JPH03162863A - Granular fixing glue for medical and dental purposes and granular bone supply material fixed with this glue - Google Patents
Granular fixing glue for medical and dental purposes and granular bone supply material fixed with this glueInfo
- Publication number
- JPH03162863A JPH03162863A JP2171551A JP17155190A JPH03162863A JP H03162863 A JPH03162863 A JP H03162863A JP 2171551 A JP2171551 A JP 2171551A JP 17155190 A JP17155190 A JP 17155190A JP H03162863 A JPH03162863 A JP H03162863A
- Authority
- JP
- Japan
- Prior art keywords
- glue
- granules
- granular
- medical
- chitin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003292 glue Substances 0.000 title claims abstract description 27
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 15
- 239000000463 material Substances 0.000 title claims abstract description 14
- 239000008187 granular material Substances 0.000 claims abstract description 41
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002101 Chitin Polymers 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920001277 pectin Polymers 0.000 claims abstract description 8
- 239000001814 pectin Substances 0.000 claims abstract description 8
- 235000010987 pectin Nutrition 0.000 claims abstract description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229920001218 Pullulan Polymers 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 11
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 10
- 239000012153 distilled water Substances 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 4
- 230000009931 harmful effect Effects 0.000 abstract description 3
- 238000012856 packing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
- 239000001506 calcium phosphate Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 241000272185 Falco Species 0.000 description 2
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000004068 calcium phosphate ceramic Substances 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
Landscapes
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
「利用分野」
本発明は、医科・歯科用顆粒を固着する糊剤及び該糊剤
で固着した顆粒状骨補填材に関する。DETAILED DESCRIPTION OF THE INVENTION Field of Application The present invention relates to a glue for fixing medical and dental granules, and a granular bone grafting material fixed with the glue.
「従来技術及びその問題点」
ハイドロキシアパタイトは、その優れた生体親和性及び
骨伝導能から歯科用あるいは医科用骨抽填材として応用
が広く研究されており、既に数種のものが実用に供され
ている。従来、骨補填材には、顆粒状のものと、予め成
形されたブロック状のものとがあるが、特に、顆粒状骨
補填材は、任意の形状の欠損部に随意に充填することが
できるので、広く用いられている。"Prior art and its problems" Due to its excellent biocompatibility and osteoconductive ability, hydroxyapatite has been widely studied for application as a dental or medical bone extraction material, and several types have already been put into practical use. has been done. Conventionally, bone grafting materials include granular materials and pre-formed block-shaped materials, but granular bone grafting materials in particular can be filled into defects of any shape at will. Therefore, it is widely used.
しかしながら、顆粒状骨補填材には、顆粒相互間の固着
がないため、新生骨と骨性癒着する前に散逸してしまう
ことが多かった。この欠点を克服するため、すなわち、
顆粒を相互に固着させるためにフィブリン糊を糊剤とし
て用いる試みがなされている（特開昭６０−２５６４６
０号、同６０−２５６４６１号公報など）。しかし，フ
ィブリン糊は、ヒトの血液から製造されるため、肝炎、
エイズ等に感染する危険性があった。However, since granular bone grafting materials do not have adhesion between granules, they often dissipate before they can form an osseous union with new bone. To overcome this drawback, i.e.
Attempts have been made to use fibrin glue as a pasting agent in order to fix granules to each other (Japanese Patent Application Laid-Open No. 60-25646).
No. 0, No. 60-256461, etc.). However, since fibrin glue is manufactured from human blood, it can cause hepatitis,
There was a risk of infection with AIDS, etc.
また、本発明者は、特願昭６３−３４９６号明細書にお
いてα−リン酸三カルシウム又はリン酸四カルシウムを
必須成分として含む顆粒を酸水溶液で固着させる方法を
提案したが、この方法は特定成分の顆粒にしか適用でき
ないという問題点があった。In addition, the present inventor proposed a method of fixing granules containing α-tricalcium phosphate or tetracalcium phosphate as an essential component with an acid aqueous solution in Japanese Patent Application No. 63-3496; There was a problem in that it could only be applied to granules of ingredients.
ｒ発明の目的Ｊ
本発明の目的は、生体に害（感染症の危険等）を及ぼさ
ず、任意の医科・歯科用顆粒に適用してる顆粒固着用糊
剤及び骨の欠損部への充填の前壱に散逸せず、顆粒相互
間の固着性に優れた顆粒９骨補填材を提供することにあ
る。rObject of the Invention J The object of the present invention is to provide a granule fixing adhesive that does not cause harm to living organisms (risk of infection, etc.) and that can be applied to any medical or dental granules and for filling bone defects. To provide a 9-granule bone grafting material that does not dissipate to the front and has excellent adhesion between granules.
「発明の構成」
本発明による医科・歯科用顆粒固着用糊剤は、ブルラン
、グリコールキチン、カルボキシメチノ１キチン及びペ
クチンの中から選ばれた１種以上苓水に溶解して含む水
溶液から成ることを特徴とづる。"Structure of the Invention" The glue for fixing medical and dental granules according to the present invention consists of an aqueous solution containing one or more selected from bullulan, glycol chitin, carboxymethino-1 chitin, and pectin dissolved in lily water. This is called a characteristic.
ブルラン、グリコールキチン、カルボキシメチルキチン
及びペクチンは、水に溶解すると、粘尤性を有する高粘
度の溶液を生じるものである。オ発明においては、水溶
液が室温で１０００ｃｐｓｇ上の粘度となるような量で
上記化合物を水に溶Ｗ１するのが好ましく、水溶液が室
温で２０００ｃｐｓ以上の粘度を有するのがより一層好
ましい。水浮液の粘度が１０００ｃＩｌｓ未満であると
、粘着性が不充分であり、かつ流動性が大きすぎるため
、顆粒を十分に固着することができない。Bullulan, glycol chitin, carboxymethyl chitin, and pectin produce a highly viscous solution when dissolved in water. E) In the present invention, it is preferable that the above compound is dissolved in water W1 in such an amount that the aqueous solution has a viscosity of 1000 cps or more at room temperature, and it is even more preferable that the aqueous solution has a viscosity of 2000 cps or more at room temperature. If the viscosity of the aqueous suspension is less than 1000 cIls, the tackiness is insufficient and the fluidity is too high, making it impossible to sufficiently fix the granules.
また、ブルラン、グリコールキチン、カルボキシメチル
キチン及びペクチンは、生体内で為害作用を起こさない
ので、本発明の糊剤は高い安全性を有する。Moreover, since bullulan, glycol chitin, carboxymethyl chitin, and pectin do not cause any harmful effects in vivo, the glue of the present invention has high safety.
本発明の糊剤を製造するには、まず、ブルラン、グリコ
ールキチン、カルボキシメチルキチン及びペクチンの中
から選ばれた１種以上を滅菌する。To produce the glue of the present invention, first, one or more selected from bullulan, glycol chitin, carboxymethyl chitin, and pectin is sterilized.
その際、滅菌方法には特に制限はないが、高圧蒸気滅菌
（オートクレープ滅菌）が望ましい。その後、滅菌済み
蒸留水に溶解させれば、本発明の糊剤が得られる。未滅
菌の原料で糊剤を調製した後に滅菌することも可能であ
り、その際の滅菌方法としては濾過滅菌あるいは高圧蒸
気滅菌がある。At that time, there are no particular restrictions on the sterilization method, but high pressure steam sterilization (autoclave sterilization) is preferable. Thereafter, by dissolving it in sterilized distilled water, the paste of the present invention can be obtained. It is also possible to prepare the paste from unsterilized raw materials and then sterilize it, and sterilization methods in this case include filtration sterilization and high-pressure steam sterilization.
濾過滅菌を行うには、該濾過液が高粘度のためガス圧又
はボンブを用いるのが望ましく、高圧蒸気滅菌を用いる
場合には、温度が２００゜Ｃ以上にならないように注意
する必要がある。２００℃以上では、粘度の低下が起こ
るおそれがある。For sterilization by filtration, it is desirable to use gas pressure or a bomb because the filtrate has a high viscosity, and when using high-pressure steam sterilization, care must be taken to ensure that the temperature does not exceed 200°C. At 200°C or higher, there is a risk that the viscosity will decrease.
このようにして調製した糊剤を医科用あるいは歯科用顆
粒と混合、練和して骨の欠損部に充填するか、あるいは
顆粒を充填した後に糊剤を添加することにより顆粒を相
互に固着させることができる。The glue prepared in this way is mixed and kneaded with medical or dental granules to fill the bone defect, or the glue is added after the granules are filled to make the granules stick together. be able to.
上記のように、本発明の糊剤は、優れた粘着性を有する
ので、骨補填材として用いられる任意の医科・歯科用顆
粒に適用することができ、穎粒を相互に固着させ、散逸
を防止することができる。As mentioned above, the glue of the present invention has excellent adhesive properties, so it can be applied to any medical or dental granules used as bone grafting materials, and it can fix the glumes to each other and prevent them from dissipating. It can be prevented.
したがって、本発明はさらに、上記の糊剤で医科・歯科
用顆粒を固着したことを特徴とする骨補填材を提供する
ものである。顆粒としては、特に制限はなく、具体的に
は、リン酸カルシウム系セラミックス！ｇ粒、アルミナ
系セラミックス顆粒、ジルコニア系セラミックス顆粒な
どを使用することができる。これらのうち、リン酸カル
シウム系セラミックス顆粒、例えばハイドロキシアバタ
イト、フッ素アバタイト、α−リン酸三カルシウム、β
−リン酸三カルシウム及びリン酸四カルシウムのうちの
１ｓ以上から成るセラミックス顆粒が好ましい。Therefore, the present invention further provides a bone grafting material characterized by having medical/dental granules fixed with the above adhesive. There are no particular restrictions on the granules, specifically calcium phosphate ceramics! G grains, alumina ceramic granules, zirconia ceramic granules, etc. can be used. Among these, calcium phosphate ceramic granules such as hydroxy abatite, fluoro abatite, α-tricalcium phosphate, β
- Ceramic granules consisting of 1s or more of tricalcium phosphate and tetracalcium phosphate are preferred.
顆粒の製造方法としては、高速攪拌造粒法、圧粉体を粉
砕する方法、湿式でケーキを作成した後、粉砕する方法
などがあるが、これらに限定されるものではない。こう
して製造した顆粒を焼成するか、又は、焼成後に顆粒状
に成形してもよい。また、顆粒は緻密質であっても、多
孔質であってもよい。Methods for producing granules include, but are not limited to, a high-speed agitation granulation method, a method of pulverizing a green compact, and a method of forming a wet cake and then pulverizing it. The granules thus produced may be calcined or shaped into granules after calcining. Further, the granules may be dense or porous.
「発明の実施例Ｊ
次に、実施例に基づいて本発明をさらに詳しく説明する
が、本発明はこれに限定されるものではない。“Example J of the Invention Next, the present invention will be explained in more detail based on Examples, but the present invention is not limited thereto.
実施例ｌ
ブルラン（林原■製、商品名ＰＩ−２０）９ｇを高圧蒸
気滅菌（温度１２１℃、圧力１ｋｇ／ｃＪ）した後、滅
菌済み蒸留水５０ｇに溶解し、糊剤を得た。この糊剤の
粘度は、室温で２０００ｃｐｓであった。Example 1 9 g of Bull Run (manufactured by Hayashibara, trade name PI-20) was sterilized with high pressure steam (temperature 121°C, pressure 1 kg/cJ) and then dissolved in 50 g of sterilized distilled water to obtain a glue. The viscosity of this glue was 2000 cps at room temperature.
得られた糊剤１ｇを市販の医科・歯科用顆粒（旭光学工
業印製、商品名アパセラムＧ）Ｉｇと混合、練和したと
ころ、顆粒は糊剤によって相互に固着し、散逸し難いも
のとなった。When 1 g of the obtained glue was mixed and kneaded with commercially available medical/dental granules (manufactured by Asahi Kogaku Kogyo Co., Ltd., trade name: APACERAM G), the granules were fixed to each other by the glue and were difficult to dissipate. became.
実施例２
ペクチン（Ｍｅｒｏ Ｒｏｕｓｓｅｌｏｔ Ｓａｔｉａ
社製、商品名ＨＭ−１）１８ｇを高圧蒸気滅菌（温度１
３２゜Ｃ圧力２ｋｇ／ａＩ？）シた後、滅菌済み蒸留水
２００ｇに溶解して糊剤を得た。ただし、溶解を早める
ため家庭用電子レンジで５分間マイクロ波加熱を行った
。この糊剤の粘度は、室温で１４０００ｃｐｓであった
。Example 2 Pectin (Mero Rousselot Satia
18g of HM-1 manufactured by
32°C pressure 2kg/aI? ), and then dissolved in 200 g of sterilized distilled water to obtain a glue. However, to accelerate dissolution, microwave heating was performed for 5 minutes in a household microwave oven. The viscosity of this glue was 14,000 cps at room temperature.
得られた糊剤１ｇを市販の医科・歯科用顆粒（旭光学工
業■製、商品名アパセラムＧ）２ｇと混合、練和したと
ころ、顆粒は糊剤によって相互に固着し、散逸し難いも
のとなった。When 1 g of the obtained glue was mixed and kneaded with 2 g of commercially available medical/dental granules (manufactured by Asahi Optical Industries ■, trade name: APACERAM G), the granules were fixed to each other by the glue and were difficult to dissipate. became.
実施例３
グリコールキチン（■加ト吉ｉ）２０■を高圧蒸気滅菌
（温度１２１゜Ｃ、圧力１ｋｇ／ａｒｔ） Ｌた後、滅
菌済み蒸留水１ｇに溶解させて糊剤を得た。Example 3 After sterilizing 20 μg of glycol chitin (Katokichi i) in high-pressure steam (temperature: 121° C., pressure: 1 kg/art), it was dissolved in 1 g of sterilized distilled water to obtain a glue.
水酸化カルシウムスラリーにリン酸水溶液を滴下する公
知の湿式法でリン酸カルシウムスラリーを得た。このス
ラリーを噴霧乾燥により粉末化し、公知の過酸化水素発
泡法を用いて多孔質ケーキを作製した。このケーキをｔ
ｔｏｏ゜Ｃで４時間焼戒した後、粉砕し、１００〜２
５ ０ Ａｔｍに分級して多孔質顆粒を得た。なお、こ
の顆粒をＸ線回折で分析したところ、β−リン酸三カル
シウム８０％とハイドロキシアパタイト２０％からなる
、いわゆるＢ Ｃ Ｐ （Ｂｉｐｈａｓｉｃ Ｃａｌｃ
ｉｕｍ Ｐｈｏｓｐｈａｔｅ，二相リン酸カルシウム）
であった。この顆粒３０■と前述の糊剤４０■を混合し
、練和したところ、パテ状物となり、散逸し難いものと
なった。A calcium phosphate slurry was obtained by a known wet method in which an aqueous phosphoric acid solution was dropped into a calcium hydroxide slurry. This slurry was pulverized by spray drying, and a porous cake was prepared using a known hydrogen peroxide foaming method. This cake
After baking at too°C for 4 hours, crush and reduce to 100~2
Porous granules were obtained by classification to 50 Atm. In addition, when this granule was analyzed by X-ray diffraction, it was found that it was composed of 80% β-tricalcium phosphate and 20% hydroxyapatite, so-called BCP (Biphasic Calc).
ium Phosphate, biphasic calcium phosphate)
Met. When 30 cm of these granules and 40 cm of the above-mentioned glue were mixed and kneaded, a putty-like material was formed that was difficult to scatter.
実施例４
グリコールキチンの代わりにカルボキシメチルキチン（
一丸ファルコス■製）を用い、１００〜２５０μｍの顆
粒の代わりに３００〜６００μｍの顆粒を用いる以外は
、実施例３と同様な操作を行なったところ、顆粒は糊剤
によって相互に固着し、敗逸し難いものとなった。なお
、用いた糊剤の粘度は、室温で１００００ｃｐｓであっ
た。Example 4 Carboxymethyl chitin (instead of glycol chitin)
When the same operation as in Example 3 was performed except that 300-600 μm granules were used instead of 100-250 μm granules using Ichimaru Falcos (manufactured by Ichimaru Falcos ■), the granules stuck to each other with the glue and failed. It became difficult. The viscosity of the adhesive used was 10,000 cps at room temperature.
「発明の効果」
本発明の顆粒固着用糊剤は、血液成分などを用いないの
で、感染症の危険がなく、生体為害性もなく、高い安全
性を有するものである。また、本発明の糊剤は、あらゆ
るｗｉ類の医科・歯科用顆粒に適用してこれらを相互に
固着することができる。"Effects of the Invention" Since the adhesive for fixing granules of the present invention does not use blood components, it has no risk of infection, is not harmful to living organisms, and has high safety. Furthermore, the adhesive of the present invention can be applied to all types of medical and dental granules to adhere them to each other.
そして、本発明の糊剤で固着された骨補填材は、散逸せ
ず、充填箇所に留まる。The bone grafting material fixed with the glue of the present invention does not dissipate and remains at the filling site.
Claims (1)
チン及びペクチンの中から選ばれた１種以上を水に溶解
して含む水溶液から成ることを特徴とする医科・歯科用
顆粒固着用糊剤。 ２、水溶液が室温で１０００ｃｐｓ以上の粘度を有する
ものである請求項１記載の糊剤。３、医科・歯科用顆粒
を請求項１記載の糊剤で固定したことを特徴とする顆粒
状骨補填材。[Scope of Claims] 1. A glue for fixing granules for medical and dental purposes, characterized by being composed of an aqueous solution containing one or more selected from pullulan, glycol chitin, carboxymethyl chitin, and pectin dissolved in water. agent. 2. The adhesive according to claim 1, wherein the aqueous solution has a viscosity of 1000 cps or more at room temperature. 3. A granular bone grafting material, characterized in that medical/dental granules are fixed with the glue according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2171551A JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21828089 | 1989-08-24 | ||
| JP1-218280 | 1989-08-24 | ||
| JP2171551A JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03162863A true JPH03162863A (en) | 1991-07-12 |
| JP2902452B2 JP2902452B2 (en) | 1999-06-07 |
Family
ID=26494241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2171551A Expired - Fee Related JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2902452B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6903146B2 (en) | 2001-05-02 | 2005-06-07 | Pentax Corporation | Prosthetic filler for a living body and method of manufacturing the prosthetic filler |
| JP2005530525A (en) * | 2002-04-03 | 2005-10-13 | マシーズ メディツィナルテヒニク アクチエンゲゼルシャフト | Kneaded and moldable bone substitute |
-
1990
- 1990-06-29 JP JP2171551A patent/JP2902452B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6903146B2 (en) | 2001-05-02 | 2005-06-07 | Pentax Corporation | Prosthetic filler for a living body and method of manufacturing the prosthetic filler |
| JP2005530525A (en) * | 2002-04-03 | 2005-10-13 | マシーズ メディツィナルテヒニク アクチエンゲゼルシャフト | Kneaded and moldable bone substitute |
| KR100975381B1 (en) * | 2002-04-03 | 2010-08-13 | 신세스 게엠바하 | Kneadable, pliable bone replacement material |
| JP2012066124A (en) * | 2002-04-03 | 2012-04-05 | Synthes Gmbh | Kneadable, pliable bone replacement material |
| JP4944363B2 (en) * | 2002-04-03 | 2012-05-30 | ジンテーズ ゲゼルシャフト ミト ベシュレンクテル ハフツング | Kneaded and moldable bone substitute |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2902452B2 (en) | 1999-06-07 |
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