JPH0338511A - External preparation - Google Patents
External preparationInfo
- Publication number
- JPH0338511A JPH0338511A JP1173275A JP17327589A JPH0338511A JP H0338511 A JPH0338511 A JP H0338511A JP 1173275 A JP1173275 A JP 1173275A JP 17327589 A JP17327589 A JP 17327589A JP H0338511 A JPH0338511 A JP H0338511A
- Authority
- JP
- Japan
- Prior art keywords
- external preparation
- skin
- transglutaminase
- hair
- smoothness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 108060008539 Transglutaminase Proteins 0.000 claims abstract description 13
- 102000003601 transglutaminase Human genes 0.000 claims abstract description 13
- 230000000694 effects Effects 0.000 abstract description 20
- 239000006210 lotion Substances 0.000 abstract description 8
- 230000035790 physiological processes and functions Effects 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 239000002932 luster Substances 0.000 abstract description 3
- 239000003094 microcapsule Substances 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 229940099259 vaseline Drugs 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 16
- 238000012360 testing method Methods 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- -1 parabens Chemical compound 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000003766 combability Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- LNLLNTMHVMIMOG-YUMQZZPRSA-N Gamma-glutamyl-Lysine Chemical group NCCCC[C@@H](C(O)=O)NC(=O)CC[C@H](N)C(O)=O LNLLNTMHVMIMOG-YUMQZZPRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、皮膚に対しては、生理機能を向上させ、皮膚
にハリを与え、美肌効果に優れ、また毛髪に対しては、
なめらかさ、つや、髪の仕上り効果を付与することので
きる新規な外用剤に関するものである。Detailed Description of the Invention (Field of Industrial Application) The present invention improves physiological functions for the skin, gives firmness to the skin, and has excellent skin beautifying effects.
The present invention relates to a novel external preparation that can impart smoothness, shine, and finishing effects to hair.
（従来の技術）
従来、老化や乾燥等種々の要因により、皮膚は生理機能
の低下、ハリの低下、肌アレ等を起こし、また毛髪にし
てもなめらかさやつやの減少等種々のトラブルが起こっ
ている。これら症状の改善のため外用剤、特に皮膚に対
しては、種々の保湿剤、たとえばグリセリン、１，３−
ブチレングリコール、ヒアルロン酸などが用いられてき
ている。(Prior art) Conventionally, due to various factors such as aging and dryness, the skin has suffered from decreased physiological functions, decreased firmness, skin irritation, etc., and hair has also suffered from various problems such as decreased smoothness and luster. . To improve these symptoms, external preparations, especially for the skin, include various moisturizers such as glycerin, 1,3-
Butylene glycol, hyaluronic acid, etc. have been used.
また毛髪に対しても、なめらかさやつやの向上のため種
々シリコーン油や各種油剤等が用いられている。Various silicone oils and various oils are also used for hair to improve its smoothness and shine.
（発明が解決しようとする課題）
しかしながら、従来使用されている上記物質は、単に皮
膚の角質層に水分を供給する効果を持つだけであったり
、また毛髪に対しても気温・湿度・風・日光などの影響
により環境条件の悪い時には、効果を望めないことが多
かった。(Problems to be Solved by the Invention) However, the above-mentioned substances that have been used in the past only have the effect of supplying moisture to the stratum corneum of the skin, and they also have a negative effect on the hair due to temperature, humidity, wind, etc. When environmental conditions are poor due to the influence of sunlight, it is often not as effective as expected.
（課題を解決するための手段）
本発明者らは、上記の課題を克服すべく鋭意研究を重ね
た結果、生体内酵素の一種であるトランスグルタミナー
ゼを皮膚または毛髪に適用した場合に、皮膚の生理機能
や美肌効果を高め、また毛髪のなめらかさやつやを著し
く向上させることができることを見い出し、かかる知見
に基づき本発明の完成に至った。(Means for Solving the Problems) As a result of intensive research to overcome the above problems, the present inventors found that when transglutaminase, which is a type of in-vivo enzyme, is applied to the skin or hair, the skin It has been discovered that physiological functions and skin beautification effects can be enhanced, and the smoothness and shine of hair can be significantly improved, and based on this knowledge, the present invention has been completed.
すなわち、本発明はトランスグルタミナーゼを含有する
ことを特徴とする外用、剤に関するものである。That is, the present invention relates to an agent for external use characterized by containing transglutaminase.
以下、本発明の詳細な説明する。The present invention will be explained in detail below.
まず、本発明に適用されるトランスグルタミナーゼは、
人を含めた動物の臓器中に分布している分子量３万〜１
０万程度の酵素たん白であり、生体内では例えば皮膚中
のりジン残基とグルタミン残基を特異的にε（γ−グル
タミルーリジン）結合で架橋する作用を有することなど
が知られていた。First, the transglutaminase applied to the present invention is
Molecular weight 30,000 to 1 distributed in the organs of animals including humans
It is an enzyme protein of about 1,000,000, and is known to have the effect of specifically cross-linking lysine residues and glutamine residues in the skin with ε (γ-glutamyl-lysine) bonds in vivo. .
また、かかるトランスグルタミナーゼは酵素活性測定の
標準物質として一部試薬としても存在しているが、これ
までこれを外用的見知から使用した例は皆無であり、し
かもその場合にお【ブる効果についても全く知られざる
ところであった。In addition, although such transglutaminase exists as a standard substance for measuring enzyme activity and as a reagent, there have been no examples of using it externally, and furthermore, in that case, there is no effect. It was also completely unknown.
そして、これを実際に得るにはモルモットなどの肝臓よ
り物理的乃至は生化学的手段等による常法により抽出し
、分画・精製し、凍結乾燥して粉末状とする方法が一般
的である。In order to actually obtain this, it is generally extracted from the liver of a guinea pig or the like using conventional methods such as physical or biochemical means, fractionated and purified, and freeze-dried to form a powder. .
但し、トランスグルタミナーゼは、水溶液中では経時的
に、有機溶媒中では瞬時に活性が低下することから、本
発明の外用剤への適用に際しては、活性の低下を防ぐた
め、ワセリンとの混合や粉末基剤と水または化粧水等と
による用時溶解調製による２剤型、またはマイクロカプ
セルによる水溶性基剤への安定化配合（特公昭５５−１
４１４０５号〉等により調製することが好ましく、その
調製も常温付近で行なうのが好ましい次に、外用剤中の
トランスグルタミナーゼ含有量は、外用剤全量に対して
、０．００１〜２０重遣％が好ましく、特にはｏ、 ｏ
ｉ〜５重量％がより好ましい。However, since the activity of transglutaminase decreases over time in an aqueous solution and instantaneously in an organic solvent, when applying it to the external preparation of the present invention, in order to prevent a decrease in activity, transglutaminase should be mixed with vaseline or powdered. Two-dose formulation prepared by dissolving the base and water or lotion before use, or stabilizing formulation into a water-soluble base using microcapsules (Japanese Patent Publication No. 55-1
No. 41405> etc., and it is also preferable to prepare it at room temperature.Next, the transglutaminase content in the external preparation should be 0.001 to 20% by weight based on the total amount of the external preparation. Preferably, especially o, o
i to 5% by weight is more preferred.
ここで、０．００１重量％より少ない量では、所望とす
る効果は明待し難く、反対に２０重量％を超える量とし
ても増量に見合った効果の増強は認められず不経済であ
る。Here, if the amount is less than 0.001% by weight, it is difficult to expect the desired effect, and on the other hand, if the amount exceeds 20% by weight, no enhancement of the effect commensurate with the increase in amount is observed, which is uneconomical.
ざらに、本発明の外用剤には必要に応じて本発明の効果
を損なわない範囲で、炭化水素・トリグリセライド・高
級アルコール等の油剤類、グリセリン等の保湿剤類・パ
ラベン等の防腐剤類、ノニオン型、アニオン型、カチオ
ン型の界面活性剤類及び香料等を使用でき、これら成分
を組成物としてローション等の可溶化系、クリーム・乳
液等の乳化系、軟骨、粉末剤等、任意の剤型をとること
ができる。In general, the external preparation of the present invention may contain oils such as hydrocarbons, triglycerides, and higher alcohols, humectants such as glycerin, preservatives such as parabens, etc., as necessary, to the extent that the effects of the present invention are not impaired. Nonionic, anionic, and cationic surfactants, fragrances, etc. can be used, and these ingredients can be used as compositions for solubilizing systems such as lotions, emulsifying systems such as creams and emulsions, cartilage, powders, etc. You can take a mold.
（実施例〉
次に本発明を実施例によって説明するが、本発明はこれ
により限定されるものではない尚、配合割合は重量部で
ある。(Example) Next, the present invention will be explained with reference to Examples, but the present invention is not limited thereto. The blending ratios are in parts by weight.
また、併せて実施例と共に比較例を用いて評価試験を行
なった。In addition, an evaluation test was conducted using both Examples and Comparative Examples.
［以下余白コ
１゜
エツセンス
第
表
（方法〉
上記第１表に示した成分をポリエチレン袋に封入し、均
一になるまで混合し、粉末状エツセンスを得る。[See the blank space below. Table 1. Essence (Method) The ingredients shown in Table 1 above are sealed in a polyethylene bag and mixed until uniform to obtain a powdered essence.
これを０．５〜２ｇを分包させ、使用の際には約５〜１
０倍量の水または化粧水に分散させ、顔または体に塗布
する。This is divided into 0.5 to 2 g packages, and when used, approximately 5 to 1
Disperse in 0x amount of water or lotion and apply to face or body.
（評価試験）
乾燥肌・荒れ肌の女性３０名を対象に、右手の甲全体に
実施例１のエツセンスを、左手の甲仝体に比較例１のエ
ツセンスをそれぞれ１日３回上記の方法にて塗布し、５
０日間の連用試験を行なった。実施期間は、乾燥感を生
じ易い１〜２月にかけて行ない、判定は２５日目と５０
日目に行なった。判定方法は、左手に比べて右手がどう
改善されたかを下記基準にて申告してもらった。結果を
第２表に示す。(Evaluation test) The essence of Example 1 was applied to the entire back of the right hand and the essence of Comparative Example 1 was applied to the back of the left hand three times a day using the above method for 30 women with dry or rough skin. ,5
A continuous use test was conducted for 0 days. The implementation period was from January to February, when dryness tends to occur, and judgments were made on the 25th and 50th day.
I did it on the first day. The evaluation method was as follows: Participants were asked to report how their right hand had improved compared to their left hand using the following criteria. The results are shown in Table 2.
第２表に示した如く、本発明品が乾燥肌・荒れ肌の改善
に優れ、美肌効果が高いことがわかる。As shown in Table 2, it can be seen that the products of the present invention are excellent in improving dry skin and rough skin, and have a high skin beautifying effect.
ミルキーローション 第 表 （＊）： 公知ナイロンマイクロカプセル化法に よりナイロンマイクロカプセルとした トランスグルタミナーゼ。milky lotion No. table （＊）： Known nylon microencapsulation method More nylon microcapsules Transglutaminase.
（方法）
上記第３表に示した１〜１０の成分を常法により混和し
て、ミルキーローションを得る。(Method) Components 1 to 10 shown in Table 3 above are mixed in a conventional manner to obtain a milky lotion.
（評価試験）
２８名の成人女性パネラ−を対象に、１４名ずつ２群に
任意に分け、一方の群には実施例２のミルキイローショ
ンを、もう一方の群には比較例２のミルキイローション
を１日２回、朝の洗＠後と夜の就寝前に全類に塗布して
もらい３０日間の連用試験を行なった。(Evaluation test) 28 adult female panelists were arbitrarily divided into 2 groups of 14 each, one group received the Milky Lotion of Example 2, and the other group received the Milky Lotion of Comparative Example 2. A 30-day continuous application test was conducted by having all types apply the product twice a day after washing in the morning and before going to bed at night.
評価は、連用試験前後の官能評価を行なった結果を第４
表に示す。The evaluation was based on the results of the sensory evaluation before and after the continuous use test.
Shown in the table.
は、 肌のハリ、 しっとり感の向上に優れている ことがわかる。teeth, skin firmness, Excellent for improving moist feeling I understand that.
３、シャンプー
（方法〉
上記第５表に示した成分１〜６をポリエチレン袋に封入
し、均一になるまで混合し、粉末状シャンプーを得る。3. Shampoo (Method) Components 1 to 6 shown in Table 5 above are sealed in a polyethylene bag and mixed until uniform to obtain a powdered shampoo.
これを適量取り出し、使用の際は約５倍量の水に再分故
させ、髪全体に塗布し、洗い流す。Take an appropriate amount of this, and when using it, redistribute it in about 5 times the amount of water, apply it all over your hair, and rinse it off.
（評価試験）
２２名の成人女性パネラ−を対象に実施例３と比較例３
の両方のシャンプーについて洗髪実使用試験を行ない、
毛髪のなめらかさ、つや、クシ通りについて評価した。(Evaluation test) Example 3 and Comparative Example 3 on 22 adult female panelists
We conducted actual hair washing tests on both shampoos.
The smoothness, shine, and combability of the hair were evaluated.
その結果を第６表に示す。The results are shown in Table 6.
第 ６ 表
第６表に示した如く、比較量に比べ本発明品は、毛髪の
なめらかさ・つや、クシ通りに対して優れた効果を有す
ることがわかる。Table 6 As shown in Table 6, it can be seen that the products of the present invention have superior effects on hair smoothness, shine, and combability compared to comparative amounts.
（発明の効果）
以上詳述した如く、本発明はトランスグルタミナーゼを
含有することにより、皮膚にハリを与え、皮膚の生理機
能を向上させ、美肌効果に優れ、毛髪に対しては、なめ
らかさ、つや、髪の仕上り効果を付与することができる
。(Effects of the Invention) As detailed above, the present invention, by containing transglutaminase, gives firmness to the skin, improves the physiological functions of the skin, has excellent skin beautifying effects, and has smoothness and smoothness for hair. It can add luster and finish to the hair.
Claims (1)
る外用剤。1) An external preparation characterized by containing transglutaminase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1173275A JPH0338511A (en) | 1989-07-05 | 1989-07-05 | External preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1173275A JPH0338511A (en) | 1989-07-05 | 1989-07-05 | External preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0338511A true JPH0338511A (en) | 1991-02-19 |
Family
ID=15957428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1173275A Pending JPH0338511A (en) | 1989-07-05 | 1989-07-05 | External preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0338511A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993020837A1 (en) * | 1992-04-21 | 1993-10-28 | Ajinomoto Co., Inc. | Remedy for wound |
| US5525336A (en) * | 1993-02-19 | 1996-06-11 | Green; Howard | Cosmetic containing comeocyte proteins and transglutaminase, and method of application |
| US6267957B1 (en) | 1998-01-20 | 2001-07-31 | Howard Green | Attaching agents to tissue with transglutaminase and a transglutaminase substrate |
| KR20030073787A (en) * | 2002-03-13 | 2003-09-19 | 한일이화주식회사 | Method for Fixing Fastening Nut |
| EP1569606A4 (en) * | 2002-12-05 | 2006-01-11 | E L Management Corp | Method of curl retention in hair and lashes |
| WO2014061728A1 (en) * | 2012-10-17 | 2014-04-24 | 味の素株式会社 | Cosmetic composition |
-
1989
- 1989-07-05 JP JP1173275A patent/JPH0338511A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993020837A1 (en) * | 1992-04-21 | 1993-10-28 | Ajinomoto Co., Inc. | Remedy for wound |
| US5525336A (en) * | 1993-02-19 | 1996-06-11 | Green; Howard | Cosmetic containing comeocyte proteins and transglutaminase, and method of application |
| US6267957B1 (en) | 1998-01-20 | 2001-07-31 | Howard Green | Attaching agents to tissue with transglutaminase and a transglutaminase substrate |
| KR20030073787A (en) * | 2002-03-13 | 2003-09-19 | 한일이화주식회사 | Method for Fixing Fastening Nut |
| EP1569606A4 (en) * | 2002-12-05 | 2006-01-11 | E L Management Corp | Method of curl retention in hair and lashes |
| WO2014061728A1 (en) * | 2012-10-17 | 2014-04-24 | 味の素株式会社 | Cosmetic composition |
| CN104736135A (en) * | 2012-10-17 | 2015-06-24 | 味之素株式会社 | Cosmetic composition |
| JPWO2014061728A1 (en) * | 2012-10-17 | 2016-09-05 | 味の素株式会社 | Cosmetic composition |
| JP2018104467A (en) * | 2012-10-17 | 2018-07-05 | 味の素株式会社 | Cosmetic composition |
| US10463594B2 (en) | 2012-10-17 | 2019-11-05 | Ajinomoto Co., Inc. | Cosmetic composition |
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