JP2902452B2 - Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue - Google Patents
Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glueInfo
- Publication number
- JP2902452B2 JP2902452B2 JP2171551A JP17155190A JP2902452B2 JP 2902452 B2 JP2902452 B2 JP 2902452B2 JP 2171551 A JP2171551 A JP 2171551A JP 17155190 A JP17155190 A JP 17155190A JP 2902452 B2 JP2902452 B2 JP 2902452B2
- Authority
- JP
- Japan
- Prior art keywords
- granules
- glue
- paste
- filling material
- bone filling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Description
【発明の詳細な説明】 「利用分野」 本発明は、医科・歯科用顆粒を固着する糊剤及び該糊
剤で固着した顆粒状骨補填材に関する。Description: FIELD OF THE INVENTION The present invention relates to a glue for fixing medical and dental granules and a granular bone filling material fixed with the glue.
「従来技術及びその問題点」 ハイドロキシアパタイトは、その優れた生体親和性及
び骨伝導能から歯科用あるいは医科用骨補填材として応
用が広く研究されており、既に数種のものが実用に供さ
れている。従来、骨補填材には、顆粒状のものと、予め
成形されたブロック状のものとがあるが、特に、顆粒状
骨補填材は、任意の形状の欠損部に随意に充填すること
ができるので、広く用いられている。“Prior art and its problems” Due to its excellent biocompatibility and osteoconductivity, hydroxyapatite has been widely studied for application as a dental or medical bone substitute, and several types have already been put to practical use. ing. Conventionally, bone substitutes include granular ones and pre-formed block-like ones. In particular, granular bone substitutes can be optionally filled into a defect of any shape. So it is widely used.
しかしながら、顆粒状骨補填材には、顆粒相互間の固
着がないため、新生骨と骨性癒着する前に散逸してしま
うことが多かった。この欠点を克服するため、すなわ
ち、顆粒を相互に固着させるためにフィブリン糊を糊剤
として用いる試みがなされている（特開昭60−256460
号、同60−256461号公報など）。しかし，フィブリン糊
は、ヒトの血液から製造されるため、肝炎、エイズ等に
感染する危険性があった。However, since the granular bone filling material has no fixation between the granules, it often dissipates before the osseous adhesion with the new bone. Attempts have been made to overcome this drawback, ie, to use fibrin glue as a sizing agent in order to adhere the granules to each other (Japanese Patent Application Laid-open No. Sho 60-256460).
No. 60-256461). However, since fibrin glue is produced from human blood, it has a risk of being infected with hepatitis, AIDS and the like.
また、本発明者は、特願昭63−3496号明細書において
α−リン酸三カルシウム又はリン酸四カルシウムを必須
成分として含む顆粒を酸水溶液で固着させる方法を提案
したが、この方法は特定成分の顆粒にしか適用できない
という問題点があった。Further, the present inventor has proposed in Japanese Patent Application No. 63-3496 a method of fixing granules containing α-tricalcium phosphate or tetracalcium phosphate as an essential component with an aqueous acid solution. There is a problem that it can be applied only to the granules of the components.
「発明の目的」 本発明の目的は、生体に害（感染症の危険等）を及ぼ
さず、任意の医科・歯科用顆粒に適用しうる顆粒固着用
糊剤及び骨の欠損部への充填の前後に散逸せず、顆粒相
互間の固着性に優れた顆粒状骨補填材を提供することに
ある。"Object of the Invention" The object of the present invention is to provide a paste for fixing granules which can be applied to any medical or dental granules without causing harm to the living body (risk of infectious disease, etc.) and for filling bone defects. An object of the present invention is to provide a granular bone filling material that does not dissipate back and forth and has excellent fixation between granules.
「発明の構成」 本発明による医科・歯科用顆粒固着用糊剤は、プルラ
ン、グリコールキチン、カルボキシメチルキチン及びペ
クチンの中から選ばれた１種以上を水に溶解して含む、
室温で1000cps以上の粘度を有する水溶液から成ること
を特徴とする。"Constitution of the invention" The paste for fixing granules for medical and dental use according to the present invention comprises one or more selected from pullulan, glycol chitin, carboxymethyl chitin and pectin dissolved in water,
It is characterized by comprising an aqueous solution having a viscosity of 1000 cps or more at room temperature.
プルラン、グリコールキチン、カルボキシメチルキチ
ン及びペクチンは、水に溶解すると、粘着性を有する高
粘度の溶液を生じるものである。本発明においては、水
溶液が室温で1000cps以上の粘度となるような量で上記
化合物を水に溶解するのが好ましく、水溶液が室温で20
00cps以上の粘度を有するのがより一層好ましい。水溶
液の粘度が1000cps未満であると、粘着性が不充分であ
り、かつ流動性が大きすぎるため、顆粒を十分に固着す
ることができない。Pullulan, glycol chitin, carboxymethyl chitin and pectin, when dissolved in water, give a sticky, highly viscous solution. In the present invention, the compound is preferably dissolved in water in such an amount that the aqueous solution has a viscosity of 1000 cps or more at room temperature.
It is even more preferred to have a viscosity of at least 00 cps. If the viscosity of the aqueous solution is less than 1000 cps, the viscosity is insufficient and the fluidity is too large, so that the granules cannot be fixed sufficiently.
また、プルラン、グリコールキチン、カルボキシメチ
ルキチン及びペクチンは、生体内で為害作用を起こさな
いので、本発明の糊剤は高い安全性を有する。Further, since pullulan, glycol chitin, carboxymethyl chitin and pectin do not cause harmful effects in vivo, the paste of the present invention has high safety.
本発明の糊剤を製造するには、まず、プルラン、グリ
コールキチン、カルボキシメチルキチン及びペクチンの
中から選ばれた１種以上を滅菌する。その際、滅菌方法
には特に制限はないが、高圧蒸気滅菌（オートクレーブ
滅菌）が望ましい。その後、滅菌済み蒸留水に溶解させ
れば、本発明の糊剤が得られる。未滅菌の原料で糊剤を
調製した後に滅菌することも可能であり、その際の滅菌
方法としては濾過滅菌あるいは高圧蒸気滅菌がある。濾
過滅菌を行うには、該濾過液が高粘度のためガス圧又は
ポンプを用いるのが望ましく、高圧蒸気滅菌を用いる場
合には、温度が200℃以上にならないように注意する必
要がある。200℃以上では、粘度の低下が起こるおそれ
がある。In order to produce the paste of the present invention, first, at least one selected from pullulan, glycol chitin, carboxymethyl chitin and pectin is sterilized. At this time, the sterilization method is not particularly limited, but high-pressure steam sterilization (autoclave sterilization) is preferable. Thereafter, the paste of the present invention is obtained by dissolving the paste in sterilized distilled water. It is also possible to sterilize after preparing the paste with unsterilized raw materials, and in this case, sterilization methods include filtration sterilization and high-pressure steam sterilization. In order to carry out filtration sterilization, it is desirable to use a gas pressure or a pump because the filtrate has a high viscosity. In the case of using high-pressure steam sterilization, care must be taken that the temperature does not exceed 200 ° C. Above 200 ° C., the viscosity may decrease.
このようにして調製した糊剤を医科用あるいは歯科用
顆粒と混合、練和して骨の欠損部に充填するか、あるい
は顆粒を充填した後に糊剤を添加することにより顆粒を
相互に固着させることができる。The paste prepared in this manner is mixed and kneaded with medical or dental granules and filled into the bone defect, or the granules are fixed to each other by adding the paste after filling the granules. be able to.
上記のように、本発明の糊剤は、優れた粘着性を有す
るので、骨補填材として用いられる任意の医科・歯科用
顆粒に適用することができ、顆粒を相互に固着させ、散
逸を防止することができる。As described above, since the paste of the present invention has excellent adhesiveness, it can be applied to any medical or dental granules used as a bone filling material, and fix the granules to each other to prevent dissipation. can do.
したがって、本発明はさらに、上記の糊剤で医科・歯
科用顆粒を固着したことを特徴とする骨補填材を提供す
るものである。顆粒としては、特に制限はなく、具体的
には、リン酸カルシウム系セラミックス顆粒、アルミナ
系セラミックス顆粒、ジルコニア系セラミックス顆粒な
どを使用することができる。これらのうち、リン酸カル
シウム系セラミックス顆粒、例えばハイドロキシアパタ
イト、フッ素アパタイト、α−リン酸三カルシウム、β
−リン酸三カルシウム及びリン酸四カルシウムのうちの
１種以上から成るセラミックス顆粒が好ましい。Therefore, the present invention further provides a bone filling material characterized by fixing medical and dental granules with the above-mentioned paste. The granules are not particularly limited, and specific examples thereof include calcium phosphate-based ceramic granules, alumina-based ceramic granules, and zirconia-based ceramic granules. Among these, calcium phosphate-based ceramic granules such as hydroxyapatite, fluorapatite, α-tricalcium phosphate, β
-Ceramic granules consisting of one or more of tricalcium phosphate and tetracalcium phosphate are preferred.
顆粒の製造方法としては、高速攪拌造粒法、圧粉体を
粉砕する方法、湿式でケーキを作成した後、粉砕する方
法などがあるが、これらに限定されるものではない。こ
うして製造した顆粒を焼成するか、又は、焼成後に顆粒
状に成形してもよい。また、顆粒は緻密質であっても、
多孔質であってもよい。Granule production methods include, but are not limited to, a high-speed stirring granulation method, a method of pulverizing a green compact, a method of preparing a cake by a wet method and then pulverizing the cake. The granules thus produced may be fired, or may be formed into granules after firing. Also, even if the granules are dense,
It may be porous.
「発明の実施例」 次に、実施例に基づいて本発明をさらに詳しく説明す
るが、本発明はこれに限定されるものではない。"Examples of the Invention" Next, the present invention will be described in more detail based on examples, but the present invention is not limited thereto.
実施例１ プルラン（林原（株）製、商品名PI−20）9gを高圧蒸
気滅菌（温度121℃、圧力1kg/cm2）した後、滅菌済み蒸
留水50gに溶解し、糊剤を得た。この糊剤の粘度は、室
温で2000cpsであった。Example 1 9 g of pullulan (manufactured by Hayashibara Co., Ltd., trade name: PI-20) was subjected to high-pressure steam sterilization (temperature: 121 ° C., pressure: 1 kg / cm 2 ), and then dissolved in 50 g of sterilized distilled water to obtain a paste. . The viscosity of this paste was 2000 cps at room temperature.
得られた糊剤1gを市販の医科・歯科用顆粒（旭光学工
業（株）製、商品名アパセラムＧ）1gと混合、練和した
ところ、顆粒は糊剤によって相互に固着し、散逸し難い
ものとなった。When 1 g of the obtained paste was mixed and kneaded with 1 g of commercially available medical / dental granules (trade name: Apaceram G, manufactured by Asahi Kogaku Kogyo Co., Ltd.), the granules were fixed to each other by the paste and hardly dissipated. It became something.
実施例２ ペクチン（Mero Rousselot Satia社製、商品名HM−
１）18gを高圧蒸気滅菌（温度132℃圧力2kg/cm2）した
後、滅菌済み蒸留水200gに溶解して糊剤を得た。ただ
し、溶解を早めるため家庭用電子レンジで５分間マイク
ロ波加熱を行った。この糊剤の粘度は、室温で14000cps
であった。Example 2 Pectin (trade name: HM-, manufactured by Mero Rousselot Satia)
1) 18 g was subjected to high-pressure steam sterilization (temperature: 132 ° C., pressure: 2 kg / cm 2 ), and then dissolved in 200 g of sterilized distilled water to obtain a paste. However, microwave heating was performed for 5 minutes in a household microwave oven to accelerate dissolution. The viscosity of this glue is 14000 cps at room temperature
Met.
得られた糊剤1gを市販の医科・歯科用顆粒（旭光学工
業（株）製、商品名アパセラムＧ）2gと混合、練和した
ところ、顆粒は糊剤によって相互に固着し、散逸し難い
ものとなった。When 1 g of the obtained paste was mixed and kneaded with 2 g of commercially available medical / dental granules (trade name: Apaceram G, manufactured by Asahi Kogaku Co., Ltd.), the granules were fixed to each other by the paste and hardly dissipated. It became something.
実施例３ グリコールキチン（（株）加ト吉製）20mgを高圧蒸気
滅菌（温度121℃、圧力1kg/cm2）した後、滅菌済み蒸留
水1gに溶解させて糊剤を得た。Example 3 20 mg of glycol chitin (manufactured by Katoyoshi Co., Ltd.) was subjected to high-pressure steam sterilization (temperature: 121 ° C., pressure: 1 kg / cm 2 ), and then dissolved in 1 g of sterilized distilled water to obtain a paste.
水酸化カルシウムスラリーにリン酸水溶液を滴下する
公知の湿式法でリン酸カルシウムスラリーを得た。この
スラリーを噴霧乾燥により粉末化し、公知の過酸化水素
発泡法を用いて多孔質ケーキを作製した。このケーキを
1100℃で４時間焼成した後、粉砕し、100〜250μｍに分
級して多孔質顆粒を得た。なお、この顆粒をＸ線回折で
分析したところ、β−リン酸三カルシウム80％とハイド
ロキシアパタイト20％からなる、いわゆるBCP（Biphasi
c Calcium Phosphate、二相リン酸カルシウム）であっ
た。この顆粒30mgと前述の糊剤40mgを混合し、練和した
ところ、パテ状物となり、散逸し難いものとなった。A calcium phosphate slurry was obtained by a known wet method in which a phosphoric acid aqueous solution was dropped into the calcium hydroxide slurry. This slurry was pulverized by spray drying, and a porous cake was prepared using a known hydrogen peroxide foaming method. This cake
After baking at 1100 ° C. for 4 hours, the mixture was pulverized and classified to 100 to 250 μm to obtain porous granules. When the granules were analyzed by X-ray diffraction, a so-called BCP (Biphasiform) composed of 80% β-tricalcium phosphate and 20% hydroxyapatite was used.
c Calcium Phosphate, biphasic calcium phosphate). When 30 mg of the granules and 40 mg of the above-mentioned paste were mixed and kneaded, a putty-like material was obtained, which was difficult to dissipate.
実施例４ グリコールキチンの代わりにカルボキシメチルキチン
（一丸ファルコス（株）製）を用い、100〜250μｍの顆
粒の代わりに300〜600μｍの顆粒を用いる以外は、実施
例３と同様な操作を行なったところ、顆粒は糊剤によっ
て相互に固着し、散逸し難いものとなった。なお、用い
た糊剤の粘度は、室温で10000cpsであった。Example 4 The same operation as in Example 3 was carried out except that carboxymethyl chitin (manufactured by Ichimaru Falcos Co., Ltd.) was used instead of glycol chitin, and 300-600 μm granules were used instead of 100-250 μm granules. However, the granules were fixed to each other by the sizing agent and became difficult to dissipate. The viscosity of the paste used was 10,000 cps at room temperature.
「発明の効果」 本発明の顆粒固着用糊剤は、血液成分などを用いない
ので、感染症の危険がなく、生体為害性もなく、高い安
全性を有するものである。また、本発明の糊剤は、あら
ゆる種類の医科・歯科用顆粒に適用してこれらを相互に
固着することができる。そして、本発明の糊剤で固着さ
れた骨補填材は、散逸せず、充填箇所に留まる。[Effects of the Invention] The paste for fixing granules of the present invention does not use blood components and the like, so that there is no risk of infection, no harm to living organisms, and high safety. Further, the paste of the present invention can be applied to all kinds of medical and dental granules to fix them to each other. Then, the bone filling material fixed by the glue of the present invention does not dissipate and stays at the filling portion.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A61L 25/00 A61L 27/00 A61K 6/00 ──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. 6 , DB name) A61L 25/00 A61L 27/00 A61K 6/00
Claims (2)
メチルキチン及びペクチンの中から選ばれた１種以上を
水に溶解して含む、室温で1000cps以上の粘度を有する
水溶液から成ることを特徴とする医科・歯科用顆粒固着
用糊剤。1. A medical treatment comprising an aqueous solution containing at least one selected from pullulan, glycol chitin, carboxymethyl chitin and pectin dissolved in water and having a viscosity of at least 1000 cps at room temperature. A paste for fixing dental granules.
固定したことを特徴とする顆粒状骨補填材。2. A granular bone filling material comprising medical and dental granules fixed with the glue according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2171551A JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21828089 | 1989-08-24 | ||
| JP1-218280 | 1989-08-24 | ||
| JP2171551A JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03162863A JPH03162863A (en) | 1991-07-12 |
| JP2902452B2 true JP2902452B2 (en) | 1999-06-07 |
Family
ID=26494241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2171551A Expired - Fee Related JP2902452B2 (en) | 1989-08-24 | 1990-06-29 | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2902452B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002325831A (en) | 2001-05-02 | 2002-11-12 | Asahi Optical Co Ltd | Filling material for organism and manufacture thereof |
| TW200400062A (en) * | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
-
1990
- 1990-06-29 JP JP2171551A patent/JP2902452B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03162863A (en) | 1991-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2700881B2 (en) | Pharmaceutical depot | |
| US4728570A (en) | Calcium-hydroxide-treated polymeric implant matrial | |
| Ooms et al. | Trabecular bone response to injectable calcium phosphate (Ca‐P) cement | |
| Katthagen | Bone regeneration with bone substitutes: an animal study | |
| EP0386253B1 (en) | Hardening material for medical and dental use | |
| Costantino et al. | Hydroxyapatite cement: I. Basic chemistry and histologic properties | |
| EP0224545B1 (en) | Pharmaceutical depot preparation | |
| Tanuma et al. | Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect | |
| Liao et al. | Size matters: Effects of PLGA‐microsphere size in injectable CPC/PLGA on bone formation | |
| JPS62268563A (en) | Bone mallow/collagen/inorganic matrix for repairing defect of bone, its preparation and method for repairing defect of bone using the same | |
| Martin-Thomé et al. | Clinical safety of a new synthetic resorbable dental membrane: a case series study | |
| JP3048289B2 (en) | Collagen-calcium phosphate composite material and use thereof | |
| JPH0734816B2 (en) | Medical and dental curable materials | |
| EP3468632B1 (en) | Settable bone void filler | |
| EP1464345B1 (en) | Bone growth and adjacent tissue regeneration composition | |
| JP2902452B2 (en) | Glue for fixing granules for medicine and dentistry and granular bone filling material fixed with the glue | |
| Driessens et al. | Applied aspects of calcium phosphate bone cement application | |
| JPH06105901A (en) | Bioimplantation material and its production | |
| EP0416398A1 (en) | Paste for bonding granular bone prosthesis and bone prosthesis using same | |
| CA2616421A1 (en) | Solid precursor for the preparation of a pasty bone replacement material by admixture of a liquid. | |
| JPS6179464A (en) | Composition for artificial bone material | |
| D'Addario et al. | Biomaterials for use in frontal sinus obliteration | |
| JPH09103478A (en) | Hardenable material for medical or dental purpose | |
| Baiomy et al. | Versatility of nano-hydroxyapatite versus nano-β-tricalcium phosphate in grafting of mandibular bone defects: experimental study | |
| Ali et al. | Clinical assessment of a synthetic biomaterial containing hydroxyapatite and beta tricalcium phosphate in socket preservation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |