JPH03232819A - Solid galenical, its production and system therefor - Google Patents

Abstract

PURPOSE:To obtain the solid galenical, a uniform compression-molded product excellent in shape retentivity without causing cracks or damages by charging a split mold with moderately dried chopped galenical followed by pressing, opening the mold under a pressed state and then releasing such state. CONSTITUTION:A quantitative feeder 3 is fed, through a belt conveyor 2, with moderately dried chopped galenical 1, and a given amount of the galenical 1 is put, using another quantitative feeder 4, into a split mold 5 brought to a closed state by both left and right cylinders. This galenical is then pressed vertically with a cylinder 6 followed by opening the split mold 5 while maintaining such pressed state and then releasing the pressed state, thus obtaining the objective solid galenical 7 consolidatedly integrated in a block form under uniform compressed state. With the present method, the decocting effect of the present galenical will be markedly improved, leading to increasing extract content and also high decreasing effect on viable cell number in general.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] This invention relates to solid herbal medicines, and improvements in their manufacturing methods and devices.

[Prior Art] Conventionally, various pressure molding methods have been proposed for producing solid herbal medicines.

For example, Japanese Patent Application Laid-Open No. 56-31756 discloses a manufacturing method in which cut herbal medicine is packed in a cylinder with open ends and compressed with two pistons from both ends.

In addition, Japanese Patent Publication No. 63-26653 proposed a manufacturing method in which moderately dried cut crude drugs were stored in a rectangular frame-shaped mold provided on the bottom plate, and the stored cut crude drugs were pressurized by a piston-type metal pressure plate. ing.

[Problem to be solved by the invention] However, since both methods involve packing and compressing the material into a fixed mold, the molded product must be forcibly pushed out of the mold to take it out after pressure molding. Moreover, when the pressure is released, the internal pressure applied to the molded product will differ depending on the part that is in direct contact with the inner wall of the frame and the part that is not, and depending on how the molded product is removed, it may crack or be damaged. there were. In particular, the greater the degree of pressurization, the more firmly the molded product is packed inside the mold, and this tendency increases, making it difficult to take out the mold and forcing it out. There was a problem in that the outer periphery of the drug was damaged and it lacked shape retention, which is essential for solid herbal medicines. Therefore, in the conventional method, there is a limit to the degree of compression due to the manufacturing method.

Moreover, in this type of manufacturing method, pressure is applied by the vertical movement of a piston within a fixed mold, so when the pressure is released, the internal pressure of the molded product that rebounds against this escapes directly upward, so that the There was a problem in that the thickness was thick and the degree of change in thickness was large, resulting in a lack of stability in thickness. Therefore, in the conventional manufacturing method, in order to obtain a molded product with a fairly thin thickness, it is necessary to apply a considerable amount of pressure, or it is necessary to apply pressure for a long time, which poses a problem in terms of productivity.

On the other hand, although the original purpose of this type of pressure molding is to solidify crude drugs, it is also known that pressurization improves the boiling effect of cut crude drugs and increases the extract content. (See Japanese Patent Publication No. 6B-26653). This is thought to be due to the fact that cracks occur in the coating due to pressure, which increases the permeability of water into the interior. Pressurization also has the effect of reducing the number of viable bacteria in general. From this point of view, it would be desirable to provide molded products in which cut crude drugs are uniformly and highly compressed, but as mentioned above, it is difficult to quickly and easily mold uniform compression molded products. This is the current situation, and solid herbal medicines with improved boiling effects and general viable bacteria count reduction effects in a uniformly compressed state have not yet been provided.

An object of the present invention is to provide a manufacturing method and apparatus for quickly and easily molding a cut herbal medicine into a uniform, highly compressed product, and also to provide a solid herbal medicine that is uniformly and highly compressed. .

[Means for solving the problem] As a result of intensive studies to achieve the above objective, we put a moderately dried cut herbal medicine into a split mold, pressurized it, and then opened the split mold under the pressurized state. We developed a manufacturing method in which a uniform compression molded product is obtained by opening the mold, then releasing the pressurized state.

In other words, we have invented a solid herbal medicine in which cut herbal medicines pressurized in a split mold are solidified and integrated in a uniformly compressed state.

Preferred equipment for producing such solid herbal medicines include:
The bottom plate and this bottom plate 2 face each other so that they can be opened and closed on both the left and right sides,
A pair of split molds with a roughly U-shaped cross section that are pressurized from both the left and right sides,
It is preferable to use a manufacturing apparatus in which the compression molding means is a pressurizing plunger that moves up and down within the split mold by a cylinder drive.

[Function] As mentioned above, this invention is a method and device that pressurizes inside a split mold instead of packing and compressing it in a regular mold as in the past, so taking out the molded product after pressure molding is easy. It can be easily taken out by opening the mold and releasing the pressure applied by a piston or the like. Furthermore, the pressurized state is released by first opening the split mold and then releasing it, so it is not forcibly extruded from one direction as in the past, so the internal pressure is applied uniformly throughout the molded product. It rarely cracks or gets damaged, and has excellent shape retention.

This effect becomes more pronounced as the degree of pressurization increases, and even a tightly packed molded product can be easily removed. Therefore, with this method and equipment, it is possible to mold not only soft medicines, but also solid herbal medicines that are solidified into blocks in a uniformly compressed state that is extremely hard, which was difficult to do in the past. can provide products.

In addition, according to this manufacturing method, the pressure is released after opening the split mold, so the internal pressure of the molded product that resists this escapes in all directions, making it possible to reduce the thickness after molding and also to reduce the degree of change in thickness. It can be pressed down and has excellent thickness stability. Therefore, even when obtaining a molded product that is quite thin, it is possible to reduce the degree of pressure applied, and moreover, a thin molded product can be obtained by applying pressure in a short time.

Further, according to this method, as mentioned above, since high compression is possible, the effect of boiling the cut herbal medicine is significantly improved, and the extract content can be increased. Moreover, it has an excellent effect of reducing the number of viable bacteria in general.

[Example] Specific examples of the method and apparatus of the present invention will be described below, but the invention is not necessarily limited thereto.

Figures 1 (A) to (E) are schematic process diagrams of the method for producing solid herbal medicines, in which (A) is the feeding process, (B) is the charging process into split molds, (C) is the pressurizing process, ( D) is the split mold release process, (E
) indicates the pressure release process. Note that thick arrows indicate the direction of progress of the process, and thin arrows indicate the direction of compression.

First, appropriately dried cut crude drug 1 is fed to quantitative feeder 3 by belt conveyor 2 (FIG. 1(A)). Next, a certain amount of the cut crude drug 1 is fed into the split mold 5 by the metered supply device 4.
(Figure 1 (B)). At this time, the split mold 5 is closed by cylinders from both the left and right sides. Subsequently, pressure is applied in the vertical direction by the cylinder 6 (see Fig. 1 (C).
)). Thereafter, while maintaining the pressurized state by the cylinder 6, the split mold 5 in the closed state is opened (FIG. 1(D)).

After opening the split mold 5, the pressurized state of the cylinder 6 is released (FIG. 1(E)) to obtain a solid crude drug 7 that is solidified and integrated into a block shape under a uniformly compressed state. Next, it is extruded by a scraper 8 and placed on a belt conveyor 9.
Carry it out. In this example, the solid crude drug is formed into a block shape, but it may be formed into an uneven shape, and a method of subsequently incorporating a packing process such as a vacuum pack can also be adopted.

By the way, FIG. 2 is a schematic diagram showing an example of a preferable apparatus for carrying out this method. With the same reference numerals as above, 3 is a quantitative feeder, 4 is a quantitative feeding device, 5 is a split mold, 6 is a cylinder, 8 is a scraper, and 9 is a belt conveyor.

In addition, 10 is a bottom plate.

On the other hand, in this embodiment, the split mold 5 consists of a pair of substantially U-shaped cross-sectional bodies 5a facing each other on both left and right sides on the bottom plate 10, as shown in FIG.
, 5b, each of which is pivotally supported at its upper part so that it can be opened and closed while drawing a circular arc in both left and right directions. 11 is a pressurizing plunger attached to the cylinder 6, 12a, 12
Reference numeral b designates cylinders attached to both sides of the lower portions of the U-shaped bodies 5a and 5b.

In addition, in the apparatus of this embodiment, as shown in FIG.
0 has stepped portions 13.13 on both sides, and correspondingly, the inner deep portions of the roughly U-shaped cross sections 5a and 5b of the split mold 5 also have stepped portions 13.
．． 13, which ensures reliable positioning in the closed state.

Although this device is of a room temperature pressurization type, it may also be a heating pressurization type. In this case, for example, heating may be performed by embedding a heater in each U-shaped body of the split mold 5, but the heating means is not necessarily limited.

By the way, using this equipment, solid herbal medicines are produced under various conditions by properly drying them in a conventional manner, cutting them into small pieces, and crushing them. Comparative tests were conducted on content.

Table 1 shows the results.

Table 1 is shown in the margin below.The general viable bacteria count test method and the negative/positive test for coliform bacteria were conducted in accordance with the Food Sanitation Act. Furthermore, the extract content is measured in accordance with the Japanese Pharmacopoeia.

From Table 1, it can be seen that as the pressurization increases, the number of viable bacteria in general decreases, and the extract content increases. It was also observed that this tendency was even greater under heating and pressurizing conditions, and by applying high pressure under heating conditions,
Compared to conventional methods, it is expected that solid herbal medicines with a lower number of viable bacteria and a higher extract content can be obtained.

0 In this invention, the raw material is particularly suitable as a hard raw material, but it is not limited to tenyaku, and various kinds such as Gennoshoko and senna can be used, and are not particularly limited.

[Effects of the Invention] As described above, the present invention is a manufacturing method and apparatus that use split molds, so it is possible to quickly and easily mold cut herbal medicines into uniformly high-compression molded products, and it is possible to quickly and easily mold cut herbal medicines into uniformly high-compression molded products. It is possible to provide solid herbal medicines.

[Brief explanation of drawings]

Figures 1 (A) to (E) are schematic process diagrams of the method for producing solid herbal medicines, in which (A) is the feeding process, (B) is the charging process into split molds, (C) is the pressurizing process, ( D) is the split mold release process, (E
) shows the pressure release process, FIG. 2 is a schematic overall view showing one embodiment of the manufacturing apparatus according to the present invention, FIG. 3 is a front view showing an example of a split mold, and FIG. 4 is a diagram of the same split mold. It is a schematic diagram showing an open state. 1... Cut crude drug 5... Split mold 6... Cylinder 7... Solid crude drug 1 10... Bottom plate 11... Plunger

Claims (3)

[Claims] (1) After putting moderately dried cut herbal medicine into the split mold and pressurizing it, open the split mold under the pressurized state, and then release the pressurized state to create a uniform compression-molded product. A method for producing a solid crude drug, characterized in that it obtains. (2) A solid crude drug characterized in that the cut crude drug pressurized in a split mold is solidified and integrated in a uniformly compressed state. (3) A bottom plate, a pair of split molds with a substantially U-shaped cross section that face each other on the bottom plate so that they can be opened and closed on both the left and right sides, and are pressurized from both the left and right sides, and a plunger that moves up and down inside the split molds by a cylinder drive. An apparatus for manufacturing solid herbal medicines, characterized in that said is used as a compression molding means.