JPH0385455A - Automatic analyser - Google Patents

Abstract

PURPOSE:To increase a treatment speed by random accessing by providing a plurality of reaction lines holding a plurality or reaction tubes to feed the same intermittently and setting said lines to independent reaction lines with respect to items different in a reaction time. CONSTITUTION:A reaction tube supply apparatus 6 supplies reaction tubes 4 of an indicated item to the reaction tube holders of reaction lines 2a, 2b and a specimen distribution apparatus 8 distributes a specimen in each of the reaction tubes and a reagent distribution apparatus 10 distributes a diluent and an enzyme labelled solution. Antigen-antibody reactions are respectively performed in the lines 2a, 2b for the time until reaching a washing apparatus 12 and the reaction tubes 4 are washed by the washing apparatus 12 and a color forming solution distribution apparatus 14 distributes a color forming solution and color forming reaction due to enzyme is performed for the time until absorbance or fluorescence is measured by a colorimeter 16 and a residual solution discharging/reaction tube disposing apparatus 18 discharges a residual solution and excludes the reaction tubes 4. As mentioned above, when a common treatment operation part is allowed to act on a plurality of the reaction lines different in a reaction time in a time sharing manner, the increase of a treatment speed and cost reduction can be achieved.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to an automatic analyzer convenient for immunoassays such as EIA (enzyme immunoassay).

(Prior art) Ordinary biochemical analyzers can perform random access for multiple analysis items, but the reaction time is limited to about 15 minutes, and the time for one reaction varies considerably. There is no such thing as random access to things.

Some EIA automatic analyzers have attempted random access, but the reaction time is fixed, for example, within 60 minutes.

(Problems to be Solved by the Invention) EIA generally requires a long reaction time. For example, depending on the item, the duration is not limited to one hour, but may be two or three hours. If you forcefully limit the reaction time to less than 60 minutes, as with commercially available EIA random access devices,
For example, for items where only a small amount of sample is present, it may be difficult to process the reagent to increase sensitivity, or this restriction may increase the number of items that cannot be implemented.

Random access is extremely useful because it frees the operator from having to make preparations such as sorting received samples into categories.1 Random access is common in normal automatic biochemical analysis, so random access can also be used for immunoassays. There is a strong need for it to be made into a

As an additional advantage of random access, it can be pointed out that it is advantageous when a chip is required at the time of sample dispensing. This is because, in immunoassays, the difference in measured values between samples can be nearly a million times, so chips are often used to avoid contamination between adjacent samples. In this case, if you use the random access method, you can dispense the required amount of one sample without changing the chip.
Tips are not wasted compared to replacing tips after each dispensing process. Therefore, a random access method with fewer restrictions on reaction time is particularly desired.

When random accessing items with different reaction times, use only one reaction line.

One possible method is to rotate this many times and perform analyzes with different reaction times, but when setting the first sample,
It is necessary to keep the reaction tube free for items that may be used several times in the future.

Efficiency decreases and processing speed decreases.

Additionally, programming the device becomes extremely difficult.

Therefore, one aspect of the present invention is that when making random access,
The purpose is to increase processing speed by providing independent reaction lines for items with different reaction times, and to suppress increases in costs.

(Means for Solving the Problems) In the present invention, among the independent reaction lines, the incubation part is made independent, and one reaction tube supply device, a specimen dispensing device,
At least one of the mechanically complex processing operation units, such as a reagent dispensing device and a cleaning device, is made common to a plurality of reaction lines having different reaction times. When moving from the common part to the incubation part, the reaction lines are branched into multiple reaction lines with different reaction times, and when they return to the common part, they are merged.

(Function) In a common part where a processing operation section is shared, the reaction tubes of multiple reaction lines can be sequentially inserted into the common part in a time-sharing manner, or
Although the multiple reaction lines themselves are not shared, they are run side by side where necessary, and a common processing operation unit acts on the multiple reaction lines in a time-sharing manner.

In any case, the operation speed of the processing operation section in the common section should be faster than the line speed of the incubation section, and the reaction lines with different reaction times should be allocated to the common processing section in a time-sharing manner. This corresponds to composing.

(Example) FIG. 1 represents one embodiment.

Two reaction lines are provided, with a reaction line 2a placed on the inside and a reaction line 2b placed on the outside. Each reaction line 2a, 2b is connected in series with 150 reaction tube holders each made of a snake chain. The inner reaction line 2a is intermittently moved three times per minute, and the outer reaction line 2b is intermittently driven once per minute.

That is, after the reaction line 2a is moved away three times every 15 seconds, the reaction line 2b is moved once 15 seconds later. Reaction line 2a1i advances 3 steps per minute, so 180 steps are sent per hour. On the other hand, the reaction line 2b advances one step per minute, so 60 steps are sent per hour. Since each reaction line 2a and 2b is equipped with 150 reaction tube holders, the time required for the reaction line 2a to go around once (the time required for advancing 150 steps) is 50 minutes, and one reaction line 2b is equipped with 150 reaction tube holders. The time required to complete one revolution (the time required to advance 150 steps) is 150 minutes.

The two reaction lines 2a and 2b have a common section running in parallel. The common section includes a cleaning device 12, a coloring liquid dispensing device 14, a colorimeter 16. Residual waste liquid/reaction tube disposal device 18,
Reaction tube supply device 6, sample dispensing device 8, and reagent dispensing device 1
0 are arranged at predetermined positions along the reaction tube traveling direction.

It is the reaction tube supply device 6 that first acts on the two reaction lines 2a, 2b. In the reaction tube supply device 6, the reaction tubes 4 prepared for each item are automatically selected according to the analysis request.
It is sequentially supplied to two reaction lines 2a and 2b. Reaction tube 4
is a microcup that separates the wells of a microplate into individual wells.

The sample dispensing device 8 collects samples 8b arranged on a turntable 8a.
The necessary amount of the sample is dispensed into the reaction tubes 4 of the two lines 2a and 2b, as many as the number of reaction tubes corresponding to the analysis item. In synchronization with the separation of the two lines 2a and 2b, 2a and 2
Dispense in groups a, 2a, 2b, 2a, 2a, 2a, 2b, etc. However, the sample dispensing section 8 may be of other types, such as a rack type.

The reagent dispensing device 10 dispenses the reagent corresponding to each reaction tube 4 item. The reagent dispensing section 10 is exemplified as a turntable type, and the reagent in the reagent bottle 1ob arranged along the circumference of the turntable 10a is transferred to the dispenser 1.
0c to the reaction tube 4. However, the reagent dispensing section 10 may also be of other types, such as a rack type.

After the reagent is dispensed, the reaction lines 2a and 2b proceed independently to perform incubation.

The time from reagent dispensing until it reaches the cleaning device 12 is 30 minutes in the reaction line 2a and 150 minutes in the reaction line 2b, and the antigen-antibody reaction progresses in the reaction tube 4 during this section.

The cleaning device 12 has a structure as shown in FIG. 8, for example. In the cleaning device 12, the vertical/direction and reaction lines 2a and 2
A cleaning nozzle 50 is provided which is supported so as to be movable in the horizontal direction.

The cleaning nozzle 50 is a double pipe. When cleaning is performed, a cleaning nozzle 50 is inserted into the reaction tube 4 of the reaction line 2a or 2b, a cleaning liquid is supplied from the inner tube, and the cleaning liquid is discharged from the outer tube.

In the washing device 12, unreacted reagents and specimens in the reaction tube 4 are washed away, and a labeled enzyme bound thereto remains on the inner wall of the reaction tube in proportion to the concentration of the analyte.

In the coloring liquid dispensing device 14, a reagent for the RPJ elementary reaction is added. For example, the coloring liquid dispensing device M14 is connected to the reaction lines 2a and 2.
A nozzle is provided which is movably supported in the horizontal direction between the spaces b, and the coloring liquid is dispensed from the nozzle.

The colorimeter 16 is provided at a certain distance from the coloring liquid dispensing device 14. For example, as shown in FIG. 9, the colorimeter 16 is configured such that white light from a light source is vertically irradiated onto each reaction tube 4 of the reaction lines 2a and 2b from above through an optical fiber 52, and transmitted through the reaction tube 4. The light passes through respective filters 54a and 54b and reaches respective photocells 56a.

The light is received by 56b.

The residual liquid discharge/reaction tube disposal device 18 removes the residual liquid before disposing of the reaction tube 4, and then removes the reaction tube 4. As shown in FIG. 10, for example, the residual liquid discharge/reaction tube disposal device 18 is provided with a nozzle body having a nozzle tip 60 made of an elastic member at the tip of a nozzle 58 so as to be movable in the vertical and horizontal directions. ing. The distal end surface of the nozzle tip 60 protrudes forward beyond the distal end of the nozzle 58.
can be switched between suction by reduced pressure and release to the atmosphere. By suctioning while lowering the nozzle 58 into the reaction tube 4, the residual liquid is suctioned and removed.
Each time the tip of the nozzle tip 60 reaches the bottom of the reaction tube 4, one reaction tube 4 is absorbed by the nozzle tip 60. Thereafter, the nozzle 58 moves upward and then horizontally until it reaches the waste port, and the nozzle 58 is opened to the atmosphere, causing the reaction tube 4 to fall into the waste port. Thereafter, the nozzle 58 is again moved onto the reaction tube 4 to be discarded in the reaction line 2a or 2b, and the same operation is repeated.

An example of the reaction tube supply device 6 will be explained with reference to FIGS. 2 to 7.

A reaction tube rack 24 is attached to the frame 22 of the reaction tube supply device 6 by a guide 26 in a direction (X
direction). A screw 30 that is moved away by a stepping motor 28 is passed through the reaction tube rack 24, and the rotation of the screw 30 causes the reaction tube rack 24 to slide and move along the guide 26. The reaction tube rack 24 and the frame 22 are arranged with a slight inclination so that one end is downward.

The reaction tube rack 24 is provided with six grooves 32 extending in the Y direction, and one lower end of each groove 32 faces the wall surface of the frame 22. In the winding groove 32, twelve reaction tubes 4a each having twelve reaction tubes connected in a straight line are arranged. The six grooves 32 correspond to different measurement items A to F, and the coupling reaction tubes 4a on which antigens or antibodies for each measurement item are immobilized are arranged in the winding grooves 32.

The connecting reaction tube 4a has the shape shown in FIG. 3 and is made of plastic. The plurality of reaction tubes 4 are linearly connected by connecting portions 4b, and the connecting portions 4b are shaped thin and can be easily folded. The reaction tube 4 has a size corresponding to one hole of a 966 microplate,
A series of reaction tubes 4 have immobilized antigens or antibodies for the same measurement item.

Returning to FIG. 2, three connected reaction tubes 4a can be arranged in each of the winding grooves 32 of the reaction tube rack 24, so that 36 reaction tubes are arranged in each groove 32.

A reaction tube take-out mechanism 34 is provided at the lower end of the frame 22. The reaction tube take-out mechanism 34 includes an air cylinder 36 for taking out one reaction tube 4 at the tip of the connected reaction tubes 4a for the measurement item selected by the stepping motor 28, and a reaction tube 4 that has been taken out and cut. compressed air inlets 38 and 1 for delivering the gas to the reaction line 2a or 2b.
A feeding mechanism (as shown) is provided for reciprocating the reaction tube take-out mechanism 34 in the X direction in order to select a reaction line for supplying reaction tubes.

FIG. 4 shows the internal structure of the reaction tube take-out mechanism 34.

A partition plate 40 that is moved vertically by an air cylinder 36 is provided within the reaction tube take-out mechanism 34, and a notch 42 is provided in the partition plate 40. The partition plate 40 is in contact with the lower end surface of the reaction tube rack 24, and when the partition plate 40 is lowered, when the reaction tube rack 24 is moved in the X direction by the stepping motor 28, the tips of the connected reaction tubes 4a are The position is regulated by a partition plate 40. A reaction tube housing section 44 is provided outside the cutout section 42 . As shown in FIG. 5, a compressed air inlet 38 is led to the reaction tube storage section 44, and the reaction tubes stored in the storage section 44 are guided to the reaction line via a tube 46 by compressed air.

When the partition plate 40 is moved upward by the air cylinder 36, the notch 42 is moved upwardly from the notch 42.
One reaction tube 4 at the tip of the connecting reaction tube 4a in the groove located at position 2 comes out from the notch 42 and enters the reaction tube storage section 44.
to go into.

The operation of selecting and taking out one reaction tube 4 using this reaction tube supply device 6 will be explained with reference to FIG.

(A) shows the state at the time of selection, first the reaction tube take-out mechanism 3
The reaction tube rack 24, whose outlet position is set to either the reaction line 2a or 2b, is connected to the stepping motor 2.
8, the reaction tube rack 24 is moved laterally as shown by the arrow and stops when the selected groove of the first reaction tube rack 24 comes to the position of the notch 42 of the partition plate.

Next, as shown in (B), the partition plate 40 is pulled up by the air cylinder 36, and the connecting reaction tube 4a is placed in the groove at the position of the notch 42.
When the partition plate 40 is lowered and the reaction tube rack 24 is moved laterally by the stepping motor 28, the connecting portion of one reaction tube breaks and one reaction tube falls into the reaction tube storage section 44. The reaction tube 4 is cut. The reaction tube 4 that has been cut and stored in the reaction tube storage section 44 is pushed out by compressed air and stored in the reaction tube holder of the reaction line 2a or 2b, as shown in FIG.

In this way, arbitrary reaction tubes 4 selected from six items are inserted one by one into the reaction tube holder of the reaction line 2a or 2b.

As another example of the partition plate, as shown in FIG. 7, it may be a partition plate 40a with a cutout portion 42a having an inverted V-shaped groove for sandwiching the reaction tube connecting portion 4b.

When this partition plate 40a is used.

Move the reaction tube rack 24 to select an item, drop one reaction tube 4 of the connected reaction tubes 4a in the groove for that item into the reaction tube storage section 44, and lower the partition plate 4°a to connect. The portion 4b is held in place by being clamped by the inverted V-shaped notch of the notch portion 42a, making it easy to disconnect the connecting portion 4b when the one-reaction tube rack 24 is moved laterally.

In place of the connected reaction tubes 4a, reaction tubes separated into individual reaction tubes 4 may be arranged in advance in the groove 32 of the reaction tube rack 24 of the reaction tube supply device 6. The operation in this case is the same as when using the connected reaction tube 4a, except that the operation of cutting the connected reaction tube 4a is not necessary.

In this embodiment, a reaction tube supply bag is used as a common processing operation unit for two reaction lines 2a and 2b having different reaction times. t6, sample dispensing bag 2!8, reagent dispensing device 10, cleaning device 12. The color-forming liquid dispensing device 114 and the residual liquid discharge/reaction tube disposal device 18 are used in a time-sharing manner to efficiently analyze reactions in parallel even if the reactions are different for one hour. The colorimeter 16 is not time-divided between the reaction lines 2a and 2b, but is connected to each reaction line 2a, 2b.
It is set up independently. As described above, it is not necessarily advisable to make all the processing operation parts common, and it is more advantageous to provide the processing operation part 1, for example, the colorimeter 16, which is easy to construct in N4, independently in each reaction line.

Next, the specific operation of this embodiment will be explained.

Reaction tube supply device! 6, the specified reaction tubes 4 are supplied to the reaction tube holders of the reaction lines 2a and 2b.

A sample is dispensed into each reaction tube 4 by a sample dispensing device 8 .

A diluent and an enzyme mm solution are dispensed by the reagent dispensing device 10.

Thereafter, antigen-antibody reactions are carried out in reaction lines 2a and 2b, respectively, until reaching the cleaning bag [12]. Washing bag g! After the reaction tube 4 is washed in step 12, the coloring solution dispensing bag is placed! ! After the coloring solution is dispensed in step 14, a coloring reaction by the enzyme is carried out during the time period until the absorbance or fluorescence is measured in the colorimeter 16.

Thereafter, the residual liquid is discharged by the residual liquid discharge/reaction tube disposal device 18, and one reaction tube 4 is discarded.

In the example, the ratio of the feed speeds of the two reaction lines 2a and 2b was described as being 3:1.

By changing this ratio, it can be used to measure even different reaction times.

Table 1 shows the case where the nine reaction lines 2a and 2b hold the same number of reaction tubes 4, and each line can hold 150 reaction tubes.

Processing speed and lines when changing the intermittent drive ratio of reaction lines 2a and 2b to 3=1 and other 2:1 or 1:1
This is a comparison of the time required to go around. The operation speed of one step of the processing operation section is set to 15 seconds. On the other hand, Table 2 shows the case where reaction line 2b holds twice the number of reaction tubes as 2a, and one reaction line 2a has 120
Compare the processing speed and time required for the line to make one revolution for various intermittent drive ratios, assuming that one reaction line 2b can hold 240 reaction tubes. This is what I did.

At this time as well, the operation speed of one step of the processing operation section is set to 15 seconds.

a is reaction line 2a, b connects reaction line 2b to it Each is represented.

Comparing Tables 1 and 2, it is found that it is more advantageous to make the number of reaction tubes that each reaction line can hold unequal, as this allows more combinations of reaction times to be obtained.

In any case, it is possible to fix the number of reaction tubes in the hardware of the automatic analyzer and then select a combination of reaction times in the form of software parameters.

FIG. 11 shows a second embodiment.

In FIG. 11, there are three reaction lines 62a with different reaction times.
, 62b, and 62c are provided. Reaction line 62a
Along the 0 reaction line 62a, which is one reaction line and also includes a common part, various processing operation parts are arranged along the direction of movement of the reaction tube. Each processing operation section performs processing operations on one reaction tube at a time.

Types of reaction tubes include reaction tube a that moves only through line 62a, reaction tube that moves through reaction lines 62a and 62b,
and a reaction tube C moving through reaction lines 62a and 62c.

One step of reaction line 62a is 15 seconds.

The reaction tube supply device 6a, the sample dispensing device 8a, and the reagent dispensing device 10a have the same structure as shown in FIG. However, in the reaction tube supply device 6a, one reaction line 62a
It is only necessary to supply reaction tubes to

Reference numeral 64 is a line branching point for determining whether to leave the reaction tube into which the reagent has been dispensed in the reaction line 62a or to branch it to the reaction line 62b or 62c. At the line branch point 64 there is a 12th
A device as shown in the figure is provided, and when it is necessary to branch into one branch, grasp the reaction tube of the reaction line 62a,
Place it in the reaction tube holder of reaction line 62b or 62c. The line confluence point 66 is equipped with the same equipment as the line branch point 64, and the reaction tubes of the 1 reaction lines 62b and 62c are returned to the reaction line 62a.
The reaction progresses one step per second, and one reaction line 62b, 62c is the reaction tube of the reaction line 62a.

When C advances, it synchronizes and advances one step, so 1
The reaction lines 62b, 62c end up advancing once every 45 seconds. Since the movements of the reaction lines 62a, 62b, and 62c are synchronous, when the reaction tubes of one reaction line 62b, 62c return to the reaction line 62a, the position to which they should return is always vacant.

Other processing operation parts are reaction stop liquid dispensing device 68° colorimeter 16a, residual liquid discharge device 18a1, reaction tube disposal device 1:18
b are devices that act on one reaction tube, and these devices can be those already used in commercially available devices. FIG. 13 shows a third embodiment.

In the embodiments shown in Figs. 1 and 11, the reaction tubes are driven one by one independently, whereas in the embodiment shown in Fig. 13, multiple reaction tubes are connected in a straight line. Drive as one. As a multiple reaction tube, 8 reaction tubes are connected.
Although a series of reaction tubes is used as an example, there are also other reaction tubes of other numbers such as 12 series, and the same applies to such reaction tubes.

It has three lines: 70a, 70b, and 70c.
Each moves eight reaction tubes in the direction indicated by the arrow. Line 70a moves one step per step, and line 70c is rotated once after line 70b is driven three times.

Transfer of the multiple reaction tubes from line 70a to line 70b, 70c is carried out by a belt 72. A stopper 74 is provided in the middle of the belt 72.

When the stopper 74 works, the multiple reaction tubes are stopped at the line 70b, and when the stopper 74 does not work, the multiple reaction tubes are sent to the line 70c.

Push metal fittings 76b and 7 are attached to the lines 70b and 70c, respectively.
6c are provided, each pushing the water in the reaction tube and moving it in the direction of the arrow. The multiple reaction tubes from lines 70b, 70c are returned to line 70a by belt 78.

The line 70a includes a cleaning device 82, a coloring liquid dispensing device 84, a colorimeter 86, a residual liquid discharging device 88, a multiple reaction tube disposal port 90, a reaction tube insertion port 92, and a reagent dispensing section 9 as processing operation sections.
4 are arranged along the reaction tube movement direction. These processing operation sections are structured to act simultaneously on a series of eight reaction tubes.

Next, the operation of the embodiment shown in FIG. 13 will be explained.

A series of eight reaction tubes are assigned to the same measurement item, and the same antigen or antibody is immobilized on the series of eight reaction tubes. A sample has already been dispensed into the reaction tube sent to the reaction tube insertion port 92. Multiple reaction tube waste port 9
After the measured reaction tubes from 0 are discarded, new multiple reaction tubes are inserted into the line 70a from the 1 reaction tube insertion port 92. Three multiple reaction tubes for line 70b arrive at reaction tube insertion port 92, then one multiple reaction tubes for line 70c arrive, and so on. If the multiple reaction tube for line 70b is b and the multiple reaction tube for line 70c is C,
In line 70a, b, b.

c9 bj b, b, c, . . . will be sent in a time-sharing manner.

The multiple reaction tubes into which reagents have been dispensed in the reagent dispensing section 94 are sent by a belt 72 and lined up in a line 70b or 70c, and after each reaction time has elapsed, they are returned to the line 70a by a belt 78. In line 70a, b, b, c,
. . . Since it is sent in a time-divided manner, when multiple reaction tubes are used, C passes through the same position, washing device 829, coloring liquid dispensing device 84, residual liquid discharging device 88, reagent dispensing device 94 only requires movement in the vertical direction.

FIG. 14 shows a fourth embodiment.

In FIG. 14, there are two reaction lines 96a with different reaction times.
and 96b are provided, and two reaction lines 96a,
96b is a common portion 98 in which each reaction tube interrupts sequentially in a time-sharing manner.

Each reaction line 96a, 96b has a reaction tube holder 100 as shown in FIG. 15, which are connected to form a snake chain. Each reaction tube holder 100
is provided with a protrusion 102, and a reaction line 96a,
Guide grooves 04a and 104b that respectively guide 96b
The protrusion 102 is inserted into the reaction tube, and the reaction tube is inserted into the guide groove 104a.
104b.

The common part 98 includes a reaction tube supply device, a sample dispensing device, a reagent dispensing device, a cleaning device 1, and a coloring liquid dispensing device.

A colorimeter, a residual liquid discharge device, and a reaction tube disposal device are arranged. Each of these processing devices is of a type that processes one reaction tube.

In the embodiments shown in FIGS. 11, 13, and 14, the reaction lines themselves are partially shared by a time-sharing method.
There is an advantage that there is no need to move processing operation units such as a dispensing device and a washing device to the positions of a plurality of reaction tubes. In particular, in the embodiment shown in Fig. 13, since multiple reaction tube blocks such as 8 or 12 are processed, it is almost impossible to move the processing operation unit, so the effect of sharing reaction lines by time sharing is big.

In the embodiment shown in FIG. 14, time division of five reaction lines can be realized by a simple method.

(Effects of the Invention) In conventional random access immunoassay analyzers, only random access with a restriction of making the reaction time of all items the same has been realized.In contrast, in the present invention, multiple By providing multiple reaction lines with different reaction times for holding reaction tubes and feeding the reaction tubes intermittently, it is possible to perform random access to immunoassays with significantly different reaction times without any restriction on reaction time. can do 1
In the present invention, at least one processing operation unit is shared by all reaction lines and acts on all reaction lines in one time division, so the cost can be reduced even though multiple reaction lines are provided. increase can be suppressed.

[Brief explanation of drawings]

FIG. 1 is a schematic plan view showing the first embodiment, FIG. 2 is a perspective view showing a reaction tube supply device used in the same embodiment, FIG. 3 is a perspective view showing connected reaction tubes, and FIG. FIG. 5 is a perspective view showing the internal structure of the tube take-out mechanism, FIG. 5 is a perspective view showing the reaction tube storage section, FIG. 6 is a plan view showing the operation of the reaction tube take-out mechanism, and FIG. 7 is another example of the partition plate. FIG. 8 is a sectional view showing a cleaning nozzle used in the same embodiment, FIG. 9 is a sectional view showing a colorimeter used in the same embodiment, and FIG. 11 is a schematic plan view showing a second embodiment; FIG. 12 shows a device used at the line branch point and line confluence of the embodiment shown in FIG. 11; FIG. 13 is a schematic perspective view, FIG. 13 is a schematic plan view showing the third embodiment, and FIG. 14 is a main part plan view showing the fourth embodiment. FIG. 5 is a perspective view showing the reaction tube holder and guide groove used in the embodiment of FIG. 14. 2a, 2b, 62a, 62. b, 62c, 70a. 70 b, 70 c, 96 a, 96 b
--Reaction line. 4...Reaction tube, 6,6a...Reaction tube supply device, 8゜8a...Sample dispensing device, 10,1
0a, 94... Reagent dispensing device, 12, 12a,
82...Cleaning device. 14, 14a, 84...Coloring liquid dispensing device, 16
゜16a, 86... Colorimeter, 18...
Residual liquid discharge/reaction tube disposal device, 18a, 88...
Residual liquid discharge device. 18b...Reaction tube disposal device.

Claims (1)

[Claims] (1) A plurality of reaction lines are provided that hold a plurality of reaction tubes and send the reaction tubes intermittently, each having a different reaction time, and at least one processing operation section is shared by all the reaction lines, and all the reaction tubes are Automatic analyzer that operates on the reaction line.