JPH0358906A - Cosmetic and powder cosmetic - Google Patents

Abstract

PURPOSE:To obtain cosmetic and powder cosmetic having excellent transparency, stability and utility, having no influence on other components in cosmetic, showing stabilizing effects on the other components for a long period of time, containing an inclusion compound comprising slight water-soluble components included in a specific mixture. CONSTITUTION:A cosmetic or powder cosmetic containing an inclusion compound prepared by including Macadamia nut, vitamin E acetate, 2-hydroxy-4- methoxybenzophenone, etc., in a mixture of cyclodextrin polymer (CDP for short) and a hydroxyalkylated cyclodextrin (HACD for short). The blending ratio of CDP and HACD is (1:9)-(9:1), preferably (2:8)-(7:3) by weight. An ordinary blending is used as the blending method. The cosmetic is completely dissolved in a small amount of water to improve utility and stability. The cosmetic is useful for toilet lotion, lotion, solution for beauty culture, foundation, lipstick, eye liner, etc.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention provides lotions, lotions, serums, foundations,
It relates to cosmetics such as lipsticks and eyeliners, and powder cosmetics. For more details, please refer to cyclodextrin polymer (
Cosmetics and powders containing clathrates of a mixture of CDP (hereinafter abbreviated as CDP) and hydroxyalkylated cyclodextrin (hereinafter abbreviated as HACD), with improved product characteristics, usability, and stability. Regarding cosmetics.

(Prior art) Cosmetics such as lotions, lotions, and serums that are well known have traditionally contained oils and fats, physiologically active substances, ultraviolet absorbers, anti-inflammatory agents, and fragrances in addition to main ingredients such as water and alcohol. Various poorly water-soluble ingredients, such as, are blended with a small amount of surfactant for the purpose of increasing usability and usefulness.

Powder cosmetics used to improve skin after sunburn etc. are made by mixing poorly water-soluble ingredients such as skin activators and drugs in a water-soluble powder base.

(Problems to be Solved by the Invention) In cosmetics, it is known that there are restrictions in terms of the amount when blending the above-mentioned poorly water-soluble ingredients.

For example, in order to uniformly solubilize a large amount of poorly water-soluble components, a large amount of surfactant, ethanol, polyol, etc. must be added, which poses a problem in terms of skin irritation. In addition, there is also the problem that the poorly water-soluble components do not dissolve uniformly, causing the cosmetics to become cloudy or lose their transparency, reducing their commercial value. Furthermore, there has also been a problem in that the poorly water-soluble ingredients incorporated act on other ingredients in the cosmetic, accelerating the deterioration and decomposition of those other ingredients.

In order to solve these problems, Japanese Patent Application Laid-Open No. 61-2275
As seen in No. 17, there is also a known technique of blending the above components using the inclusion action of CDP, but using only CDP, there is a limit to the amount of inclusion of poorly water-soluble components. It has been difficult to incorporate a large amount of poorly water-soluble ingredients into cosmetics and powder cosmetics.

In addition, when highly polar oils such as diethylene glycol monopropyl ether, polyoxyethylene polyoxypropylene, and pentaerythritol are present in cosmetics, CDP alone has the disadvantage that the inclusion ability decreases.

Therefore, as a result of extensive studies to solve these problems, the present invention has revealed that by mixing a specific amount of CDP and HACD to include a slightly water-soluble component, the inclusion power for the poorly water-soluble component is greater than that of CDP or HACD alone. It was discovered that the flight 3κ was significantly higher than that in the case where the ball was used, and this led to the present invention.

In addition, in the case of powdered cosmetics that are commercially available in powder form and are used by adding water before use, a small amount of water is used to dissolve them in the palm of the hand, so poorly water-soluble ingredients are not dissolved uniformly. Sometimes, along with Zaratsuku, there was a problem that it did not have sufficient medicinal efficacy.

Techniques for increasing the amount of surfactant or using CDP have been proposed as means for solving these problems, but these have not sufficiently solved the above problems.

Therefore, the present invention, like the above invention, uses CDP and HACD.
The solubility, usability, and stability of powder cosmetic 4-1 are improved by mixing a specific amount of the powder and incorporating a large amount of poorly water-soluble components in this mixture.

(Means for Solving the Problems) That is, the present invention provides: 1) a cosmetic containing a clathrate in which a poorly water-soluble component is clasped with a mixture of a cyclodextrin polymer and a hydroxyalkylated cyclodextrin; ) A powder cosmetic characterized by containing a clathrate in which a poorly water-soluble component is clathrated with a mixture of a cyclodextrin polymer and a hydroxyalkylated cyclodextrin.

The invention of claim 1 will be explained in detail below.

In the present invention, CDP and HACD are mixed in a specific range, and the mixture is used to obtain an inclusion product.

The mixing ratio of CDP and HACD is 1:9 to 9: by weight.
It is possible to mix up to 1:1, but preferably 2:8-7
:3, more preferably 6:5 to 5:6. A common mixing method is used.

Experimental examples of the present invention are shown below.

[Experimental Example] A 10% by weight aqueous solution of CDP, a 10% by weight aqueous solution of HACD, and a 10% by weight aqueous solution of CDP and HACD (1:1) were prepared. On the other hand, as water pheasant-soluble components, limonene, 2-hydroxy-4-methoxybenzophenone, ethylbalaben, and menthol were selected as clathrates (hereinafter referred to as guests), and the prepared water of each of these guests was The inclusion amount for M was investigated and the results are shown in Table 1 below.
It was shown to.

Table 1 Results: The amount of guest inclusion by the mixture of CDP and HACD was significantly improved compared to when CDP or HACD was used alone.

In this experiment, the amount of inclusion in the prepared aqueous solution was investigated, but other water-soluble solvents such as methanol, ethanol,
Similar results were obtained for acetone and water/ethanol solutions.

Next, the poorly water-soluble component used in the present invention will be explained. The term "poorly water-soluble component" means a cosmetic component that substantially does not dissolve in water at all or only slightly dissolves in water. Examples include natural animal and vegetable oils such as macadamia nut oil, evening primrose oil, olive oil, mink oil, jojoba extract, lanolin, and squalane, waxes such as liquid paraffin, paraffin wax, and carnauba wax, cetanol, isosetanol, stearyl alcohol, and Higher alcohols such as stearyl alcohol, myristic acid, valmitic acid, stearic acid, behenic acid, isostearic acid,
Oleic acid, linolenic acid, linoleic acid, linoleic acid,
Higher fatty acids such as oxyacids, esters such as isoprobyl myristic acid, isobrobyl balmitic acid, isobrobyl isostearic acid, glyceryl 2-ethylhexanoate, other diethylene glycol monobrobyl ether, polyoxyethylene polyoxybrobylene bentaerythritol ether , polar oils such as polyoxypropylene butyl ether, ethyl linoleate, silicone oil, vitamins such as vitamin A1, vitamin D1, vitamin E1, tocopherol acetate, ascorbic acid ester, and 7
- Vitamins and vitamin-like active substances such as oryzanol, folic acid, hormones such as benzoic acid, estradiol, estradiol valerate, ethinyl estradiol, prostaglandins, testosterone propionate, penzophenone, 4-tert-butyl-4'methoxydi UV absorbers such as benzoylmethane, glyceryl dimethoxycinnamate ethylhexanoate, p-aminobenzoic acid ester, octyl paramethoxycinnamate, and phenyl salicylate; anti-inflammatory agents such as L-menthol and camphor;
, preservatives such as ethylparaben, probilparaben, and butylparaben, disinfectants such as glycyrrhetinic acid, triclosan, and dibutylhydroxytoluene, oil-soluble pigments such as oil red, naphthol yellow, tartrazine, and bubbleka, and fragrance ingredients such as linalool and linal. lyl acetate, limonene, citrol, methylionone benzyl acetate, methyl dehydrojasmonate,
These include phenylethyl alcohol, musk ketone, sandalol, alpha-hexyl cinnamic aldehyde, TEC, citronellol, and crude drugs.

The properties of these poorly water-soluble components may be either liquid or crystalline, and may be in the form of a single component or a mixture of two or more.

In order to produce a clathrate using such poorly water-soluble components, CDP, and HACD, the following well-known method is used.

A mixture of CDP and HACD (weight ratio 1:9 to 9:l) is dissolved in water in a range of 1 to 60% by weight, and to this aqueous solution, the above water S-soluble component is added to 1 part by weight of the mixture. 0.
It is added in a proportion of 0,001 to 0.5 parts by weight.

Stirring is carried out at 20° C. to 50° C. and 50 to 3000 rpm, and the inclusion time is 2 to 24 hours.

The clathrates obtained in this way are solubilized or emulsified in an aqueous solution and can be used as is, but this aqueous solution can be used after being pulverized by freeze-drying, spray-drying, etc. You can also. In the cosmetic composition of the present invention, it is possible to incorporate the compound either in the form of a reaction liquid or in the form of mold powder.

The amount of clathrates to be incorporated into cosmetics depends on the type of poorly water-soluble ingredients included and the type of cosmetics, but in general, it is possible to incorporate clathrates in liquid form at 100% by weight of the total cosmetics. is preferably up to 50% by weight. Although it is technically possible to mix more than this, the disadvantage of stickiness arises in terms of usability. Furthermore, when blending in a finely powdered state, the amount may be 100% by weight of the total cosmetic, but preferably up to 50% by weight.

CDP, which is a component of the mixture of the present invention, is a C H 2 O H C H C
It can be made by substituting H2-.

Methods for polymerizing cyclodextrin include a method using shrimp chlorohydrin, a method of reacting with diisocyanate, dieboxy compound, polyhydric alcohol, polybasic acid, etc. to form a crosslinked polymer, and a method using a functional group that reacts with the hydroxyl group of cyclodextrin. A method of polymerizing a cyclodextrin vinyl monomer obtained by reacting with a vinyl compound having such a functional group, or a method of reacting a cyclodextrin with a polymer having such a functional group and immobilizing it are known.

An example of a method for producing CDP will be described below.

Add 5 ml of water to 10 g of β-cyclodextrin and knead. To this, 15 ml of 30% aqueous sodium hydroxide and 100 mg of sodium borohydride are added to make a homogeneous solution. This is kept at 50°C and stirred at a speed of 20 rpm. 3+++1 of epichlorohydrin was added dropwise over 15 minutes, and the mixture was kept at 50° C. for an additional 3 hours. Thereafter, the mixture was neutralized with hydrochloric acid, desalted using a dialysis membrane, and then freeze-dried to obtain about 15 g of CD polymer.

Further, HACD, which is another component of the mixture of the present invention, is a product in which a hydroxyalkyl group is introduced into the hydroxyl group of cyclodextrin, which is conventionally well known as a cyclic oligosaccharide.

As the hydroxyalkyl group, substituents such as hydroxymethyl, hydroxyethyl, hydroxybutyl, hydroxybutyl are mainly used, and as a result of these substitution reactions, hydroxymethylcyclodextrin, hydroxyethylcyclodextrin, hydroxybutylcyclodextrin, etc. HACDs such as oral dextrin, hydroxybutylcyclodextrin, etc. can be obtained.

Cyclodextrins (hereinafter abbreviated as CDs) are CDs (hereinafter abbreviated as CDs) that have α, β, and 7 structures depending on the number of glucose atoms.
Hereinafter, they will be abbreviated as α-CD, β-CD, and 7-CD. ), but the present invention is directed to one or two of these CDs.
More than one species can be hydroxyalkylated and used. α, β
, 7 CDs can also be used.

In addition, hydroxyethylated CD or hydroxybutylated CD is a mixture of α, β, and 7 at the time of manufacture, but even if it is a mixture, hydroxybutylated CD of α, β, and 7 It can also be used in isolation.

Several methods have been known for manufacturing HACD, and one example will be shown below.

β-CD (manufactured by Nihon Shokuhin Kako, trade name: Celldex N)
100 g was dissolved in 150 ml of a 20% NaOH aqueous solution, 50 ml of propylene oxide was gradually added dropwise while maintaining the temperature at 30°C, and the reaction was continued by stirring for 20 hours. After the reaction was completed, the solution was neutralized to pH 6.0 with hydrochloric acid, placed in a dialysis membrane tube, and desalted under running water for 24 hours. Thereafter, it was dried in a freeze dryer to obtain about 90 g of hydroxybutylated β-cyclodextrin.

C of this hydroxybulated β-cyclodextrin
The degree of substitution per D was 5.1.

In addition to the above-mentioned ingredients, the cosmetics of the present invention may contain other cosmetic ingredients depending on the product characteristics, such as moisturizing agents such as hyaluronic acid, water-soluble drugs such as vitamin C, carboxyvinyl polymer cellulose, polyester, etc. vinyl alcohol,
Polymer viscosity modifiers such as suntan gum, pH adjusters, preservatives, bactericidal agents, antioxidants, fragrances, pigments, and the like can be incorporated into cosmetics.

The claimed invention uses the same inclusions as those used in the invention claimed in claim 1. However, in order to maintain the dry product form until immediately before use, the clathrate is also added to the mixture of CDP and HACD in a dry, finely powdered state to the other base components.

The amount of inclusions in the mixture to be incorporated into the powdered cosmetic is 50% by weight of the total powdered cosmetic in a finely powdered state, preferably 40% by weight of the total powdered cosmetic.
up to % by weight. Even if the amount is 50% by weight or more, there is no problem with solubility, but there is a problem of stickiness during use.

The powder cosmetic of the present invention may contain soluble powder bases such as D-mannitol, lactose, sugar, starch, glucose, fructose, amino acids, enzymes, etc., in addition to the encapsulation of the mixture of CDP and HACD, and may also contain soluble powder bases such as D-mannitol, lactose, sugar, starch, glucose, fructose, amino acids, enzymes, etc. , other cosmetic ingredients, e.g.
Moisturizing agents such as hyaluronic acid, water-soluble drugs such as vitamin C, polymeric viscosity modifiers such as carboxyvinyl polymer, cellulose, polyvinyl alcohol, and suntan gum, pH adjusters, preservatives, bactericidal agents, antioxidants, and fragrances. ,
Pigments, extenders such as labonite, bentonite, montmorillonite, clay minerals such as smectite, extender pigments such as silica, talc, miryoku, kaolin, colored pigments such as titanium oxide, iron oxide, zinc white, nylon powder, silk powder, wool. Powder etc. can be added.

(Effects) In the invention of claim 1, it is possible to incorporate any amount of poorly water-soluble ingredients, which have traditionally been limited in their formulation, without relying on the power of surfactants or alcohol, resulting in transparency, stability, safety,
We were able to obtain a cosmetics clinic with excellent usability. Furthermore, since the poorly water-soluble substance is included in the mixture of CDP and HACD, it has the effect of stabilizing the other ingredients for a long period of time without affecting the other ingredients in the cosmetic.

In addition, it has become possible to incorporate a large amount of poorly water-soluble substances into cosmetic products, which could not be incorporated using CDP alone, thereby increasing the medicinal efficacy of cosmetic products.

Moreover, in the invention of claim 2, a powder cosmetic product was obtained which was completely dissolved in a small amount of water and had excellent usability and stability.

(Example) Next, the present invention will be explained in more detail with reference to Examples. The blending amount is shown in weight%.

Example 1 Moisturizing lotion (% by weight) ■ Mixture of agent Φ β-COP and hydroxib a-bilated β-CD (8:3) 10.00 Macadamia nut oil ■ Vitamin E acetate ■ Ion exchange water 0 .1 0.01 40.0 Ion Exchanger Okusui Rubitol 1.3 Ptylene glycol Lactate Sodium lactate Monoammonium tricyrrhizate Pigment Phenoxyethanol 32.069 5.0 12.0 0.02 0.1 0.1 o ．． oo1 0.5 (Production method) Dissolve 1 agent Φ in 40 g of ion-exchanged water, roughly
(2) was added and stirred to prepare a drug containing a clathrate of a mixture of C, DP and HPCD.

Next, the above-mentioned first agent was added to the second agent to obtain a moisturizing lotion in which oil and drugs were stably blended.

Example 2 Whole body lotion 1 mixture of Φ β-CDP and hydroxybutylated β-CD (
2:8) 2-hydro+r-4-methoxypensophenone 4-t-
Butyl-4゛Methoxydibesisoylmethanehinokitiol Ion exchange water (wt%) 7.0 0,05 0,01 0.01 20,0 2 agents ■ Ion exchange water 29.9299 ■ PEG400 ■ Luffa extract O Iris extract 0 Denatured 95% ethanol ■ Pigment (manufacturing method) 1.0 1,0 1.0 40.0 0.0001 Dissolve Φ in 1 agent in ion-exchanged water, roughly
Add the ultraviolet absorber and drug, stir, and perform CDP and HPC.
A drug containing a clathrate clathrated by the mixture of D was prepared.

Next, the above-mentioned first agent was added to the two agents to obtain a whole body lotion containing a stable combination of the ultraviolet absorber and the drug.

Example 3 Essence 1 drug ■ α-CDP and Hido 11! f sibropylation a -C
Mixture of D (9:1) ■ Ethylparaben ■ Fragrance ■ 7-linoleic acid ■ Ion exchange water (wt%) 11.0 0.2 0.01 0.02 2060 2 agents ■ Ion exchange water ■ Dibu-a pyrene glycol ■ Maltitol 58. 38 5.0 5.0 ■ Aspartic acid ■ Shi-7luginine ■ Sodium hexametaphosphate ■ Carboxy vinyl polymer 0.04 0.1 0.05 0.2 (Production method) Add 1 agent ■ to ion-exchanged water. The mixture was dissolved, and then 1, 2, and 0 were added and stirred to prepare a drug containing a clathrate clathrated by a mixture of CDP and hydroxybutylated α-CD.

Next, the above-mentioned first agent was added to the second agent to obtain an essence containing a stable combination of oil, preservative, and fragrance.

Example 4 Lotion 1 ■ Mixture of 7-CDP and hydroxybrobylated 7-CD (CI) ■ Talycyrrhetinic acid ■ Diethylene glycol monob [2-biyl ether ■
Ion exchange water (wt%) 1.0 0.001 5.0 25.0 2 agents■ Ion exchange 1 moxibustion water
55.242■ Glycerin
1.0 ■
1,3 butylene 9 recalls
2.0 ■ Lactic acid
o. oosO Sodium lactate
0.2■ Monoammonium talycyrrhizinate O. OS ■
A0 engineering extraction 1 night 0.5 ■
Modified 95″XIta)-L
10.00 Dye 0
．． 002 (Production method) 1 drug (■) is dissolved in ion-exchanged water, 2 (2) and 2 (2) are added to the colander, and stirred to prepare 1 drug (containing the clathrate clathrated by CDP and hydroxybutylated 71CD (7p mixture)). Next, the above-mentioned first agent was adjusted to the second agent.Next, the above-mentioned first agent was added to the second agent to obtain a lotion containing a stable anti-inflammatory agent.

Example 5 1 non-alcoholic lotion
(% by weight) Φ Mixture of CDP and hydro[2'f-dimethylated β-CD (8:2) Menthol fragrance ion exchange water 10.0 1 0.01 20.0 2 agents ■ Ion exchange water ■ Dibrobirenv Recall ■ Citric acid ■ Sodium citrate O Methyl paraben ■ Phenoxyethanol ■ Calsamine 58.46 10 0.03 0.05 0.1 0.3 0.05 (?! method) 1 agent Φ in ion exchange water The mixture was dissolved and mixed with (1) and (2) in a colander and stirred to prepare a drug containing a clathrate clathrated by a mixture of CDP and hydroxymethylated β-CD.

Next, the above-mentioned one agent was added to the two agents to obtain a non-alcoholic lotion stably containing an anti-inflammatory agent and fragrance.

Example 6 1 powdered lotion Φ Mixture of CDP and hydroxybutylated β-CD (
2:8) OL-Menthol ■ Camphor ■ Fragrance ■ Ion exchange water 8.0 0.3 0.5 0.15 15.0 Ion exchange water Talicelin Asparagine modified 95% ethanol Zinc flower Kaolin Methyl paraben bentonite 67.65 1.0 0. O5 5.0 1.5 0.5 0.05 0.3 (Production method) Dissolve ■ in one agent in ion-exchanged water, and roughly mix ■, ■, ■
Add and stir to combine CDP and hydroxybutylated β-CD.
An l agent containing a clathrate clathrated by a mixture of was prepared.

Next, the above-mentioned first agent was added to the second agent to obtain a powdered lotion stably containing an anti-inflammatory agent and 1 liter of fragrance.

Example 7 Boundary foundation 1 agent
(wt%) Φ Mixture of CDP and hydroxyethylated β-CD (674)
5.00 Ethylparaben
0.2 ■ Ion exchange water 20
．． 0 Mica talc Yellow iron oxide Red iron oxide Black iron oxide 40.0 20.3 10.0 7.0 1.0 ■ Titanium dioxide ■ Sorbitan t-skioleate 15.3 1.2 (Production method) Add 1 agent ■ to ion-exchanged water Add ■, stir, and spray dry to dissolve CDP and hydroxyethylated β-C.
A drug containing a clathrate clathrated by the mixture D was prepared.

Next, the above-mentioned first agent was added to the two agents to obtain a powder foundation in which a bactericidal agent was stably blended.

Example 1 agent Φ 8 Mixture of white powder CDP and hydro[2-xybrobylated CD mix (7:3) 2-hydroxy-methoxyinsophenone 4-tert-butyl-4'-methoxydipenso-ilmecundimethquine cinnamic acid Lylceryl ethylhexanoate fragrance ion-exchanged water ←wt%) 10.0 0.1 O. O.S.O. 01 0.01 10.0 2-drug Φ D-mannift
74.74■ L-ascorbic acid 3.0■
L-ascorbic acid divalmitic acid ester
12.0 ■ Monoammonium glutyrrhizinate O. OSO L-7 Scorpic Acid Phosphate Mg O
．． 01 ■ L-7 Scorbic acid sulfate Ha
0.01■ Lipoflavin
0.02
(Manufacturing method) Dissolve ■ in one agent in ion-exchanged water, and roughly coat ■, ■, ■
, (2) were added and stirred to prepare a drug containing a clathrate clathrated by a mixture of CDP and hydroxybutylated mix. This preparation was made into a powder by spray drying.

Next, the powder of the above-mentioned first agent was added to the second agent to obtain a white powder in which an ultraviolet absorber was stably blended.

Example 9 Essence powder 1 agent (weight%) ■ β-
A mixture of CDP and hydroxybutylated CD mix (
6:4) ■ 7-linoleic acid ■ α-tocopherol O Hyaluronic acid ■ Ion exchange water 30.0 0.1 0.05 0.001 50.0 2 agents ■ Clay mineral ■ Ascorbic acid phosphate ■ Polymethyl methacrylate 50.0 0.02 9.849 (Production method) Dissolve Φ and ■ in 1 agent in ion-exchanged water, and then add ■ and ■
was added and stirred to prepare a drug containing a clathrate containing a mixture of CDP and HACD mix.

Next, add the powder of the above L agent to the 2 agent to remove oil, antioxidant,
An essence powder containing a stable humectant was obtained.

Example 10 1 sun care powder ■Mixture of CDP and hydroxy-pylated a-CD (CI)■4-tert-butyl-4°-methoxyhexanoic acid glycerin■Isaiton exchange water (wt%) 20. O 0.05 79.95 2 drugs ■ Mixture of CDP and hydroformed sibropylated β-CD (
1:1) 4-t-Butyl-4'-methoxydibenzoylmethane p-aminobenzoic acid ester ion-exchanged water 9.0 0.02 0.5 90.48 3 agents ■ D-Mannitol ■ 2-Hydoxy -4 Methoxybensophenone-5
- Sotium sulfonate ■ Urocanic acid ■ Monoammonium clycyrrhizinate 69.39
9 1.0 0.001 0.03 (Manufacturing method) One drug (■) was dissolved in ion-exchanged water, and (■) was added, stirred and spray-dried to obtain a powdered composite.

Next, the second agent (1) was dissolved in ion-exchanged water, the second agent (2) and the second agent (2) were added, stirred and spray-dried, and the first agent and the second agent were mixed to obtain a sun care powder.

Furthermore, three drugs Φ, ■, ■, and ■ were mixed to make three drugs.

Finally, a new sun care powder was obtained by adding the L agent and the 2 agent to the 3 agents.

Example 11 Lipstick 1 ■ Mixture of CDP and hydroxybrovir β-CD (6:4) ■ 2-Hydroxy-4methoxybensophenone ■
Fragrance ■ Ion-exchanged water (weighted percentage) 5.0 0.1 0.01 20.0 Two agents ■ Carnauba wax ■ Camp Rilla wax 1.0 6.0 ■ T-resin
6.00 Microcrystalline wax 1.0■
castor oil
30.0■ Olive oil
20■ Talisely Loosey 2-Hebutylundikanoar}
19.0 ■ Red No. 202 4
．． 0 ■ Yellow No. 4 aluminum
3.00 Titanium dioxide
3.00 Red iron oxide 1.
870 Vitamin E
O. 02 (Production method) One agent CDP and hydroxypropylated β-CD were dissolved in ion-exchanged water, and ■ and ■ were added and stirred to form an ultraviolet absorber composite solution and dried by spray drying to prepare agent 1. .

Next, one agent was added to the mixture of two agents Φ to O and stirred to obtain a lipstick in which a UV absorber and fragrance were stably blended.

Example 12 Eyeliner 1 ■Mixture of CDP and hydroxybutylated β-CD (5:
5) Fragrance ion exchange water 5.0 0.02 20.0 2 agents■ Iron oxide (black) 14.0■
polyacrylate emulsion
45.00 Glycerin
5.00 Ruboxymethyl tululose (10% water soluble?l)
15. 00 Ion exchange water
15.680 Methylparaben 0.
3 (Production method) Dissolve 1 agent ■ in ion-exchanged water, add ■ and stir.
After spray drying, the CD inclusion material was prepared.

Next, the above-mentioned first agent was added to the second agent to obtain an eyeliner that is safe for the skin.

Claims (1)

[Scope of Claims] 1) A cosmetic comprising a clathrate in which a poorly water-soluble component is clathrated with a mixture of a cyclodextrin polymer and a hydroxyalkylated cyclodextrin. 2) A powder cosmetic containing a clathrate in which a poorly water-soluble component is clathrated with a mixture of a cyclodextrin polymer and a hydroxyalkylated cyclodextrin.