JPH03261467A - Cancer treating device - Google Patents
Cancer treating deviceInfo
- Publication number
- JPH03261467A JPH03261467A JP2061694A JP6169490A JPH03261467A JP H03261467 A JPH03261467 A JP H03261467A JP 2061694 A JP2061694 A JP 2061694A JP 6169490 A JP6169490 A JP 6169490A JP H03261467 A JPH03261467 A JP H03261467A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- light
- treatment device
- semiconductor
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 77
- 201000011510 cancer Diseases 0.000 title claims abstract description 68
- 238000011282 treatment Methods 0.000 claims abstract description 53
- 239000004065 semiconductor Substances 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 abstract description 24
- 210000004185 liver Anatomy 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000523 sample Substances 0.000 abstract description 4
- 238000004020 luminiscence type Methods 0.000 abstract 4
- 230000005540 biological transmission Effects 0.000 abstract 1
- 210000000080 chela (arthropods) Anatomy 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000003252 repetitive effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 22
- 210000000988 bone and bone Anatomy 0.000 description 18
- 239000003795 chemical substances by application Substances 0.000 description 16
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 230000001699 photocatalysis Effects 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 7
- 210000004872 soft tissue Anatomy 0.000 description 7
- 208000018084 Bone neoplasm Diseases 0.000 description 6
- 230000010355 oscillation Effects 0.000 description 6
- 238000002604 ultrasonography Methods 0.000 description 6
- 239000010419 fine particle Substances 0.000 description 5
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 230000001678 irradiating effect Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 210000000496 pancreas Anatomy 0.000 description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 229920002379 silicone rubber Polymers 0.000 description 4
- 239000004945 silicone rubber Substances 0.000 description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 3
- 239000012670 alkaline solution Substances 0.000 description 3
- 229910010293 ceramic material Inorganic materials 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000004840 adhesive resin Substances 0.000 description 2
- 229920006223 adhesive resin Polymers 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000009291 secondary effect Effects 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003364 biologic glue Substances 0.000 description 1
- 239000005081 chemiluminescent agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Radiation-Therapy Devices (AREA)
- Surgical Instruments (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、生体内の深部に発生した癌、例えば肝臓、膵
臓等の臓器に発生した癌や骨腫瘍等を治療するための癌
治療装置に関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention provides a cancer treatment device for treating cancer that occurs deep within a living body, such as cancer that occurs in organs such as the liver and pancreas, bone tumors, etc. Regarding.
［従来の技術］
従来、癌等の悪性腫瘍を治療する方法として、光励起さ
れた半導体表面が有する強い反応性を利用して、癌細胞
を死滅させる治療方法が知られている。[Prior Art] Conventionally, as a method for treating malignant tumors such as cancer, there has been known a method of killing cancer cells by utilizing the strong reactivity of a photo-excited semiconductor surface.
上述の効果を応用した治療法としては、例えば特願平１
−２３３４３３号に示すように、食道プロステーセス、
ＥＲＢＤチューブのような生体管路に挿入する管状体の
表面における腫瘍組織と接触する部分に、光励起半導体
であるＴ ｉ ０２を設け、内視鏡的に光を照射するこ
とで腫瘍組織を死滅させる方法や、特願平１−２３１４
０３号に示すように、生体内に挿入するバルーンの外表
面に光励起半導体であるＴ ｉ ０２を設け、バルーン
を患部に接触させ、このバルーンの内側から半導体物質
に向けて光を照射する治療方法が知られている。As a treatment method applying the above-mentioned effects, for example, Japanese Patent Application No. 1999
As shown in No.-233433, esophageal prosthesis,
T i 02, which is a photo-excited semiconductor, is provided on the surface of a tubular body inserted into a biological conduit such as an ERBD tube in a portion that comes into contact with tumor tissue, and the tumor tissue is killed by endoscopically irradiating it with light. Method and patent application Hei 1-2314
As shown in No. 03, a treatment method in which T i 02, which is a photoexcitable semiconductor, is provided on the outer surface of a balloon to be inserted into a living body, the balloon is brought into contact with the affected area, and light is irradiated from the inside of the balloon toward the semiconductor material. It has been known.
［発明が解決しようとする課題］
しかしながら、上述のような治療装置の治療部は、内視
鏡やバルーンカテーテルが挿入でき、しかも光照射が容
易に行なえる食道、尿道、胆管等の管腔臓器に限定され
てしまい、例えば、肝臓、膵臓等の光照射が困難な臓器
や骨組織等に発生した癌に対しては治療することができ
ないという問題がある。[Problems to be Solved by the Invention] However, the treatment section of the above-mentioned treatment device is a hollow organ such as the esophagus, urethra, bile duct, etc., into which an endoscope or balloon catheter can be inserted, and in which light irradiation can be easily performed. There is a problem in that, for example, it is not possible to treat cancers that occur in organs that are difficult to irradiate with light, such as the liver and pancreas, or in bone tissue.
本発明は、上記課題に着目してなされたもので、その目
的は、光照射が困難な生体の深部に発生した癌に対して
、容易に繰り返し治療が可能な癌治療装置を提供するこ
とにある。The present invention has been made in view of the above-mentioned problems, and its purpose is to provide a cancer treatment device that can easily and repeatedly treat cancers that occur deep within the body, where it is difficult to irradiate with light. be.
［課題を解決するための手段］
前記課題を解決するために、本発明の癌治療装置は、超
音波により音響化学ルミネッセンスを起こす音響化学ル
ミネッセンス作用物質と、前記音響化学ルミネッセンス
作用物質を収納する収納容器とからなり、前記収納容器
の少なくとも一部が音響化学ルミネッセンス作用物質か
らの発光光線を透過する透光部材で形成され、透光部材
外表面の少なくとも一部に光励起半導体が設けられてい
る。[Means for Solving the Problems] In order to solve the above problems, the cancer treatment device of the present invention includes a sonochemiluminescence agent that causes sonochemiluminescence by ultrasonic waves, and a storage for storing the sonochemiluminescence agent. At least a portion of the storage container is formed of a light-transmitting member that transmits light emitted from the sonochemiluminescence agent, and a photoexcitable semiconductor is provided on at least a portion of the outer surface of the light-transmitting member.
［作用］
本発明に係わる癌治療装置では、音響化学ルミネッセン
ス作用物質を収納した収納容器を生体の深部に発生した
癌、例えば肝臓、膵臓等の臓器、あるいは骨組織等の光
照射が困難な部位に発生した癌組織に接触させて留置し
、体外から超音波を照射することにより、収納容器内の
音響化学ルミネッセンス作用物質は、超音波により発生
するキャビチルジョン気泡の圧壊の際に二次的効果とし
て光を発生し、この発光した光は収納容器の透光部材を
透過して光励起半導体に照射される。その結果、光励起
半導体は酸化反応を起こし、光触媒効果によって光励起
半導体と接触した癌組織を死滅させる。そして、超音波
の照射により生体外から繰り返し治療が行こなわれる。[Function] In the cancer treatment device according to the present invention, the storage container containing the sonochemiluminescence agent is used to treat cancers that occur deep within the living body, such as organs such as the liver and pancreas, or areas that are difficult to irradiate with light, such as bone tissue. By placing it in contact with the cancerous tissue that has developed in the body and irradiating it with ultrasound from outside the body, the sonochemiluminescence agent inside the storage container can be used as a secondary agent when the cavitation bubbles generated by the ultrasound are collapsed. As an effect, light is generated, and the emitted light passes through the transparent member of the storage container and is irradiated onto the photoexcited semiconductor. As a result, the photoexcited semiconductor causes an oxidation reaction, and the photocatalytic effect kills cancer tissue that has come into contact with the photoexcited semiconductor. Then, treatment is repeatedly performed from outside the body by irradiating ultrasound waves.
［実施例コ
以下図面を参照しながら本発明の実施例について説明す
る。[Embodiments] Examples of the present invention will be described below with reference to the drawings.
第１図乃至第４図は、本発明の第１実施例に係わる癌治
療装置を示している。第１図に示す癌治療装置本体２は
、ポリビニルアルコール（ＰＶＡ）ハイドロゲル、シリ
コーンゴム等の生体軟組織の音響インピーダンスと比較
的近い音響インピーダンスを持つ素材からなる収納容器
としての容器部６と、透光性を有する石英ガラス等から
なる透光部材としての透光性蓋部８とで構成されている
。1 to 4 show a cancer treatment device according to a first embodiment of the present invention. The cancer treatment device main body 2 shown in FIG. It is composed of a light-transmitting lid portion 8 as a light-transmitting member made of quartz glass or the like having optical properties.
この容器部６の内部には空間部４が設けられている。そ
して、容器部６と透光性蓋部８は、接合部１０で接着固
定されているい。A space portion 4 is provided inside this container portion 6 . The container portion 6 and the translucent lid portion 8 are adhesively fixed at a joint portion 10.
また、容器部６の空間部４内には、外部から与えられる
超音波により発生するキャビテーション気泡の圧壊の際
に、二次的効果で光を発生する音響化学ルミネッセンス
作用物質１２が充填されている。この音響化学ルミネッ
センス作用物質１２としては、例えばルミノールのアル
カリ性水溶液（例えば、溶液ＩＩ中に約５ｇのＮａ２Ｃ
ｏ３と約０．１ｇのルミノールを溶かしたもの）等があ
る。Furthermore, the space 4 of the container 6 is filled with an acoustochemiluminescence agent 12 that generates light as a secondary effect when cavitation bubbles generated by externally applied ultrasonic waves are collapsed. . The sonochemiluminescence agent 12 may be, for example, an alkaline aqueous solution of luminol (for example, about 5 g of Na2C in solution II).
o3 and approximately 0.1g of luminol dissolved).
上記透光性蓋部８の外表面には、第２図に示すように、
光触媒効果を有する光励起半導体としてのＴｉＯ２から
なる半導体電極１４が設けられている。この半導体電極
１４は、ＴｉＯ２微粒子を接着性の樹脂と混合し、透光
性蓋部８の表面に吹付けて付着させたものであり、この
半導体電極１４は、透光性蓋部８の表面に一体的に固着
されている。なお、ＴｉＯ２微粒子の大きさは、一般に
０．１μ−〜１ｍｇ＋の間である力（，０，１〜１０μ
匝程度が好ましい。また、容器部６、蓋部８を合わせた
大きさとしては、３〜３０ｍｍ程度が好ましい。As shown in FIG. 2, on the outer surface of the translucent lid part 8,
A semiconductor electrode 14 made of TiO2 as a photoexcited semiconductor having a photocatalytic effect is provided. This semiconductor electrode 14 is made by mixing TiO2 fine particles with an adhesive resin and spraying the mixture onto the surface of the transparent lid 8 to adhere it. is integrally fixed to. Note that the size of TiO2 fine particles is generally determined by a force (,0,1~10μ), which is between 0.1μ and 1mg+.
A size of about 100g is preferable. Further, the combined size of the container portion 6 and the lid portion 8 is preferably about 3 to 30 mm.
次に、本発明の第１実施例に係わる癌治療装置を用いて
、生体内軟組織深部、例えば肝臓の表面に発生した癌を
治療する方法について説明する。Next, a method for treating cancer generated deep in the soft tissue of a living body, for example, on the surface of the liver, using the cancer treatment device according to the first embodiment of the present invention will be described.
第３図に示すように、肝臓１８に発生した癌組織２０の
上部もしくは近接した部位の生体皮膚組織１６に第１の
シース２２を穿刺する。そして、第１のシース２２の内
孔に観察用の光学視管３２を挿通ずる。その後、第１の
シース２２近傍の生体皮膚組織１６に、第２のシース２
４を穿刺する。As shown in FIG. 3, the first sheath 22 is punctured into the living skin tissue 16 above or in the vicinity of the cancerous tissue 20 that has developed in the liver 18. Then, an optical viewing tube 32 for observation is inserted into the inner hole of the first sheath 22. Thereafter, the second sheath 2 is applied to the biological skin tissue 16 near the first sheath 22.
Puncture 4.
そして、第２のシース２４に挿通された把持鉗子２８に
より癌治療装置本体２を把持し、肝臓１８表面の癌組織
２０に導びく。この作業は、第１のシース２２内に挿通
した光学視管３２で観察しながら行なう。また、癌治療
装置本体２の留置を行なう場合、第４図に示すように癌
治療装置本体２の透光性蓋部８の外表面に設けられた半
導体装置１４が、癌組織２０に接するように光学視管３
２で観察を行ないながら留置する。Then, the cancer treatment device main body 2 is grasped by the grasping forceps 28 inserted through the second sheath 24 and guided to the cancerous tissue 20 on the surface of the liver 18 . This operation is performed while observing with the optical viewing tube 32 inserted into the first sheath 22. Furthermore, when the cancer treatment device body 2 is placed, the semiconductor device 14 provided on the outer surface of the translucent lid portion 8 of the cancer treatment device body 2 is placed in contact with the cancer tissue 20, as shown in FIG. Optical viewing tube 3
The tube will be left in place while being observed in step 2.
また、上記癌治療装置本体２を長時間体内に留置する場
合は、癌治療装置本体２をフィブリン等の生体用接着剤
を用いて癌組織に接着固定したり、もしくは癌治療装置
本体２をクリップで覆ったり、あるいは癌治療装置本体
２を光学視管３２で観察しながら癌組織に縫合固定して
も良い。In addition, when the cancer treatment device body 2 is left in the body for a long time, the cancer treatment device body 2 may be adhesively fixed to the cancer tissue using a biological adhesive such as fibrin, or the cancer treatment device body 2 may be held with a clip. Alternatively, the cancer treatment device main body 2 may be sutured and fixed to the cancer tissue while being observed through the optical viewing tube 32.
癌治療装置本体２の埋設後は、第１のシース２２、第２
のシース２４また各々に挿通した光学視管３２、把持鉗
子２８を生体皮膚組織１６から抜く。その後、第４図に
示すように、生体外に配置した超音波発振装置２６より
超音波信号を発振する。発振された超音波信号は、アン
プ３０により増幅され、超音波発振プローブ３４に設け
られた超音波発振素子３６から増幅された超音波として
発振され、その結果、生体皮膚組織１６に密着固定した
パウチ３８を介して生体内の癌組織２０の近傍に留置し
た癌治療装置本体２に向けて超音波が照射される。After embedding the cancer treatment device main body 2, the first sheath 22, the second
The sheath 24 and the optical viewing tube 32 and grasping forceps 28 inserted through each are removed from the living skin tissue 16. Thereafter, as shown in FIG. 4, an ultrasonic signal is oscillated by an ultrasonic oscillator 26 placed outside the living body. The oscillated ultrasonic signal is amplified by the amplifier 30 and oscillated as an amplified ultrasonic wave from the ultrasonic oscillation element 36 provided in the ultrasonic oscillation probe 34. As a result, the pouch tightly fixed to the biological skin tissue 16 is emitted. Ultrasonic waves are irradiated via 38 toward the cancer treatment device main body 2 placed near the cancer tissue 20 in the living body.
上記癌治療装置本体２の容器部３は、生体軟組織と音響
インピーダンスが近いポリビニルアルコールハイドロゲ
ルやシリコーンゴム等から形成されているため、照射さ
れた超音波は、容器部６の空間部４に設けられた音響化
学ルミネッセンス作用物質１２に到達する。Since the container portion 3 of the cancer treatment device main body 2 is made of polyvinyl alcohol hydrogel, silicone rubber, etc., which has an acoustic impedance close to that of biological soft tissues, the irradiated ultrasonic waves are transmitted to the space portion 4 of the container portion 6. The sono-chemiluminescent agent 12 thus obtained is reached.
音響化学ルミネッセンス作用物質１２に超音波が照射さ
れると、キャビテーション気泡が発生し、このキャビテ
ーション気泡が圧壊する際の温度上昇に共なう二次的効
果のイオン生成で、３５０〜６００ｎ■のスペクトル領
域で連続的な光を発光する。発光した光は、癌治療装置
本体２の透光性蓋部８を介して、透光性蓋部８外表面に
設けられたＴ ｉ ０２よりなる半導体電極１４に照射
される。そして、半導体電極１４に４００ｎ■前後の紫
外光が照射されると、半導体電極１４上では酸化反応が
起こり、光触媒効果によって、半導体電極１４と接触し
た癌組織２０を死滅させる。When the sonochemiluminescence agent 12 is irradiated with ultrasonic waves, cavitation bubbles are generated, and when the cavitation bubbles collapse, ions are generated as a secondary effect as the temperature rises, resulting in a spectrum of 350 to 600 nm. Emit continuous light in an area. The emitted light is applied to the semiconductor electrode 14 made of T i 02 provided on the outer surface of the transparent lid 8 through the transparent lid 8 of the cancer treatment device main body 2 . When the semiconductor electrode 14 is irradiated with ultraviolet light of around 400 nm, an oxidation reaction occurs on the semiconductor electrode 14, and the cancer tissue 20 in contact with the semiconductor electrode 14 is killed by the photocatalytic effect.
このように構成された癌治療装置は、生体外から超音波
を照射することで肝臓、膵臓等の光照射が困難な臓器に
発生した癌や骨肉腫瘍等に対して体外から容易に繰り返
し治療を行なうことができる。従って、従来の光励起半
導体を用いた治療装置のように治療可能な部位が、内視
鏡やバルーンカテーテルが挿入でき、光照射が可能な管
腔臓器に限定されることはない。The cancer treatment device configured in this way can easily and repeatedly treat cancers and bone and flesh tumors that occur in organs that are difficult to irradiate with light, such as the liver and pancreas, by irradiating ultrasound from outside the body. can be done. Therefore, unlike conventional treatment devices using photoexcited semiconductors, the areas that can be treated are not limited to hollow organs into which an endoscope or balloon catheter can be inserted and which can be irradiated with light.
なお、上記第１実施例では、半導体電極を透光性蓋部８
の表面に吹付けて設けているが、素材中に半導体微粒子
を混入させて、透光性蓋部８を形成しても良い。Note that in the first embodiment, the semiconductor electrode is connected to the light-transmitting lid part 8.
The light-transmitting lid portion 8 may be formed by mixing semiconductor fine particles into the material.
また、上記実施例では癌治療装置本体２を１個だけ埋設
する場合について述べたが、癌組織２０の大きさに合わ
せ、複数個埋設しても良い。Further, in the above embodiment, the case where only one cancer treatment device main body 2 is buried has been described, but a plurality of cancer treatment device main bodies 2 may be buried depending on the size of the cancer tissue 20.
第５図乃至第６図は、本発明の第２実施例に係わる癌治
療装置を示している。5 and 6 show a cancer treatment device according to a second embodiment of the present invention.
第２実施例の癌治療装置本体４０は、透光性を有するポ
リメタクリル酸メチル（ＰＭＭＡ）、ポリメタクリル酸
２−ヒドロキシエチル（ＰＨＨＭＡ） 、ポリビニルア
ルコールハイドロゲル、シリコーンゴム等の生体の軟組
織の音響インピーダンスと比較的近い音響インピーダン
スを持つ第１の透光性容器部４２と、第２の透光性容器
部４４とから構成されている。The cancer treatment device main body 40 of the second embodiment is made of a material such as translucent polymethyl methacrylate (PMMA), poly 2-hydroxyethyl methacrylate (PHHMA), polyvinyl alcohol hydrogel, silicone rubber, etc. It is composed of a first translucent container section 42 and a second translucent container section 44, each having an acoustic impedance relatively close to the impedance.
第１の透光性容器部４２、第２の透光性容器部４４で形
成された空間部４６には、第１実施例と同様に、超音波
の照射により発光するルミノールのアルカリ性溶液から
なる音響化学ルミネッセンス作用物質１２が充填されて
いる。そして、第１の透光性容器部４２と第２の透光性
容器部４４は、接合部４８で接着固定されている。The space 46 formed by the first translucent container part 42 and the second translucent container part 44 is filled with an alkaline solution of luminol that emits light when irradiated with ultrasonic waves, as in the first embodiment. It is filled with a sonochemiluminescent agent 12 . The first translucent container part 42 and the second translucent container part 44 are adhesively fixed at a joint part 48.
また、第１の透光性容器部４２と第２の透光性容器部４
４の表面上、すなわち癌治療装置本体４０の全周上には
、第１実施例で説明した光触媒効果を有する半導体物質
としてのＴ ｉ Ｏ２からなる半導体電極５０が、接着
性を有する樹脂と混合されて吹付けにより付着されてい
る。なお、Ｔ ｉ ０２微粒子の大きさは、第１実施例
と同様に０．１μｍ〜１０μｍ程度のものが採用され、
また癌治療装置本体４０の大きさとしては、第１実施例
と同じく５〜３０１１程度が好ましい。Moreover, the first translucent container part 42 and the second translucent container part 4
4, that is, on the entire circumference of the cancer treatment device main body 40, a semiconductor electrode 50 made of T i O 2 as a semiconductor material having a photocatalytic effect as described in the first embodiment is mixed with a resin having adhesive properties. It is applied by spraying. Note that the size of the T i 02 fine particles is about 0.1 μm to 10 μm, as in the first example.
Further, the size of the cancer treatment device main body 40 is preferably about 5 to 3011 mm, same as in the first embodiment.
第２実施例に係わる癌治療装置を用いて、生体内軟組織
深部に発生した癌を治療する際には、シース２２、把持
鉗子２８、光学視管３２を用いて、第６図に示すように
癌治療装置本体４０を、第１の透光性容器部４２、第２
の透光性容器部４４の表面上に設けられた半導体電極５
０が癌組織２０に接するように、外科的に体内に挿入し
て留置する。When using the cancer treatment device according to the second embodiment to treat cancer that has occurred deep in the soft tissues of a living body, the sheath 22, grasping forceps 28, and optical viewing tube 32 are used to treat cancer as shown in FIG. The cancer treatment device main body 40 is connected to the first transparent container part 42 and the second translucent container part 42.
The semiconductor electrode 5 provided on the surface of the translucent container portion 44 of
It is surgically inserted into the body and left in place so that 0 is in contact with the cancerous tissue 20.
その後、生体外に配置された超音波発振装置２６、アン
プ３０、超音波発振プローブ３４、パウチ３８等を介し
て生体内の癌治療装置本体４０に向けて超音波を照射す
る。Thereafter, ultrasonic waves are irradiated toward the cancer treatment device main body 40 inside the living body via the ultrasound oscillation device 26, amplifier 30, ultrasound oscillation probe 34, pouch 38, etc. arranged outside the living body.
第１．第２の透光性容器部４２．４４は、生体軟組織と
音響インピーダンスが近いＰＭＭＡ。1st. The second translucent container portions 42 and 44 are made of PMMA, which has an acoustic impedance close to that of biological soft tissue.
ＰＨＥＭＡ、ＰＶＡハイドロゲル、シリコーンゴム等か
ら形成されているため、照射された超音波は、第１．第
２の透光性容器部４２．４４の空間部４６内に充填され
た音響化学ルミネッセンス作用物質１２に到達する。Since it is made of PHEMA, PVA hydrogel, silicone rubber, etc., the irradiated ultrasonic waves are It reaches the sonochemiluminescence agent 12 filled in the space 46 of the second translucent container part 42,44.
そして、ルミノールのアルカリ溶液からなる音響化学ル
ミネッセンス作用物質１２が発光し、第１ 第２の透光
性容器部４２．４４を透過して表面上に設けられたＴ
ｉ ０２よりなる半導体電極５０に光が照射される。照
射された光によって半導体電極５０上では酸化反応が起
こり、光触媒効果によって半導体電極５０と接触した癌
組織２０を死滅させることができる。Then, the sonochemiluminescence agent 12 made of an alkaline solution of luminol emits light and passes through the first and second light-transmitting container portions 42 and 44, and is then exposed to the T provided on the surface.
Light is irradiated onto the semiconductor electrode 50 made of i02. An oxidation reaction occurs on the semiconductor electrode 50 due to the irradiated light, and the cancer tissue 20 that has come into contact with the semiconductor electrode 50 can be killed by the photocatalytic effect.
このように構成され癌治療装置では、音響化学ルミネッ
センス作用物質を充填した第１の透光性容器部４２、第
２の透光性容器部４４の両者をＰＭＭＡ、ＰＨＥＭＡ、
ＰＶＡハイドロゲル、シリコーンゴム等の透光性部材で
形成しているため、第１実施例と比べてさらに広範囲の
癌組織に対して生体外から容易に繰り返し治療を行なう
ことができる。In the cancer treatment device configured as described above, both the first translucent container section 42 and the second translucent container section 44 filled with the sonochemiluminescence agent are made of PMMA, PHEMA,
Since it is made of a translucent material such as PVA hydrogel or silicone rubber, it is possible to easily and repeatedly treat a wider range of cancer tissues from outside the body than in the first embodiment.
第７図乃至第８図は、本発明の第３実施例に係わる癌治
療装置を示している。7 to 8 show a cancer treatment device according to a third embodiment of the present invention.
第３実施例は、骨腫瘍摘出後の再発防止に用いられる治
療装置に関するものである。第７図に示すように、骨腫
瘍摘出後の窪みには透光外骨充填材５２が充填されるが
、この透光外骨充填材５２は、β−ＴＣＰ、ハイドロキ
シアパタイト（ＲＡＰ） 、アルミナ等の生体適合性を
有するセラミック材料からなり、これらのセラミック材
料は、ＨＩＰ処理を施して緻密かつ透光性を有するよう
に形成されている。透光外骨充填材５２には孔部５４が
設けられ、孔部５４には、シリコーン等の透明且つ生体
軟組織と音響インピーダンスが近い素材で形成された透
明袋状部材５６が接着等により固定されている。そして
、透明袋状部材５６の内部には、ルミノールのアルカリ
性溶液からなる音響化学ルミネッセンス作用物質１２が
充填されている。The third embodiment relates to a treatment device used to prevent recurrence after bone tumor removal. As shown in FIG. 7, the hollow after bone tumor removal is filled with a translucent external bone filling material 52, and this translucent external bone filling material 52 is made of β-TCP, hydroxyapatite (RAP), alumina, etc. It is made of a biocompatible ceramic material, and these ceramic materials are formed to be dense and translucent by HIP treatment. A hole 54 is provided in the transparent external bone filling material 52, and a transparent bag-like member 56 made of a material such as silicone that is transparent and has an acoustic impedance close to that of biological soft tissue is fixed by adhesive or the like. There is. The inside of the transparent bag-like member 56 is filled with a sonochemiluminescent substance 12 made of an alkaline solution of luminol.
また、透光外骨充填材５２の外表面の適宜部位には、第
８図に示すように、光触媒効果を有する半導体物質とし
てＴｉ０２５８にＰｔ６０を担持させた半導体電極層６
２が、接着性を有する樹脂と混合されて吹付けにより付
着されている。なお、Ｔ ｉ ０２にｐｔを担持させた
微粒子の大きさは０．１〜１０μｍ程度である。Furthermore, as shown in FIG. 8, a semiconductor electrode layer 6 in which Pt60 is supported on Ti0258 as a semiconductor material having a photocatalytic effect is provided at an appropriate portion of the outer surface of the light-transmitting external bone filling material 52.
2 is mixed with an adhesive resin and attached by spraying. In addition, the size of the fine particles in which pt is supported on T i 02 is about 0.1 to 10 μm.
次に、第３実施例に係わる透光外骨充填材５２を用いて
、骨腫瘍摘出後の再発を防止する方法について説明する
。Next, a method for preventing recurrence after bone tumor removal using the light-transmitting external bone filling material 52 according to the third embodiment will be described.
まず、透光外骨充填材５２を骨腫瘍摘出後の骨組織６４
の窪みに充填する。そして、アルミナ、β−ＴＣＰ％Ｈ
ＡＰ等の生体適合性を有するセラミック材料で形成され
た骨ビン６６により骨組織６４に対してねじ込み固定す
る。骨腫瘍摘出部に腫瘍組織が再発した場合には、第１
．第２実施例と同じく生体外に配置した超音波発振装置
２６、アンプ３０、超音波発振プローブ３４、パウチ３
８等を介して生体内の透光外骨充填材５２に向けて超音
波を照射する。照射された超音波は、生体軟組織を介し
て透光外骨充填材５２の孔部５４に設けられた透明袋状
部材５６に到達するが、透明袋状部材５６は、シリコー
ン等の生体軟組織と音響インピーダンスが近い材料によ
り形成されているため、さらに透明袋状部材５６内の音
響化学ルミネッセンス作用物質１２に到達する。そして
、第１．第２実施例と同じく、音響化学ルミネ・ンセン
ス作用物質１２は発光し、透明袋状部材５６、透光外骨
充填材５２を介して、透光外骨充填材５２の表面上に設
けられた’ｒｉｏ、、、ｐｔよりなる半導体電極層６２
に光が照射される。First, the light-transmitting external bone filling material 52 is applied to the bone tissue 64 after bone tumor removal.
Fill the hollow. and alumina, β-TCP%H
A bone via 66 made of a biocompatible ceramic material such as AP is screwed into the bone tissue 64 and fixed. If tumor tissue recurs at the site where the bone tumor was removed, the first
．． Ultrasonic oscillation device 26, amplifier 30, ultrasonic oscillation probe 34, and pouch 3 placed outside the living body as in the second embodiment
Ultrasonic waves are irradiated toward the light-transmitting external bone filling material 52 in the living body through a tube such as 8 or the like. The irradiated ultrasonic waves reach the transparent bag-like member 56 provided in the hole 54 of the light-transmitting external bone filling material 52 via the soft tissue of the living body, but the transparent bag-like member 56 is made of soft tissue such as silicone and acoustically Since it is made of materials with similar impedance, it further reaches the sonochemiluminescence agent 12 inside the transparent bag-like member 56. And the first. As in the second embodiment, the acoustochemiluminescence agent 12 emits light and passes through the transparent bag-like member 56 and the translucent external bone filling material 52 to the 'rio' provided on the surface of the translucent external bone filling material 52. , , Semiconductor electrode layer 62 made of PT
light is irradiated on.
照射された光により、ＴｉＯ２，Ｐｔよりなる半導体電
極層６２上では酸化反応が起こり、光触媒効果によって
半導体電極層６２と接触している再発腫瘍組織を死滅さ
せることができる。The irradiated light causes an oxidation reaction on the semiconductor electrode layer 62 made of TiO2 and Pt, and the recurrent tumor tissue in contact with the semiconductor electrode layer 62 can be killed by the photocatalytic effect.
このように構成した癌治療装置では、透光性骨充環材５
２表面上に、光触媒効果を有する半導体物質としてのＴ
ｉＯ２にｐｔを担持させた半導体電極層６２が設けられ
ているため、前記第１．第２実施例のＴ ｉ ０２単体
を用いた場合と比べて癌組織死滅効果がより大きくなる
。In the cancer treatment device configured in this way, the transparent bone filling material 5
2. T as a semiconductor material with photocatalytic effect on the surface
Since the semiconductor electrode layer 62 in which iO2 supports pt is provided, the first. The cancer tissue killing effect is greater than that in the case of using T i 02 alone in the second example.
［発明の効果］
以上説明したように本発明に係わる癌治療装置では、従
来の光励起半導体を用いた治療装置のように、治療部位
が食道、尿道、胆管等の内視鏡やバルーンカテーテルが
挿入でき、しかも光照射が容易に行なえる管腔臓器に限
定されることはなく、肝臓、膵臓等の臓器あるいは骨組
織等の光照射が困難な生体深部に発生した癌に対して生
体外から容易に繰り返し治療を行なうことができる。[Effects of the Invention] As explained above, in the cancer treatment device according to the present invention, unlike conventional treatment devices using photoexcited semiconductors, the cancer treatment device can be used to treat areas such as the esophagus, urethra, bile duct, etc. through which an endoscope or balloon catheter is inserted. Moreover, it is not limited to hollow organs that can be easily irradiated with light, and can be easily applied ex vivo to cancers that occur deep within the body, such as organs such as the liver and pancreas, or bone tissue, where it is difficult to irradiate with light. Treatment can be repeated.
第１図は本発明の第１実施例に係わる癌治療装置の縦断
面図、第２図は第１実施例に係わる癌治療装置の透光部
材の外表面を示す断面図、第３図は前記癌治療装置の埋
設方法を示す側面図、第４図は前記癌治療装置の作動状
態を示す図、第５図は本発明の第２実施例に係わる癌治
療装置の縦断面図、第６図は第２実施例に係わる癌治療
装置の作動状態を示す図、第７図は本発明の第３実施例
に係わる癌治療装置の作動状態を示す図、第８図は第３
実施例に係わる透光部材の表面を示す断面図である。
２・・・癌治療装置本体、６・・・容器部（収納容器）
、８・・・透光性蓋部（透光部材）、１２・・・音響化
学ルミネッセンス作用物質、１４・・・半導体電極（光
励起半導体）FIG. 1 is a longitudinal cross-sectional view of a cancer treatment device according to a first embodiment of the present invention, FIG. 2 is a cross-sectional view showing the outer surface of a transparent member of the cancer treatment device according to the first embodiment, and FIG. FIG. 4 is a side view showing the method of embedding the cancer treatment device, FIG. 4 is a diagram showing the operating state of the cancer treatment device, FIG. 5 is a longitudinal sectional view of the cancer treatment device according to the second embodiment of the present invention, and FIG. 7 shows the operating state of the cancer treatment device according to the third embodiment of the present invention, and FIG. 8 shows the operating state of the cancer treatment device according to the third embodiment of the present invention.
FIG. 3 is a cross-sectional view showing the surface of a light-transmitting member according to an example. 2... Cancer treatment device main body, 6... Container part (storage container)
, 8... Translucent lid part (light-transmitting member), 12... Sonochemiluminescence agent, 14... Semiconductor electrode (photoexcited semiconductor)
Claims (1)
ルミネッセンス作用物質と、この音響化学ルミネッセン
ス作用物質を収納する収納容器とからなり、前記収納容
器の少なくとも一部が前記音響化学ルミネッセンス作用
物質からの発光光線を透過させる透光部材で形成され、
この透光部材の外表面の少なくとも一部に光励起半導体
が設けられていることを特徴とする癌治療装置。It comprises a sonochemiluminescence agent that causes sonochemiluminescence by ultrasonic waves, and a storage container that stores the sonochemiluminescence agent, and at least a portion of the storage container transmits light emitted from the sonochemiluminescence agent. It is formed of a transparent member that allows
A cancer treatment device characterized in that a photoexcitable semiconductor is provided on at least a portion of the outer surface of the light-transmitting member.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2061694A JPH03261467A (en) | 1990-03-13 | 1990-03-13 | Cancer treating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2061694A JPH03261467A (en) | 1990-03-13 | 1990-03-13 | Cancer treating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03261467A true JPH03261467A (en) | 1991-11-21 |
Family
ID=13178616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2061694A Pending JPH03261467A (en) | 1990-03-13 | 1990-03-13 | Cancer treating device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03261467A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5944748A (en) * | 1996-07-25 | 1999-08-31 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
| EP1834646A4 (en) * | 2005-10-26 | 2008-03-19 | Toto Ltd | Ultrasonic cancer therapy accelerator and cytotoxic agent |
| JP2010012218A (en) * | 2008-06-04 | 2010-01-21 | Japan Health Science Foundation | Ultrasonic medical apparatus |
| WO2012127441A1 (en) | 2011-03-23 | 2012-09-27 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
-
1990
- 1990-03-13 JP JP2061694A patent/JPH03261467A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5944748A (en) * | 1996-07-25 | 1999-08-31 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
| EP1834646A4 (en) * | 2005-10-26 | 2008-03-19 | Toto Ltd | Ultrasonic cancer therapy accelerator and cytotoxic agent |
| US8992958B2 (en) | 2005-10-26 | 2015-03-31 | Toto Ltd. | Ultrasonic cancer treatment enhancer and cell killer |
| JP2010012218A (en) * | 2008-06-04 | 2010-01-21 | Japan Health Science Foundation | Ultrasonic medical apparatus |
| US8515524B2 (en) | 2008-06-04 | 2013-08-20 | National Cerebral And Cardiovascular Center | Extracorperal ultrasonic irradition of titanium oxide (TiO2) coated implant for angiogenesis stimulation |
| WO2012127441A1 (en) | 2011-03-23 | 2012-09-27 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
| US9464079B2 (en) | 2011-03-23 | 2016-10-11 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
| US10092565B2 (en) | 2011-03-23 | 2018-10-09 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
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