JP4147624B2 - Method for producing powdery composition and powdery composition - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a powdery composition that enables granulation of water repellent powder such as highly hygroscopic natural extract powder and enzyme powder, bacterial powder such as bifidobacteria inactivated by water, and deliquescent crystals such as magnesium chloride. The present invention relates to a production method and a powdery composition obtained thereby.
[0002]
[Prior art]
Conventionally, when trying to granulate an extremely hygroscopic powder with an aqueous solution, the particles dissolve faster than the moisture drying rate, and the powder becomes solid or coarse particles can be formed to achieve good granulation. I couldn't get anything. Moreover, in the powder containing the active substance weak to water and the water repellent powder containing the bifidobacteria, etc., even if granulation was possible, the bioactive substance in the powder was decomposed and the inactivation of the bifidobacteria was inevitable. Further, in order to solve these problems, a granulation method in which pregelatinized starch or dextrin is added at the time of granulation and this is sprayed on an excipient is disclosed in Japanese Patent Publication No. 55-12889, The amount of water repellent powder that can be added to the total amount is limited. Furthermore, when a large amount of powder is added, there is a problem in productivity, such as a long time for granulation and drying.
Japanese Patent Application Laid-Open No. 7-8795 discloses a granulation method in which a core material is coated with fats and oils, but there is a problem in thermal stability such that the fats and oils on the surface are easily melted by heating. From these facts, a production method capable of easily and stably coating and granulating the moisture repellent powder has been desired.
[0003]
[Problems to be solved by the invention]
The object of the present invention is to facilitate the granulation of water repellent powder, which has been difficult in the past, and for powders that cause a decrease in activity during granulation without reducing the activity and good fluidity. It is providing the manufacturing method for obtaining the stable granulated material which has. Another object is to provide a stable powdery composition in which moisture absorption obtained by the above production method is well suppressed.
[0004]
[Means for Solving the Problems]
As a result of various studies on the granulation method of the moisture repellent powder, the present inventors have found the following coating granulation method. In the first invention of the present invention, a fine powdery oil having a melting point of 40 ° C. or higher is brought into contact with the water repellent powder, and the water repellent powder is coated with the oil in advance, and then this is further treated in a fluidized bed granulator. A method for producing a powdery composition comprising spraying a solution of a water-soluble binder of 0.1 to 30% by weight as a solid content while fluidizing and floating, and granulating using a water-soluble binder. The The second invention is a powdery composition obtained by the first invention, the inner is covered with oil, the outside is powdery composition coated with a water-soluble binder.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail.
In the present invention, the moisture repellent powder is, for example, a herb medicine extract, a natural extract powder with high hygroscopicity such as vegetables, fish meat, basidiomycete extract, an enzyme whose activity decreases by contact with water, fungi such as bifidobacteria, and water. Examples thereof include salts such as magnesium chloride deliquescent by contact, crystal powder such as xylitol, and the like, but are not limited to this example as long as they are adversely affected by moisture.
[0006]
In the present invention, the oil and fat coating method includes both a method in which a water repellent powder and a fine powder of oil and fat having a melting point of 40 ° C. or more are brought into contact with each other and a method in which oil and fat are sprayed in a liquid state on the water repellent powder flowing in the fluidized bed. Is possible.
[0007]
Examples of the fats and oils having a melting point of 40 ° C. or higher that can be used for contact collision in the present invention include animal fats and oils such as beef tallow, pork tallow, and fish oil obtained naturally, palm tallow, coconut oil, rapeseed oil, soybean oil, cottonseed oil, and the like. Vegetable fats and oils of these oils and fats, fat-soluble emulsifiers such as fatty acid monoglyceride, fatty acid diglyceride, sucrose fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, fat-soluble vitamins such as tocopherol, One or more kinds selected from complex lipids such as phospholipids and glycolipids, fatty acids, alcohols, waxes, sterols, hydrocarbons and the like can be used in combination. Of course, there is no problem even if the fats and oils are processed by refining, deodorizing, curing, and transesterification. Of these fats and oils, hardened oils are preferably used. These fats and oils are used by pulverizing solids or pulverizing them by a spray cooling method or the like.
Oils and fats that can be used for contact collision in the present invention must have a melting point of 40 ° C. or higher. With fats and oils having a melting point of less than 40 ° C., it is difficult to obtain finely powdered fats and oils, and it is difficult to obtain a good fat and oil coating by contact collision.
[0008]
In addition, the fats and oils that can be used for spray coating in the present invention include animal fats and oils such as beef tallow, pork tallow, and fish oil that are naturally obtained, and plants such as palm tallow, coconut oil, rapeseed oil, soybean oil, and cottonseed oil. Oils and fats, hardened oils of these oils, fatty acid monoglycerides, fatty acid diglycerides, sucrose fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, and the like, fat-soluble vitamins such as tocopherol, phospholipids, glycolipids, etc. One or more selected from complex lipids, fatty acids, alcohols, waxes, sterols, hydrocarbons, and the like can be used in combination.
Of course, the above fats and oils can be processed by refining, deodorizing, curing, transesterification and the like. Moreover, the fats and oils that can be used here can be used by melting liquid, semi-solid or solid.
[0009]
Examples of the method for colliding the water repellent powder and the fine powdered fat used in the present invention include a method in which powders are agitated and mixed to collide, a method in which collision is performed in a high-speed air stream, and the like.
Examples of the apparatus for colliding the water repellent powder and the fine powdered oil used in the present invention include a high-efficiency powder mixer, a high-speed airflow grinder, a ball mill, an electric mortar, and various stirring granulators. It is not limited to.
[0010]
In the present invention, the fluidized bed granulator used for oil spray coating is not only a fluidized bed granulator generally used for foods, but also a stirred fluidized bed granulator equipped with a stirring blade, Any apparatus may be used as long as the powder can be operated in a fluidized state, such as a rolling fluidized bed granulator with a plate and a Wurster fluidized bed coater capable of coating powder with fine particles.
[0011]
In the present invention, the ratio (weight ratio) of the oil and fat used for the moisture repellent powder and the oil coating can be in the range of 98: 2 to 30:70, but 95: 5 for efficient granulation of the water repellent powder. A range of ˜50: 50 is preferred. This is the same for both contact collision and spray coating.
[0012]
The water-soluble binder used when granulating the oil-coated powder in the present invention includes, for example, dextrin, corn starch, sugar, sugar sugar such as lactose, trehalose or sugar alcohol, starch and its decomposition products, gelatin, skim milk powder, soy protein , Proteins such as wheat protein, corn protein, gum arabic, xanthan gum, pullulan, curdlan, carrageenan, thickened polysaccharides and gums such as sodium alginate, cellulose derivatives such as carboxymethylcellulose and methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, Examples thereof include synthetic polymers such as polyvinyl acetate, polyethylene glycol, polyacrylic acid, polymethacrylic acid, and vinyl acetate resin. Natural extracts, such as a kiss or animal extract is of course also available.
The addition amount of the water-soluble binder is usually 0.5 to 100 parts by weight, preferably 0.5 to 50 parts by weight with respect to 100 parts by weight of the water repellent powder. The water-soluble binder is preferably added in the form of a solution to the oil-coated powder during granulation, but a part of it may be added directly.
Although there is no restriction | limiting in particular about the density | concentration of a water-soluble binder liquid, When considering the workability | operativity of the spray as a binder, about 0.1 to 30 weight% is suitable as solid content.
These can be used mainly by dissolving or dispersing in water or hot water, but in some cases, a solvent such as ethanol can also be used.
[0013]
In the present invention, the granulator used for granulation is not only a fluidized bed granulator generally used for foods, but also an agitated fluidized bed granulator equipped with a stirring blade and a rolling plate. Any apparatus may be used as long as the powder can be operated in a fluidized state, such as a rolling type fluidized bed granulator with a mark and a Wurster type fluidized bed coating machine capable of coating powder with fine particles. At this time, it is important that the powder is fluidized and floating, and if the powder forms a continuous phase during granulation, such as extrusion granulation or stirring granulation, the sprayed moisture is repelled by moisture. It moves to the powder side and the intended purpose is not achieved.
[0014]
【Example】
The present invention will be described in more detail with reference to the following examples and comparative examples, but the present invention is not limited thereto.
Example 1
100 g of rapeseed extremely hardened oil fine powder (melting point: 42 ° C.) is added to 300 g of magnesium chloride, and the temperature inside the machine is 20 ° C. with nitrogen gas sealed in a stirring type granulator (OMD-3 type manufactured by Nara Machinery Co., Ltd.). The mixture was stirred for 10 minutes under conditions of a main shaft rotation speed of 500 rpm and a sub-shaft rotation speed of 500 rpm to obtain an oil-coated magnesium chloride powder.
This oil-coated magnesium chloride powder was charged into a fluidized bed granulator (Flow coater mini manufactured by Freund Sangyo Co., Ltd.), and granulated by spraying 75 g of a 5 wt% corn starch aqueous solution. The operating conditions for granulation were such that the supply air temperature was 60 ° C. and the exhaust temperature was 35 ° C., and the supply / exhaust amount was adjusted according to the flow state.
When granulated under the above conditions, granulation was possible in about 30 minutes. The obtained powdery composition had no coarse particles and good fluidity.
[0015]
Comparative Example 1
400 g of magnesium chloride was charged into a fluidized bed granulator (Flowcoater Mini manufactured by Freund Sangyo Co., Ltd.) and granulated by spraying 75 g of a 5% by weight corn starch aqueous solution. The operating conditions for granulation were such that the supply air temperature was 60 ° C. and the exhaust temperature was 35 ° C., and the supply / exhaust amount was adjusted according to the flow state.
When granulation was performed under the above conditions, magnesium chloride was deliquescent from the initial stage of granulation, and granulation was impossible.
[0016]
Reference example 2
2000 g of commercially available soy sauce powder (manufactured by Kikkoman Co., Ltd.) was charged into a flow coater FLO-5 type (fluidized bed granulator), and room temperature air was introduced and allowed to flow while hardening oil (beef tallow hardened oil) 1000 g (melting point 48 ° C.) was dissolved and sprayed to obtain an oil-coated soy sauce powder. 900 g of dextrin (Matsutani Chemical Industry Co., Ltd., Paindex # 2) was added to and mixed with this oil-coated soy sauce powder and granulated by spraying 500 g of a 5 wt% corn starch aqueous solution. The granulation conditions at this time were such that the supply air temperature was 60 ° C. and the exhaust temperature was 35 ° C., and the supply / exhaust amount was adjusted according to the flow state. When granulated under the above conditions, granulation was possible in about 30 minutes. The obtained powdery composition had no coarse particles and good fluidity.
[0017]
Comparative Example 2
The same 2000 g of soy sauce powder, 1000 g of hardened oil powder, and 900 g of dextrin were charged and granulated by spraying 500 g of a 5% by weight corn starch aqueous solution. The granulation conditions at this time were such that the supply air temperature was 60 ° C. and the exhaust temperature was 35 ° C., and the supply / exhaust amount was adjusted according to the flow state.
When granulation was performed under the above conditions, soy sauce powder adhered to the inside of the machine, and granulation could not be continued in about 10 minutes.
[0018]
Comparative Example 3
2000 g of soy sauce powder (produced by Kikkoman Co., Ltd.) similar to that in Example 2 was charged into a flow coater FLO-5 type (fluidized bed granulator), and room temperature air was introduced and allowed to flow while hardening oil in the layer. 1000 g (cured tallow oil melting point 48 ° C.) was dissolved and sprayed to obtain an oil-coated soy sauce powder. 900 g of lactose was added to 600 g of the oil-coated soy sauce powder, a small amount of water was added, and the mixture was stirred and kneaded. This kneaded product was extruded and granulated with an extrusion granulator (Fuji Powder Co., Ltd. DG-L1).
During granulation, fats and oils slid between powders in the granulator, so high temperature was generated by the extrusion pressure, melting in the cylinder, making extrusion impossible.
[0019]
Example 3
100 g of ginseng extract powder, 100 g of beef tallow oil fine powder (melting point: 54 ° C.) is added, and the stirring temperature granulator (OMD-3 type, manufactured by Nara Machinery Co., Ltd.) is used. The mixture was stirred for 10 minutes under the conditions of a main shaft rotation speed of 500 rpm and a sub-shaft rotation speed of 500 rpm to obtain an oil- and fat-coated ginseng extract powder.
This oil-coated ginseng extract powder was charged into a fluidized bed granulator (Flow coater mini manufactured by Freund Sangyo Co., Ltd.) and granulated by spraying 75 g of a 5% by weight dextrin aqueous solution. The operating conditions for granulation were such that the supply air temperature was 60 ° C. and the exhaust temperature was 35 ° C., and the supply / exhaust amount was adjusted according to the flow state.
When granulated under the above conditions, granulation was possible in about 28 minutes. The obtained powdery composition had no coarse particles and good fluidity.
[0020]
Comparative Example 4
When 300 g of the same ginseng extract powder as in Example 3 and 100 g of dextrin (Matsutani Chemical Industry Co., Ltd., Paindex # 2) were powder-mixed and granulated under the same granulation conditions as in Example 3, 5 g Coarse particles started to appear immediately after the start of spraying of the weight% dextrin aqueous solution, and the operation could not be continued 12 minutes after the start.
[0021]
Comparative Example 5
300 g of ginseng extract powder as in Example 3, 100 g of beef tallow oil fine powder, and 50 g of dextrin (Matsutani Chemical Industry Co., Ltd., Paindex # 2) were charged, and 5 wt% dextrin under the same granulation conditions as in Example 3. The aqueous solution 75g was sprayed and granulated.
When granulated under the above conditions, ginseng extract powder adhered to the inside of the machine, and granulation could not be continued in about 10 minutes.
[0022]
【The invention's effect】
Since the present invention uses a special method of granulating with a water-soluble binder after coating the water repellent powder with fats and oils, the water repellent powder, which has been difficult in the past, has been suppressed by suppressing the influence of water. The granulated product can be easily obtained in a short time. Therefore, the obtained powdery composition has good fluidity and stability because the absorption of moisture is well suppressed, and has good fluidity and stability. It can be used for cosmetics.

Claims (2)

The fine powder of melting point 40 ° C. or more fat by contacting collide with water repellent powder, after coating with advance oil water repellent powder, while further fluidized in a fluidized bed granulator this floating, as solids A method for producing a powdery composition , which comprises spraying a solution of 0.1 to 30% by weight of a water- soluble binder and granulating using the water-soluble binder. A powdery composition obtained by the production method according to claim 1, wherein the inside is coated with oil and fat, and the outside is coated with a water-soluble binder.