JPH0377170B2 - - Google Patents
Info
- Publication number
- JPH0377170B2 JPH0377170B2 JP3092984A JP3092984A JPH0377170B2 JP H0377170 B2 JPH0377170 B2 JP H0377170B2 JP 3092984 A JP3092984 A JP 3092984A JP 3092984 A JP3092984 A JP 3092984A JP H0377170 B2 JPH0377170 B2 JP H0377170B2
- Authority
- JP
- Japan
- Prior art keywords
- chlorine dioxide
- product
- stabilized chlorine
- present
- drowsiness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims description 38
- 239000004155 Chlorine dioxide Substances 0.000 claims description 19
- 235000019398 chlorine dioxide Nutrition 0.000 claims description 19
- 206010041349 Somnolence Diseases 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 17
- 239000003205 fragrance Substances 0.000 claims description 16
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 8
- 239000002304 perfume Substances 0.000 claims description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 4
- 241000723346 Cinnamomum camphora Species 0.000 claims description 4
- 235000014435 Mentha Nutrition 0.000 claims description 4
- 241001072983 Mentha Species 0.000 claims description 4
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 4
- 229940116229 borneol Drugs 0.000 claims description 4
- 229930008380 camphor Natural products 0.000 claims description 4
- 229960000846 camphor Drugs 0.000 claims description 4
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 4
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 4
- 229960001047 methyl salicylate Drugs 0.000 claims description 4
- 230000000694 effects Effects 0.000 description 13
- 239000007788 liquid Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000032140 Sleepiness Diseases 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000006742 locomotor activity Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000037321 sleepiness Effects 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229940098795 (3z)- 3-hexenyl acetate Drugs 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- NPFVOOAXDOBMCE-PLNGDYQASA-N cis-3-Hexenyl acetate Natural products CC\C=C/CCOC(C)=O NPFVOOAXDOBMCE-PLNGDYQASA-N 0.000 description 1
- RRGOKSYVAZDNKR-ARJAWSKDSA-M cis-3-hexenylacetate Chemical compound CC\C=C/CCCC([O-])=O RRGOKSYVAZDNKR-ARJAWSKDSA-M 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- NPFVOOAXDOBMCE-UHFFFAOYSA-N trans-3-hexenyl acetate Natural products CCC=CCCOC(C)=O NPFVOOAXDOBMCE-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Fats And Perfumes (AREA)
Description
【発明の詳細な説明】
本発明は、睡気防止用香料組成物に関するもの
である。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a fragrance composition for preventing drowsiness.
従来、一般的に睡気防止効果を持つと言われて
いる香料は種々知られており、このような香料に
は、例えば、ハツカ、ユーカリ、レモンなどの精
油類、オニオン、ガーリツクなどのエキス類、蟻
酸、酢酸などのエステル類等が挙げられる。しか
しながら、このような香料の場合、その睡気防止
効果は極めて不十分なものである。 Conventionally, various fragrances have been known that are generally said to have the effect of preventing drowsiness.These fragrances include, for example, essential oils such as peppermint, eucalyptus, and lemon, and extracts such as onion and garlic. , formic acid, acetic acid, and other esters. However, in the case of such perfumes, the effect of preventing drowsiness is extremely insufficient.
本発明者らは、このような睡気防止効果を持つ
香料において、その睡気防止効果の高められたも
のを開発すべく鋭意研究を重ねた結果、前記香料
に安定化二酸化塩素を添加し、放置した後、残留
安定化二酸化塩素を除去して得られる生成物は、
著しく改良された睡気防止効果を有することを見
出し、本発明を完成するに到つた。 The present inventors have conducted intensive research to develop a fragrance with an enhanced drowsiness prevention effect, and as a result, they added stabilized chlorine dioxide to the fragrance, After standing, the product obtained by removing the residual stabilized chlorine dioxide is
The present inventors have discovered that the present invention has a significantly improved drowsiness prevention effect, and have completed the present invention.
即ち、本発明によれば、サリチル酸メチル、ボ
ルネオール、メンタオイル、カンフア及びジフエ
ニルオキサイドからなる香料組成物に安定化二酸
化塩素を添加し、放置した後、残留安定化二酸化
塩素を除去して得られる生成物からなる睡気防止
用香料組成物が提供される。 That is, according to the present invention, stabilized chlorine dioxide is added to a fragrance composition consisting of methyl salicylate, borneol, mentha oil, camphor and diphenyl oxide, and after standing, residual stabilized chlorine dioxide is removed. An anti-drowsiness perfume composition comprising the product is provided.
本発明で用いる睡気防止効果を持つ香料組成物
は、サリチル酸メチル、ボルネオール、メンタオ
イル、カンフア及びジフエニルオキサイドからな
る。この香料組成物には、他の香料、例えば、ク
マリン、シス−３−ヘキセニルアセテート等を添
加することもできる。 The fragrance composition having a drowsiness prevention effect used in the present invention consists of methyl salicylate, borneol, mentha oil, camphor, and diphenyl oxide. Other fragrances such as coumarin, cis-3-hexenyl acetate, etc. can also be added to this fragrance composition.
本発明においては、前記香料組成物に対して、
安定化二酸化塩素を添加する。この場合、安定化
二酸化塩素の添加量は、香料100重量部に対し、
溶液として、0.02〜１重量部、好ましくは0.1〜
0.2重量部である。添加する安定化二酸化塩素は、
通常、安定化剤として、過炭酸ナトリウム
（Na2CO3・H2O2）又は重炭酸ナトリウムを少量
添加した二酸化塩素濃度4.5〜5.5％の水溶液とし
て用いられる。 In the present invention, for the fragrance composition,
Add stabilized chlorine dioxide. In this case, the amount of stabilized chlorine dioxide added is:
As a solution, 0.02 to 1 part by weight, preferably 0.1 to 1 part by weight
It is 0.2 parts by weight. The stabilized chlorine dioxide to be added is
Usually, it is used as an aqueous solution with a chlorine dioxide concentration of 4.5 to 5.5% to which a small amount of sodium percarbonate (Na 2 CO 3 .H 2 O 2 ) or sodium bicarbonate is added as a stabilizer.
本発明において、安定化二酸化塩素を添加した
香料組成物は、温度０〜15℃、好ましくは10〜13
℃において12〜72時間、好ましくは24〜36時間放
置される。 In the present invention, the fragrance composition to which stabilized chlorine dioxide is added has a temperature of 0 to 15°C, preferably 10 to 13°C.
C. for 12 to 72 hours, preferably 24 to 36 hours.
次に、前記のようにして安定化二酸化塩素と接
触処理された香料組成物は、安定化二酸化塩素除
去処理され、処理生成物中に残留する安定化二酸
化塩素を除去する。この場合の安定化二酸化塩素
の除去処理は、加熱や減圧処理等によつて実施す
ることができ、一般には、チオ硫酸ソーダの存在
下において、温度20〜22℃の攪拌加熱処理が採用
される。この場合の加熱処理時間は、通常50〜
120秒で充分である。 Next, the fragrance composition that has been contacted with stabilized chlorine dioxide as described above is subjected to a stabilized chlorine dioxide removal treatment to remove the stabilized chlorine dioxide remaining in the treated product. In this case, the removal treatment of stabilized chlorine dioxide can be carried out by heating, depressurization, etc., and generally a stirring heat treatment at a temperature of 20 to 22°C in the presence of sodium thiosulfate is adopted. . In this case, the heat treatment time is usually 50~
120 seconds is sufficient.
前記のようにして得られた生成物は、変性香料
組成物を含むもので、この生成物は、未変性の香
料組成物に比べ、著しく高められた睡気防止効果
を有する。 The product thus obtained contains a modified perfume composition, which product has a significantly enhanced anti-drowsiness effect compared to the unmodified perfume composition.
本発明による二酸化塩素により変性を受けた香
料組成物は、液状の他、ペースト状、固形状、又
は粉末等の種々の形態で用いることができる。例
えば、ペースト状のものを得るには、液状物に増
粘剤を加えればよいし、固形物状のものを得るに
は、液状物にゲル化剤を加えてゲル化させればよ
く、また粉末状のものを得るには、シリカゲルや
ゼオライト等の吸着剤に液状物を加えて吸着させ
ればよい。さらに、ワツクス状物などの成形用素
材と混合して、成形し、成形品として用いること
もできる。 The perfume composition modified with chlorine dioxide according to the present invention can be used in various forms such as liquid, paste, solid, or powder. For example, to obtain a paste-like product, you can add a thickener to the liquid, and to obtain a solid, you can add a gelling agent to the liquid to make it gel. In order to obtain a powder, a liquid may be added to an adsorbent such as silica gel or zeolite for adsorption. Furthermore, it can be mixed with a molding material such as a wax-like material, molded, and used as a molded product.
次に本発明を実施例によりさらに詳細に説明す
る。 Next, the present invention will be explained in more detail with reference to Examples.
実施例香料成分
組成（重量％）
(1) サリチル酸メチル 0.2
(2) ボルネオール 15.0
(3) メンタオイル 55.0
(4) カンフア 25.0
(5) ジフエニルオキサイド 4.8
前記香料混合物100重量部に、安定化二酸化塩
素５％水溶液0.1重量部を添加し、均一に混合し
た。この混合物を、室温において30時間放置し
た。次に、この生成物を、チオ硫酸ソーダ存在下
において、温度20℃で、60秒加熱して残留安定化
二酸化塩素を除去した。この結果、次のような性
状を有する本発明の生成物（製品Ａ）が得られ
た。Example fragrance ingredient composition (wt%) (1) Methyl salicylate 0.2 (2) Borneol 15.0 (3) Mentha oil 55.0 (4) Camphor 25.0 (5) Diphenyl oxide 4.8 Stabilized chlorine dioxide was added to 100 parts by weight of the above fragrance mixture. 0.1 part by weight of a 5% aqueous solution was added and mixed uniformly. This mixture was left at room temperature for 30 hours. The product was then heated in the presence of sodium thiosulfate at a temperature of 20° C. for 60 seconds to remove residual stabilized chlorine dioxide. As a result, a product of the present invention (product A) having the following properties was obtained.
(1) 色……無色〜やや淡黄色透明液体
(2) 香り……草原を連想させる清涼な香気
(3) 比重……0.905
一方、比較のために、安定化二酸化塩素を添加
しない香料混合物の液体（製品Ｂ）を調製した。(1) Color: colorless to slightly pale yellow transparent liquid (2) Aroma: refreshing aroma reminiscent of grassland (3) Specific gravity: 0.905 On the other hand, for comparison, a fragrance mixture without the addition of stabilized chlorine dioxide A liquid (Product B) was prepared.
このようにして得られた本発明の製品(A)の睡気
防止効果を次のように試験した。 The drowsiness prevention effect of the thus obtained product (A) of the present invention was tested as follows.
(1) 脳波において、睡眠波の見られる被検者に、
本発明製品(A)の香気をかがせたところ、その睡
眠波は徐々に消えていつた。(1) For subjects who have sleep waves in their brain waves,
When the scent of the product (A) of the present invention was exposed to the scent, the sleep waves gradually disappeared.
(2) ドライバ及び夜勤者を被検者とし、それぞれ
の６例について、本発明製品(A)の睡気に及ぼす
影響について調べたところ、次の結果が得られ
た。(2) The effects of the product (A) of the present invention on sleep were investigated in six cases of drivers and night shift workers, and the following results were obtained.
(イ) 睡気が無くなつた ……３例
(ロ) 睡気が軽減した ……５例
(ハ) 変化なかつた ……４例
この結果から、睡気の軽減又は解消されたもの
は、全体の66％の割合で、本発明品は、睡気防止
効果があることが確認された。 (B) Sleepiness disappeared...3 cases (B) Sleepiness decreased...5 cases (C) No change...4 cases Based on these results, the cases where sleepiness was reduced or eliminated were as follows: It was confirmed that the product of the present invention has a drowsiness prevention effect at a rate of 66% of the total.
(3) ネズミの運動量、即ち、睡気防止作用を検討
する目的で、ネズミに本発明品の香気を連続的
にかがせ、24時間の運動量をNazumex運動測
定装置を用いて経済的に測定した。その結果、
本発明品を0.9cm2の径の器に入れたものから発
生する香気ではほとんど効果が見られなかつた
が、９cm2の径の器に入れたものから発生する香
気では明らかにネズミの運動量は増加し、本発
明品は睡気防止効果を有することが確認され
た。(3) In order to examine the locomotor activity of rats, that is, the effect of preventing drowsiness, rats were continuously exposed to the scent of the product of the present invention, and their locomotor activity over a 24-hour period was economically measured using a Nazumex exercise measuring device. did. the result,
Almost no effect was observed with the aroma generated from a container with a diameter of 0.9 cm 2 , but the scent generated from a container with a diameter of 9 cm 2 clearly affected the locomotor activity of rats. It was confirmed that the product of the present invention has an effect of preventing drowsiness.
また、前記の試験を比較用製品(B)についても行
つたが、この場合には顕著な効果は得られず、例
えば、前記試験(2)においては、睡気を軽減又は解
消された例は全体の25％であり、また、試験(3)に
おいては、ネズミの運動量は極くわずかに増加す
る程度であつた。 The above test was also conducted on the comparative product (B), but in this case no significant effect was obtained.For example, in the above test (2), there were no cases where drowsiness was reduced or eliminated. 25% of the total, and in test (3), the amount of exercise of the rats increased only slightly.
Claims (1)
イル、カンフア及びジフエニルオキサイドからな
る香料組成物に安定化二酸化塩素を添加し、放置
した後、残留安定化二酸化塩素を除去して得られ
る生成物からなる睡気防止用香料組成物。1 An anti-drowsiness product consisting of a product obtained by adding stabilized chlorine dioxide to a fragrance composition consisting of methyl salicylate, borneol, mentha oil, camphor and diphenyl oxide, leaving it to stand, and then removing the remaining stabilized chlorine dioxide perfume composition for use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3092984A JPS60174712A (en) | 1984-02-20 | 1984-02-20 | Antihypnotic perfume composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3092984A JPS60174712A (en) | 1984-02-20 | 1984-02-20 | Antihypnotic perfume composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60174712A JPS60174712A (en) | 1985-09-09 |
| JPH0377170B2 true JPH0377170B2 (en) | 1991-12-09 |
Family
ID=12317369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3092984A Granted JPS60174712A (en) | 1984-02-20 | 1984-02-20 | Antihypnotic perfume composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60174712A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110580A (en) * | 1989-09-14 | 1992-05-05 | Iolab Corporation | Method and apparatus for chlorine dioxide manufacture |
| CN1087590C (en) * | 1998-06-16 | 2002-07-17 | 徐忠奎 | Sterilizing agent for person and its preparing method |
-
1984
- 1984-02-20 JP JP3092984A patent/JPS60174712A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60174712A (en) | 1985-09-09 |
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