an insertion channel of an endoscope. The surface of the semiconductor electrode is irradiated with laser light emitted from the tip surface of the probe. When the semiconductor electrode is irradiated with laser light, an oxidation reaction occurs on the semiconductor electrode, and a reduction reaction occurs on the platinum electrode. Since there is a cancerous site between the two electrodes, the reaction occurs in the moisture component, and oxygen is generated on the semiconductor electrode and moisture is generated on the platinum electrode, that is, a photocatalytic effect occurs.

[Problems to be Solved by the Invention] However, the above-mentioned treatment device introduces a therapeutic probe into a living body through an insertion channel of an endoscope, and uses a semiconductor electrode and a platinum electrode that have a photocatalytic effect to target cancer tissue or the like. The problem is that the treatment is localized, and treatment is difficult depending on the shape of the affected area, which limits the treatment area in the human body.

The present invention has been made in view of the above problems, and its purpose is to provide a treatment device that can reliably treat even if the shape of the affected area is rough, and that can treat a large area of the affected area at one time. It is about providing.

[Means and Effects for Solving the Problems] In order to solve the above problems, the treatment device of the present invention includes a balloon made of an inflatable and deflated transparent member in an insertion section inserted into a living body, and a balloon made of an inflatable and deflated transparent member. A semiconductor material having a photocatalytic effect is provided on the outer surface, and a light guiding means for irradiating the balloon with light is provided in the insertion portion.

When the insertion part is inserted into a living body and the balloon is brought into contact with the affected area, and light is irradiated from inside the balloon toward the semiconductor material, the semiconductor material undergoes an oxidation reaction and kills the malignant tumor.

[Example code] Hereinafter, each embodiment of the present invention will be described based on the drawings.

1 to 5 show a first embodiment. 1st
The figure shows the entire treatment device 1, and 2 is an insertion portion inserted into a body cavity. The insertion section 2 is formed of a flexible tube, and as shown in FIG. 2, an air supply line 3 is provided in the axial direction. A balloon 4 made of a transparent material such as silicone that can be expanded and contracted is provided at the distal end of the insertion section 2. A connecting tube body 5 is provided at the base end of the insertion section 2, and this connecting tube body 5 communicates with an air supply syringe 7 via an air tube 6 communicating with the air supply conduit 3. Further, a light guide fiber 8 as a light guide stage for irradiating light is inserted into the air supply blue A: 13 of the insertion section 2,
The distal end faces the inside of the hull 74, and the proximal end is connected to the light source device 9.

As shown in FIG. 3, the outer surface of the balloon 4 is provided with semiconductor electrodes 10 made of TiO2 as a semiconductor material having a photocatalytic effect. This semiconductor electrode 10 is made by spraying and adhering TiO2 fine particles onto the surface of the balloon 4 after the dipping manufacturing process.
As shown in FIG.
0 is integrally fixed.

FIG. 3 shows an example of the use of the treatment device 1, in which the balloon 4 is brought into contact with a malignant tumor, for example, a cancerous tissue 12, which has developed in a body cavity 11. That is, when air is supplied by the air supply syringe 7, air is supplied to the balloon 4 through the air supply pipe line 3, and the balloon 4 is inflated. The semiconductor electrodes 10 attached to the outer surface of the balloon 4 are in contact with the cancerous tissue 12.

In this state, when the light guide fiber 8 is inserted into the air supply pipe 3 of the Kakihachi section 2 and the light emitted from the light source device 9 is guided toward the inner peripheral surface of the balloon 4, the illumination light is transmitted through the transparent member. The light passes through the peripheral wall of a certain balloon 4 and reaches the semiconductor electrode 10.

When the semiconductor electrode 10 is irradiated with illumination light, an oxidation reaction occurs on the semiconductor electrode 10, and cancer tissue 12 is removed by the photocatalytic effect.
can be killed. In this case, even if the cancerous tissue 12 is spread over a wide area, the balloon 4 will cover the entire surface of the cancerous tissue 12, so that a wide area can be treated at once, and
Since the balloon 4 is elastically deformed, it closely follows the shape of the affected area and can be treated even if the affected area has a complicated shape.

Note that as a means of attaching the semiconductor electrode 10 to the balloon 4, Tie2 fine particles were sprayed onto the surface of the balloon after the diving manufacturing process, but TiO
2. Fine particles may be mixed. Further, as shown in FIG. 5, a metal 13 made of PT fine particles may be supported on a Ti02 semiconductor electrode 10 having a photocatalytic effect.

When Tie2 carries pt, the photocatalytic ability of TiO2 increases significantly, and cancer tissue 12 can be effectively killed.

Furthermore, the light guiding means is not limited to the illumination light from the light source device 9, and may also be irradiated with laser light. In addition, the laser is
Those with wavelengths shorter than 410 nm, such as excimer lasers,
Ultraviolet lasers such as excimer Dyc lasers and Crybton lasers are preferred.

FIG. 6 shows a second embodiment, in which a direct viewing endoscope 14
A balloon 4 similar to that of the first embodiment is provided at the distal end 16 of the insertion section 15.

An image guide fiber 1.6, a light guide fiber 17, etc. are installed inside the insertion section 15.

Therefore, the balloon 4 is brought into contact with the cancerous tissue 12 generated in the body cavity 11, and the cancerous tissue 12 can be observed by the image guide fiber 16 through the balloon 4, and the illumination light emitted from the light guide fiber 17 is transmitted to the semiconductor 71S pole 1.
When the temperature reaches 0, an oxidation reaction occurs on the semiconductor electrode 10, and the cancer tissue 12 can be killed by the pre-catalytic effect. In other words, the cancer silk fabric 12 can be treated while being observed.

FIG. 7 shows a third embodiment, in which an opening 2 is formed on the side of one tip of a flexible tube 18.
0 is set. A balloon 4 substantially similar to that of the first embodiment is provided in this opening 20 so as to close the opening. An air supply conduit 21 is provided inside the insertion portion 18, and a light guide fiber 22 is inserted into this air supply conduit 21. Therefore, the affected area 24 presses the balloon 4 in the area where the affected area 24 protrudes from the lower surface of the body cavity 23, and the affected area 24 and the balloon 4 come into close contact. In this state, when illumination light is emitted from the light guide fiber 22, an oxidation reaction occurs on the semiconductor electrode 10 as in the previous embodiment, and the affected area 24 can be treated by the photocatalytic effect.

FIG. 8 shows a fourth embodiment, in which a light guiding fiber 26 and an air supply pipe 27 are provided in a divine part 25 made of a flexible tube.
is provided. A transparent rubber 29 is provided at the distal end 28 of the insertion portion 25 to match with the light guide fiber 26, and the distal end 28 is provided with a transparent rubber 29 so as to surround the transparent rubber 29, substantially the same as in the first embodiment. A balloon 30 is provided.

Therefore, in the case of cancer tissue 32 that has developed on the inner peripheral surface of the lumen 31, when the balloon 30 is inflated with the insertion portion 25 pushed into the interior of the lumen 31, the balloon 30 comes into close contact with the cancer tissue 32. . In this state, when illumination light is emitted from the light guide fiber 26, the semiconductor electrode 10
An oxidation reaction occurs above the cancer tissue 3 due to the photocatalytic effect.
2 can be treated.

FIG. 9 shows a fifth embodiment, and 33 is an endoscope 34.
It is an insertion part, and the tip part has a ccDl solid-state image sensor 3.
5. A drive circuit 36 is provided. Further, the insertion section 33 is provided with an insertion channel 37, into which a probe 38 as a treatment device is inserted. The probe 38 is equipped with a light guide fiber 39 and an air supply line (not shown), and a mirror 41 is provided at the tip 40 of the probe 38, facing the exit surface of the three light guide fibers. Further, the distal end portion 40 is provided with a balloon 42 substantially similar to the first embodiment.

Therefore, in the case of cancerous tissue 44 that has developed on the lower surface of the body cavity 43, with the insertion section 33 inserted inside the body cavity 43,
When the balloon 42 is inflated, the balloon 42 expands into the cancerous tissue 4.
Closely attached to 4. In this state, when illumination light is emitted from the three light guide fibers, an oxidation reaction occurs on the semiconductor electrode 10 as in the previous embodiment, and the photocatalytic effect causes cancer tissue 44.
can be treated.

[Effects of the Invention] As explained above, according to the present invention, a balloon made of an inflatable and deflated transparent member is provided in the insertion portion inserted into a living body, and a semiconductor material having a photocatalytic effect is coated on the outer surface of the balloon. On the other hand, since a light guiding means for irradiating the balloon with light is provided in the insertion part, when the light is irradiated toward the semiconductor material, the semiconductor material causes an oxidation reaction and the malignant tumor is killed. Therefore, it is possible to provide a treatment device that can reliably treat even the most affected areas, and can treat a wide area of affected areas at once.

[Brief explanation of drawings]

1 to 5 show a first embodiment of the present invention, FIG. 1 is a side view of the treatment device, FIG. 2 is a longitudinal sectional view of the device in use, and FIG. 3 shows a part of the balloon. FIG. 4 shows an enlarged cross-sectional view of TiO2 fine particles, FIG. 5 shows an enlarged cross-sectional view of TiO2 fine particles carrying PT, and FIG. 6 shows a second embodiment of the present invention. 7 is a cross-sectional view of the treatment device in use, showing a third embodiment of the present invention; FIG. 8 is a cross-sectional view of the treatment device in use, showing a fourth embodiment of the present invention. FIG. 9 is a cross-sectional view of the treatment device in use according to the fifth embodiment of the present invention, and FIG. 10 is a diagram showing a photoelectrochemical reaction process. DESCRIPTION OF SYMBOLS 1... Treatment device, 2... Insertion part, 4... Balloon, 8... Light guide fiber, 10... Semiconductor electrode.

Claims (1)

[Claims] An insertion section inserted into a living body, a balloon made of an inflatable and deflated transparent member provided in the insertion section, a semiconductor material having a photocatalytic effect provided on the outer surface of the balloon, and a semiconductor substance provided in the insertion section made of a transparent material that can be expanded and contracted. A treatment device comprising: a light guiding means for irradiating light onto the balloon.