JPH0370183B2 - - Google Patents
Info
- Publication number
- JPH0370183B2 JPH0370183B2 JP63282630A JP28263088A JPH0370183B2 JP H0370183 B2 JPH0370183 B2 JP H0370183B2 JP 63282630 A JP63282630 A JP 63282630A JP 28263088 A JP28263088 A JP 28263088A JP H0370183 B2 JPH0370183 B2 JP H0370183B2
- Authority
- JP
- Japan
- Prior art keywords
- layer
- gel
- fluid
- sample
- porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 claims description 42
- 239000008280 blood Substances 0.000 claims description 42
- 239000003153 chemical reaction reagent Substances 0.000 claims description 32
- 239000012530 fluid Substances 0.000 claims description 32
- 238000009792 diffusion process Methods 0.000 claims description 28
- 230000004888 barrier function Effects 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000000499 gel Substances 0.000 description 60
- 239000012491 analyte Substances 0.000 description 31
- 239000000758 substrate Substances 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 238000005534 hematocrit Methods 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 239000011553 magnetic fluid Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000004159 blood analysis Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011554 ferrofluid Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/007,858 US4288228A (en) | 1979-01-31 | 1979-01-31 | Whole blood analyses and diffusion apparatus therefor |
US7858 | 1979-01-31 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP947780A Division JPS55132955A (en) | 1979-01-31 | 1980-01-31 | Method of obtaining aliquots of fluid sample and method of reacting same with analyte of sample and analyzer and diffusion switch for same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH01308965A JPH01308965A (ja) | 1989-12-13 |
JPH0370183B2 true JPH0370183B2 (US06650917-20031118-M00005.png) | 1991-11-06 |
Family
ID=21728474
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP947780A Granted JPS55132955A (en) | 1979-01-31 | 1980-01-31 | Method of obtaining aliquots of fluid sample and method of reacting same with analyte of sample and analyzer and diffusion switch for same |
JP63282630A Granted JPH01308965A (ja) | 1979-01-31 | 1988-11-10 | 分析装置 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP947780A Granted JPS55132955A (en) | 1979-01-31 | 1980-01-31 | Method of obtaining aliquots of fluid sample and method of reacting same with analyte of sample and analyzer and diffusion switch for same |
Country Status (7)
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4529706A (en) * | 1983-03-17 | 1985-07-16 | Becton Dickinson And Company | Method of stirring |
US4522786A (en) * | 1983-08-10 | 1985-06-11 | E. I. Du Pont De Nemours And Company | Multilayered test device for detecting analytes in liquid test samples |
US4826759A (en) * | 1984-10-04 | 1989-05-02 | Bio-Metric Systems, Inc. | Field assay for ligands |
DE3508427A1 (de) * | 1985-03-09 | 1986-09-11 | Merck Patent Gmbh, 6100 Darmstadt | Mittel und verfahren zur abtrennung von plasma oder serum aus vollblut |
US4678757A (en) * | 1985-04-11 | 1987-07-07 | Smithkline Diagnostics, Inc. | Device and method for whole blood separation and analysis |
JPS61262661A (ja) * | 1985-05-16 | 1986-11-20 | Konishiroku Photo Ind Co Ltd | 生化学分析ユニツト |
US4889812A (en) * | 1986-05-12 | 1989-12-26 | C. D. Medical, Inc. | Bioreactor apparatus |
US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
US4790979A (en) * | 1986-08-29 | 1988-12-13 | Technimed Corporation | Test strip and fixture |
US4883764A (en) * | 1987-07-20 | 1989-11-28 | Kloepfer Mary A | Blood test strip |
US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
US5652148A (en) * | 1993-04-20 | 1997-07-29 | Actimed Laboratories, Inc. | Method and apparatus for red blood cell separation |
US5766552A (en) * | 1993-04-20 | 1998-06-16 | Actimed Laboratories, Inc. | Apparatus for red blood cell separation |
US5660798A (en) * | 1993-04-20 | 1997-08-26 | Actimed Laboratories, Inc. | Apparatus for red blood cell separation |
DE69636389T2 (de) * | 1995-05-09 | 2006-11-23 | Beckman Coulter, Inc., Fullerton | Vorrichtungen und verfahren zur abtrennung zellulärer blutbestandteile von flüssigen blutanteilen |
US5981294A (en) * | 1995-11-29 | 1999-11-09 | Metrika, Inc. | Device for blood separation in a diagnostic device |
US5945345A (en) * | 1996-08-27 | 1999-08-31 | Metrika, Inc. | Device for preventing assay interference using silver or lead to remove the interferant |
US5879951A (en) * | 1997-01-29 | 1999-03-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing unidirectional flow |
US5939252A (en) * | 1997-05-09 | 1999-08-17 | Lennon; Donald J. | Detachable-element assay device |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6551842B1 (en) | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6696240B1 (en) | 1999-10-26 | 2004-02-24 | Micronix, Inc. | Capillary test strip to separate particulates |
US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
US6455007B1 (en) * | 2000-06-13 | 2002-09-24 | Symyx Technologies, Inc. | Apparatus and method for testing compositions in contact with a porous medium |
US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
US7431883B2 (en) | 2003-09-30 | 2008-10-07 | Beckman Coulter, Inc. | Clinical analysis system |
US7150995B2 (en) | 2004-01-16 | 2006-12-19 | Metrika, Inc. | Methods and systems for point of care bodily fluid analysis |
DE202006007817U1 (de) * | 2006-05-16 | 2006-07-27 | Pfaff, Dieter | Separator und Separationsstreifen zum Separieren von Blutserum aus einer Blutprobe |
WO2008079731A1 (en) * | 2006-12-22 | 2008-07-03 | Home Diagnostics, Inc. | Gel formation to reduce hematocrit sensitivity in electrochemical test |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3146163A (en) * | 1962-01-23 | 1964-08-25 | John H Brewer | Apparatus for separating certain components from blood |
US3368872A (en) * | 1964-08-31 | 1968-02-13 | Scientific Industries | Automatic chemical analyzer |
US3526480A (en) * | 1966-12-15 | 1970-09-01 | Xerox Corp | Automated chemical analyzer |
FR1573936A (US06650917-20031118-M00005.png) * | 1967-02-16 | 1969-07-11 | ||
US3511608A (en) * | 1967-12-14 | 1970-05-12 | Harold P Anderson | Multiple layer paper test strip |
US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
US3811840A (en) * | 1969-04-01 | 1974-05-21 | Miles Lab | Test device for detecting low concentrations of substances in fluids |
NO124603B (US06650917-20031118-M00005.png) * | 1969-05-03 | 1972-05-08 | Rolf Saxholm | |
US3607079A (en) * | 1969-06-02 | 1971-09-21 | Scientific Industries | Analysis arrangement for chemical analyzing apparatus |
US3798004A (en) * | 1972-04-18 | 1974-03-19 | Ames Yissum Ltd | Test device |
DE2332760C3 (de) * | 1972-06-30 | 1982-03-04 | Eastman Kodak Co., 14650 Rochester, N.Y. | Material für die quantitative spektrophotometrische Analyse einer Flüssigkeit |
US3891776A (en) * | 1972-11-02 | 1975-06-24 | Lever Brothers Ltd | Protein product |
CA1056282A (en) * | 1974-03-25 | 1979-06-12 | Charles T. Goodhue | Multilayer analytical elements for use in the assay of cholesterol |
DE2416047A1 (de) * | 1974-04-03 | 1975-10-09 | Ludwig Clarius Wolfgang Dipl P | Transparenter teststreifen inkonstanter dicke oder dichte und verfahren zur analyse chemischer loesungen |
US3901657A (en) * | 1974-04-29 | 1975-08-26 | Sun Scient Inc | Device for testing solutions and body fluids |
FR2280081A1 (fr) * | 1974-07-23 | 1976-02-20 | Kodak Pathe | Produit composite unitaire pour l'analyse chimique ou biologique |
US3933594A (en) * | 1974-08-16 | 1976-01-20 | Polaroid Corporation | Method and device for determining the concentration of a substance in a fluid |
US3990849A (en) * | 1975-02-07 | 1976-11-09 | Technicon Instruments Corporation | Separation of cells from liquid components of blood |
US4050898A (en) * | 1976-04-26 | 1977-09-27 | Eastman Kodak Company | Integral analytical element |
US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
CA1095819A (en) * | 1977-01-14 | 1981-02-17 | Eastman Kodak Company | Element for analysis of liquids |
-
1979
- 1979-01-31 US US06/007,858 patent/US4288228A/en not_active Expired - Lifetime
-
1980
- 1980-01-15 CA CA000343678A patent/CA1140775A/en not_active Expired
- 1980-01-25 GB GB8002648A patent/GB2042721B/en not_active Expired
- 1980-01-30 DE DE19803038017 patent/DE3038017A1/de active Granted
- 1980-01-30 FR FR8001963A patent/FR2448151A1/fr active Granted
- 1980-01-30 DE DE19803003189 patent/DE3003189A1/de active Granted
- 1980-01-31 IT IT67149/80A patent/IT1133057B/it active
- 1980-01-31 JP JP947780A patent/JPS55132955A/ja active Granted
-
1988
- 1988-11-10 JP JP63282630A patent/JPH01308965A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DE3038017A1 (de) | 1981-06-11 |
IT8067149A0 (it) | 1980-01-31 |
DE3003189A1 (de) | 1980-11-13 |
IT1133057B (it) | 1986-07-09 |
CA1140775A (en) | 1983-02-08 |
US4288228A (en) | 1981-09-08 |
JPS55132955A (en) | 1980-10-16 |
FR2448151B1 (US06650917-20031118-M00005.png) | 1985-05-24 |
GB2042721A (en) | 1980-09-24 |
GB2042721B (en) | 1983-07-20 |
JPH01308965A (ja) | 1989-12-13 |
JPH0131140B2 (US06650917-20031118-M00005.png) | 1989-06-23 |
DE3038017C2 (US06650917-20031118-M00005.png) | 1988-10-20 |
FR2448151A1 (fr) | 1980-08-29 |
DE3003189C2 (US06650917-20031118-M00005.png) | 1989-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH0370183B2 (US06650917-20031118-M00005.png) | ||
US4260392A (en) | Method and apparatus for obtaining an aliquot of a liquid in a gel medium | |
US5296192A (en) | Diagnostic test strip | |
US7113875B2 (en) | Humoral testing unit and a humoral testing apparatus | |
JP3173798B2 (ja) | 体液の分析対象成分を決定する方法および装置 | |
US5147609A (en) | Assay element | |
RU2256167C2 (ru) | Способ изготовления содержащего реагент медицинского диагностического устройства и устройство | |
CA2267919C (en) | Process for the production of analytical devices | |
US20030186457A1 (en) | Blood testing unit and blood testing method and apparatus | |
US8506903B2 (en) | Test sensor and method for manufacturing the same | |
US20020052050A1 (en) | Device for determination of an analyte a in body fluid | |
JPS60155942A (ja) | 液体試料点着装置 | |
GB2090659A (en) | Analytical device | |
US5047206A (en) | Reagent test strip | |
US20080317633A1 (en) | Multiplex lateral flow devices and methods | |
EP1202060B1 (en) | Biosensor and method for its preparation | |
AU588449B2 (en) | Biological diagnostic device | |
EP0621478B1 (en) | Dry analytical film chip | |
JPH0572195A (ja) | 試薬の濃度を測定する装置 | |
RU2418300C2 (ru) | Нанесение реагента на матричный материал | |
JP3460142B2 (ja) | 余剰液溜めを有する毛細管により液体試料を分析する試験具 | |
JP3460140B2 (ja) | 溝を有する毛細管により液体試料を分析する試験具 | |
JP3460141B2 (ja) | 幅の一様でない毛細管により液体試料を分析する試験具 | |
JP3527980B2 (ja) | 複数の排気口を有する毛細管により液体試料を分析する試験具 |