JPH0369585B2 - - Google Patents
Info
- Publication number
- JPH0369585B2 JPH0369585B2 JP58101873A JP10187383A JPH0369585B2 JP H0369585 B2 JPH0369585 B2 JP H0369585B2 JP 58101873 A JP58101873 A JP 58101873A JP 10187383 A JP10187383 A JP 10187383A JP H0369585 B2 JPH0369585 B2 JP H0369585B2
- Authority
- JP
- Japan
- Prior art keywords
- film coating
- article
- solvent
- colored
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007888 film coating Substances 0.000 claims abstract description 54
- 238000009501 film coating Methods 0.000 claims abstract description 54
- 238000000034 method Methods 0.000 claims abstract description 46
- 239000002904 solvent Substances 0.000 claims abstract description 34
- 239000000725 suspension Substances 0.000 claims abstract description 32
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 30
- 238000005507 spraying Methods 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 239000011248 coating agent Substances 0.000 claims description 35
- 238000000576 coating method Methods 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000004014 plasticizer Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 150000002576 ketones Chemical class 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 235000009508 confectionery Nutrition 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 238000007373 indentation Methods 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 description 49
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 22
- 239000007921 spray Substances 0.000 description 11
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 9
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 9
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 9
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 239000007941 film coated tablet Substances 0.000 description 8
- 239000003086 colorant Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- -1 turmeric Natural products 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- AYJRCSIUFZENHW-UHFFFAOYSA-L barium carbonate Chemical compound [Ba+2].[O-]C([O-])=O AYJRCSIUFZENHW-UHFFFAOYSA-L 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 239000004203 carnauba wax Substances 0.000 description 2
- 235000013869 carnauba wax Nutrition 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000009500 colour coating Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 235000012756 tartrazine Nutrition 0.000 description 2
- 239000004149 tartrazine Substances 0.000 description 2
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 2
- 229960000943 tartrazine Drugs 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000008991 Curcuma longa Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- ZMRUPTIKESYGQW-UHFFFAOYSA-N propranolol hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 ZMRUPTIKESYGQW-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 239000012463 white pigment Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
- B05D5/06—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain multicolour or other optical effects
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/28—Apparatus for decorating sweetmeats or confectionery
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
- A23G3/54—Composite products, e.g. layered, coated, filled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2258/00—Small objects (e.g. screws)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Laminated Bodies (AREA)
Description
æ¬çºæã¯ã圫蟌ã¿ãé¡èåããã
ïŒhighlightedïŒåœ«èŸŒã¿ãæããç©åã®æ¹è¯ããã
補æ³ã«é¢ããã ãšãŒãããç¹èš±åºé¡ç¬¬82300586.3å·ïŒå ¬é第
60023A1ïŒæ现æžã«ã¯ãç¹ã«ãçè²ãããåºäœç©
åäŸãã°é¡èåããã圫蟌ã¿ãå°ãªããšãïŒåæ
ããå»è¬é å€ã®è£œæ³ãèšèŒãããŠãããããã¯ã
çè²ãããïŒå³ã¡çœè²ã§ãªãïŒåœ«èŸŒã¿ãæããç©
åã«ã2.00ãã倧ãããªãæå°å±æçãæããå
åŠçç°æ¹æ§ç©è³ªå°ãªããšãïŒçš®åã³ãã€ã«ã ã³ãŒ
ãã€ã³ã°å€å°ãªããšãïŒçš®ãããªããã€ã«ã ã³ãŒ
ãã€ã³ã°æžæ¿æ¶²ãæœãããã®æ¹æ³ãæ £çšã®ãã€ã«
ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããŠã
ãç©åã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§å®æœ
ããããšãããªãïŒä»¥åŸã¯ãã®æ¹æ³ãæ³ãšç§°ã
ãïŒã åæ¥åºé¡ç¹éæ59â5112å·ïŒè±åœç¹èš±åºé¡ç¬¬
8216816å·ïŒæ现æžäžã«ã¯ãç¹ã«çè²åºäœç©åäŸ
ãã°é¡èåããã圫蟌ã¿å°ãªããšãïŒåãæãã
å»è¬é å€ã®è£œæ³ãèšèŒãããŠãããããã¯ã圫蟌
ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããªãæå°
å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããšãïŒçš®
ãããªããããã€ã«ã ã³ãŒãã€ã³ã°å€ãå«æããª
ããé©åœãªæ¶²äœäžã®æžæ¿æ¶²ãæœããããã®æ¹æ³ã
æ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€
ã³ãããŠããç©åã®éã§æ©æŠäœçšãèµ·ãããããª
æ¹æ³ã§å®æœããããšãããªãïŒä»¥åŸãããæ³ãš
称ããïŒã æ¬æ现æžäžã§ãã圫蟌ã¿ãæããç©åããšã¯ã
åºäœç©åäŸãã°å§çž®æŒæããå蟌ã¿åã¯åœ«å»æ³ã§
åã¯é¡äŒŒå¹æãåŸãä»»æã®ä»ã®æ¹æ³ã§ãç©åã®è¡š
é¢ã«åœ«èŸŒãŸãããåã¯åœ¢æãããå°ãªããšãïŒå
ã®æš¡æ§ãèšå·åã¯æååã¯ãããã®ä»»æã®çµåã
ãæããé å€ãæå³ãããæŽã«ãæ¬æ现æžäžã§ã
ãå åŠçç°æ¹æ§ç©è³ªããšã¯ãçš®ã ã®æ¹åã§çš®ã ã®
å±æçã瀺ãç©è³ªãæå³ããã åèšïŒ¡æ³åã³ïŒ¢æ³ã®é¡èåããã補åäžã§ã¯ã
圫蟌ã¿ãšãã®ç©åã®æ®ãã®éšåãšã®éã«ã¯æ確ãª
å·®ç°ããããããããªãããå Žåã«ãã€ãŠã¯ãå
èšè£œåã¯ã圫蟌ã¿ãšãã®ç©åã®æ®ãã®éšåãšã®é
ã®å·®ç°ãæžããåŸåã®ããå ããªç²ã€ãœãå€èŠ³ã
æããããšãèŠã€ããããã®é¡èåæ³ããããªã
倧ããèŠæš¡ã§ãæ¯èŒç倧ããªå転ãã©ã ã³ãŒãã€
ã³ã°è£ 眮äŸãã°60ã€ã³ãã¢ã¯ã»ã©ãŒã³ãŒã¿ãŒïŒ60
inch AccelaâCotaïŒManestry Machines PLC.
Speke.Liverpool 24 EnglandïŒäžã§å®æœããé
ã«ããã®ããšã¯ããæå¹ã§ããããšããã§ãæå€
ã«ãããã®é¡èåå·¥çšã®åŸã«ã¹ãã¬ãŒå·¥çšãçšã
ããšã圫蟌ã¿ãšç©åã®æ®ãã®éšåãšã®éã«ããè¯
奜ãªå·®ç°ãããåªããå€èŠ³ã®é¡èåããã補åã
åŸãããããšãçºèŠããããã«æ¬çºæã®åºæ¬ãã
ãã æ¬çºæã«ããã°ãé¡èåããã圫蟌ã¿
ïŒhighlighted intagliationïŒå°ãªããšãïŒåãæ
ããçè²åºäœç©åã®è£œæ³ãåŸãããããã¯ã (1) (A) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããå
ã¯ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãã圫蟌
ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããªã
æå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªã
ãšãïŒçš®åã³ãã€ã«ã ã³ãŒãã€ã³ã°å€å°ãªã
ãšãïŒçš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æžæ¿
液ãæœããããã®æœäžãæ £çšã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããç©å
ã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§å®æœã
ããå㯠(B) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããåã¯
ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãã圫蟌ã¿
ãæããçè²ç©åã«ã2.00ãã倧ãããªãæ
å°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ããæããããã€ã«ã ã³ãŒãã€ã³ã°å€
ãå«æããªãæžæ¿æ¶²ãæœããããã®æœäžãæ £
çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒã
ã€ã³ã°ãããç©åã®éã§æ©æŠäœçšãèµ·ããã
ããªæ¹æ³ã§å®æœãããã€ã (2) çããé¡èåããã圫蟌ã¿å°ãªããšãïŒåã
æããçè²åºäœç©åã«ãæ £çšã®ãã€ã«ã ã³ãŒã
ã€ã³ã°è£ 眮äžã§ãåèšç©åã®éã§æ©æŠäœçšãèµ·
ãããããªæ¹æ³ã§ã溶å€ãã¹ãã¬ãŒããããšã
ç¹åŸŽãšããŠããã æ¬çºæã®ãã®æ¹æ³ã¯ãåºç¯ã«é©çšå¯èœã§ããã
åŸã€ãŠäŸãã°ãå»è¬åã¯ç£å»çšåéã§äŸãã°å»è¬
åã¯ç£å»çšåäœé©çšåœ¢äŸãã°é¡èåããã圫蟌ã¿
å°ãªããšãïŒåãæããå»è¬é å€åã¯ç£å»çšé å€
ïŒå€§ããäžžè¬ãšããŠå ¬ç¥ïŒã®è£œé ã«ãåã¯ç³èã®
åéã§ãäŸãã°é¡èåãããç³èçäŸãã°å»è¬é
å€ãšã»ãŒåã寞æ³ã®ãã³ãã³åã¯ãã€ã³ãã€ã®è£œ
é ã«äœ¿çšã§ããã æ³ã¯ã次ã®ããã«èŠçŽããããšãã§ããïŒ (1) åºçºç©è³ªãšããŠçšããããç©åã¯é©åœãªå¯žæ³
ã®åœ«èŸŒã¿ãæããçè²ç©åäŸãã°åœ«èŸŒã¿ãæã
ãçè²å»è¬é å€ã§ããã (2) ãã®åœ«èŸŒã¿ãæããçè²ç©åã«ã2.00ãã倧
ãããªãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ª
å°ãªããšãïŒçš®åã³ãã€ã«ã ã³ãŒãã€ã³ã°å€å°
ãªããšãïŒçš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æž
æ¿æ¶²ïŒä»¥åŸãããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ãš
称ããïŒãæœããã (3) ãã®é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ãã圫蟌ã¿ã
æããçè²ç©åã«ãæ £çšæ³ã§ãæ £çšã®ãã€ã«ã
ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããç©
åã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§æœã
ãã æ³ã«ãããåºçºç©è³ªãšããŠçšãããã圫蟌ã¿
ãæããçè²ç©åã¯ãã³ãŒãã€ã³ã°ãããŠããªã
ãŠãããã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãããã
åŸè ã®å Žåã«ããã€ã«ã ã³ãŒãã¯ä»»æã®ãã€ã«ã
ã³ãŒãã€ã³ã°å€äŸãã°ã»ã«ããŒã¹ãšãŒãã«é¡äŸã
ã°ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹åã¯ãšã
ã«ã»ã«ããŒã¹åã¯é ¢é žã»ã«ããŒã¹ãã·ãšã©ãã¯å
ã¯ã¢ã¯ãªã«ç³»æš¹èåã¯ãããã®æ··åç©ããæã€ãŠ
ããŠãããããã¯ïŒçš®ä»¥äžã®å ¬ç¥ã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°ã¢ãžãŠãã³ãäŸãã°å¯å¡å€äŸãã°ã°ãªã»
ããŒã«åã³ïŒåã¯çé¢æŽ»æ§å€åã³ïŒåã¯ã¯ãã¯ã¹
ãå«æããŠããŠãããããã®ãã€ã«ã ã³ãŒãã¯ã
æ £çšæ¹æ³ã§ãæ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮
ã§ãææ©æº¶å€ãåºç€ãšããæ¹æ³äŸãã°äºå¡©åã¡ã
ã¬ã³ãšã¡ã¿ããŒã«ãšã®æ··åç©ãå å«ããæ¹æ³åã¯
æ°Žæ§æ¹æ³ãçšããŠé©çšãããããã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°è£ 眮ã¯ãäŸãã°ã³ãŒãã€ã³ã°ãã³åã¯ã³
ãŒãã€ã³ã°ãã©ã äŸãã°åŽé¢åºå£ä»ç©¿åãã©ã ã³
ãŒãã€ã³ã°è£ 眮åã¯ãããããŠã«ã¹ã¿ãŒã³ãŒãã€
ã³ã°è£ 眮ïŒWurster coating apparatusïŒæµååº
ã³ãŒãã€ã³ã°è£ 眮ïŒã§ãã€ãŠããã æ³ã§çšããããŠãã圫蟌ã¿ãæããåèšçè²
ç©åã®ç¹åŸŽã§ããè²ã¯ãç©åå šäœã«ã€ããŠããŠã
ããåã¯ãã®è¡šé¢ã«æœããããŠããŠãããåŸã€
ãŠãäŸãã°ãçè²å€ã¯ãçè²ãã€ã«ã ã³ãŒãã€ã³
ã°æº¶æ¶²åã¯æžæ¿æ¶²ã®åœ¢ã§çœè²ç©åã®è¡šé¢äžã«æœã
ãããšãã§ãããåœè©²ç®çäŸãã°å»è¬ç®çã«èªå®¹
ãããä»»æã®çè²å€ãäŸãã°é žåéïŒèµ€è²ãé»è²
åã¯é»è²ïŒãã«ãŒãã³ã倩ç¶ææäŸãã°ãããã
βâã«ããã³ã氎溶æ§ææäŸãã°ã¿ãŒãã©ãžã³ã
åã¯æ°Žæº¶æ§ææã®ã¢ã«ãããŠã ã¬ãŒãããå Žåã«
ãã€ãŠã¯å°ãªããšãïŒçš®ã®äžéæçœè²é¡æäŸãã°
äºé žåãã¿ã³ãšæ··åããŠäœ¿çšããããšãã§ããã å åŠçç°æ¹æ§ç©è³ªã¯ç²æ«ã®åœ¢ã§äœ¿çšãããã奜
é©ãªå åŠçç°æ¹æ§ç©è³ªãšããŠã¯ãäŸãã°çœè²ã®å
åŠçç°æ¹æ§ç©è³ªäŸãã°å ¬ç¥ã®éæãªçœè²é¡æïŒå³
ã¡ãšã¯ã¹ãã³ããŒåã¯äžæŽ»æ§çœè²é¡æãšããŠãå ¬
ç¥ïŒãäŸãã°æ°Žé žåã¢ã«ãããŠã ããã€ã€ãã¯ã¬
ãŒïŒã«ãªãªã³ïŒãã¿ã«ã¯ãçé žã«ã«ã·ãŠã åã¯ç
é žããªãŠã ãæãããããä»ã®å¥œé©ãªå åŠçç°æ¹
æ§ç©è³ªã¯çé žãã°ãã·ãŠã ïŒè»œè³ªåã¯é質圢ïŒã
çèç³ïŒãµãã«ããŒã¹ïŒãä¹³ç³åã¯é ç³é žã§ããã
æŽã«ãå»è¬é å€åã¯äžžè¬ã®å Žåã«ããã®äžã«ååš
ããå»è¬ååã¯ç£å»çšè¬åãå åŠçç°æ¹æ§ç©è³ªãš
ããŠäœ¿çšããããšãã§ãããå³ã¡ããã®å»è¬åå
ã¯ç£å»çšè¬åã¯ãäºéã®åœ¹å²ãæããŠãå³ã¡ãé
å€åã¯äžžè¬åã®æå¹æåãšããŠãã€å åŠçç°æ¹æ§
ç©è³ªãšããŠäœ¿çšããããã é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²äžã§çšããããã®å¥œ
é©ãªãã€ã«ã ã³ãŒãã€ã³ã°å€ã¯åèšã®ãã®ã§ã
ãã åèšã®ããã«ãå åŠçç°æ¹æ§ç©è³ªã¯2.00ãã倧
ãããªãæå°å±æçãæããããã®ç©è³ªã®éžæ
ã¯ããããšå ±ã«é©çšããããã€ã«ã ã³ãŒãã€ã³ã°
å€ã«äŸã決ãŸãããã€ã«ã ã³ãŒãã€ã³ã°å€ã®å±æ
çãšåãåã¯é¡äŒŒã®æå°å±æçãæããå åŠçç°
æ¹æ§ç©è³ªã䜿çšãã¹ãã§ãããæè¯ã®èçŒççµæ
ãçããããã«ããã®æå°å±æçãšã¯ã§ããã ã
ç°ãªãæ倧å±æçãæããå åŠçç°æ¹æ§ç©è³ªã䜿
çšããã®ãæå©ã§ããã䜿çšã§ããå žåçç©è³ªã®
詳现ã¯æ¬¡ã®ãšããã§ããïŒ ãã€ã«ã ã³ãŒãã€ã³ã°å€ å±æç ã¡ãã«ã»ã«ããŒã¹ 1.50 ãšãã«ã»ã«ããŒã¹ 1.47 ããããã·ãšãã«ã»ã«ããŒã¹ 1.51 ããããã·ãããã«ã»ã«ããŒã¹ 1.56 ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ 1.49 ã«ã«ããã·ã¡ãã«ã»ã«ããŒã¹ãããªãŠã 1.52 é ¢é žã»ã«ããŒã¹ 1.48 ã·ãšã©ã㯠1.52 ã¢ã¯ãªã«ç³»æš¹è 1.48
ïŒhighlightedïŒåœ«èŸŒã¿ãæããç©åã®æ¹è¯ããã
補æ³ã«é¢ããã ãšãŒãããç¹èš±åºé¡ç¬¬82300586.3å·ïŒå ¬é第
60023A1ïŒæ现æžã«ã¯ãç¹ã«ãçè²ãããåºäœç©
åäŸãã°é¡èåããã圫蟌ã¿ãå°ãªããšãïŒåæ
ããå»è¬é å€ã®è£œæ³ãèšèŒãããŠãããããã¯ã
çè²ãããïŒå³ã¡çœè²ã§ãªãïŒåœ«èŸŒã¿ãæããç©
åã«ã2.00ãã倧ãããªãæå°å±æçãæããå
åŠçç°æ¹æ§ç©è³ªå°ãªããšãïŒçš®åã³ãã€ã«ã ã³ãŒ
ãã€ã³ã°å€å°ãªããšãïŒçš®ãããªããã€ã«ã ã³ãŒ
ãã€ã³ã°æžæ¿æ¶²ãæœãããã®æ¹æ³ãæ £çšã®ãã€ã«
ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããŠã
ãç©åã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§å®æœ
ããããšãããªãïŒä»¥åŸã¯ãã®æ¹æ³ãæ³ãšç§°ã
ãïŒã åæ¥åºé¡ç¹éæ59â5112å·ïŒè±åœç¹èš±åºé¡ç¬¬
8216816å·ïŒæ现æžäžã«ã¯ãç¹ã«çè²åºäœç©åäŸ
ãã°é¡èåããã圫蟌ã¿å°ãªããšãïŒåãæãã
å»è¬é å€ã®è£œæ³ãèšèŒãããŠãããããã¯ã圫蟌
ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããªãæå°
å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããšãïŒçš®
ãããªããããã€ã«ã ã³ãŒãã€ã³ã°å€ãå«æããª
ããé©åœãªæ¶²äœäžã®æžæ¿æ¶²ãæœããããã®æ¹æ³ã
æ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€
ã³ãããŠããç©åã®éã§æ©æŠäœçšãèµ·ãããããª
æ¹æ³ã§å®æœããããšãããªãïŒä»¥åŸãããæ³ãš
称ããïŒã æ¬æ现æžäžã§ãã圫蟌ã¿ãæããç©åããšã¯ã
åºäœç©åäŸãã°å§çž®æŒæããå蟌ã¿åã¯åœ«å»æ³ã§
åã¯é¡äŒŒå¹æãåŸãä»»æã®ä»ã®æ¹æ³ã§ãç©åã®è¡š
é¢ã«åœ«èŸŒãŸãããåã¯åœ¢æãããå°ãªããšãïŒå
ã®æš¡æ§ãèšå·åã¯æååã¯ãããã®ä»»æã®çµåã
ãæããé å€ãæå³ãããæŽã«ãæ¬æ现æžäžã§ã
ãå åŠçç°æ¹æ§ç©è³ªããšã¯ãçš®ã ã®æ¹åã§çš®ã ã®
å±æçã瀺ãç©è³ªãæå³ããã åèšïŒ¡æ³åã³ïŒ¢æ³ã®é¡èåããã補åäžã§ã¯ã
圫蟌ã¿ãšãã®ç©åã®æ®ãã®éšåãšã®éã«ã¯æ確ãª
å·®ç°ããããããããªãããå Žåã«ãã€ãŠã¯ãå
èšè£œåã¯ã圫蟌ã¿ãšãã®ç©åã®æ®ãã®éšåãšã®é
ã®å·®ç°ãæžããåŸåã®ããå ããªç²ã€ãœãå€èŠ³ã
æããããšãèŠã€ããããã®é¡èåæ³ããããªã
倧ããèŠæš¡ã§ãæ¯èŒç倧ããªå転ãã©ã ã³ãŒãã€
ã³ã°è£ 眮äŸãã°60ã€ã³ãã¢ã¯ã»ã©ãŒã³ãŒã¿ãŒïŒ60
inch AccelaâCotaïŒManestry Machines PLC.
Speke.Liverpool 24 EnglandïŒäžã§å®æœããé
ã«ããã®ããšã¯ããæå¹ã§ããããšããã§ãæå€
ã«ãããã®é¡èåå·¥çšã®åŸã«ã¹ãã¬ãŒå·¥çšãçšã
ããšã圫蟌ã¿ãšç©åã®æ®ãã®éšåãšã®éã«ããè¯
奜ãªå·®ç°ãããåªããå€èŠ³ã®é¡èåããã補åã
åŸãããããšãçºèŠããããã«æ¬çºæã®åºæ¬ãã
ãã æ¬çºæã«ããã°ãé¡èåããã圫蟌ã¿
ïŒhighlighted intagliationïŒå°ãªããšãïŒåãæ
ããçè²åºäœç©åã®è£œæ³ãåŸãããããã¯ã (1) (A) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããå
ã¯ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãã圫蟌
ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããªã
æå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªã
ãšãïŒçš®åã³ãã€ã«ã ã³ãŒãã€ã³ã°å€å°ãªã
ãšãïŒçš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æžæ¿
液ãæœããããã®æœäžãæ £çšã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããç©å
ã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§å®æœã
ããå㯠(B) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããåã¯
ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãã圫蟌ã¿
ãæããçè²ç©åã«ã2.00ãã倧ãããªãæ
å°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ããæããããã€ã«ã ã³ãŒãã€ã³ã°å€
ãå«æããªãæžæ¿æ¶²ãæœããããã®æœäžãæ £
çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒã
ã€ã³ã°ãããç©åã®éã§æ©æŠäœçšãèµ·ããã
ããªæ¹æ³ã§å®æœãããã€ã (2) çããé¡èåããã圫蟌ã¿å°ãªããšãïŒåã
æããçè²åºäœç©åã«ãæ £çšã®ãã€ã«ã ã³ãŒã
ã€ã³ã°è£ 眮äžã§ãåèšç©åã®éã§æ©æŠäœçšãèµ·
ãããããªæ¹æ³ã§ã溶å€ãã¹ãã¬ãŒããããšã
ç¹åŸŽãšããŠããã æ¬çºæã®ãã®æ¹æ³ã¯ãåºç¯ã«é©çšå¯èœã§ããã
åŸã€ãŠäŸãã°ãå»è¬åã¯ç£å»çšåéã§äŸãã°å»è¬
åã¯ç£å»çšåäœé©çšåœ¢äŸãã°é¡èåããã圫蟌ã¿
å°ãªããšãïŒåãæããå»è¬é å€åã¯ç£å»çšé å€
ïŒå€§ããäžžè¬ãšããŠå ¬ç¥ïŒã®è£œé ã«ãåã¯ç³èã®
åéã§ãäŸãã°é¡èåãããç³èçäŸãã°å»è¬é
å€ãšã»ãŒåã寞æ³ã®ãã³ãã³åã¯ãã€ã³ãã€ã®è£œ
é ã«äœ¿çšã§ããã æ³ã¯ã次ã®ããã«èŠçŽããããšãã§ããïŒ (1) åºçºç©è³ªãšããŠçšããããç©åã¯é©åœãªå¯žæ³
ã®åœ«èŸŒã¿ãæããçè²ç©åäŸãã°åœ«èŸŒã¿ãæã
ãçè²å»è¬é å€ã§ããã (2) ãã®åœ«èŸŒã¿ãæããçè²ç©åã«ã2.00ãã倧
ãããªãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ª
å°ãªããšãïŒçš®åã³ãã€ã«ã ã³ãŒãã€ã³ã°å€å°
ãªããšãïŒçš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æž
æ¿æ¶²ïŒä»¥åŸãããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ãš
称ããïŒãæœããã (3) ãã®é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ãã圫蟌ã¿ã
æããçè²ç©åã«ãæ £çšæ³ã§ãæ £çšã®ãã€ã«ã
ã³ãŒãã€ã³ã°è£ 眮äžã§ãã³ãŒãã€ã³ã°ãããç©
åã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§æœã
ãã æ³ã«ãããåºçºç©è³ªãšããŠçšãããã圫蟌ã¿
ãæããçè²ç©åã¯ãã³ãŒãã€ã³ã°ãããŠããªã
ãŠãããã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠãããã
åŸè ã®å Žåã«ããã€ã«ã ã³ãŒãã¯ä»»æã®ãã€ã«ã
ã³ãŒãã€ã³ã°å€äŸãã°ã»ã«ããŒã¹ãšãŒãã«é¡äŸã
ã°ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹åã¯ãšã
ã«ã»ã«ããŒã¹åã¯é ¢é žã»ã«ããŒã¹ãã·ãšã©ãã¯å
ã¯ã¢ã¯ãªã«ç³»æš¹èåã¯ãããã®æ··åç©ããæã€ãŠ
ããŠãããããã¯ïŒçš®ä»¥äžã®å ¬ç¥ã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°ã¢ãžãŠãã³ãäŸãã°å¯å¡å€äŸãã°ã°ãªã»
ããŒã«åã³ïŒåã¯çé¢æŽ»æ§å€åã³ïŒåã¯ã¯ãã¯ã¹
ãå«æããŠããŠãããããã®ãã€ã«ã ã³ãŒãã¯ã
æ £çšæ¹æ³ã§ãæ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮
ã§ãææ©æº¶å€ãåºç€ãšããæ¹æ³äŸãã°äºå¡©åã¡ã
ã¬ã³ãšã¡ã¿ããŒã«ãšã®æ··åç©ãå å«ããæ¹æ³åã¯
æ°Žæ§æ¹æ³ãçšããŠé©çšãããããã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°è£ 眮ã¯ãäŸãã°ã³ãŒãã€ã³ã°ãã³åã¯ã³
ãŒãã€ã³ã°ãã©ã äŸãã°åŽé¢åºå£ä»ç©¿åãã©ã ã³
ãŒãã€ã³ã°è£ 眮åã¯ãããããŠã«ã¹ã¿ãŒã³ãŒãã€
ã³ã°è£ 眮ïŒWurster coating apparatusïŒæµååº
ã³ãŒãã€ã³ã°è£ 眮ïŒã§ãã€ãŠããã æ³ã§çšããããŠãã圫蟌ã¿ãæããåèšçè²
ç©åã®ç¹åŸŽã§ããè²ã¯ãç©åå šäœã«ã€ããŠããŠã
ããåã¯ãã®è¡šé¢ã«æœããããŠããŠãããåŸã€
ãŠãäŸãã°ãçè²å€ã¯ãçè²ãã€ã«ã ã³ãŒãã€ã³
ã°æº¶æ¶²åã¯æžæ¿æ¶²ã®åœ¢ã§çœè²ç©åã®è¡šé¢äžã«æœã
ãããšãã§ãããåœè©²ç®çäŸãã°å»è¬ç®çã«èªå®¹
ãããä»»æã®çè²å€ãäŸãã°é žåéïŒèµ€è²ãé»è²
åã¯é»è²ïŒãã«ãŒãã³ã倩ç¶ææäŸãã°ãããã
βâã«ããã³ã氎溶æ§ææäŸãã°ã¿ãŒãã©ãžã³ã
åã¯æ°Žæº¶æ§ææã®ã¢ã«ãããŠã ã¬ãŒãããå Žåã«
ãã€ãŠã¯å°ãªããšãïŒçš®ã®äžéæçœè²é¡æäŸãã°
äºé žåãã¿ã³ãšæ··åããŠäœ¿çšããããšãã§ããã å åŠçç°æ¹æ§ç©è³ªã¯ç²æ«ã®åœ¢ã§äœ¿çšãããã奜
é©ãªå åŠçç°æ¹æ§ç©è³ªãšããŠã¯ãäŸãã°çœè²ã®å
åŠçç°æ¹æ§ç©è³ªäŸãã°å ¬ç¥ã®éæãªçœè²é¡æïŒå³
ã¡ãšã¯ã¹ãã³ããŒåã¯äžæŽ»æ§çœè²é¡æãšããŠãå ¬
ç¥ïŒãäŸãã°æ°Žé žåã¢ã«ãããŠã ããã€ã€ãã¯ã¬
ãŒïŒã«ãªãªã³ïŒãã¿ã«ã¯ãçé žã«ã«ã·ãŠã åã¯ç
é žããªãŠã ãæãããããä»ã®å¥œé©ãªå åŠçç°æ¹
æ§ç©è³ªã¯çé žãã°ãã·ãŠã ïŒè»œè³ªåã¯é質圢ïŒã
çèç³ïŒãµãã«ããŒã¹ïŒãä¹³ç³åã¯é ç³é žã§ããã
æŽã«ãå»è¬é å€åã¯äžžè¬ã®å Žåã«ããã®äžã«ååš
ããå»è¬ååã¯ç£å»çšè¬åãå åŠçç°æ¹æ§ç©è³ªãš
ããŠäœ¿çšããããšãã§ãããå³ã¡ããã®å»è¬åå
ã¯ç£å»çšè¬åã¯ãäºéã®åœ¹å²ãæããŠãå³ã¡ãé
å€åã¯äžžè¬åã®æå¹æåãšããŠãã€å åŠçç°æ¹æ§
ç©è³ªãšããŠäœ¿çšããããã é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²äžã§çšããããã®å¥œ
é©ãªãã€ã«ã ã³ãŒãã€ã³ã°å€ã¯åèšã®ãã®ã§ã
ãã åèšã®ããã«ãå åŠçç°æ¹æ§ç©è³ªã¯2.00ãã倧
ãããªãæå°å±æçãæããããã®ç©è³ªã®éžæ
ã¯ããããšå ±ã«é©çšããããã€ã«ã ã³ãŒãã€ã³ã°
å€ã«äŸã決ãŸãããã€ã«ã ã³ãŒãã€ã³ã°å€ã®å±æ
çãšåãåã¯é¡äŒŒã®æå°å±æçãæããå åŠçç°
æ¹æ§ç©è³ªã䜿çšãã¹ãã§ãããæè¯ã®èçŒççµæ
ãçããããã«ããã®æå°å±æçãšã¯ã§ããã ã
ç°ãªãæ倧å±æçãæããå åŠçç°æ¹æ§ç©è³ªã䜿
çšããã®ãæå©ã§ããã䜿çšã§ããå žåçç©è³ªã®
詳现ã¯æ¬¡ã®ãšããã§ããïŒ ãã€ã«ã ã³ãŒãã€ã³ã°å€ å±æç ã¡ãã«ã»ã«ããŒã¹ 1.50 ãšãã«ã»ã«ããŒã¹ 1.47 ããããã·ãšãã«ã»ã«ããŒã¹ 1.51 ããããã·ãããã«ã»ã«ããŒã¹ 1.56 ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ 1.49 ã«ã«ããã·ã¡ãã«ã»ã«ããŒã¹ãããªãŠã 1.52 é ¢é žã»ã«ããŒã¹ 1.48 ã·ãšã©ã㯠1.52 ã¢ã¯ãªã«ç³»æš¹è 1.48
ãè¡šã
é©çšãããå
åŠçç°æ¹æ§ç©è³ªã®éã¯ãææã®è²
å·®ã®åºŠåãç©è³ªã®å±æçåã³ãã®ç²åºŠã«äŸã決ãŸ
ããåŸã€ãŠãäŸãã°ãã€ã«ã ã³ãŒãã€ã³ã°å€ãã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ã§ãããåºçº
ç©è³ªãšããŠçšãããã圫蟌ã¿ãæããé å€ãèµ€è²
åã¯é»è²ã®é žåéã§çè²ãããŠãããã€ã«ã ã³ãŒ
ããæããå Žåã«ã¯ã䜿çšãããå åŠçç°æ¹æ§ç©
質ã®éïŒé å€ééã®ïŒ·ïŒïŒ·ïŒ ãšããŠè¡šçŸïŒã¯ã
0.1ã1.0ïŒ ã®éã§å€åãããå€æ°ã®ãã¹ãã«è²èª¿
ã§çè²ããããã€ã«ã ã³ãŒããæããçžå¿ããé
å€ã®å Žåã«ã¯ããã®éã¯ã0.5ã5.0ïŒ ã®éã§å€å
ãããé質çé žãã°ãã·ãŠã ã¯ãåãå¹æãéæ
ããããã«ã軜質çé žãã°ãã·ãŠã ã«æ¯ã¹ãŠçŽïŒ
åå¿ èŠã§ããã æ³ã§äœ¿çšãããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²
ã¯ãå Žåã«ãã€ãŠããã€ã«ã ã³ãŒãã€ã³ã°æ³ã«æ £
çšã®ã³ãŒãã€ã³ã°ã¢ãžãŠãã³ãïŒçš®ä»¥äžäŸãã°å¯
å¡å€äŸãã°ã°ãªã»ããŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ãããªãšãã¬ã³ã°ãªã³ãŒã«ããã¿ã«é žãžãšã
ã«ãã°ãªã»ãªã«ã¢ãã¹ãã¢ã¬ãŒãåã¯ããã·æ²¹å
ã³çé¢æŽ»æ§å€äŸãã°ããªãªãã·ãšãã¬ã³ãœã«ãã¿
ã³ã¢ããªã¬ãšãŒããTween 80ïŒåååïŒãåã³ã
ãŠäŸãã°ããããŠãã«ã«ããŠãããŠãå«æããŠã
ãŠãããä»å çã«ãåèšæ··åç©ã¯ãå Žåã«ãã€ãŠ
ã¯ãå°ãªããšãïŒçš®ã®çè²å€äŸãã°åèšã®è©³çŽ°ãª
çè²å€ïŒçš®ä»¥äžãå«æããŠããŠããããã®çã®å¹
æã¯ãåœè©²ã®è²ãå³ã¡ãäžæ¹ã§ãç©åã®äž»äœã®è²
åã³åœ«èŸŒã¿ã®è²åã³ä»æ¹ã§é¡èåã³ãŒãã®è²ãã
çžäºã«è² ã«åœ±é¿ããããšã§ããïŒEncyclopaedia
BritanicaïŒMicropaediaïŒå·»1974幎22é å
ç §ïŒããã®ããã«å€ãã®è²çµåããå¯èœã§ããã
éäŸã圫蟌ã¿ã¯ãçè²ãããé¡èåã³ãŒãã®èæ·¡
ãè²ãšããŠèŠãããç©åã®äž»äœåã³é¡èåã³ãŒã
ã®è²ãããããè£è²ïŒåèšæç®åç §ïŒã§ããã°ã
ãã®ç©åã®äž»äœã¯é»ãèŠãã圫蟌ã¿ã¯æ·¡åœ©è²ïŒå³
ã¡é¡èåã³ãŒãã®è²ã®èæ·¡ãè²ïŒãšããŠèŠããã æ³ã§çšããããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²
ã¯ãäŸãã°æº¶å€ãäºå¡©åã¡ãã¬ã³ãšã¡ã¿ããŒã«ãš
ã®æ··åç©ã§ããå Žåã¯ãææ©æº¶å€ãåºç€ãšããæž
æ¿æ¶²ã§ãã€ãŠãããåã¯ããã¯æ°Žæ§æžæ¿æ¶²ã§ãã€
ãŠããããã¹ãŠã®æåã氎溶æ§ã§ããå Žåã«ãã
ããã¯ãææ©æº¶å€ãåºç€ãšããæžæ¿æ¶²äžã§é©çšã
ã¹ãã§ããã æ³ã®åèšæŠèŠã¯ãå¿ èŠãªå€æŽãå ããŠïŒ¢æ³ã«
é©çšãããäœããåŸè ã®å Žåã«ã¯ã圫蟌ã¿ãæã
ãçè²ç©åã«ãé©åœãªæº¶å€äžã«2.00ãã倧ãããª
ãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ãå«æããããã€ã«ã ã³ãŒãã€ã³ã°å€ãå«
æããªãæžæ¿æ¶²ãæœãããåºçºç©è³ªãšããŠäœ¿çšã
ãã圫蟌ã¿ãæããçè²ç©åããã®è¡šé¢ã«ãã€ã«
ã ã³ãŒãã€ã³ã°å€ãæããªããåã¯ããã®è¡šé¢ã«
æ¯èŒç氎溶æ§ã®ãã€ã«ã ã³ãŒãã€ã³ã°å€äŸãã°ã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ãæããå Žå
ã«ã奜é©ãªæ¶²äœã¯äŸãã°æ°Žåã¯å€ããã²ã³åãã
ãC1ã4âã¢ã«ã«ã³ãšC1ã4âã¢ã«ã«ããŒã«ãšã®æ··å
ç©äŸãã°äºå¡©åã¡ãã¬ã³ãšã¡ã¿ããŒã«ãšã®æ··åç©
ã§ãããåèšã®åœ«èŸŒã¿ãæããçè²ç©åããã®è¡š
é¢äžã«æ¯èŒçæ°Žã«äžæº¶ã®ãã€ã«ã ã³ãŒãã€ã³ã°å€
äŸãã°ãšãã«ã»ã«ããŒã¹ãæããå Žåã«ã奜é©ãª
液äœã¯ãææ©æº¶å€äŸãã°å€ããã²ã³åãããC1ã4
âã¢ã«ã«ã³äŸãã°äºå¡©åã¡ãã¬ã³åã¯ççŽ ååæ°
ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³äŸãã°ã¢ã»ãã³ã§ã
ãã液äœãæ°Žã§ããå Žåã«ãå°ãªããšãïŒçš®ã®ç
é¢æŽ»æ§å€äŸãã°ããªãšãã¬ã³ãœã«ãã¿ã³ã¢ããªã¬
ãšãŒããTween 80ïŒåååïŒããå Žåã«ããååš
ããŠããŠããã液äœãæ°Žåã¯å€ããã²ã³åããã
C1ã4âã¢ã«ã«ã³ãšC1ã4âã¢ã«ã«ããŒã«ãšã®æ··åç©
ã§ããå Žåã«ãå°ãªããšãïŒçš®ã®æ¹¿æœ€å€äŸãã°ã°
ãªã»ããŒã«ããããã¬ã³ã°ãªã³ãŒã«åã¯äœååé
ããªãšãã¬ã³ã°ãªã³ãŒã«äŸãã°ããªãšãã¬ã³ã°ãª
ã³ãŒã«300ãå Žåã«ããååšããŠããŠããã液äœ
ãææ©æº¶å€ã§ããå Žåã«ãåœè©²ãã€ã«ã ã³ãŒãã€
ã³ã°å€ã«å¯ŸããŠé©åœãªå¯å¡å€äŸãã°ãžâC1ã4âã¢
ã«ãã«ãã¿ã¬ãŒãäŸãã°ãã¿ã«é žãžãšãã«ãå Žå
ã«ããååšããŠããŠããã æ³ã®æå©ãªå®æœæ æ§ã§ã¯ã2.00ãã倧ãããª
ãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ãå«æããåèšæžæ¿æ¶²ã®é©çšã«åŒç¶ããã
ã€ã«ã ã³ãŒãã€ã³ã°å€å°ãªããšãïŒçš®ãå Žåã«ã
ã€ãŠã¯ãã€ã«ã ã³ãŒãã€ã³ã°ã¢ãžãŠãã³ãå°ãªã
ãšãïŒçš®åã³å Žåã«ãã€ãŠã¯çè²å€å°ãªããšãïŒ
çš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æº¶æ¶²åã¯æžæ¿æ¶²
å°ãªããšãïŒçš®ãæ £çšæ³ã§é©çšããã ã¹ãã¬ãŒå·¥çšïŒå³ã¡ç¬¬ïŒå·¥çšïŒã§çšãããã溶
å€ïŒãããæ¬çºæãç¹åŸŽã¥ããŠããïŒã¯ãé¡èå
ãããç©åã®å€é¢äžã§ã®ä»»æã®ãã€ã«ã ã³ãŒãã€
ã³ã°å€ã®æ°Žæº¶æ§ã«äŸã決ãŸãããã€ã«ã ã³ãŒãã€
ã³ã°å€ãæ¯èŒç氎溶æ§ã§ãããäŸãã°ããããã·
ãããã«ã¡ãã«ã»ã«ããŒã¹ã§ãããåèšå€é¢äžã«
ãã€ã«ã ã³ãŒãã€ã³ã°å€ãååšããªãå Žåã®å¥œé©
ãªæº¶å€ã®äŸã¯æ¬¡ã®ãã®ã§ããïŒ (a) æ°Ž (b) æ°ŽãšC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿ããŒã«å
ã¯ãšã¿ããŒã«ãšã®æ··åç© (c) å€ããã²ã³åãããC1ã4âã¢ã«ã«ã³äŸãã°äº
å¡©åã¡ãã¬ã³ãC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿
ããŒã«å㯠(d) 溶å€(c)ãšççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ã
ã³äŸãã°ã¢ã»ãã³ãšã®æ··åç© åèšæº¶å€(a)ã(b)ã(c)åã¯(d)ã¯ãå Žåã«ããå°
ãªããšãïŒçš®ã®æ¹¿æœ€å€äŸãã°ã°ãªã»ããŒã«ãã
ããã¬ã³ã°ãªã³ãŒã«åã¯äœååéããªãšãã¬ã³
ã°ãªã³ãŒã«äŸãã°ååé190ã600ãæããããª
ãšãã¬ã³ã°ãªã³ãŒã«äŸãã°ããªãšãã¬ã³ã°ãªã³
ãŒã«300ãå«æããŠããŠããã湿最å€ã䜿çšã
ãéã«ãé¡èå補åããã®æ¹æ³ã®æåŸã«ç²çæ§
ãæããªãããšã¯ææ³å€ã®ããšã§ããã åèšå€é¢äžã®ãã€ã«ã ã³ãŒãã€ã³ã°å€ãæ¯èŒ
çæ°Žã«äžæº¶æ§ã§ããå ŽåäŸãã°ãšãã«ã»ã«ããŒ
ã¹ãã·ãšã©ãã¯åã¯ã¢ã¯ãªã«æš¹èã§ããå Žåã«
奜é©ãªæº¶å€ã®äŸã¯æ¬¡ã®ãã®ã§ããïŒ (e) å€ããã²ã³åãããC1ã4âã¢ã«ã«ã³äŸãã°äº
å¡©åã¡ãã¬ã³ (f) ççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³äŸãã°
ã¢ã»ãã³ (g) 溶å€(e)ãš(f)ãšã®æ··åç©å㯠(h) 溶å€(g)ãšC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿ããŒ
ã«ãšã®æ··åç© åèšæº¶å€(e)ã(f)ã(g)åã¯(h)ã¯ãå Žåã«ãã€ãŠ
ã¯ãåœè©²ãã€ã«ã ã³ãŒãã€ã³ã°å€ã«å¯Ÿãã奜é©ãª
å¯å¡å€ã§ããããšãæç®ã«å ¬ç¥ã®å¯å¡å€å°ãªããš
ãïŒçš®äŸãã°ãã¿ã«é žãžãšãã«åã¯ãã¿ã«é žãžâ
ïœâããã«åã¯ã°ãªã»ããŒã«ãšã¢ã«ã«ã³é žãšã®ãš
ã¹ãã«äŸãã°ã°ãªã»ãªã«ããªã¢ã»ããŒãåã¯ã°ãª
ã»ãªã«ã¢ãã¹ãã¢ã¬ãŒãåã¯æ€ç©æ²¹äŸãã°ããã·
æ²¹ãå«æããŠããŠããã æ¬çºæã®ç¹åŸŽã§ããã¹ãã¬ãŒå·¥çšããåœè©²æº¶å€
ã«å¯ŸããŠå¥œé©ãªæ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°æ¡ä»¶
äžã§ããã€åœè©²ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§å®
æœããã é å€äžã«ã¹ãã¬ãŒããã溶å€ã¯ãé å€äžã®ããª
ããŒã³ãŒãã€ã³ã°ãè»åãããé å€éã®æ©æŠäœçš
ã«ããå§åã§ããªããŒã³ãŒãã€ã³ã°ãæµååã
ããã³ãŒãã€ã³ã°ãäžæ§ã«ããã®ã§ããã®æº¶å€ã¹
ãã¬ãŒå·¥çšã«ãããããæ¹è¯ããã補åå€èŠ³ãåŸ
ãããã ææã®å Žåã«ã¯ãæçµå·¥çšãšããŠãæ¬çºæã®é¡
èå補åããå°ãªããšãïŒçš®ã®ããŠäŸãã°ããã
ãŠåã¯ã«ã«ããŠãããŠãçšããŠæ £çšæ¹æ³ã§ã€ãåº
ããããŠå€èŠ³ãè¯ãããããšãã§ããã 次ã«å®æœäŸã«ã€ãæ¬çºæã説æãããæ¬çºæã¯
ããã®ã¿ã«éå®ããããã®ã§ã¯ãªãã äŸ ïŒ åœ«èŸŒã¿ãæããçœè²ã®å¡©é žããããããŒã«10mg
é å€ïŒå¹³åéé95mgïŒ10Kgãšåœ«èŸŒã¿ãæããçœè²
ã®ãã©ã»ãé å€ïŒå¹³åéé95mgïŒ350Kgãšã®é å€
æ··åç©ã次ã®ããã«åŠçããïŒ (a) çè²ã³ãŒãã€ã³ã°å·¥çš 次ã®æåãããªãæŸæã³ãŒãã€ã³ã°æº¶æ¶²ãäœ
ã€ãïŒ ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ãPharmacoat 606ïŒåååïŒãShinâEtsu
Chemical Company Ltd.Tokyo.Japanã 8.4Kg ã°ãªã»ããŒã« 1.68Kg è±ã€ãªã³æ°Ž 63 ãã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²ïŒãé¡èåå·¥çš
ïŒåŸèšåç §ïŒã§ã®äœ¿çšã®ããã«åã€ãŠãããã
次ã«ãã®ããã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²ã®æ®åã«
æ·»å ããïŒ æ¡è²è²çŽ åæ£æ¶²ãOpaspray ïŒâïŒâ1399B
ïŒåååïŒColorcon PLC.Orpington.Kent.
Englandã 5.4Kg è±ã€ãªã³æ°Ž å šé108 ããããŠçè²ã³ãŒãã€ã³ã°æº¶æ¶²ãåŸãããã åèšã®é å€æ··åç©ããåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ã60ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒ
ã¿ïŒAccelaâCotaïŒãäžã§ãçè²ã³ãŒãã€ã³ã°
溶液ãçšããŠæ¬¡ã®æ¡ä»¶äžã§ãã€ã«ã ã³ãŒãã€ã³
ã°ããïŒ è£ å ¥ç©ºæ°æž©åºŠ 70ã75â æåºç©ºæ°æž©åºŠ 51ã54â 空æ°æµé 4100ft3ã»mm-1 ç空床 â0.4ãw.g. ã¹ãã¬ãŒé床 660ã700mlã»mm-1 é§å空æ°å§ 70ã73psi ãã©ã é床 æåã®ïŒæé4r.p.m æåŸã®1.5æé4.5r.p.m ããããŠã圫蟌ã¿ãæããæ¡è²ãã€ã«ã ã³ãŒ
ãã€ã³ã°ãããé å€ã®æ··åç©ãåŸãããã (b) é¡èåå·¥çš é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ã次ã®ããã«ããŠ
補é ããïŒ ç²ç¶ã®è»œè³ªçé žãã°ãã·ãŠã ïŒ1.296KgïŒã
è±ã€ãªã³æ°ŽïŒïŒïŒäžã«å ååæ£ãããããã®
æžæ¿æ¶²ã«ãåèšã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²(a)å·¥çš
åç §ïŒïŒãæ·»å ããåŸãããæžæ¿æ¶²ãè±ã€ãª
ã³æ°Žã§42ãšãã次ãã§ãå質ã«ãªããŸã§å å
ã«æ··åããã åèšã®ã圫蟌ã¿ãæããæ¡è²ã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°ãããé å€æ··åç©ã«ã60ã€ã³ãã»ã¢ã¯
ã»ã©ãŒã³ãŒã¿ãŒäžã§ã(a)å·¥çšã«èšèŒã®æ¡ä»¶äž
ã§ãäœãããã©ã é床5r.p.mã§ãé¡èåã³ãŒã
ã€ã³ã°æžæ¿æ¶²ã§ãã€ã«ã ã³ãŒãã€ã³ã°ãããã
ãããŠé¡èåé å€ã®æ··åç©ãåŸãããã (c) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåå·¥çšãå®äºãããçŽã¡ã«ãè±ã€ãªã³æ°Ž
ïŒ20ïŒããé¡èåå·¥çšã§çšãããšåãæ¡ä»¶äž
ã«é å€äžã«ã¹ãã¬ãŒããããã¹ãŠã®æ°Žãé©çšã
ãããããã©ã ãæ¢ããé å€ãåé€ããããã
ããŠãåªããå€èŠ³ã®é¡èåé å€ã®æ··åç©ãåŸã
ããã äŸ ïŒ (a) é¡èåå·¥çš åŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24
ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§ã圫蟌ã¿ãæ
ããçè²ãã€ã«ã ã³ãŒãã€ã³ã°ããããã©ã»ã
åã³å»è¬é å€ã®æ··åç©ïŒééç¯å²94ã640mgïŒ
10Kgã60âã«å ç±ãããã°ãªã»ããŒã«0.65WïŒ
ïŒ¶ïŒ ãå«æãã軜質çé žãã°ãã·ãŠã ïŒ30ïœïŒ
ãäžã«æžæ¿ãããŠããããããã·ãããã«ã»ã«
ããŒã¹ãPharmacoat606ïŒåååïŒãã®3.3WïŒ
ïŒ¶ïŒ æ°Žæº¶æ¶²ïŒããäœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ã
çšããŠã50mlã»min-1ã§é£ç¶çã«é©çšãããã
ã©ã é床ã16r.p.mã«ãè£ å ¥ç©ºæ°ã®æž©åºŠã60â
ã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãé©çšããããã
ãã©ã ãæ¢ããé å€ãåãåºãããããããŠçœ
è²ã«é¡èåããã圫蟌ã¿ãæããçè²ãã€ã«ã
ã³ãŒãã€ã³ã°ãããé å€ã®æ··åç©ãåŸãããã (b) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåé å€ã®æ··åç©ãåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©âã³ãŒ
ã¿ïŒäžã§60ãã«å ç±ããããªãšãã¬ã³ã°ãªã³ãŒ
ã«300ã®1WïŒïŒ¶ïŒ 氎溶液ïŒ200mlïŒãé£ç¶çã«ã
äœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1
ã§é©çšããããã©ã é床ã10r.p.mã«ããã€è£
å ¥ç©ºæ°ã®æž©åºŠã60âã«ä¿æããããã¹ãŠã®æº¶æ¶²
ãé©çšããããããã©ã ãæ¢ããé å€ãåãåº
ãããããããŠãåªããå€èŠ³ã®é¡èåé å€ã®æ··
åç©ãåŸãããã äŸ ïŒ (a) (i) é¡èåå·¥çš åœ«èŸŒã¿ãæããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°
ããããã©ã»ã410mgé å€24400åãåŽé¢åºå£
ä»ç©¿åãã©ã ãã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³
ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±ã
ããããªãšãã¬ã³ã°ãªã³ãŒã«300 0.65WïŒïŒ¶
ïŒ ãå«æããäžã«è»œè³ªçé žãã°ãã·ãŠã ïŒ30
ïœïŒãæžæ¿ããŠããããããã·ãããã«ã¡ã
ã«ã»ã«ããŒã¹ãPharmacoat606ïŒåååïŒã
ã®3.3WïŒïŒ¶ïŒ 氎溶液ïŒããäœå§ãšã¢ã»ã¹
ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1ã§é£ç¶çã«
æœãããããã©ã é床ã16r.p.mã«ãè£ å ¥ä¹Ÿ
ç¥ç©ºæ°ã®æž©åºŠã60âã«ä¿æããããã¹ãŠã®æž
æ¿æ¶²ãæœããããããã©ã ãæ¢ããé å€ãå
ãåºãããããããŠã圫蟌ã¿ãæããçœè²ã«
é¡èåãããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°ãã
ãé å€ãåŸãããã (a) (ii) é¡èåå·¥çš åœ«èŸŒã¿ãæããè€è²ãã€ã«ã ã³ãŒãã€ã³ã°
ããããã©ã»ã270mgé å€37000åãåŽé¢åºå£
ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»
ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±ãããã
ãªãšãã¬ã³ã°ãªã³ãŒã«300 0.65WïŒïŒ¶ïŒ ãã¿
ãŒãã©ãžã³æ°Žæº¶æ§ææïŒé£åãå»è¬åã³å粧
åçšã€ãšããŒNo.ïŒïŒ0.1WïŒïŒ¶ïŒ ãå«æãã
軜質çé žãã°ãã·ãŠã ãäžã«æžæ¿ããŠããã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ïŒPharmacoat606ïŒåååïŒãã®3.3WïŒïŒ¶ïŒ æ°Ž
溶液ïŒããé£ç¶çã«äœå§ãšã¢ãŒã¹ãã¬ãŒè£
眮ãçšããŠã50mlã»min-1ã§æœãããããã©
ã é床ã16r.p.mã«ãè£ å ¥ç©ºæ°æž©åºŠã60âã«
ä¿æããããã¹ãŠã®æžæ¿æ¶²ããæœããããã
ã©ã ãæ¢ããé å€ãåãåºãããããããŠã
é»è²ã«é¡èåããã圫蟌ã¿ãæããè€è²ãã€
ã«ã ã³ãŒãã€ã³ã°ãããé å€ãåŸãããã (b) 溶å€ã¹ãã¬ãŒå·¥çš åèš(a)(i)ã«èšèŒã®ããã«ããŠåŸãæ¡è²ã®é¡è
åé å€ïŒKgãåèš(a)(ii)ã«èšèŒã®ããã«ããŠåŸã
è€è²ã®é¡èåé å€ïŒKgãåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒ
ã¿ïŒäžã«å ¥ãã60âã«å ç±ãããïŒïŒ1VïŒïŒ¶
ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒïŒïŒããé«å§
ãšã¢ã¬ã¹ã¹ãã¬ãŒè£ 眮ãçšããŠã300mlã»
min-1ã§é£ç¶çã«æœãããããã©ã é床ã15r.
p.mã«ããã€è£ å ¥ç©ºæ°æž©åºŠã60âã«ä¿æããã
ãã¹ãŠã®æº¶å€ãæœããããããã©ã ãæ¢ããŠé
å€ãåãåºãããããããŠãåªããå€èŠ³ã®é¡è
åãããé å€ãåŸãããã äŸ ïŒ ïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒ
ãïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³äžã®
ããªãšãã¬ã³ã°ãªã³ãŒã«300ã®0.5WïŒïŒ¶æº¶æ¶²ïŒ
ã«ä»£ããŠãäŸïŒã«èšèŒã®æº¶å€ã¹ãã¬ãŒå·¥çšãç¹°ã
è¿ãããããããŠãåªããå€èŠ³ã®é¡èåãããé
å€ãåŸãããã äŸ ïŒ (a) ã«ã©ãŒã³ãŒãã€ã³ã°å·¥çš 圫蟌ã¿ãæããçœè²å»è¬200mgé å€50000å
ããåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮
ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å
ç±ãããã°ãªã»ããŒã«1.4WïŒïŒ¶ïŒ åã³æ¡è²è²
çŽ åæ£æ¶²ã175ïœãOpaspray pinkïŒåååïŒã
Colorcon PLC.Orpington.Kent.Englandãã
å«æããããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ïŒPharmacoat606ïŒã®9WïŒïŒ¶ïŒ 氎溶液2.6ãã
äœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1
ã§é£ç¶çã«æœãããããã©ã é床ã12r.p.mã«
ãã€è£ å ¥ç©ºæ°æž©åºŠã60âã«ä¿æããããã¹ãŠã®
æžæ¿æ¶²ãæœããããããã©ã ãæ¢ããé å€ãå
ãåºãããããããŠã圫蟌ã¿ãæããæ¡è²ãã€
ã«ã ã³ãŒãã€ã³ã°ãããé å€ãåŸãããã (b) é¡èåå·¥çš åœ«èŸŒã¿ãæããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°ã
ããé å€ããåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³
ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60
âã«å ç±ãããïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©
åã¡ãã¬ã³äžã®è»œè³ªçé žãã°ãã·ãŠã ã®
1.5WïŒïŒ¶ïŒ æžæ¿æ¶²ïŒãé«å§ãšã¢ã¬ã¹ã¹ãã¬
ãŒè£ 眮ãçšããŠã300mlã»min-1ã§é£ç¶çã«æœ
ãããããã©ã é床ã15r.p.mã«ãã€è£ å ¥ç©ºæ°
枩床ã60âã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãæœã
ããããã©ã ãæ¢ããé å€ãåãåºããããã
ããŠåœ«èŸŒã¿ãæãçœè²ã«é¡èåãããæ¡è²é å€
ãåŸãããã (c) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåãããæ¡è²é å€ããåŽé¢åºå£ä»ç©¿åã
ã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒ
ã³ãŒã¿ïŒäžã§ã60âã«å ç±ãããïŒïŒ1VïŒïŒ¶
ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒïŒïŒããé«å§
ãšã¢ã¬ã¹ã¹ãã¬ãŒè£ 眮ãçšããŠ300mlã»min-1
ã§é£ç¶çã«æœãããããã©ã é床ã15r.p.mã«ã
è£ å ¥ç©ºæ°ã60âã«ä¿æããããã¹ãŠã®æº¶å€ãæœ
ããããããã©ã ãæ¢ããé å€ãåãåºããã
ããããŠãæºè¶³ãªå€èŠ³ãæããé¡èåãããé
å€ãåŸãããã äŸ ïŒ (a) é¡èåå·¥çš åœ«èŸŒã¿ãæããçè²ãã€ã«ã ã³ãŒãã€ã³ã°ã
ãããã©ã»ããšå»è¬é å€ãšã®æ··åç©ïŒééç¯å²
100ã640mgïŒ10KgãåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒ
ãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒ
äžã§60âã«å ç±ãããããªãšãã¬ã³ã°ãªã³ãŒã«
300 1WïŒïŒ¶ïŒ ãå«æãã軜質çé žãã°ãã·ãŠ
ã ïŒ30ïœïŒããã®äžã«æžæ¿ããŠããããããã·
ãããã«ã¡ãã«ã»ã«ããŒã¹ïŒPharmacoat606ïŒ
ã®5WïŒïŒ¶ïŒ 氎溶液ïŒããäœå§ãšã¢ãŒã¹ãã¬
ãŒè£ 眮ãçšããŠã50mlã»min-1ã§ãé£ç¶çã«æœ
ãããããã©ã é床ã16r.p.mã«ãã€è£ å ¥ç©ºæ°
枩床ã60âã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãæœã
ãããããã©ã ãæ¢ããé å€ãåãåºãããã
ãããŠã圫蟌ã¿ãæããçœè²ã«é¡èåãããç
è²ãã€ã«ã ã³ãŒãã€ã³ã°ãããé å€ã®æ··åç©ã
åŸãããã (b)溶å€ã¹ãã¬ãŒå·¥çš åèš(a)ã«èšèŒãããŠããããã«ããŠåŸãçœè²
ã«é¡èåããã圫蟌ã¿ãæããçè²ãã€ã«ã ã³
ãŒãã€ã³ã°ãããé å€çŽ400åããçœè²ãã©ã»
ã190mgé å€çŽ52000åã«å ãããé å€ã®æ··åç©
ãåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24
ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±
ããã¡ã¿ããŒã«ãšæ°Žãšã®æ··åç©ïŒ60ïŒ40VïŒ
ïŒ500mlããäœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšã
ãŠã50mlã»min-1ã§ãé£ç¶çã«æœãããããã©
ã é床ã16r.p.mã«ããã€ãè£ å ¥ç©ºæ°æž©åºŠã60
âã«ä¿æããããã¹ãŠã®æº¶å€ãæœãããããã©
ã ãæ¢ããé å€ãåãåºãããããããŠãæºè¶³
ãããå€èŠ³ã®é¡èåãããé å€ãåŸãããã äŸ ïŒ æº¶å€ã¹ãã¬ãŒå·¥çšã§ã¡ã¿ããŒã«ïŒæ°ŽïŒ60ïŒ
40VïŒïŒ¶ïŒ500mlã®ä»£ãã«ã¡ã¿ããŒã«ïŒã¢ã»ãã³
ïŒ70ïŒ30VïŒïŒ¶ïŒïŒãçšããŠãäŸïŒã«èšèŒã®é¡
èåå·¥çšåã³æº¶å€ã¹ãã¬ãŒå·¥çšãç¹°ãè¿ãããã
ãããŠãæºè¶³ãããå€èŠ³ã®é¡èåãããé å€ãåŸ
ãããã
å·®ã®åºŠåãç©è³ªã®å±æçåã³ãã®ç²åºŠã«äŸã決ãŸ
ããåŸã€ãŠãäŸãã°ãã€ã«ã ã³ãŒãã€ã³ã°å€ãã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ã§ãããåºçº
ç©è³ªãšããŠçšãããã圫蟌ã¿ãæããé å€ãèµ€è²
åã¯é»è²ã®é žåéã§çè²ãããŠãããã€ã«ã ã³ãŒ
ããæããå Žåã«ã¯ã䜿çšãããå åŠçç°æ¹æ§ç©
質ã®éïŒé å€ééã®ïŒ·ïŒïŒ·ïŒ ãšããŠè¡šçŸïŒã¯ã
0.1ã1.0ïŒ ã®éã§å€åãããå€æ°ã®ãã¹ãã«è²èª¿
ã§çè²ããããã€ã«ã ã³ãŒããæããçžå¿ããé
å€ã®å Žåã«ã¯ããã®éã¯ã0.5ã5.0ïŒ ã®éã§å€å
ãããé質çé žãã°ãã·ãŠã ã¯ãåãå¹æãéæ
ããããã«ã軜質çé žãã°ãã·ãŠã ã«æ¯ã¹ãŠçŽïŒ
åå¿ èŠã§ããã æ³ã§äœ¿çšãããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²
ã¯ãå Žåã«ãã€ãŠããã€ã«ã ã³ãŒãã€ã³ã°æ³ã«æ £
çšã®ã³ãŒãã€ã³ã°ã¢ãžãŠãã³ãïŒçš®ä»¥äžäŸãã°å¯
å¡å€äŸãã°ã°ãªã»ããŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ãããªãšãã¬ã³ã°ãªã³ãŒã«ããã¿ã«é žãžãšã
ã«ãã°ãªã»ãªã«ã¢ãã¹ãã¢ã¬ãŒãåã¯ããã·æ²¹å
ã³çé¢æŽ»æ§å€äŸãã°ããªãªãã·ãšãã¬ã³ãœã«ãã¿
ã³ã¢ããªã¬ãšãŒããTween 80ïŒåååïŒãåã³ã
ãŠäŸãã°ããããŠãã«ã«ããŠãããŠãå«æããŠã
ãŠãããä»å çã«ãåèšæ··åç©ã¯ãå Žåã«ãã€ãŠ
ã¯ãå°ãªããšãïŒçš®ã®çè²å€äŸãã°åèšã®è©³çŽ°ãª
çè²å€ïŒçš®ä»¥äžãå«æããŠããŠããããã®çã®å¹
æã¯ãåœè©²ã®è²ãå³ã¡ãäžæ¹ã§ãç©åã®äž»äœã®è²
åã³åœ«èŸŒã¿ã®è²åã³ä»æ¹ã§é¡èåã³ãŒãã®è²ãã
çžäºã«è² ã«åœ±é¿ããããšã§ããïŒEncyclopaedia
BritanicaïŒMicropaediaïŒå·»1974幎22é å
ç §ïŒããã®ããã«å€ãã®è²çµåããå¯èœã§ããã
éäŸã圫蟌ã¿ã¯ãçè²ãããé¡èåã³ãŒãã®èæ·¡
ãè²ãšããŠèŠãããç©åã®äž»äœåã³é¡èåã³ãŒã
ã®è²ãããããè£è²ïŒåèšæç®åç §ïŒã§ããã°ã
ãã®ç©åã®äž»äœã¯é»ãèŠãã圫蟌ã¿ã¯æ·¡åœ©è²ïŒå³
ã¡é¡èåã³ãŒãã®è²ã®èæ·¡ãè²ïŒãšããŠèŠããã æ³ã§çšããããé¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²
ã¯ãäŸãã°æº¶å€ãäºå¡©åã¡ãã¬ã³ãšã¡ã¿ããŒã«ãš
ã®æ··åç©ã§ããå Žåã¯ãææ©æº¶å€ãåºç€ãšããæž
æ¿æ¶²ã§ãã€ãŠãããåã¯ããã¯æ°Žæ§æžæ¿æ¶²ã§ãã€
ãŠããããã¹ãŠã®æåã氎溶æ§ã§ããå Žåã«ãã
ããã¯ãææ©æº¶å€ãåºç€ãšããæžæ¿æ¶²äžã§é©çšã
ã¹ãã§ããã æ³ã®åèšæŠèŠã¯ãå¿ èŠãªå€æŽãå ããŠïŒ¢æ³ã«
é©çšãããäœããåŸè ã®å Žåã«ã¯ã圫蟌ã¿ãæã
ãçè²ç©åã«ãé©åœãªæº¶å€äžã«2.00ãã倧ãããª
ãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ãå«æããããã€ã«ã ã³ãŒãã€ã³ã°å€ãå«
æããªãæžæ¿æ¶²ãæœãããåºçºç©è³ªãšããŠäœ¿çšã
ãã圫蟌ã¿ãæããçè²ç©åããã®è¡šé¢ã«ãã€ã«
ã ã³ãŒãã€ã³ã°å€ãæããªããåã¯ããã®è¡šé¢ã«
æ¯èŒç氎溶æ§ã®ãã€ã«ã ã³ãŒãã€ã³ã°å€äŸãã°ã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ãæããå Žå
ã«ã奜é©ãªæ¶²äœã¯äŸãã°æ°Žåã¯å€ããã²ã³åãã
ãC1ã4âã¢ã«ã«ã³ãšC1ã4âã¢ã«ã«ããŒã«ãšã®æ··å
ç©äŸãã°äºå¡©åã¡ãã¬ã³ãšã¡ã¿ããŒã«ãšã®æ··åç©
ã§ãããåèšã®åœ«èŸŒã¿ãæããçè²ç©åããã®è¡š
é¢äžã«æ¯èŒçæ°Žã«äžæº¶ã®ãã€ã«ã ã³ãŒãã€ã³ã°å€
äŸãã°ãšãã«ã»ã«ããŒã¹ãæããå Žåã«ã奜é©ãª
液äœã¯ãææ©æº¶å€äŸãã°å€ããã²ã³åãããC1ã4
âã¢ã«ã«ã³äŸãã°äºå¡©åã¡ãã¬ã³åã¯ççŽ ååæ°
ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³äŸãã°ã¢ã»ãã³ã§ã
ãã液äœãæ°Žã§ããå Žåã«ãå°ãªããšãïŒçš®ã®ç
é¢æŽ»æ§å€äŸãã°ããªãšãã¬ã³ãœã«ãã¿ã³ã¢ããªã¬
ãšãŒããTween 80ïŒåååïŒããå Žåã«ããååš
ããŠããŠããã液äœãæ°Žåã¯å€ããã²ã³åããã
C1ã4âã¢ã«ã«ã³ãšC1ã4âã¢ã«ã«ããŒã«ãšã®æ··åç©
ã§ããå Žåã«ãå°ãªããšãïŒçš®ã®æ¹¿æœ€å€äŸãã°ã°
ãªã»ããŒã«ããããã¬ã³ã°ãªã³ãŒã«åã¯äœååé
ããªãšãã¬ã³ã°ãªã³ãŒã«äŸãã°ããªãšãã¬ã³ã°ãª
ã³ãŒã«300ãå Žåã«ããååšããŠããŠããã液äœ
ãææ©æº¶å€ã§ããå Žåã«ãåœè©²ãã€ã«ã ã³ãŒãã€
ã³ã°å€ã«å¯ŸããŠé©åœãªå¯å¡å€äŸãã°ãžâC1ã4âã¢
ã«ãã«ãã¿ã¬ãŒãäŸãã°ãã¿ã«é žãžãšãã«ãå Žå
ã«ããååšããŠããŠããã æ³ã®æå©ãªå®æœæ æ§ã§ã¯ã2.00ãã倧ãããª
ãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªããš
ãïŒçš®ãå«æããåèšæžæ¿æ¶²ã®é©çšã«åŒç¶ããã
ã€ã«ã ã³ãŒãã€ã³ã°å€å°ãªããšãïŒçš®ãå Žåã«ã
ã€ãŠã¯ãã€ã«ã ã³ãŒãã€ã³ã°ã¢ãžãŠãã³ãå°ãªã
ãšãïŒçš®åã³å Žåã«ãã€ãŠã¯çè²å€å°ãªããšãïŒ
çš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æº¶æ¶²åã¯æžæ¿æ¶²
å°ãªããšãïŒçš®ãæ £çšæ³ã§é©çšããã ã¹ãã¬ãŒå·¥çšïŒå³ã¡ç¬¬ïŒå·¥çšïŒã§çšãããã溶
å€ïŒãããæ¬çºæãç¹åŸŽã¥ããŠããïŒã¯ãé¡èå
ãããç©åã®å€é¢äžã§ã®ä»»æã®ãã€ã«ã ã³ãŒãã€
ã³ã°å€ã®æ°Žæº¶æ§ã«äŸã決ãŸãããã€ã«ã ã³ãŒãã€
ã³ã°å€ãæ¯èŒç氎溶æ§ã§ãããäŸãã°ããããã·
ãããã«ã¡ãã«ã»ã«ããŒã¹ã§ãããåèšå€é¢äžã«
ãã€ã«ã ã³ãŒãã€ã³ã°å€ãååšããªãå Žåã®å¥œé©
ãªæº¶å€ã®äŸã¯æ¬¡ã®ãã®ã§ããïŒ (a) æ°Ž (b) æ°ŽãšC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿ããŒã«å
ã¯ãšã¿ããŒã«ãšã®æ··åç© (c) å€ããã²ã³åãããC1ã4âã¢ã«ã«ã³äŸãã°äº
å¡©åã¡ãã¬ã³ãC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿
ããŒã«å㯠(d) 溶å€(c)ãšççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ã
ã³äŸãã°ã¢ã»ãã³ãšã®æ··åç© åèšæº¶å€(a)ã(b)ã(c)åã¯(d)ã¯ãå Žåã«ããå°
ãªããšãïŒçš®ã®æ¹¿æœ€å€äŸãã°ã°ãªã»ããŒã«ãã
ããã¬ã³ã°ãªã³ãŒã«åã¯äœååéããªãšãã¬ã³
ã°ãªã³ãŒã«äŸãã°ååé190ã600ãæããããª
ãšãã¬ã³ã°ãªã³ãŒã«äŸãã°ããªãšãã¬ã³ã°ãªã³
ãŒã«300ãå«æããŠããŠããã湿最å€ã䜿çšã
ãéã«ãé¡èå補åããã®æ¹æ³ã®æåŸã«ç²çæ§
ãæããªãããšã¯ææ³å€ã®ããšã§ããã åèšå€é¢äžã®ãã€ã«ã ã³ãŒãã€ã³ã°å€ãæ¯èŒ
çæ°Žã«äžæº¶æ§ã§ããå ŽåäŸãã°ãšãã«ã»ã«ããŒ
ã¹ãã·ãšã©ãã¯åã¯ã¢ã¯ãªã«æš¹èã§ããå Žåã«
奜é©ãªæº¶å€ã®äŸã¯æ¬¡ã®ãã®ã§ããïŒ (e) å€ããã²ã³åãããC1ã4âã¢ã«ã«ã³äŸãã°äº
å¡©åã¡ãã¬ã³ (f) ççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³äŸãã°
ã¢ã»ãã³ (g) 溶å€(e)ãš(f)ãšã®æ··åç©å㯠(h) 溶å€(g)ãšC1ã4âã¢ã«ã«ããŒã«äŸãã°ã¡ã¿ããŒ
ã«ãšã®æ··åç© åèšæº¶å€(e)ã(f)ã(g)åã¯(h)ã¯ãå Žåã«ãã€ãŠ
ã¯ãåœè©²ãã€ã«ã ã³ãŒãã€ã³ã°å€ã«å¯Ÿãã奜é©ãª
å¯å¡å€ã§ããããšãæç®ã«å ¬ç¥ã®å¯å¡å€å°ãªããš
ãïŒçš®äŸãã°ãã¿ã«é žãžãšãã«åã¯ãã¿ã«é žãžâ
ïœâããã«åã¯ã°ãªã»ããŒã«ãšã¢ã«ã«ã³é žãšã®ãš
ã¹ãã«äŸãã°ã°ãªã»ãªã«ããªã¢ã»ããŒãåã¯ã°ãª
ã»ãªã«ã¢ãã¹ãã¢ã¬ãŒãåã¯æ€ç©æ²¹äŸãã°ããã·
æ²¹ãå«æããŠããŠããã æ¬çºæã®ç¹åŸŽã§ããã¹ãã¬ãŒå·¥çšããåœè©²æº¶å€
ã«å¯ŸããŠå¥œé©ãªæ £çšã®ãã€ã«ã ã³ãŒãã€ã³ã°æ¡ä»¶
äžã§ããã€åœè©²ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮äžã§å®
æœããã é å€äžã«ã¹ãã¬ãŒããã溶å€ã¯ãé å€äžã®ããª
ããŒã³ãŒãã€ã³ã°ãè»åãããé å€éã®æ©æŠäœçš
ã«ããå§åã§ããªããŒã³ãŒãã€ã³ã°ãæµååã
ããã³ãŒãã€ã³ã°ãäžæ§ã«ããã®ã§ããã®æº¶å€ã¹
ãã¬ãŒå·¥çšã«ãããããæ¹è¯ããã補åå€èŠ³ãåŸ
ãããã ææã®å Žåã«ã¯ãæçµå·¥çšãšããŠãæ¬çºæã®é¡
èå補åããå°ãªããšãïŒçš®ã®ããŠäŸãã°ããã
ãŠåã¯ã«ã«ããŠãããŠãçšããŠæ £çšæ¹æ³ã§ã€ãåº
ããããŠå€èŠ³ãè¯ãããããšãã§ããã 次ã«å®æœäŸã«ã€ãæ¬çºæã説æãããæ¬çºæã¯
ããã®ã¿ã«éå®ããããã®ã§ã¯ãªãã äŸ ïŒ åœ«èŸŒã¿ãæããçœè²ã®å¡©é žããããããŒã«10mg
é å€ïŒå¹³åéé95mgïŒ10Kgãšåœ«èŸŒã¿ãæããçœè²
ã®ãã©ã»ãé å€ïŒå¹³åéé95mgïŒ350Kgãšã®é å€
æ··åç©ã次ã®ããã«åŠçããïŒ (a) çè²ã³ãŒãã€ã³ã°å·¥çš 次ã®æåãããªãæŸæã³ãŒãã€ã³ã°æº¶æ¶²ãäœ
ã€ãïŒ ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ãPharmacoat 606ïŒåååïŒãShinâEtsu
Chemical Company Ltd.Tokyo.Japanã 8.4Kg ã°ãªã»ããŒã« 1.68Kg è±ã€ãªã³æ°Ž 63 ãã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²ïŒãé¡èåå·¥çš
ïŒåŸèšåç §ïŒã§ã®äœ¿çšã®ããã«åã€ãŠãããã
次ã«ãã®ããã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²ã®æ®åã«
æ·»å ããïŒ æ¡è²è²çŽ åæ£æ¶²ãOpaspray ïŒâïŒâ1399B
ïŒåååïŒColorcon PLC.Orpington.Kent.
Englandã 5.4Kg è±ã€ãªã³æ°Ž å šé108 ããããŠçè²ã³ãŒãã€ã³ã°æº¶æ¶²ãåŸãããã åèšã®é å€æ··åç©ããåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ã60ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒ
ã¿ïŒAccelaâCotaïŒãäžã§ãçè²ã³ãŒãã€ã³ã°
溶液ãçšããŠæ¬¡ã®æ¡ä»¶äžã§ãã€ã«ã ã³ãŒãã€ã³
ã°ããïŒ è£ å ¥ç©ºæ°æž©åºŠ 70ã75â æåºç©ºæ°æž©åºŠ 51ã54â 空æ°æµé 4100ft3ã»mm-1 ç空床 â0.4ãw.g. ã¹ãã¬ãŒé床 660ã700mlã»mm-1 é§å空æ°å§ 70ã73psi ãã©ã é床 æåã®ïŒæé4r.p.m æåŸã®1.5æé4.5r.p.m ããããŠã圫蟌ã¿ãæããæ¡è²ãã€ã«ã ã³ãŒ
ãã€ã³ã°ãããé å€ã®æ··åç©ãåŸãããã (b) é¡èåå·¥çš é¡èåã³ãŒãã€ã³ã°æžæ¿æ¶²ã次ã®ããã«ããŠ
補é ããïŒ ç²ç¶ã®è»œè³ªçé žãã°ãã·ãŠã ïŒ1.296KgïŒã
è±ã€ãªã³æ°ŽïŒïŒïŒäžã«å ååæ£ãããããã®
æžæ¿æ¶²ã«ãåèšã®æŸæã³ãŒãã€ã³ã°æº¶æ¶²(a)å·¥çš
åç §ïŒïŒãæ·»å ããåŸãããæžæ¿æ¶²ãè±ã€ãª
ã³æ°Žã§42ãšãã次ãã§ãå質ã«ãªããŸã§å å
ã«æ··åããã åèšã®ã圫蟌ã¿ãæããæ¡è²ã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°ãããé å€æ··åç©ã«ã60ã€ã³ãã»ã¢ã¯
ã»ã©ãŒã³ãŒã¿ãŒäžã§ã(a)å·¥çšã«èšèŒã®æ¡ä»¶äž
ã§ãäœãããã©ã é床5r.p.mã§ãé¡èåã³ãŒã
ã€ã³ã°æžæ¿æ¶²ã§ãã€ã«ã ã³ãŒãã€ã³ã°ãããã
ãããŠé¡èåé å€ã®æ··åç©ãåŸãããã (c) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåå·¥çšãå®äºãããçŽã¡ã«ãè±ã€ãªã³æ°Ž
ïŒ20ïŒããé¡èåå·¥çšã§çšãããšåãæ¡ä»¶äž
ã«é å€äžã«ã¹ãã¬ãŒããããã¹ãŠã®æ°Žãé©çšã
ãããããã©ã ãæ¢ããé å€ãåé€ããããã
ããŠãåªããå€èŠ³ã®é¡èåé å€ã®æ··åç©ãåŸã
ããã äŸ ïŒ (a) é¡èåå·¥çš åŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24
ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§ã圫蟌ã¿ãæ
ããçè²ãã€ã«ã ã³ãŒãã€ã³ã°ããããã©ã»ã
åã³å»è¬é å€ã®æ··åç©ïŒééç¯å²94ã640mgïŒ
10Kgã60âã«å ç±ãããã°ãªã»ããŒã«0.65WïŒ
ïŒ¶ïŒ ãå«æãã軜質çé žãã°ãã·ãŠã ïŒ30ïœïŒ
ãäžã«æžæ¿ãããŠããããããã·ãããã«ã»ã«
ããŒã¹ãPharmacoat606ïŒåååïŒãã®3.3WïŒ
ïŒ¶ïŒ æ°Žæº¶æ¶²ïŒããäœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ã
çšããŠã50mlã»min-1ã§é£ç¶çã«é©çšãããã
ã©ã é床ã16r.p.mã«ãè£ å ¥ç©ºæ°ã®æž©åºŠã60â
ã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãé©çšããããã
ãã©ã ãæ¢ããé å€ãåãåºãããããããŠçœ
è²ã«é¡èåããã圫蟌ã¿ãæããçè²ãã€ã«ã
ã³ãŒãã€ã³ã°ãããé å€ã®æ··åç©ãåŸãããã (b) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåé å€ã®æ··åç©ãåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©âã³ãŒ
ã¿ïŒäžã§60ãã«å ç±ããããªãšãã¬ã³ã°ãªã³ãŒ
ã«300ã®1WïŒïŒ¶ïŒ 氎溶液ïŒ200mlïŒãé£ç¶çã«ã
äœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1
ã§é©çšããããã©ã é床ã10r.p.mã«ããã€è£
å ¥ç©ºæ°ã®æž©åºŠã60âã«ä¿æããããã¹ãŠã®æº¶æ¶²
ãé©çšããããããã©ã ãæ¢ããé å€ãåãåº
ãããããããŠãåªããå€èŠ³ã®é¡èåé å€ã®æ··
åç©ãåŸãããã äŸ ïŒ (a) (i) é¡èåå·¥çš åœ«èŸŒã¿ãæããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°
ããããã©ã»ã410mgé å€24400åãåŽé¢åºå£
ä»ç©¿åãã©ã ãã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³
ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±ã
ããããªãšãã¬ã³ã°ãªã³ãŒã«300 0.65WïŒïŒ¶
ïŒ ãå«æããäžã«è»œè³ªçé žãã°ãã·ãŠã ïŒ30
ïœïŒãæžæ¿ããŠããããããã·ãããã«ã¡ã
ã«ã»ã«ããŒã¹ãPharmacoat606ïŒåååïŒã
ã®3.3WïŒïŒ¶ïŒ 氎溶液ïŒããäœå§ãšã¢ã»ã¹
ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1ã§é£ç¶çã«
æœãããããã©ã é床ã16r.p.mã«ãè£ å ¥ä¹Ÿ
ç¥ç©ºæ°ã®æž©åºŠã60âã«ä¿æããããã¹ãŠã®æž
æ¿æ¶²ãæœããããããã©ã ãæ¢ããé å€ãå
ãåºãããããããŠã圫蟌ã¿ãæããçœè²ã«
é¡èåãããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°ãã
ãé å€ãåŸãããã (a) (ii) é¡èåå·¥çš åœ«èŸŒã¿ãæããè€è²ãã€ã«ã ã³ãŒãã€ã³ã°
ããããã©ã»ã270mgé å€37000åãåŽé¢åºå£
ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»
ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±ãããã
ãªãšãã¬ã³ã°ãªã³ãŒã«300 0.65WïŒïŒ¶ïŒ ãã¿
ãŒãã©ãžã³æ°Žæº¶æ§ææïŒé£åãå»è¬åã³å粧
åçšã€ãšããŒNo.ïŒïŒ0.1WïŒïŒ¶ïŒ ãå«æãã
軜質çé žãã°ãã·ãŠã ãäžã«æžæ¿ããŠããã
ãããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ïŒPharmacoat606ïŒåååïŒãã®3.3WïŒïŒ¶ïŒ æ°Ž
溶液ïŒããé£ç¶çã«äœå§ãšã¢ãŒã¹ãã¬ãŒè£
眮ãçšããŠã50mlã»min-1ã§æœãããããã©
ã é床ã16r.p.mã«ãè£ å ¥ç©ºæ°æž©åºŠã60âã«
ä¿æããããã¹ãŠã®æžæ¿æ¶²ããæœããããã
ã©ã ãæ¢ããé å€ãåãåºãããããããŠã
é»è²ã«é¡èåããã圫蟌ã¿ãæããè€è²ãã€
ã«ã ã³ãŒãã€ã³ã°ãããé å€ãåŸãããã (b) 溶å€ã¹ãã¬ãŒå·¥çš åèš(a)(i)ã«èšèŒã®ããã«ããŠåŸãæ¡è²ã®é¡è
åé å€ïŒKgãåèš(a)(ii)ã«èšèŒã®ããã«ããŠåŸã
è€è²ã®é¡èåé å€ïŒKgãåŽé¢åºå£ä»ç©¿åãã©ã
ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒ
ã¿ïŒäžã«å ¥ãã60âã«å ç±ãããïŒïŒ1VïŒïŒ¶
ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒïŒïŒããé«å§
ãšã¢ã¬ã¹ã¹ãã¬ãŒè£ 眮ãçšããŠã300mlã»
min-1ã§é£ç¶çã«æœãããããã©ã é床ã15r.
p.mã«ããã€è£ å ¥ç©ºæ°æž©åºŠã60âã«ä¿æããã
ãã¹ãŠã®æº¶å€ãæœããããããã©ã ãæ¢ããŠé
å€ãåãåºãããããããŠãåªããå€èŠ³ã®é¡è
åãããé å€ãåŸãããã äŸ ïŒ ïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒ
ãïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³äžã®
ããªãšãã¬ã³ã°ãªã³ãŒã«300ã®0.5WïŒïŒ¶æº¶æ¶²ïŒ
ã«ä»£ããŠãäŸïŒã«èšèŒã®æº¶å€ã¹ãã¬ãŒå·¥çšãç¹°ã
è¿ãããããããŠãåªããå€èŠ³ã®é¡èåãããé
å€ãåŸãããã äŸ ïŒ (a) ã«ã©ãŒã³ãŒãã€ã³ã°å·¥çš 圫蟌ã¿ãæããçœè²å»è¬200mgé å€50000å
ããåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮
ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å
ç±ãããã°ãªã»ããŒã«1.4WïŒïŒ¶ïŒ åã³æ¡è²è²
çŽ åæ£æ¶²ã175ïœãOpaspray pinkïŒåååïŒã
Colorcon PLC.Orpington.Kent.Englandãã
å«æããããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹
ïŒPharmacoat606ïŒã®9WïŒïŒ¶ïŒ 氎溶液2.6ãã
äœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšããŠ50mlã»min-1
ã§é£ç¶çã«æœãããããã©ã é床ã12r.p.mã«
ãã€è£ å ¥ç©ºæ°æž©åºŠã60âã«ä¿æããããã¹ãŠã®
æžæ¿æ¶²ãæœããããããã©ã ãæ¢ããé å€ãå
ãåºãããããããŠã圫蟌ã¿ãæããæ¡è²ãã€
ã«ã ã³ãŒãã€ã³ã°ãããé å€ãåŸãããã (b) é¡èåå·¥çš åœ«èŸŒã¿ãæããæ¡è²ãã€ã«ã ã³ãŒãã€ã³ã°ã
ããé å€ããåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³
ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60
âã«å ç±ãããïŒïŒ1VïŒïŒ¶ã¡ã¿ããŒã«ïŒäºå¡©
åã¡ãã¬ã³äžã®è»œè³ªçé žãã°ãã·ãŠã ã®
1.5WïŒïŒ¶ïŒ æžæ¿æ¶²ïŒãé«å§ãšã¢ã¬ã¹ã¹ãã¬
ãŒè£ 眮ãçšããŠã300mlã»min-1ã§é£ç¶çã«æœ
ãããããã©ã é床ã15r.p.mã«ãã€è£ å ¥ç©ºæ°
枩床ã60âã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãæœã
ããããã©ã ãæ¢ããé å€ãåãåºããããã
ããŠåœ«èŸŒã¿ãæãçœè²ã«é¡èåãããæ¡è²é å€
ãåŸãããã (c) 溶å€ã¹ãã¬ãŒå·¥çš é¡èåãããæ¡è²é å€ããåŽé¢åºå£ä»ç©¿åã
ã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒ
ã³ãŒã¿ïŒäžã§ã60âã«å ç±ãããïŒïŒ1VïŒïŒ¶
ã¡ã¿ããŒã«ïŒäºå¡©åã¡ãã¬ã³ïŒïŒïŒããé«å§
ãšã¢ã¬ã¹ã¹ãã¬ãŒè£ 眮ãçšããŠ300mlã»min-1
ã§é£ç¶çã«æœãããããã©ã é床ã15r.p.mã«ã
è£ å ¥ç©ºæ°ã60âã«ä¿æããããã¹ãŠã®æº¶å€ãæœ
ããããããã©ã ãæ¢ããé å€ãåãåºããã
ããããŠãæºè¶³ãªå€èŠ³ãæããé¡èåãããé
å€ãåŸãããã äŸ ïŒ (a) é¡èåå·¥çš åœ«èŸŒã¿ãæããçè²ãã€ã«ã ã³ãŒãã€ã³ã°ã
ãããã©ã»ããšå»è¬é å€ãšã®æ··åç©ïŒééç¯å²
100ã640mgïŒ10KgãåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒ
ãã€ã³ã°è£ 眮ïŒ24ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒ
äžã§60âã«å ç±ãããããªãšãã¬ã³ã°ãªã³ãŒã«
300 1WïŒïŒ¶ïŒ ãå«æãã軜質çé žãã°ãã·ãŠ
ã ïŒ30ïœïŒããã®äžã«æžæ¿ããŠããããããã·
ãããã«ã¡ãã«ã»ã«ããŒã¹ïŒPharmacoat606ïŒ
ã®5WïŒïŒ¶ïŒ 氎溶液ïŒããäœå§ãšã¢ãŒã¹ãã¬
ãŒè£ 眮ãçšããŠã50mlã»min-1ã§ãé£ç¶çã«æœ
ãããããã©ã é床ã16r.p.mã«ãã€è£ å ¥ç©ºæ°
枩床ã60âã«ä¿æããããã¹ãŠã®æžæ¿æ¶²ãæœã
ãããããã©ã ãæ¢ããé å€ãåãåºãããã
ãããŠã圫蟌ã¿ãæããçœè²ã«é¡èåãããç
è²ãã€ã«ã ã³ãŒãã€ã³ã°ãããé å€ã®æ··åç©ã
åŸãããã (b)溶å€ã¹ãã¬ãŒå·¥çš åèš(a)ã«èšèŒãããŠããããã«ããŠåŸãçœè²
ã«é¡èåããã圫蟌ã¿ãæããçè²ãã€ã«ã ã³
ãŒãã€ã³ã°ãããé å€çŽ400åããçœè²ãã©ã»
ã190mgé å€çŽ52000åã«å ãããé å€ã®æ··åç©
ãåŽé¢åºå£ä»ç©¿åãã©ã ã³ãŒãã€ã³ã°è£ 眮ïŒ24
ã€ã³ãã»ã¢ã¯ã»ã©ãŒã³ãŒã¿ïŒäžã§60âã«å ç±
ããã¡ã¿ããŒã«ãšæ°Žãšã®æ··åç©ïŒ60ïŒ40VïŒ
ïŒ500mlããäœå§ãšã¢ãŒã¹ãã¬ãŒè£ 眮ãçšã
ãŠã50mlã»min-1ã§ãé£ç¶çã«æœãããããã©
ã é床ã16r.p.mã«ããã€ãè£ å ¥ç©ºæ°æž©åºŠã60
âã«ä¿æããããã¹ãŠã®æº¶å€ãæœãããããã©
ã ãæ¢ããé å€ãåãåºãããããããŠãæºè¶³
ãããå€èŠ³ã®é¡èåãããé å€ãåŸãããã äŸ ïŒ æº¶å€ã¹ãã¬ãŒå·¥çšã§ã¡ã¿ããŒã«ïŒæ°ŽïŒ60ïŒ
40VïŒïŒ¶ïŒ500mlã®ä»£ãã«ã¡ã¿ããŒã«ïŒã¢ã»ãã³
ïŒ70ïŒ30VïŒïŒ¶ïŒïŒãçšããŠãäŸïŒã«èšèŒã®é¡
èåå·¥çšåã³æº¶å€ã¹ãã¬ãŒå·¥çšãç¹°ãè¿ãããã
ãããŠãæºè¶³ãããå€èŠ³ã®é¡èåãããé å€ãåŸ
ãããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ é¡èåããã圫蟌ã¿å°ãªããšãïŒåãæãã
çè²åºäœç©åã補é ããããã«ã (1) (A) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããå
ã¯ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠããã圫
蟌ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããª
ãæå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãª
ããšãïŒçš®åã³ãã€ã«ã ã³ãŒãã€ã³ã°å€å°ãª
ããšãïŒçš®ãããªããã€ã«ã ã³ãŒãã€ã³ã°æž
æ¿æ¶²ãæœããããã®æœäžããæ £çšã®ãã€ã«ã
ã³ãŒãã€ã³ã°è£ 眮ã§ãã³ãŒãã€ã³ã°ãããç©
åã®éã§æ©æŠäœçšãèµ·ãããããªæ¹æ³ã§å®æœ
ããããå㯠(B) ããèªäœã³ãŒãã€ã³ã°ãããŠããªããåã¯
ãã€ã«ã ã³ãŒãã€ã³ã°ãããŠããŠããã圫蟌
ã¿ãæããçè²ç©åã«ã2.00ãã倧ãããªã
æå°å±æçãæããå åŠçç°æ¹æ§ç©è³ªå°ãªã
ãšãïŒçš®ãããªãããã€ã«ã ã³ãŒãã€ã³ã°å€
ãå«æããªãæžæ¿æ¶²ãæœããããã®æœäžãæ £
çšã®ãã€ã«ã ã³ãŒãã€ã³ã°è£ 眮ã§ãã³ãŒãã€
ã³ã°ãããç©åã®éã§æ©æŠäœçšãèµ·ãããã
ãªæ¹æ³ã§å®æœãããã€ã (2) çãããé¡èåããã圫蟌ã¿å°ãªããšãïŒå
ãæããçè²åºäœç©åã«ãæ £çšã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°è£ 眮ã§ãåèšç©åã®éã§æ©æŠäœçšãèµ·
ãããããªæ¹æ³ã§ã溶å€ãã¹ãã¬ãŒããããšã
ç¹åŸŽãšãããé¡èåããã圫蟌ã¿ãæããç©å
ã®è£œæ³ã ïŒ åœ«èŸŒã¿ãæããçè²ç©åã¯ãå»è¬åã¯ç£å»çš
åäœé©çšåœ¢ã§ãããåã¯å»è¬é å€ãšã»ãŒåã寞æ³
ãæããç³èã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒ
ã®æ¹æ³ã ïŒ å»è¬åã¯ç£å»çšåäœé©çšåœ¢ã¯å»è¬åã¯ç£å»çš
ã®é å€ã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹
æ³ã ïŒ é¡èåããã圫蟌ã¿å°ãªããšãïŒåãæãã
çè²åºäœç©åã¯ããã€ã«ã ã³ãŒãã€ã³ã°å€ããã®
å€é¢äžã«æãããåã¯æ¯èŒç氎溶æ§ã®ãã€ã«ã ã³
ãŒãã€ã³ã°å€ããã®å€é¢äžã«æãã第(2)å·¥çšã§çš
ãããã溶å€ã¯ã(a)æ°Žã(b)æ°ŽãšC1ã4âã¢ã«ã«ããŒ
ã«ãšã®æ··åç©ã(c)å€ããã²ã³åãããC1ã4âã¢ã«
ã«ã³ãšC1ã4âã¢ã«ã«ããŒã«ãšã®æ··åç©åã¯(d)溶å€
(c)ãççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³ãšã®æ··
åç©ã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ æº¶å€ã¯å°ãªããšãïŒçš®ã®æ¹¿æœ€å€ãå«æããã
ç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ æ¹¿æœ€å€ã¯ãã°ãªã»ããŒã«ããããã¬ã³ã°ãªã³
ãŒã«åã¯äœååéã®ããªãšãã¬ã³ã°ãªã³ãŒã«ã§ã
ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ æº¶å€ã¯æ°Žã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒ
ã®æ¹æ³ã ïŒ é¡èåããã圫蟌ã¿å°ãªããšãïŒåãæãã
çè²åºäœç©åã¯æ¯èŒçæ°Žã«äžæº¶æ§ã®ãã€ã«ã ã³ãŒ
ãã€ã³ã°å€ããã®å€é¢äžã«æãã第(2)å·¥çšã§çšã
ããã溶å€ã¯ã(e)å€ããã²ã³åãããC1ã4âã¢ã«
ã«ã³ã(f)ççŽ ååæ°ïŒä»¥äžã®ãžã¢ã«ãã«ã±ãã³ã
(g)溶å€(e)ãš(f)ãšã®æ··åç©åã¯(h)溶å€(g)ãšC1ã4âã¢
ã«ã«ããŒã«ãšã®æ··åç©ã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬
ïŒé èšèŒã®æ¹æ³ã ïŒ æº¶å€ã¯ãæ¯èŒçæ°Žã«äžæº¶æ§ã®ãã€ã«ã ã³ãŒã
ã€ã³ã°å€ã«å¯ŸããŠå¥œé©ãªå¯å¡å€å°ãªããšãïŒçš®ã
å«æããŠãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹
æ³ã ïŒïŒ å¯å¡å€ã¯ããžâC1ã4âã¢ã«ãã«ãã¿ã¬ãŒ
ããã°ãªã»ããŒã«ãšã¢ã«ã«ã³é žãšã®ãšã¹ãã«åã¯
æ€ç©æ²¹ã§ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹
æ³ã
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8216815 | 1982-06-10 | ||
| GB8216815 | 1982-06-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS595054A JPS595054A (ja) | 1984-01-11 |
| JPH0369585B2 true JPH0369585B2 (ja) | 1991-11-01 |
Family
ID=10530930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58101873A Granted JPS595054A (ja) | 1982-06-10 | 1983-06-09 | é¡èåããã圫蟌ã¿ãæããçè²åºäœç©åã®è£œæ³ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4522840A (ja) |
| EP (1) | EP0096982B1 (ja) |
| JP (1) | JPS595054A (ja) |
| AT (1) | ATE29664T1 (ja) |
| DE (1) | DE3373624D1 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58152813A (ja) * | 1982-03-08 | 1983-09-10 | Sumitomo Chem Co Ltd | é®®æãªå»å°ãæããé å€ããã³ãã®è£œæ³ |
| KR840000624A (ko) * | 1982-06-02 | 1984-02-25 | ìë³žë¯žêž°ì¬ | ë¶ììµì íìžíž ì¡°ì±ë¬Œ |
| US4880636A (en) * | 1988-05-13 | 1989-11-14 | Franz Robert M | Film coated tablet of ranitidine HCl |
| NZ241613A (en) * | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
| AUPO855897A0 (en) * | 1997-08-13 | 1997-09-04 | Usf Filtration And Separations Group Inc. | Automatic analysing apparatus II |
| AU2007233243B2 (en) * | 2006-03-29 | 2011-11-17 | Wm. Wrigley Jr. Company | Non-contact printed comestible products and apparatus and method for producing same |
| AU2017244982A1 (en) * | 2016-03-31 | 2018-11-01 | Intercept Pharmaceuticals, Inc. | Film-coated tablet having high chemical stability of active ingredient |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3125490A (en) * | 1964-03-17 | Tablet with contrasting indicia and method | ||
| US3015610A (en) * | 1957-11-04 | 1962-01-02 | Jr Roy Y Sanders | Marked pharmaceutical tablet |
| JPS5331211B2 (ja) * | 1972-09-28 | 1978-09-01 | ||
| IN158328B (ja) * | 1981-03-09 | 1986-10-18 | Ici Plc |
-
1983
- 1983-05-23 AT AT83302945T patent/ATE29664T1/de not_active IP Right Cessation
- 1983-05-23 DE DE8383302945T patent/DE3373624D1/de not_active Expired
- 1983-05-23 EP EP83302945A patent/EP0096982B1/en not_active Expired
- 1983-05-31 US US06/499,400 patent/US4522840A/en not_active Expired - Lifetime
- 1983-06-09 JP JP58101873A patent/JPS595054A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS595054A (ja) | 1984-01-11 |
| US4522840A (en) | 1985-06-11 |
| ATE29664T1 (de) | 1987-10-15 |
| EP0096982A2 (en) | 1983-12-28 |
| DE3373624D1 (en) | 1987-10-22 |
| EP0096982B1 (en) | 1987-09-16 |
| EP0096982A3 (en) | 1984-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1178853A (en) | Coated coloured intagliated articles | |
| CA2104096C (en) | A method of highlighting intagliations in tablets | |
| US3390049A (en) | Pharmaceutical tablets coated with wax-free ammonia solubilized water soluble shellac | |
| US3256111A (en) | Method for coating tablets | |
| US4661367A (en) | Process for the manufacture of colored intagliated articles | |
| MXPA01010929A (es) | Metodo para recubrir formas farmaceuticas de dosificacion. | |
| US3480468A (en) | Process of preparing pharmaceutical tablet with orange-peel-like protective sugar coating | |
| JPH0369585B2 (ja) | ||
| US3275518A (en) | Tablet coating | |
| US3407157A (en) | Tablet coating compositions comprising methyl vinyl ethermaleic anhydride copolymer,plasticizer and surface active agent | |
| CA2084668C (en) | Gelatin coated medicament and process for making same | |
| JPS625403B2 (ja) | ||
| GB2191117A (en) | The production of coated intagliated articles | |
| RU2214235C2 (ru) | ÐÐœÑеÑПÑПлÑбОлÑÐœÐ°Ñ ÐŸÐ±ÐŸÐ»ÐŸÑка О ÑпПÑПб пПкÑÑÑÐžÑ ÑакПй ПбПлПÑкПй ÑвеÑÐŽÑÑ ÑаÑЌаÑевÑОÑеÑÐºÐžÑ ÐºÐŸÐŒÐ¿ÐŸÐ·ÐžÑОй | |
| HU190693B (en) | Process for coating pharmaceutical compositions with film |