JPH0358349B2 - - Google Patents

Info

Publication number
JPH0358349B2
JPH0358349B2 JP5018683A JP5018683A JPH0358349B2 JP H0358349 B2 JPH0358349 B2 JP H0358349B2 JP 5018683 A JP5018683 A JP 5018683A JP 5018683 A JP5018683 A JP 5018683A JP H0358349 B2 JPH0358349 B2 JP H0358349B2
Authority
JP
Japan
Prior art keywords
mitomycin
compound
kbr
nmr
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP5018683A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59175493A (ja
Inventor
Kazumichi Kono
Yutaka Saito
Joji Goto
Kimikatsu Shirahata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP5018683A priority Critical patent/JPS59175493A/ja
Priority to DE1983307423 priority patent/DE116208T1/de
Priority to DE8383307423T priority patent/DE3376114D1/de
Priority to EP19830307423 priority patent/EP0116208B1/en
Publication of JPS59175493A publication Critical patent/JPS59175493A/ja
Publication of JPH0358349B2 publication Critical patent/JPH0358349B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5018683A 1982-12-07 1983-03-25 マイトマイシン誘導体 Granted JPS59175493A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP5018683A JPS59175493A (ja) 1983-03-25 1983-03-25 マイトマイシン誘導体
DE1983307423 DE116208T1 (de) 1982-12-07 1983-12-06 Mitomycin-analoge.
DE8383307423T DE3376114D1 (en) 1982-12-07 1983-12-06 Mitomycin analogues
EP19830307423 EP0116208B1 (en) 1982-12-07 1983-12-06 Mitomycin analogues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5018683A JPS59175493A (ja) 1983-03-25 1983-03-25 マイトマイシン誘導体

Publications (2)

Publication Number Publication Date
JPS59175493A JPS59175493A (ja) 1984-10-04
JPH0358349B2 true JPH0358349B2 (cs) 1991-09-05

Family

ID=12852145

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5018683A Granted JPS59175493A (ja) 1982-12-07 1983-03-25 マイトマイシン誘導体

Country Status (1)

Country Link
JP (1) JPS59175493A (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840008362A (ko) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 아미노 이황산염
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
DE3674043D1 (de) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk Pharmakologisch aktive mitomycinderivate.
JPH0745503B2 (ja) * 1986-08-29 1995-05-17 協和醗酵工業株式会社 マイトマイシン誘導体
EP0280741B1 (en) * 1986-08-29 1994-12-07 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
EP1504010B1 (en) 2002-05-15 2009-03-25 Endocyte, Inc. Vitamin-mitomycin conjugates
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101784565B (zh) 2007-06-25 2014-12-10 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CA2703491C (en) 2007-10-25 2017-06-13 Endocyte, Inc. Tubulysins and processes for preparing
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
AU2013331440A1 (en) 2012-10-16 2015-04-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using

Also Published As

Publication number Publication date
JPS59175493A (ja) 1984-10-04

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