JPH03204801A - Apparatus for preserving organ - Google Patents

Abstract

PURPOSE:To obtain an apparatus capable of removing peripheral heat generated in feeding a low-temperature perfusate and preventing preservation environment from deteriorating by providing a cooling means in a pump head of a roller pump for feeding the perfusate in an apparatus for circulating the low- temperature perfusate to an extirpated organ and preserving the organ. CONSTITUTION:An organ chamber 3, a reservoir 4 for storing a perfusate, a bubble trap 5 and a filter 6 are provided in a low-temperature thermostatic chamber 1 and the outside thereof is equipped with a roller pump 2 and a pump head 7 having plural rollers 8 on the rotation outer periphery of a rotating unit 9. The center of the rotating unit 9 is equipped with a shaft (9a) pivoted in the direction intersecting the paper surface at right angles to rotate the pump head 7 with the shaft as a fulcrum. A casing 11 is provided with a U-shaped tube guide 10 and a tube guide groove 13 of a tube 14 for a cooling liquid on the outside thereof. A perfusate passing through the tube 12 therefor is prevented from its being heated at high temperatures with frictional heat, etc., and deteriorating.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an organ preservation device for perfusing and preserving excised human or animal organs.

[Conventional technology]

Various organ preservation devices have been proposed so far that preserve the extracted organ by circulating a low-temperature perfusion solution therein.

For example, in Japanese Patent Laid-Open No. 63-270601, the inside of a low-temperature constant temperature bath is cooled to a predetermined temperature, for example, 4 DEG C., by a temperature controller, and a board is removably mounted in the low-temperature constant temperature bath.

This board is removably equipped with an oxygenator, a filter, a pressure sensor, a bubble remover, an organ preservation container, and a perfusate storage tank. The perfusion tube circulates through a non-pulsating roller pump installed externally to the oxygenator, the filter, the pressure sensor, the p)l sensor, the bubble remover, the organ storage container, and the perfusate storage tank. Disclosed is a system in which the organs are connected to each other to supply perfusion fluid to an organ stored in an organ storage container.

FIG. 9 is a perspective view of the external appearance of the organ preservation device in the conventional example, showing a state in which perfusion fluid is supplied using an organ roller pump 43 housed in a low-temperature constant temperature bath 42.

[Problem to be solved by the invention]

However, in the method of supplying perfusate to organs using a roller pump as in the conventional example above, in addition to the heat generated by the motor for rotationally driving the rotor having rollers, etc. Ambient heat is generated in the pump head of a roller pump due to frictional heat generated between the roller and the outer wall of the tube during rubbing, and frictional heat generated during rotation of the shaft that is the support shaft for rotational drive of the rotor.

As a result, the temperature of the perfusate supplied to the organ increases, causing bacteria to propagate in the perfusate, causing deterioration of the perfusate, resulting in a deterioration of the environment in which the organ is stored.

SUMMARY OF THE INVENTION An object of the present invention is to provide an organ preservation device in which a pump head of a roller pump is provided with a cooling means to suppress a rise in temperature of the perfusion fluid, thereby preventing deterioration of the perfusion fluid.

[Means and effects for solving the problem] The present invention is proposed to solve the above-mentioned problems, and in order to achieve the above-mentioned object, an organ preservation device that circulates a low-temperature perfusion solution to an excised organ for perfusion preservation includes: A pump head forming the vicinity of the roller of a roller pump for supplying irrigation fluid is provided with a cooling means for cooling ambient heat generated during supply of irrigation fluid.

By doing so, even if heat is generated from various parts of the pump head, the heat is radiated by the cooling means, and a rise in temperature of the irrigation fluid in the tube can be suppressed.

〔Example〕

1 and 2 show a first embodiment of the present invention,
Of these, FIG. 1 is a schematic diagram of the entire organ preservation device. The low-temperature constant temperature bath 1 is equipped with an organ chamber 3 for storing organs, a reservoir 4 for storing perfusion fluid, a bubble trap 5 for removing air bubbles from the perfusion fluid, and a filter 6 for filtering unnecessary substances from the perfusion fluid. A roller pump 2 is provided outside the constant temperature bath 1.

Note that 7 is a pump head.

These are connected by a tube so that the perfusion fluid from the reservoir 4 flows out through the tube and is sequentially supplied toward the organ chamber 3 by the action of the roller pump 2.

When the perfusion liquid is supplied from the roller pump 2 to the storage chamber 3, it passes through a filter 6 and a bubble trap 5, and is made into a suitable perfusion liquid. The perfusion fluid supplied to the organ returns to the reservoir 4 again, and the perfusion fluid circulates within the closed circuit to preserve the organ.

FIG. 2 is an enlarged sectional view of the pump head 7 of the roller pump 2. FIG. The pump head 7 is configured such that a plurality of rollers 8 are provided on the rotating outer periphery of a rotating body 9, and a shaft 9a is provided on the shaft of the rotating body 9 and is pivoted in a direction perpendicular to the plane of the drawing, so that the pump head 7 rotates about this as a fulcrum. There is. The shirt 9a is connected to a motor (not shown) and receives power.

A casing 11 that is provided to hold a rotor consisting of a roller 8, a rotary body 9, etc. has a U-shaped tube guide 10 formed around the rotor, and a cooling liquid tube 14 outside the tube guide 10. A tube guide groove 13 is formed. The irrigant tube 12 is installed in a U-shape along the tube guide 10, and the roller 8 of the rotor rubs the outer wall of the irrigant tube 12 continuously against the surface of the tube guide 10 along the flow path during rotation. move. In addition, the cooling tube 14 is connected to the tube guide groove 13.
It is installed and fixed in a U-shape. This coolant tube 1
4 is connected to a coolant circulation device 16 provided with a liquid feed pump 15.

In order to preserve the organ in this embodiment configured as described above, the roller pump is operated to supply perfusion fluid through the closed circuit, and the liquid feeding pump is operated to supply the cooling fluid to the cooling fluid tube 14. It passes through the inside of the pump head 7 via. When the roller pump is operated, heat generated from the motor connected to the shaft 9a, frictional heat between the roller 8 and the irrigation fluid tube 12, and frictional heat around the rotation of the shaft 98 accumulates in the pump head, raising the temperature. . However, in this embodiment, as shown in FIG. 2, the cooling fluid tube is positioned so as to hold the rotor and the irrigation fluid tube 12, so the entire pump head is cooled, and the temperature rise of the irrigation fluid can be suppressed. . Therefore, deterioration of the perfusate can be prevented without causing bacterial growth in the perfusate.

FIG. 3 shows a second embodiment of the present invention, in which parts corresponding to those in the first embodiment are given the same reference numerals (the same applies to the following embodiments).

This embodiment is also similar to the first embodiment in that the irrigation fluid tube 12 is attached along the tube guide 10 formed in the casing 11, and the irrigation fluid is sent out by the rotor. Next, in this embodiment, the tube guide 10
A recessed groove 17 is formed in the casing portion along the back surface of the casing, and a semiconductor cooling element 18 is attached to the recessed groove 17 with its cooling surface facing the irrigant tube 12 and its heat radiation surface facing the outside air.

The semiconductor cooling element 18 is connected to a power source 2o via a lead wire 19.

With this configuration, during organ preservation, perfusion fluid is supplied to the organ via the rotor and at the same time the semiconductor cooling element 1
The pump head 7 can be cooled by applying a voltage to the pump head 8 . It goes without saying that this embodiment can also cool the irrigation fluid to prevent deterioration, but since the semiconductor cooling element 18 is used as the cooling means, there is an advantage that the pump head can be made smaller.

FIG. 4 shows a third embodiment of the present invention, in which the casing 11 is provided with a perfusate tube 12 and a rotor to supply perfusate to organs, but the structure is the same as in the above embodiments. A fan is used as a cooling means for the head. In the first and second embodiments, the irrigation fluid tube 12
However, in this embodiment, a fan 21 is provided in the casing 11 so as to face the rotor, and air is blown directly to the rotor to prevent the temperature of the pump head from becoming higher than the outside air temperature. Note that 22 connects the motor 21 to a power source 23 through a lead wire.

FIG. 5 shows a roller pump 2 according to a fourth embodiment of the present invention, which has an organ chamber, a reservoir, a bubble trap, a filter, and a roller pump in a low-temperature constant temperature bath, and these are connected to a perfusion fluid tube. This is the same as in the first embodiment in that they are connected to form a closed circuit.

To explain the inside of the main body of the roller pump 2 of this embodiment, a motor 24 is fixed to the bottom at the center of the inside, and the front surface of the motor 24 is maintained at a predetermined distance from the front surface of the main body through a spacer 25. A rotating shaft 26 of the motor 24 extends into the pump head 7 and is connected to the shaft of the rotor.

A cooling surface 28 of a Peltier element 27 provided inside the main body of the roller pump 2 is in contact with the pump head 7 . Further, the heating surface 29 of the Peltier element 27 is provided with fins 30 for heat radiation.

Further, a heat dissipation fan 31 is provided on the top surface of the roller pump 2 body, and ventilation holes 32 are provided on the bottom surface.

In order to preserve an organ in this embodiment configured as described above, the roller pump 2 is operated to supply perfusion fluid to the organ. At the same time, the Peltier element 27 inside the roller pump 2 is activated to cool the area around the pump head 7. That is, the heat generated on the heating surface 29 of the Peltier element 27 is diffused by the heat radiation fins 30. The air warmed by the heat radiation is discharged to the outside of the roller pump 2 through the ventilation hole 32 by the air blown by the radiation fan 31.

As described above, in this embodiment, since the motor 24 in the roller pump 2 is provided apart from the pump head 7,
Since the heat generated by driving the motor 24 is less likely to be transferred to the pump head 7, the temperature rise of the pump head 7 and the irrigation fluid flowing inside it can be considerably suppressed. Furthermore, since the area around the pump head 7 is forcibly cooled by the Peltier element 27, an increase in temperature of the pump head 7 and the irrigation fluid can be suppressed.

FIG. 6 shows a fifth embodiment of the present invention, and is a perspective view of a pump head 7 of a roller pump.

A plurality of rollers 8 are provided on the rotating outer circumference of a rotating body 9, and a shaft 9a perpendicular to the rotating body 9 is attached to the center to form a rotor, and the shaft 9a is connected to the rotating shaft of a motor so as to receive power. This is the same as in the first and third embodiments. A U-shaped tube guide 10 is formed around the rotor in the casing 11, and a tube 12 for irrigation fluid is attached in a U-shape along the tube guide 10, so that when the roller 8 of the rotor rotates, Similar to the previous embodiment, the outer wall of the tube 12 is continuously rubbed against the surface of the tube guide 10 along the flow path.

The perfusate tube 12 of this embodiment is a multi-lumen tube having a plurality of channels inside, and the tube guide 1
A large-diameter flow path 33 near the zero plane is used as a cooling liquid flow path, and a smaller diameter flow path 34 is used as an irrigation liquid flow path. With this configuration, if the cooling liquid is circulated through the irrigation liquid tube 12 at the same time as the irrigation liquid is circulated, the pump head 7 can be efficiently cooled without taking up a large space for the cooling means. I can do it.

FIG. 7 shows a modification of the multi-lumen tube according to the fifth embodiment, in which an irrigation fluid channel is formed in the center of the irrigation fluid tube 12, and cooling fluid channels are formed on both sides of the irrigation fluid channel. It is something that By configuring like this, −
It can be made into a multi-lumen tube with good cooling efficiency.

FIG. 8 shows an embodiment of an apparatus using the multi-lumen tube according to the fifth embodiment as a perfusion fluid tube. A transportable organ preservation device 37 is connected to a hospital-based control device 38, and an oxygenator 3 is connected to the perfusion circuit.
9. A heat exchanger 40 is provided. The irrigation fluid tube 12 is attached to the pump head 7 of the roller pump 2 connected to the transport type organ preservation device 37. The coolant supply tube 41 to the heat exchanger 40 is branched in the middle, and one end is connected to the coolant flow path in the perfusion liquid tube 12 . The other end is connected to a cooling device (not shown) so that cooled irrigation fluid can be supplied. In this manner, by driving the roller pump 2, the cooling liquid is supplied simultaneously with the supply of the perfusion liquid, thereby cooling the pump head 7.

[Effects of the Invention] As described above, the present invention provides a cooling means in the pump head of a roller pump and cools the entire pump head at the same time as the perfusion fluid is supplied to the organ, thereby suppressing the temperature rise of the perfusion fluid. Deterioration can be prevented, and the organ preservation environment can be prevented from deteriorating.

[Brief explanation of drawings]

FIG. 1 is a schematic diagram of a device showing a first embodiment of the present invention, FIG. 2 is an enlarged sectional view of the same pump head, and FIG. 3 is a perspective view of a pump head according to a second embodiment of the present invention. , FIG. 4 is a perspective view of a pump head according to a third embodiment of the present invention, FIG. 5 is a sectional view of a roller pump according to a fourth embodiment of the present invention, and FIG. 6 is a perspective view of a pump head according to a fourth embodiment of the present invention. FIG. 7 is a cross-sectional view showing a modified example of the irrigation fluid tube; FIG. 8 is an overall perspective view of the device using the fifth embodiment; FIG. 9 is a perspective view of a pump head according to the fifth embodiment; FIG. 2 is a perspective view of a conventional device. 7...Pump head 11...Casing 12...Irrigation fluid tube Figure 1 0 12 Figure 5 Figure 6

Claims (1)

[Scope of Claims] 1. In an organ preservation device that circulates a low-temperature perfusate to an excised organ for perfusion preservation, the pump head forming the vicinity of the roller of a roller pump for supplying the perfusate is provided with the following: An organ preservation device characterized by being provided with a cooling means for cooling heat.