JPH0358264B2 - - Google Patents

Description

[Detailed description of the invention]

<Industrial Application Field> The present invention relates to a method for producing a coated preparation of water-soluble vitamins to be added as an additive in the fields of food, feed, etc. <Prior Art> Research has been conducted on methods for producing coated preparations of water-soluble vitamins, and approximately two conventional methods have become common. One method is to obtain a coating by suspending water-soluble vitamins in dissolved hydrogenated oil, wax, etc., and then spraying and cooling using a spray or rotating disk to solidify (for example, Japanese Patent Publication No. 50-13192). "Live bait feed composition for fish farming" described in the publication, JP-A-58-205461
``Fish feed'' etc. described in the Publication No. 1). In other methods, water-soluble vitamins are floated by wind force from the bottom using a method called the fluidized bed method, and then a dissolved coating material such as hydrogenated oil or wax is sprayed from the top. (For example, ``Method of coating vitamin particle material'' described in Japanese Patent Application Laid-Open No. 50-52221, etc.). <Problems to be Solved by the Invention> Coated preparations of water-soluble vitamins are used as food additives and feed additives as vitamin reinforcing agents, and their coating performance is very important. When used as a feed additive, especially as an additive for fish farming, thiamin (vitamin B ₁ ) is broken down by thiaminase contained in the raw fish body, which causes death due to thiamin deficiency in farmed fish. Also, other vitamins tend to lose their effectiveness as vitamins due to external moisture, light, heat, pH, etc. Furthermore, when added to food, the odor and taste of various vitamins may have an adverse effect on the food, but this can be masked by coating. However, conventionally developed methods provide insufficient coverage and do not exhibit sufficient performance for the above uses. Furthermore, since the content of water-soluble vitamins, which are core substances, is low, it is necessary to add a large amount of coating preparation before use, which is a cause of increased costs. Furthermore, it is necessary to consume a large amount of energy to melt and spray the coating material or to form a fluidized bed, and the work including the maintenance of the equipment is complicated. <Object of the Invention> Therefore, an object of the present invention is to provide a method for producing a water-soluble vitamin-coated preparation that allows sufficient coating. Another object of the present invention is to provide a method for producing water-soluble vitamins in which there is no need to melt the coating, thus avoiding the consumption of a large amount of energy, and in which the equipment used is easy to maintain. Still another object of the present invention is to provide water-soluble vitamins that have a high content of core substances, such as water-soluble vitamins, so that a sufficient effect as a vitamin can be obtained by using a small amount of coating preparation, and therefore, the cost can be reduced. An object of the present invention is to provide a method for producing a vitamin-coated preparation. <Means for solving the problem> According to the present invention, a water-soluble vitamin powder is contacted with a lipid powder having a melting point of 40°C or higher as a skin substance.
The water-soluble vitamin powder is made to collide with the water-soluble vitamin powder to adhere and coat the entire peripheral surface of the lipid powder, thereby producing a preparation coated with lipids using the water-soluble vitamins as a core material. A method for manufacturing a vitamin-coated preparation is provided. <Description of the Invention> According to the present invention, the water-soluble vitamins serving as the core substance may be naturally occurring or synthetically obtained, and their properties may be crystalline or powdery at room temperature. It can be used as it is as a raw material for coated preparations, or it may be granulated or pre-coated with a water-soluble component or an oily substance. Water-soluble vitamins that can be preferably used in the present invention include vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin B ₁₃ , vitamin B ₁₄ , vitamin
_B15 , lipoic acid, nicotinic acid, nicotinamide, pantothenic acid, folic acid, para-aminobenzoic acid, biotin, choline, inositol, vitamin L, vitamin U, vitamin C, vitamin P, etc., and vitamin A, Water-soluble derivatives of oil-soluble vitamins such as vitamin D, vitamin E and vitamin K may also be mentioned. In addition, calcium salts, sodium salts, potassium salts and other metal salts of the above vitamins, salts such as hydrochlorides and nitrates, phosphate esters, acetate esters, succinate esters, maleate esters, glutamate esters, etc. Other derivatives can also be used as water-soluble vitamins. Depending on the intended use, two or more of the above water-soluble vitamins may be used in combination. Furthermore, water-soluble components that can be used for granulation and pre-coating of water-soluble vitamins include sugars, proteins, amino acids, and inorganic salts. As oily substances, natural oils, hydrogenated oils, waxes, fatty acid monoglycerides, fatty acid diglycerides, fatty acids and other lipids can be used. Furthermore, other components may include organic and inorganic polymeric substances derived from natural or synthetic sources. The lipid powder with a melting point of 40°C or higher used as a coating agent includes naturally occurring animal and vegetable oils such as beef tallow, hydrogenated beef tallow oil, hydrogenated fish oil, hydrogenated soybean oil, fatty acid monoglyceride, fatty acid diglyceride, propylene glycol fatty acid ester, and sucrose. Fatty acid esters, fatty acids, fatty acid salts, higher alcohols, waxes, phosphorus- or nitrogen-containing phospholipids, glycolipids with sugar as a constituent, sulfolipids with sulfonic acid groups, sterols, hydrocarbons, and hydrogenated products of these, etc. Or you can choose from two or more types. If the melting point was less than 40°C, a desirable lipid powder could not be obtained, and a good coating preparation could not be obtained. The method of bringing the powder containing water-soluble vitamins, which is the core substance, and the powdered lipid, which is the coating agent, into contact with each other and collides with each other is to use a known ball mill, electric mortar, or high-efficiency powder mixing device. It is possible to use a device that brings the powder into contact with each other by convection of high-speed air currents, thereby causing the powder to come into contact with each other and collide with the inner wall of the device and the auxiliary tool to uniformly coat the powder. When contacting and colliding, it is preferable to bring the materials into contact under mild conditions, as there is a risk of pulverization of the core material if the action is too violent. Moreover, the coating performance can be improved by premixing the core material powder and the coating agent powder in advance when bringing them into contact with each other using the above-mentioned device. The mixing ratio of the core material and the coating material (core material powder weight/coating material powder weight) can be used in the range of 0.1 to 50, but it can be adjusted in relation to the particle size ratio. preferable. When the particle size ratio is large, it is preferable to increase the mixing ratio, and when the particle size ratio is small, it is desirable to set the mixing ratio to 4 or less.
Simply reducing the mixing ratio does not necessarily improve the coating performance; in fact, in some cases, the larger the mixing ratio, the better the performance. Further, even if the mixing ratio is the same, the coating performance can be improved by dividing the coating agent powder into two or more parts and coating the powder several times. In any case, it is necessary that the coating material covers and adheres to the entire peripheral surface of the core material. This is because if the entire surrounding surface is not covered or adhered, the core substance inside will be eluted to the outside. <Effects of the Invention> The coated water-soluble vitamin formulation produced by the method of the present invention has significantly improved coating performance compared to conventionally known formulations, and as a result, contact with other ingredients can be prevented. Furthermore, it has become possible to block water-soluble vitamins from light, heat, moisture, and the outside air. Therefore, the effects of various water-soluble vitamins are not impaired when used in the fields of food and feed. Also, when the core substance is released to the outside,
Since it is released gradually, long-term effects can be expected. Furthermore, according to the method of the present invention, since the content of water-soluble vitamins in the preparation is increased, it is possible to reduce the amount of the preparation itself to be added, and therefore, it is possible to reduce the cost of using the preparation. Furthermore, the method for producing the preparation of the present invention can be simplified in terms of energy and workability compared to conventional production methods. As described above, the coated preparation of the present invention has many effects not seen before and is extremely useful. <Example> Reference example 1 Hydrogenated rapeseed oil (melting point
64.1°C, Nippon Oil & Fats Co., Ltd.) was added to 2 kg, and thoroughly dispersed using a homomixer. This mixture was sprayed into a room at 30°C using a rotating disk type sprayer to obtain a powder product. Reference Example 2 Nicotinic acid (average particle size
114 μm, manufactured by Givaudan) was added and thoroughly dispersed using a homomixer. A powder product was obtained by performing the same operation as in Reference Example 1. Reference example 3 Dissolved stearic acid monoglyceride (melting point
After adding 600 g of riboflavin (average particle size 146 μm, Nippon Rotsuyu Co., Ltd. product, trade name Robiflav) to 1.2 kg (64.7°C, manufactured by Riken Bitine Co., Ltd.), it was sufficiently dispersed with a homomixer. By performing the same operation as in Reference Example 1, a powder product having a particle size of 80 to 250 μm was obtained. Example 1 Thiamine nitrate (average particle size 124 μm, Nihon Rotsuyu Co., Ltd. product) 42 g and rapeseed hydrogenated oil (average particle size 8.6 μm,
Melting point 64.1°C, manufactured by Nippon Oil & Fats Co., Ltd.)) was placed in a centrifugal rotary mixer (Mechanomilu MM10, manufactured by Okada Seiko Co., Ltd.) together with 20 brass balls, and mixed for 4 hours at a rotational speed of 300 rpm. The obtained powder was mixed with the powder obtained in Reference Example 1 into minced anchovies at 10 mg/100 g as thiamine nitrate.
The decomposition rate of thiamine over time was investigated at 30°C. Thiamine was measured based on the Japanese Pharmacopoeia by adding a cyanogen bromide test solution to the extract and then measuring the absorbance at a wavelength of 368 nm.

【table】

[Table] By implementing the operation according to the present invention as described above, the decomposition rate of thiamine nitrate could be significantly reduced. Example 2 160 g of nicotinic acid (average particle size 114 μm, product of Givaudan) and carnauba wax (average particle size 8 μm)
After mixing 40 g of the powder (Noda Wax Co., Ltd. product, Nippon Oil & Fats Co., Ltd. pulverized product) with a melting point of 83.57°C, the mixture was treated with a Nara Hybridization System (manufactured by Nara Kikai Seisakusho Co., Ltd.) at 5600 rpm for 4 minutes.
The generated powder (nicotinic acid content 80%) was used as reference example 2.
(Nicotinic acid content: 40%). For the elution test, an amount of the generated powder equivalent to 0.3 g of nicotinic acid and 50 ml of water were placed in an Erlenmeyer flask, and the mixture was shaken 100 times per minute using a constant temperature shaker. The amount was determined by titration with a sodium oxide solution. Table 2 shows the results of shaking time, dissolution, and dissolution rate (dissolution rate is
(The ratio of eluted nicotinic acid to the total amount of nicotinic acid is expressed as a percentage).

[Table] This result shows that according to the present invention, a product with a high nicotinic acid content and good coating performance can be produced. Example 3 45 g of the powder obtained in Reference Example 3, 5 g of stearic acid monoglyceride fine powder (average particle size 17 μm, melting point 64.7°C, manufactured by Riken Vitamin Co., Ltd., crushed product by NOF Corporation) and 15 balls made of brass were added. Centrifugal rotary mixer (manufactured by Okada Seiko Co., Ltd., Mechanomiru)
MM10) and reacted for 2 hours at a rotation speed of 500 rpm. The obtained powder was subjected to a dissolution test together with the powder of Reference Example 3 using an automatic dissolution test system manufactured by Toyama Sangyo Co., Ltd. A phosphate buffer solution of pH 7 was used as the eluent, and the wavelength was 265 nm. The results are shown in Table 3.

[Table] From these results, it was possible to significantly improve the performance by applying the coating according to the present invention to the core material, which was insufficiently coated only by applying a preliminary coating.

Claims (1)

[Claims] 1. A water-soluble vitamin powder is brought into contact with and collided with a lipid powder having a melting point of 40°C or higher as a coating agent, and the lipid powder is coated on the entire circumferential surface of the water-soluble vitamin powder. 1. A method for producing a water-soluble vitamin-coated preparation, which comprises adhering and coating a water-soluble vitamin-coated preparation with a lipid-coated preparation using water-soluble vitamins as a core material. 2. Claim 1, wherein the core substance is water-soluble vitamins that are crystalline or powdery at room temperature, or water-soluble vitamins granulated or pre-coated with a water-soluble component, oily substance, or polymeric substance. The method for producing the coated water-soluble vitamin preparation described in Section 1. 3. The water-soluble vitamin coating according to claim 1 or 2, wherein the mixing ratio of the core material and the coating material (core material powder weight/coating material powder weight) is 0.1 to 50. Method of manufacturing the formulation.