JPH03127724A - Bath agent - Google Patents
Bath agentInfo
- Publication number
- JPH03127724A JPH03127724A JP26467489A JP26467489A JPH03127724A JP H03127724 A JPH03127724 A JP H03127724A JP 26467489 A JP26467489 A JP 26467489A JP 26467489 A JP26467489 A JP 26467489A JP H03127724 A JPH03127724 A JP H03127724A
- Authority
- JP
- Japan
- Prior art keywords
- ascorbic acid
- bath
- kojic acid
- agent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013040 bath agent Substances 0.000 title claims abstract description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 48
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 24
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 24
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229960004705 kojic acid Drugs 0.000 claims abstract description 24
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 17
- 150000000996 L-ascorbic acids Chemical class 0.000 claims abstract description 14
- 229940072107 ascorbate Drugs 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 230000002087 whitening effect Effects 0.000 abstract description 10
- 239000003795 chemical substances by application Substances 0.000 abstract description 7
- 239000008187 granular material Substances 0.000 abstract description 5
- 239000007787 solid Substances 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 239000000654 additive Substances 0.000 description 10
- 239000003788 bath preparation Substances 0.000 description 10
- 230000000996 additive effect Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 150000000994 L-ascorbates Chemical class 0.000 description 5
- 206010040829 Skin discolouration Diseases 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 244000184734 Pyrus japonica Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000003287 bathing Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 3
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012286 potassium permanganate Substances 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- -1 yunohana Substances 0.000 description 2
- CSTRPYAGFNTOEQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;octadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCCCC(O)=O CSTRPYAGFNTOEQ-MGMRMFRLSA-N 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- BLQKIGOLRJPVAW-RXSVEWSESA-N OP(O)(=O)OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O Chemical compound OP(O)(=O)OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O BLQKIGOLRJPVAW-RXSVEWSESA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 239000004260 Potassium ascorbate Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- POXJXWXPDYFTJM-ZAFYKAAXSA-N [(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-yl] dihydrogen phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1OP(O)(O)=O POXJXWXPDYFTJM-ZAFYKAAXSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 150000004691 decahydrates Chemical class 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- YKEKHNWEUINKJV-UHFFFAOYSA-N kojate Chemical class OCC1=CC(=O)C(=O)CO1 YKEKHNWEUINKJV-UHFFFAOYSA-N 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000019275 potassium ascorbate Nutrition 0.000 description 1
- 229940017794 potassium ascorbate Drugs 0.000 description 1
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、コウジ酸またはコウジ酸塩配合浴用剤にアス
コルビン酸またはアスコルビン酸塩、アスコルビン酸誘
導体を配合することにより、コウジ酸とアスコルビン酸
の相乗効果により色白効果を高めることができる浴用剤
に関するものである。Detailed Description of the Invention [Industrial Field of Application] The present invention is a method of combining kojic acid and ascorbic acid by blending ascorbic acid, an ascorbate salt, or an ascorbic acid derivative into a bath preparation containing kojic acid or a kojate salt. The present invention relates to a bath agent that can enhance the skin whitening effect through a synergistic effect.
［従来の技術］
浴用剤は入浴に際し、湯にとかして使用するちので、従
来その目的とするところは、大きくわけて次のようなも
のである。[Prior Art] Bath preparations are used by dissolving them in hot water when taking a bath, and their conventional purposes can be broadly divided into the following.
（１）硬水を軟化−し洗浄を容易にする。（２）湯に色
と芳香をあたえ、心をやわらげ気分を爽快にさせる。（
３）温泉の有効成分、あるいは薬剤を入れ、治療ないし
は美容効果を出す。（４）皮膚の洗浄を目的とする。(1) Softens hard water and makes cleaning easier. (2) Gives color and aroma to the hot water, soothing the mind and refreshing the mood. (
3) Add active ingredients or medicines from hot springs to produce therapeutic or beauty effects. (4) For the purpose of cleaning the skin.
これらの浴用剤はホウ砂、塩化ナトリウム、炭酸ナトリ
ウム、炭酸水素ナトリウムなどの無機塩を主体として、
これに香料、着色料などを加えたもので簡単に湯に溶け
るものが用いられている。These bath agents mainly contain inorganic salts such as borax, sodium chloride, sodium carbonate, and sodium hydrogen carbonate.
This is used to add flavorings, colorants, etc., which easily dissolves in hot water.
軟水化剤としては、炭酸ナトリウム（１０水和物・ｌ水
和物）、セスキ炭酸ナトリウム、リン酸ナトリウムなど
があげられる。また、殺菌、漂白剤として過マンガン酸
カリウム、過ホウ酸ナトリウムなどが配合され、薬効成
分としては、センキュウ、トウキ、ケイガイ、ハツカ、
イオウ、ホウ砂、湯の花、鉱泉などが配合されている。Examples of water softeners include sodium carbonate (decahydrate and lhydrate), sodium sesquicarbonate, and sodium phosphate. In addition, potassium permanganate, sodium perborate, etc. are included as sterilizing and bleaching agents, and the medicinal ingredients include nebula, japonica, japonica, japonica, and other medicinal ingredients.
Contains sulfur, borax, yunohana, mineral springs, etc.
植物抽出成分としてカミツレやラベンダーなどが使用さ
れることもある。Chamomile and lavender are sometimes used as plant extracts.
従来コウジ酸は、漂白、色白効果を有する成分として知
られており、コウジ酸を色白成分として浴用剤に配合し
て、その効果をあげている（特公昭６３−２７３２２）
。Conventionally, kojic acid has been known as a component that has bleaching and skin-lightening effects, and kojic acid has been added to bath additives as a skin-lightening component to achieve these effects (Japanese Patent Publication No. 63-27322).
.
また、アスコルビン酸またはアスコルビン酸塩、アスコ
ルビン酸誘導体も、色白効果を有する成分として古くか
ら知られており、コウジ酸同様、浴用剤に配合してその
効果をあげている（特開昭６２−９６４１０）。In addition, ascorbic acid, ascorbate salts, and ascorbic acid derivatives have long been known as ingredients that have a skin-whitening effect, and like kojic acid, they have been added to bath preparations to achieve this effect (Japanese Patent Laid-Open No. 62-96410). ).
［発明が解決しようとする問題点］
コウジ酸またはコウジ酸塩を浴用剤に配合すると色白効
果が見られ、シミ・ソバカスの予防等に効果がある。し
かしながら、コウジ酸またはコウジ酸塩のみでは、その
色白効果は弱く、毎日使用しても効果があられれるまで
１カ月近くもかがるという欠点があった。[Problems to be Solved by the Invention] When kojic acid or kojic acid salts are added to bath preparations, a skin whitening effect can be seen, and it is effective in preventing spots and freckles. However, the use of kojic acid or kojic acid salt alone has a weak skin whitening effect and has the disadvantage that it takes nearly a month for the effect to be seen even when used daily.
アスコルビン酸、アスコルビン酸塩、アスコルビン酸誘
導体も、コウジ酸同様色白効果が見られるが、その色白
効果はコウジ酸よりも弱く、さらに強い色白効果がある
浴用剤が望まれていた。Like kojic acid, ascorbic acid, ascorbate salts, and ascorbic acid derivatives have a skin-lightening effect, but their skin-lightening effect is weaker than that of kojic acid, and a bath agent with an even stronger skin-lightening effect has been desired.
本発明者等は、さらに色白効果の優れた浴用剤を開発す
べく、鋭意研究を重ねた結果、コウジ酸またはコウジ酸
塩配合浴用剤にアスコルビン酸またはアスコルビン酸塩
、アスコルビン酸誘導体を配合することにより、コウジ
酸とアスコルビン酸の相乗効果から、さらに高い色白効
果がある浴用剤を得ることができることを見いだし、本
発明を完成するに至った。The present inventors have conducted extensive research in order to develop a bath agent with an even better skin whitening effect, and as a result, they have found that ascorbic acid, an ascorbate salt, or an ascorbic acid derivative is blended into a bath agent containing kojic acid or a kojic acid salt. They discovered that a bath agent with even higher skin whitening effect could be obtained from the synergistic effect of kojic acid and ascorbic acid, and completed the present invention.
すなわち、本発明は、コウジ酸またはコウジ酸塩とアス
コルビン酸、アスコルビン酸塩およびアスコルビン酸誘
導体から選ばれる少なくとも１１ｆｔを含有することを
特徴とする浴用剤に関するものである。That is, the present invention relates to a bath agent characterized by containing kojic acid or a kojic acid salt and at least 11 ft selected from ascorbic acid, ascorbate and ascorbic acid derivatives.
以下に本発明の詳細な説明する。The present invention will be explained in detail below.
本発明に適用されるコウジ酸は、化学名が５−オキシ−
２−才キジメチル−γ−ピロン（Ｃ６Ｈ、０４）であり
、主として、アスペルギルス属等の微生物の発酵液より
抽出又は再結晶等を行って得られるものであるが、もち
ろん合成的手段によって得られるものも使用可能である
。コウジ酸は極めて毒性が弱く、皮膚に対しても、コウ
ジ酸は一時刺激および累積刺激がなく、アレルギー反応
ちまったく見られない安全な物質である。Kojic acid applied to the present invention has a chemical name of 5-oxy-
It is 2-year-old pheasant methyl-γ-pyrone (C6H, 04), which is mainly obtained by extraction or recrystallization from the fermentation liquid of microorganisms such as Aspergillus, but of course it can also be obtained by synthetic means. is also available. Kojic acid has extremely low toxicity and is a safe substance that causes no temporary or cumulative irritation to the skin, and no allergic reactions are observed.
本発明に使用するアスコルビン酸、アスコルビン酸塩、
アスコルビン酸誘導体は、０体、Ｌ体、ラセミ体のどれ
を用いてちかまわない。アスコルビン酸塩としては、ア
スコルビン酸ナトリウム、アスコルビン酸カリウムが一
般的に用いられるが、還元作用があり、色白効果が認め
られるものであれば、これらに限定されるものではない
。また、アスコルビン酸誘導体としては、脂溶性のアス
コルビン酸パルミチン酸エステル、アスコルビン酸ステ
アリン酸エステル、アスコルビン酸２ル／
６パルミテート、アスク・ビン酸の安定な誘導体として
、３位のＯＨ基をリン酸エステル化したアスコルビン酸
−３−リン酸エステルマグネシウムなどが一１ｉｌＱ的
に用いられるが、還元作用があり色白効果が認められる
ものであれば、これらに限定されるものではない。Ascorbic acid, ascorbate used in the present invention,
The ascorbic acid derivative may be 0-form, L-form, or racemic form. As the ascorbate, sodium ascorbate and potassium ascorbate are generally used, but the ascorbate is not limited to these as long as it has a reducing effect and has a skin-whitening effect. In addition, ascorbic acid derivatives include fat-soluble ascorbic acid palmitate, ascorbic acid stearate, ascorbic acid 2/6 palmitate, and stable derivatives of ascorbic acid such as phosphate ester with the OH group at the 3-position. Magnesium ascorbic acid 3-phosphate is commonly used, but the present invention is not limited to these as long as it has a reducing effect and has a whitening effect.
本発明に使用する浴用剤の基剤は一般に浴用剤に使用さ
れている基剤である。例えば、炭酸ガス気泡発生剤とし
て酒石酸、クエン酸、軟水化剤として、炭酸ナトリウム
、リン酸ナトリウム、セスキ炭酸ナトリウムなどの無機
塩１、過マンガン酸カリウムなどの殺菌漂白剤、食塩な
どの皮膚活力賦活成分、その他各種の薬用成分ならびに
色素、香料などである。また固形剤・顆粒剤等の剤形に
形成する際に、賦形剤・結合剤（カルボキシメチルセル
ロースなど）・崩壊剤・滑沢剤（ステアリン酸マグネシ
ウムなど）を加えてもよい。当然のことながら、これら
は、本発明の効果を損なわない質的、量的範囲内で使用
されなければならない。The base of the bath additive used in the present invention is a base commonly used in bath additives. For example, tartaric acid and citric acid are used as carbon dioxide gas bubble generators, inorganic salts such as sodium carbonate, sodium phosphate, and sodium sesquicarbonate are used as water softeners, sterilizing bleaches such as potassium permanganate, and skin revitalizing agents such as table salt are used. ingredients, various other medicinal ingredients, pigments, fragrances, etc. Furthermore, when forming into a dosage form such as a solid agent or granule, an excipient, a binder (such as carboxymethyl cellulose), a disintegrant, or a lubricant (such as magnesium stearate) may be added. Naturally, these must be used within a qualitative and quantitative range that does not impair the effects of the present invention.
め
以上４１浴用剤の基剤にコウジ酸またはコウジ酸塩と、
アスコルビン酸、アスコルビン酸塩、アスコルビン酸誘
導体から選ばれる少なくとも１種を加える。Above 41, kojic acid or kojic acid salt is used as the base of the bath agent,
At least one selected from ascorbic acid, ascorbate, and ascorbic acid derivatives is added.
浴用剤の剤形は、固形剤・液剤・粉剤・顆粒剤・カプセ
ル剤・ゼリー状の固形剤などがあげられ、特にこれらに
限定されるものではない。The dosage forms of bath preparations include solid preparations, liquid preparations, powder preparations, granules, capsules, and jelly-like solid preparations, but are not particularly limited to these.
また、本発明の浴用剤は、浴槽に添加する使用方法だけ
でなく、シャワーヘッド内らしくはシャワーヘッド表面
に装着して使用することも可能である。Furthermore, the bath additive of the present invention can be used not only by adding it to a bathtub, but also by being attached to the surface of the shower head.
本発明の浴用剤において、色白成分であるコウジ酸、コ
ウジ酸塩は、浴槽中の湯水あるいはシャワーより散水さ
れる湯水１１２当りに０．２５〜１２５ｍｇ、アスコル
ビン酸、アスコルビン酸塩、アスコルビン酸誘導体は、
浴槽中の湯水あるいは、シャワーより散水される湯水ｌ
Ｉ２当りに０．５０ｍｇ〜２００ｍｇ配合される様に、
浴用剤に添加するのが好ましい。かかる特定範囲内でコ
ウジ酸、コウジ酸塩、アスコルビン酸、アスコルビン酸
塩、アスコルビン酸誘導体を配合した場合、それぞれ単
独で用いるよりもより大きい色白効果を得ることができ
る。In the bath preparation of the present invention, kojic acid and kojic acid salts, which are skin fairing ingredients, are present in an amount of 0.25 to 125 mg per 112 of hot water in a bathtub or water sprinkled from a shower, and ascorbic acid, ascorbate, and ascorbic acid derivatives are ,
Hot water in the bathtub or hot water sprinkled from the shower
So that 0.50mg to 200mg is mixed per I2,
Preferably, it is added to bath preparations. When kojic acid, kojic acid salts, ascorbic acid, ascorbate salts, and ascorbic acid derivatives are blended within such specific ranges, a greater skin whitening effect can be obtained than when each is used alone.
［実施例］
以下本発明を実施例によって示すが、本発明はちとより
これらの実施例のみに限定されるものではない。[Examples] The present invention will be illustrated below by Examples, but the present invention is not limited to these Examples.
実施例１
−ａ
−ｂ
−ｃ
食
塩
８．８ｇ
８．８ｇ
８．８ｇ
８．８ｇ
コ
ウ
ジ
酸
８．０ｇ
６．０ｇ
合計 ９２ｇ １００．Ｏｇ １００．Ｏｇ １００．
０’ｇセスキ炭酸ナトリウム、食塩、硫酸ナトリウムを
ブレンダーでよくかきまぜながら、他の成分を均一に加
え混合する。これをＬｏｇずつ（１−ａの配合例のみ９
．２ｇ）アルミパックに分配、密封して浴用剤とした。Example 1 -a -b -c Salt 8.8g 8.8g 8.8g 8.8g Kojic acid 8.0g 6.0g Total 92g 100. Og 100. Og 100.
While stirring 0'g sodium sesquicarbonate, salt, and sodium sulfate in a blender, add the other ingredients evenly and mix. This is calculated in Log increments (9 for the formulation example of 1-a only)
．． 2g) Distributed into aluminum packs and sealed to prepare a bath agent.
実施例２
−ａ
−ｂ
−ｃ
−ｄ
色 素
香 料
防腐・抗菌剤
精製水
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
適量
上記物質を均一に混合して、押し出し造粒法を用いて顆
粒を造形し、約３２℃で乾燥後、１２号ふるい（１４１
０ｐｍ）を通過して、４８号ふるい（２９１＃Ｉ＋）に
残留する大きさの顆粒を選択した。さらにこれらの顆粒
をプラスチック容器に充填し、シャワー入浴の際に用い
る浴用剤とした。Example 2 -a -b -c -d Color Fragrance Preservative/Antibacterial Agent Purified water appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount appropriate amount The above substances were mixed uniformly and extrusion granulation method After drying at approximately 32°C, granules were formed using a No. 12 sieve (141
0 pm) and remained on a No. 48 sieve (291 #I+). Furthermore, these granules were filled into a plastic container to prepare a bath agent for use in showering.
試験１
８月に海岸で背部を３時間曝露した男子４０名を、各１
０名づつ、Ａ、Ｂ、Ｃ，Ｄの４群に分けた。Test 1 In August, 40 men were exposed to the back at the beach for 3 hours.
The participants were divided into 4 groups: A, B, C, and D, each with 0 participants.
Ａ群
実施例１−ａの浴用剤を２０Ｃ１２容量の浴槽に１パツ
クずつ加え、毎日１回３０分の浴用を６０日間続けた。One pack of the bath preparation of Example 1-a of Group A was added to a 20C12 bathtub, and the baths were continued for 30 minutes once a day for 60 days.
Ｂ群
実施例１−ｂの浴用剤を２００ｆｉ容量の浴槽に１パツ
クずつ加え、毎日１回３０分の浴用を６０日間続けた。One pack of the bath preparation of Group B Example 1-b was added to a bathtub with a capacity of 200 fi, and bathing was continued for 30 minutes once a day for 60 days.
０群
実施例１−ｃの浴用剤を２００ｆｌ容量の浴槽に１パツ
クずつ加え、毎日１回３０分の浴用を６０日間続けた。Group 0: One pack of the bath preparation of Example 1-c was added to a 200 fl bathtub, and the baths were continued for 30 minutes once a day for 60 days.
Ｄ群
実施例１−ｄの浴用剤を２００℃容量の浴槽に１パツク
ずつ加え、毎日１回３０分の浴用を６０日間続けた。One pack of the bathing agent of Example 1-d in Group D was added to a bathtub with a capacity of 200°C, and the bathing agent was bathed for 30 minutes once a day for 60 days.
計
そして、日焼むづの状態を１０日ごとに色差尋を用いて
明度を測定した。その結果を表１に示した。Then, the brightness of the sun-baked grains was measured every 10 days using a color difference meter. The results are shown in Table 1.
表 １
（平均値±ＳＤ）
表１に示すように、本発明による浴用剤はＡ、Ｂ、Ｃ群
、すべてと比較して、効果が現れる時期が早く、またそ
の色白効果は最とも大きい結果になっており、コウジ酸
とＬ−アスコルビン酸−２リン酸エステルの相乗的な色
白効果が認められた。Table 1 (Mean value ± SD) As shown in Table 1, the bath additive according to the present invention takes effect earlier than all of Groups A, B, and C, and its skin whitening effect is the greatest. The synergistic skin whitening effect of kojic acid and L-ascorbic acid diphosphate was observed.
試験２
女性４０名を各１０名づつＡ、Ｂ、Ｃ，Ｄの４群に分け
た。Test 2 40 women were divided into 4 groups, A, B, C, and D, each with 10 women.
Ａ群
実施例２−ａの浴用剤を４．４ｇずつ、プラスチック容
器を用いてシャワーヘッド表面に装着し、１日１回３０
分のシャワー入浴を６週間続けた。4.4 g each of the bath additive of Group A Example 2-a was attached to the surface of the shower head using a plastic container, and administered once a day for 30 g.
I continued to take showers and baths for 6 weeks.
Ｂ群
実施例２−ｂの浴用剤を５．Ｏｇずつ、プラスチック容
器を用いてシャワーヘッド表面に装着し、１日１回３０
分のシャワー入浴を６週間続けた。5. The bath additive of Group B Example 2-b. Attach Og to the surface of the shower head using a plastic container and apply 30 g once a day.
I continued to take showers and baths for 6 weeks.
Ｃ群
実施例２−ｃの浴用剤を５．Ｏｇずつ、プラスチック容
器を用いてシャワーヘッド表面に装■
着し、１日１回３０分のシャワー入浴を６週間続けた。5. Bath additive of Group C Example 2-c. Each child was placed in a plastic container on the surface of a shower head, and the subjects continued to take a 30-minute shower once a day for 6 weeks.
Ｄ群
実施例２−ｄの浴用剤を５．Ｏｇずつ、プラスチック容
器を用いてシャワーヘッド表面に装着し、１日１回３０
分のシャワー入浴を６週間続けた。5. Bath additive of Example 2-d of Group D. Attach Og to the surface of the shower head using a plastic container and apply once a day for 30 minutes.
I continued to take showers and baths for 6 weeks.
その後、表２に示す方法で官能評価試験を行った。Thereafter, a sensory evaluation test was conducted using the method shown in Table 2.
表 ２
表
表３に示すように、本発明による浴用剤は、Ａ、Ｂ、Ｃ
群すべてと比較して評点が高い結果になっている。Ｄ群
の効果は、Ｂ、Ｃ群両方の９ｊ＋果を兼ね合わせており
、特に、肌の張り、くすみにたいして顕著な効果を確認
することができた。Table 2 As shown in Table 3, the bath additives according to the present invention are A, B, C
This results in higher scores than all groups. The effects of Group D combined the 9j+ effects of both Groups B and C, and in particular, remarkable effects on skin tension and dullness could be confirmed.
Claims (1)
コルビン酸塩およびアスコルビン酸誘導体から選ばれる
少なくとも１種を含有することを特徴とする浴用剤。A bath agent characterized by containing kojic acid or a kojic acid salt and at least one selected from ascorbic acid, ascorbate and ascorbic acid derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26467489A JPH03127724A (en) | 1989-10-11 | 1989-10-11 | Bath agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26467489A JPH03127724A (en) | 1989-10-11 | 1989-10-11 | Bath agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03127724A true JPH03127724A (en) | 1991-05-30 |
Family
ID=17406627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26467489A Pending JPH03127724A (en) | 1989-10-11 | 1989-10-11 | Bath agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03127724A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10182421A (en) * | 1996-12-27 | 1998-07-07 | Kose Corp | Bath preparation |
| JP2004352627A (en) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | External preparation for skin |
-
1989
- 1989-10-11 JP JP26467489A patent/JPH03127724A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10182421A (en) * | 1996-12-27 | 1998-07-07 | Kose Corp | Bath preparation |
| JP2004352627A (en) * | 2003-05-28 | 2004-12-16 | Kuraray Co Ltd | External preparation for skin |
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