JPH0262814A - Powdery cosmetic - Google Patents
Powdery cosmeticInfo
- Publication number
- JPH0262814A JPH0262814A JP21259488A JP21259488A JPH0262814A JP H0262814 A JPH0262814 A JP H0262814A JP 21259488 A JP21259488 A JP 21259488A JP 21259488 A JP21259488 A JP 21259488A JP H0262814 A JPH0262814 A JP H0262814A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- cosmetic
- skin
- ascorbyl
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 47
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 39
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 37
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 37
- 239000000843 powder Substances 0.000 claims abstract description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 15
- 239000002245 particle Substances 0.000 claims abstract description 6
- 239000011777 magnesium Substances 0.000 claims description 24
- 229910052749 magnesium Inorganic materials 0.000 claims description 24
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 12
- 238000010298 pulverizing process Methods 0.000 claims description 11
- 239000002131 composite material Substances 0.000 claims description 9
- KIENGQUGHPTFGC-JLAZNSOCSA-N L-ascorbic acid 6-phosphate Chemical compound OP(=O)(O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O KIENGQUGHPTFGC-JLAZNSOCSA-N 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 4
- 238000013019 agitation Methods 0.000 claims description 3
- 229940091250 magnesium supplement Drugs 0.000 claims 2
- 239000011259 mixed solution Substances 0.000 claims 1
- 238000001238 wet grinding Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 25
- 239000000203 mixture Substances 0.000 abstract description 11
- 238000003756 stirring Methods 0.000 abstract description 9
- 239000004137 magnesium phosphate Substances 0.000 abstract description 7
- 229960002261 magnesium phosphate Drugs 0.000 abstract description 7
- 229910000157 magnesium phosphate Inorganic materials 0.000 abstract description 7
- 235000010994 magnesium phosphates Nutrition 0.000 abstract description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000002244 precipitate Substances 0.000 abstract description 5
- 150000000996 L-ascorbic acids Chemical class 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 16
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 10
- 239000006210 lotion Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000002002 slurry Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 229960005070 ascorbic acid Drugs 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 230000002087 whitening effect Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000002211 L-ascorbic acid Substances 0.000 description 4
- 235000000069 L-ascorbic acid Nutrition 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- -1 Preferably Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 210000004127 vitreous body Anatomy 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明はヒアルロン酸、或いはヒアルロン酸ナトリウム
（以下ヒアルロン酸（塩）と略記する）とＬ−アスコル
ビン酸誘導体とを含有する粉末状の化粧料に関するもの
である。Detailed Description of the Invention (Industrial Application Field) The present invention provides a powdered cosmetic containing hyaluronic acid or sodium hyaluronate (hereinafter abbreviated as hyaluronic acid (salt)) and an L-ascorbic acid derivative. It is related to.
（従来の技術）
従来の粉末状の化粧料或いは顆粒状化粧料は主として美
白化粧料であり、主たる基材としては水溶性粉体と、美
白効果を有するアスコルビン酸とからなっている。使用
にあたっては、粉末状化粧料或いは顆粒状化粧料を手の
ひら等にとって、水或いは化粧水に溶かしてから顔等に
塗布する。(Prior Art) Conventional powdered cosmetics or granular cosmetics are mainly whitening cosmetics, and the main base materials are water-soluble powder and ascorbic acid, which has a whitening effect. To use, take a powdered cosmetic or granular cosmetic in the palm of your hand, dissolve it in water or lotion, and then apply it to your face.
ヒアルロン酸ナトリウムの保湿作用とアスコルビン酸の
美白作用とを組み合わせることが出来れば、優れた化粧
品となることが予想されたが、アスコルビン酸の還元力
でヒアルロン酸の分子鎖が切断されて急激な分子量低下
が起こることが知られてし）るため（八ｇｒｉｃ、Ｂｉ
ｏ１．ｃｈｅｍ、、２５７９〜２５８３．１９８６）
、両成分を組み合わせることは従来行われていなかった
。It was predicted that if the moisturizing effect of sodium hyaluronate and the whitening effect of ascorbic acid could be combined, it would be an excellent cosmetic product, but the reducing power of ascorbic acid would cleave the molecular chains of hyaluronic acid, resulting in a rapid increase in molecular weight. (8gric, Bi
o1. chem, 2579-2583.1986)
, it has not been done in the past to combine both components.
（発明が解決しようとする諜Ｂ）
従来の粉末状化粧料或いは顆粒状化粧料は、手のひらの
上で粉体或いは顆粒体を液体で均一に分散させ或いは溶
解させて肌に塗布する際に、次のような欠点があった。(Intelligence B to be Solved by the Invention) Conventional powdered cosmetics or granular cosmetics are made by dispersing or dissolving the powder or granules uniformly in a liquid on the palm of the hand and applying it to the skin. It had the following drawbacks.
■水とのなじみが悪く、粉末、特に顆粒がつぶれて生じ
た粉末が水に浮く。■It has poor compatibility with water, and powder, especially powder formed by crushing granules, floats on water.
■肌につけた時にざらつき悪がある。■Feels rough when applied to the skin.
本発明者等は、上記の欠点の改善について鋭意研究した
結果、ヒアルロン酸（塩）とリン酸−Ｌ−アスコルビル
マグネシウムとを複合したものを微粉末化すれば、この
欠点が解消することを見い出し、更にヒアルロン酸（塩
）の分子量低下も小さいことを見い出して本発明を完成
した。As a result of intensive research into improving the above-mentioned drawbacks, the present inventors have discovered that this drawback can be overcome by making a composite of hyaluronic acid (salt) and magnesium phosphate-L-ascorbyl into a fine powder. Furthermore, they discovered that the decrease in the molecular weight of hyaluronic acid (salt) was also small, and completed the present invention.
（課題を解決するための手段）
本発明は、ヒアルロン酸（塩）とリン酸−Ｌ−アスコル
ビルマグネシウムとの複合体を含有することを特徴とす
る粉末状化粧料である。(Means for Solving the Problems) The present invention is a powdered cosmetic containing a complex of hyaluronic acid (salt) and magnesium phosphate-L-ascorbyl.
本発明に用いるヒアルロン酸は、関節、硝子体、調帯、
軟骨、皮膚、鳥類のとさか等の結合組織中にその構成成
分として存在し、組織の柔軟性、構造維持、細胞の代謝
調節等に重要な機能を果たしている。またヒアルロン酸
ナトリウムは、高分子物質であり、その溶液は強い粘弾
性を持ち、保水作用を有するところから、化粧品原料と
して広く使用されるほか、眼科治療薬、目薬、関節症治
療薬としての用途がある。The hyaluronic acid used in the present invention can be used for joints, vitreous body, tension zone,
It exists as a component in connective tissues such as cartilage, skin, and bird crests, and plays important functions in maintaining tissue flexibility, structure, and regulating cell metabolism. In addition, sodium hyaluronate is a polymeric substance, and its solution has strong viscoelasticity and water-retaining properties, so it is widely used as a raw material for cosmetics, as well as as an ophthalmological drug, eye drops, and arthropathy drug. There is.
従来、ヒアルロン酸ナトリウムは工業的には、にわとり
のとさか、牛の目の硝子体、又は調帯等からの抽出法か
、或いはヒアルロン酸を生産する能力を持つ微生物を培
地に培養して製造する方法（発酵法）が行われている。Traditionally, sodium hyaluronate has been produced industrially by extraction from chicken combs, the vitreous body of cows' eyes, or by extracting it from the vitreous body of a cow's eye, or by culturing microorganisms capable of producing hyaluronic acid in a medium. method (fermentation method) is being carried out.
本発明に用いられるヒアルロン酸（塩）は、抽出法或い
は発酵法いずれの方法で製造されたものであってもかま
わない。The hyaluronic acid (salt) used in the present invention may be produced by either an extraction method or a fermentation method.
Ｌ−アスコルビン酸くビタミンＣ）は動植物界に広く分
布し、特に野菜・果物に豊富に含まれる。L-ascorbic acid (vitamin C) is widely distributed in the animal and plant kingdoms, and is particularly abundant in vegetables and fruits.
Ｌ−アスコルビン酸は、多様な生理作用・薬理作用を持
つことが知られているが、そのなかでも皮膚の異状色素
沈着症への効果は古くから化粧品関係者の間で知られて
いた。皮膚の色を決定する最大の因子はメラニン色素で
あるが、Ｌ−アスコルビン酸はメラニンに関し、次の２
つの作用があると言われている。L-ascorbic acid is known to have a variety of physiological and pharmacological actions, and among these, its effect on skin dyspigmentation has long been known among those involved in cosmetics. The biggest factor that determines skin color is melanin, and L-ascorbic acid has the following effects on melanin:
It is said that there are two effects.
■メラニン形成の初期段階で生成されるドーパキノンを
ドーパに還元しメラニン形成を抑制する。■It suppresses melanin formation by reducing dopaquinone, which is produced in the early stages of melanin formation, to dopa.
■メラニンを還元して淡色型にする。■Reducing melanin to make it lighter colored.
ただ、Ｌ−アスコルビン酸は乾燥時には比較的に安定で
あるが、水溶液中では空気と光により容易に酸化される
欠点を持つので、水溶性で、安定性が高く、化粧品に配
合しやすいし一アスコルビン酸の誘導体が種々研究され
た結果、美白用化粧品原料として下記構造式を持つリン
酸−Ｌ−アスコルビルマグネシウムが開発された。本発
明ではこのリン酸−Ｌ−アスコルビルマグネシウムを用
いる。However, although L-ascorbic acid is relatively stable when dry, it has the disadvantage that it is easily oxidized by air and light in an aqueous solution. As a result of research into various derivatives of ascorbic acid, magnesium L-ascorbyl phosphate having the following structural formula was developed as a raw material for whitening cosmetics. In the present invention, this L-ascorbyl magnesium phosphate is used.
本発明のヒアルロン酸く塩）とリン酸−Ｌ−アスコルビ
ルマグネシウムとの複合化は、例えば次のように行う。The hyaluronic acid salt of the present invention) and L-ascorbyl magnesium phosphate are combined, for example, as follows.
ヒアルロン酸（塩）の０．０５〜２．０重量％水溶液に
リン酸−Ｌ−アスコルビルマグネシラムラ攪拌しつつ、
徐々に添加して完全に溶解せしめる。リン酸−Ｌ−アス
コルビルマグネシウム水？’Ｊ ？ｆｌにヒアルロン酸
（塩）を加えても良い。ヒアルロン酸（塩）水溶液の濃
度は０．０５重量％以下でも良いが、濃度が薄いと沈澱
する時に用いる溶剤の量が多くなって不経済であり、逆
にヒアルロン酸（塩）水溶液の濃度が２．０重量％以上
となると溶液粘度が粘稠となりすぎて沈澱作業がうまく
いかない。While stirring phosphoric acid-L-ascorbyl magnesi to a 0.05 to 2.0% by weight aqueous solution of hyaluronic acid (salt),
Add slowly until completely dissolved. Phosphate-L-ascorbyl magnesium water? 'J? Hyaluronic acid (salt) may be added to fl. The concentration of the hyaluronic acid (salt) aqueous solution may be 0.05% by weight or less, but if the concentration is too low, the amount of solvent used during precipitation will increase, which is uneconomical. If it exceeds 2.0% by weight, the viscosity of the solution becomes too viscous, making precipitation difficult.
このようにして得られたヒアルロン酸（塩）とリン酸−
Ｌ−アスコルビルマグネシウムとの複合溶液を攪拌しつ
つ、水溶液でヒアルロン酸（塩）とリン酸−Ｌ−アスコ
ルビルマグネシウムの双方に非溶媒である溶剤を徐々に
添加して、ヒアルロン酸（塩）とリン酸−Ｌ−アスコル
ビルマグネシウムを同時に析出せしめる。析出したヒア
ルロン酸（塩）とリン酸−Ｌ−アスコルビルマグネシウ
ム複合体スラリーを液中で微粉砕する。′Ｒ１粉砕終了
後、遠心分離機か濾過機を用いて沈澱物を母液から分離
し、減圧乾燥してヒアルロン酸（塩）とリン酸−Ｌ−ア
スコルビルマグネシウムとの複合体を得る。Hyaluronic acid (salt) and phosphoric acid obtained in this way
While stirring the composite solution with L-ascorbyl magnesium, a non-solvent solvent was gradually added to both hyaluronic acid (salt) and phosphoric acid-L-ascorbyl magnesium in an aqueous solution to separate hyaluronic acid (salt) and phosphorus. Magnesium acid-L-ascorbyl is simultaneously precipitated. The precipitated hyaluronic acid (salt) and magnesium phosphate-L-ascorbyl magnesium composite slurry is pulverized in a liquid. After completion of R1 pulverization, the precipitate is separated from the mother liquor using a centrifuge or a filter and dried under reduced pressure to obtain a complex of hyaluronic acid (salt) and L-ascorbyl magnesium phosphate.
本発明において、ヒアルロン酸（塩）とリン酸−Ｌ−ア
スコルビルマグネシウムの比は任意に変え得るが、実用
的にはヒアルロン酸（塩）１に対しリン酸−Ｌ−アスコ
ルビルマグネシウムは０．１〜１０が望ましい、沈澱に
用いる溶剤は、メタノール、エタノール、アセトン等が
あるが、得られた複合体が化粧品原料であることから、
エタノールを用いることが望ましい。析出したヒアルロ
ン酸（塩）とリン酸−Ｌ−アスコルビルマグネシウム複
合体スラリーを液中で微粉砕する方法としては、湿式粉
砕法である媒体攪拌式粉砕法、或いは湿式高速回転ミル
式粉砕法が良い結果をもたらす。又、微粉砕時に界面活
性剤を用いることも出来る。In the present invention, the ratio of hyaluronic acid (salt) to L-magnesium phosphate-L-ascorbyl can be changed arbitrarily, but practically, the ratio of magnesium phosphate-L-ascorbyl to 1 hyaluronic acid (salt) is 0.1 to 1. 10 is desirable. Solvents used for precipitation include methanol, ethanol, acetone, etc., but since the obtained composite is a raw material for cosmetics,
Preferably, ethanol is used. As a method for finely pulverizing the precipitated hyaluronic acid (salt) and magnesium phosphate-L-ascorbyl composite slurry in a liquid, a wet pulverization method such as a media agitation pulverization method or a wet high speed rotation mill pulverization method is preferable. bring results. Moreover, a surfactant can also be used during pulverization.
本発明の化粧料は、粉末状で使用されるので、粒度が重
要な要素となる。本発明の化粧料の使用目的を満たすた
めには
１０手のひらに取って水或いは化粧水に溶かすとき速や
かに溶けること、
２、肌につけたとき、ざらつき感がないこと、３、二剤
タイプの化粧料として用いるとき、水或いは化粧水に速
やかに溶けること、
４、皮膚の毛穴に入り込んでしまう程の微粒子でないこ
と、
が必要である。この為には、粉体の粒度は０．５〜４０
μであることが望ましい。Since the cosmetic of the present invention is used in powder form, particle size is an important factor. In order to fulfill the purpose of use of the cosmetic of the present invention, 1. It should dissolve quickly when taken in the palm of your hand and dissolved in water or lotion, 2. It should not have a rough feeling when applied to the skin, and 3. It should be a two-drug type makeup. When used as a cosmetic, it must dissolve quickly in water or lotion, and (4) it must not be so fine that it can enter the pores of the skin. For this purpose, the particle size of the powder must be between 0.5 and 40.
It is desirable that μ.
又、上記湿式粉砕法でヒアルロン酸（塩）とリン酸−Ｌ
−アスコルビルマグネシウム複合体スラリーを液中微粉
砕すると、機械的剪断力でヒアルロン酸（塩）の分子量
が約３０％程低下する。従って、原料に用いるヒアルロ
ン酸く塩）の分子量は、予めこのことを考慮に入れて選
ぶ必要がある。In addition, hyaluronic acid (salt) and phosphoric acid-L can be
- When ascorbyl magnesium complex slurry is pulverized in liquid, the molecular weight of hyaluronic acid (salt) is reduced by about 30% due to mechanical shearing force. Therefore, the molecular weight of the hyaluronic acid salt used as a raw material must be selected in advance with this in mind.
ヒアルロン酸（塩）の粉末は、水に溶かす場合、溶液の
粘度が非常に高くなるだけでなく、いわゆるママコが出
来るために、完全に溶解させるのに長時間を要するとい
う欠点を持つ。しかし、本発明の方法で得られたヒアル
ロン酸（塩）とリン酸し−アスコルビルマグネシウムと
の複合体の微粉砕品は、ヒアルロン酸（塩）の単なる微
粉砕品に比しママコになり難く、短時間で水に溶解する
。When hyaluronic acid (salt) powder is dissolved in water, it not only has a very high viscosity, but also has the disadvantage that it takes a long time to completely dissolve it, as so-called "mamako" forms. However, the finely ground product of the complex of hyaluronic acid (salt) and phosphoric acid-ascorbyl magnesium obtained by the method of the present invention is less likely to become lumpy compared to a simply finely ground product of hyaluronic acid (salt). Dissolves in water in a short time.
又、ヒアルロン酸（塩）の微粉砕品とリン酸−Ｌ−アス
コルビルマグネシウムの微粉砕品との単なる混合物は、
水に溶かした場合、かなり急激な粘度低下をおこすのに
対し、本発明の方法で得らレタヒアルロン酸（塩）とリ
ン酸−Ｌ−アスコルビルマグネシウムとの複合体の微粉
砕品は、驚くべきことに水に溶かした場合、殆ど粘度低
下をおこさない。In addition, a mere mixture of a finely ground product of hyaluronic acid (salt) and a finely ground product of magnesium phosphate-L-ascorbyl is
When dissolved in water, the viscosity decreases quite rapidly, whereas the finely pulverized product of the complex of retahyaluronic acid (salt) and magnesium phosphate-L-ascorbyl obtained by the method of the present invention is surprisingly In particular, when dissolved in water, there is almost no decrease in viscosity.
かかる特徴がある為、化粧水と粉体とからなる二剤タイ
プの化粧品の粉体サイドの化粧品原料として本発明のヒ
アルロン酸（塩）とリン酸−Ｌアスコルビルマグネシウ
ムとの複合体の？ｊ＆ Ｆ 砕品を用いることが出来る
。Because of these characteristics, the complex of hyaluronic acid (salt) and phosphoric acid-L-ascorbyl magnesium of the present invention can be used as a cosmetic raw material on the powder side of a two-part cosmetic product consisting of lotion and powder. j&F crushed products can be used.
又、本発明のヒアルロン酸（塩）とリン酸−Ｌ−アスコ
ルビルマグネシウムとの複合体の微粉砕品を手のひらの
上に乗せ、水或いは化粧水を添加して溶解させる時、水
或いは化粧水に容易に溶けるので、肌に塗布する際のざ
らつき惑がなくなる。In addition, when placing the finely pulverized composite of hyaluronic acid (salt) and L-ascorbyl magnesium phosphate of the present invention on the palm of your hand and adding water or lotion to dissolve it, it is possible to dissolve it in the water or lotion. Since it dissolves easily, it eliminates the feeling of roughness when applied to the skin.
又、リン酸−Ｌ−アスコルビルマグネシウム単独の粉末
を水に溶かしたものに比べて、本発明の粉末の水溶液は
粘稠なので肌へも塗布し易い。従って、手のひらの上で
、水或いは化粧水に溶解させて、肌に塗布する型の粉体
化粧料として用いることが出来る。Furthermore, compared to a solution of a powder of L-ascorbyl magnesium phosphate alone dissolved in water, the aqueous solution of the powder of the present invention is more viscous and therefore easier to apply to the skin. Therefore, it can be used as a powder cosmetic that is applied to the skin by dissolving it in water or lotion on the palm of the hand.
かかる化粧料は、当然ヒアルロン酸（塩）の保湿作用と
リン酸−Ｌ−アスコルビルマグネシウムとの美白作用と
を併せ持つ。Such cosmetics naturally have both the moisturizing effect of hyaluronic acid (salt) and the whitening effect of magnesium phosphate-L-ascorbyl.
本発明の粉状化粧料中には、上記の必須成分の他、顔料
・色素・粉体・酸化防止剤・紫″外線吸収剤・香料等を
加えることが出来る。In addition to the above-mentioned essential ingredients, the powdered cosmetic of the present invention may contain pigments, pigments, powders, antioxidants, ultraviolet absorbers, fragrances, and the like.
（発明の効果）
かくして得られた本発明のヒアルロン酸（塩）とリン酸
−Ｌ−アスコルビルマグネシウムとの複合体は、次のよ
うな特徴を持っている。(Effects of the Invention) The thus obtained complex of hyaluronic acid (salt) and magnesium ascorbyl phosphate of the present invention has the following characteristics.
■ヒアルロン酸（塩）の大幅な分子量低下がない。■There is no significant decrease in the molecular weight of hyaluronic acid (salt).
■水とのなじみが良く、ママコになりにくい。■It blends well with water and does not easily become sticky.
■ヒアルロン酸（塩）単体より短時間で水に溶解する。■Dissolves in water in a shorter time than hyaluronic acid (salt) alone.
■肌につけた時にざらつきがなく、すべすべする。■When applied to the skin, there is no roughness and it is smooth.
■保湿作用と美白作用とを合わせ持つ。■Has both moisturizing and whitening effects.
（実施例） 以下、実施例に基づき本発明を具体的に説明する。(Example) Hereinafter, the present invention will be specifically explained based on Examples.
実施例１ （本発明の化粧料の作製）リン酸−Ｌ−ア
スコルビルマグネシウム１．０ｇを純水１００ｍ１中に
溶解した溶液にヒアルロン酸ナトリウム（分子量１１０
万）を０．５ｇ添加し溶解させた。Example 1 (Preparation of cosmetics of the present invention) Sodium hyaluronate (molecular weight 110
0.5 g of 1,000 yen) was added and dissolved.
次にエタノール５００−を水冷上攪拌しながら滴下し沈
澱を生成させた。。Next, 500 ml of ethanol was added dropwise while stirring while cooling with water to form a precipitate. .
上澄を捨て、新たにエタノール５００ ｄを加え、２時
間攪拌した。そのスラリーをミキサーで粉砕後、エタノ
ール中で媒体撹拌式粉砕機・流通管型（−へＢ製ＤＹＮ
ＯＭｒＬＬ ＴＹＰＥ−ＫＤＬ）でグラインディングエ
レメントとしてガラスピーズ直径０．５〜０．７５ｍｍ
を用い、３０００ｒｐｍで７分間連続的に運転し微粉砕
化した。その後、孔径０．４５Ｊ！ｍのミリポアフィル
タ−でろ集し、恒温真空乾燥機（５０℃）で乾燥させ粉
末１．３ｇを得た。分析結果を、第１表に示す。分子量
の測定は高速液体クロマトグラフィーを用いた。The supernatant was discarded, 500 d of ethanol was added, and the mixture was stirred for 2 hours. After pulverizing the slurry with a mixer, it is placed in ethanol using a media agitation type pulverizer/flow tube type (DYN made by B.
OMrLL TYPE-KDL) with glass beads diameter 0.5-0.75mm as a grinding element
The mixture was pulverized by continuous operation for 7 minutes at 3000 rpm. After that, the hole diameter was 0.45J! The mixture was collected by filtration using a Millipore filter, and dried in a constant temperature vacuum dryer (50°C) to obtain 1.3 g of powder. The analysis results are shown in Table 1. High performance liquid chromatography was used to measure the molecular weight.
実施例２ （本発明の化粧料の作製）
発酵法で製造したヒアルロン酸ナトリウムの精製水溶液
３００ｊ？（ヒアルロン酸ナトリウム濃度二０．３％）
に０．２モル／ｌになるように食塩を熔解せしめた。Example 2 (Preparation of cosmetics of the present invention) Purified aqueous solution of sodium hyaluronate produced by fermentation method 300j? (Sodium hyaluronate concentration 20.3%)
Salt was dissolved to a concentration of 0.2 mol/l.
この溶液にリン酸−Ｌ−アスコルビルマグネシウムを１
．８０Ｋｇ添加し、攪拌して完全に溶解せしめた。Add 1 magnesium L-ascorbyl phosphate to this solution.
．． 80 kg was added and stirred to completely dissolve.
この溶液を激しく攪拌しつつ、エタノール９００１を徐
々に添加して沈澱を析出させた。攪拌を停止し、濾過法
で母液を分離した後、得られた沈澱物にエタノール９０
０βを添加して、再度攪拌を行い洗浄を行った。洗浄終
了後、濾過法で母液を分離した。While vigorously stirring this solution, ethanol 9001 was gradually added to precipitate the solution. After stopping stirring and separating the mother liquor by filtration, 90% ethanol was added to the resulting precipitate.
0β was added and stirring was performed again to perform washing. After washing, the mother liquor was separated by filtration.
得られたヒアルロン酸ナトリウム沈澱物にエタノール３
Ｍを攪拌しつつ添加し均一なスラリーとじた。このスラ
リーにソルビンタンモノオレエート０．２７Ｋｇを加え
、２時間攪拌して完全に溶解せしめた。Add 3 ethanol to the obtained sodium hyaluronate precipitate.
M was added with stirring to form a uniform slurry. 0.27 kg of sorbitan monooleate was added to this slurry and stirred for 2 hours to completely dissolve it.
このスラリーを湿式高速回転ミル（商品名：ボソクボル
トホモジナイザー、中央機工製）を用いて、下記条件で
微粉砕した。This slurry was pulverized using a wet high-speed rotation mill (trade name: Bosoku Bolt Homogenizer, manufactured by Chuo Kiko) under the following conditions.
クリアランス ０．０７〜０．０８ｍｍフィード速
度 ＩＱ ｌ ／ｍｉｎ。Clearance 0.07-0.08mm Feed speed IQl/min.
微粉砕は循環して行い、１０分間行った。微粉砕された
スラリーは、吸引濾過によってエチルアルコールと分離
した後、減圧乾燥を行った。得られた乾燥微粉砕品の重
量は２．３５Ｋｇであった。この微粉砕品の平均粒径は
１２．６−であった。Fine pulverization was carried out in circulation for 10 minutes. The finely ground slurry was separated from ethyl alcohol by suction filtration, and then dried under reduced pressure. The weight of the obtained dry and pulverized product was 2.35 kg. The average particle size of this finely pulverized product was 12.6-.
実施例１で行ったように分子量等の測定を行い、第１表
の結果を得た。The molecular weight etc. were measured as in Example 1, and the results shown in Table 1 were obtained.
第１表
実施例３ （本発明の化粧料の性能試験結果）実施例１
で得られた粉末状化粧料を手のひらに取って、水で溶か
して顔に塗布する化粧料として用いた。Table 1 Example 3 (Performance test results of cosmetics of the present invention) Example 1
The obtained powdered cosmetic was taken into the palm of the hand, dissolved with water, and used as a cosmetic to be applied to the face.
比較例１
３０μ以下に粉砕したヒアルロン酸ナトリウム（分子量
７１万） ２９．３部とリン酸−Ｌ−アスコルビルマグ
ネシウム６５．９部を均一に混合したものを、手のひら
に取って、水で溶かして顔に塗布する化粧料として用い
た。Comparative Example 1 A uniform mixture of 29.3 parts of sodium hyaluronate (molecular weight 710,000) crushed to 30μ or less and 65.9 parts of magnesium L-ascorbyl phosphate was taken in the palm of the hand, dissolved with water, and applied to the face. It was used as a cosmetic to be applied to the skin.
実施例３および比較例１の各化粧料について、水に対す
る溶解度と感触をテストし、第２表の結果を得た。The cosmetics of Example 3 and Comparative Example 1 were tested for water solubility and feel, and the results shown in Table 2 were obtained.
試験方法は次の如く行った。The test method was as follows.
１００−のビーカーに５０−の水を入れ、マグネチソク
スターラーで一定の回転速度で攪拌する。試料を５０ｍ
ｇ投入後、水に完全に溶解するまでの時間を測定する。Pour 50 ml of water into a 100 ml beaker and stir with a magnetic stirrer at a constant rotational speed. Sample 50m
After adding g, measure the time until it completely dissolves in water.
（感触テスト〕
約１５■の試料を手のひらの上に取り、これに水を約０
．３ｄ加え指先でかきまぜて、肌に塗布しその感触を調
べた。(Touch test) Take a sample of about 15 cm on the palm of your hand and add about 0.0 ml of water to it.
．． 3d was added, mixed with fingertips, applied to the skin, and its feel was examined.
感触テストの判定
肌につけた時のざらつき感無し・・○
肌につけた時のざらつき感有り・・Ｘ
本発明の粉末状化粧料は、単なる混合品に比べて短時間
に溶解し、肌に塗布した時の感触も良かった。Feeling Test Judgment: No rough feeling when applied to the skin...○ Rough feeling when applied to the skin...X The powdered cosmetic of the present invention dissolves in a shorter time than a simple mixture and is applied to the skin. It felt good when I did it.
実施例４ （本発明の化粧料の性能試験結果）実施例１
で得られた粉末状化粧料を用時調整型（二剤タイプ）の
化粧料として用いた。Example 4 (Performance test results of cosmetics of the present invention) Example 1
The powdered cosmetic obtained was used as a ready-to-use (two-drug type) cosmetic.
比較例２
３０μ以下に粉砕したヒアルロン酸ナトリウム（分子量
７１万）２９゜３部とリン酸−Ｌ−アスコルビルマグネ
シウム６５．９部を均一に混合したものを、化粧料とし
て用いた。Comparative Example 2 A uniform mixture of 29.3 parts of sodium hyaluronate (molecular weight: 710,000) pulverized to 30 μm or less and 65.9 parts of magnesium L-ascorbyl phosphate was used as a cosmetic.
実施例４および比較例２の各化粧料について、その１０
０曙を１００艷の下記に記載の化粧水に溶かし、その溶
液の粘度変化を調べた。その結果は、第３表の如くであ
った。For each cosmetic of Example 4 and Comparative Example 2, Part 10
0 Akebono was dissolved in 100 艷 lotion described below, and the change in viscosity of the solution was examined. The results were as shown in Table 3.
（化粧水の組成〕
グリセリン ３．０％
プロピレングリコール ４．０％
ジプロピレングリコール ４．０％
オレイルアルコール ０．１％
ポリオキシエチレンソルビタン
モノラウリン酸エステル １６５％
エチルアルコール ５．０％
バラヒドロキシ安息香酸メチル
エステル ０．１％
精製水 ８２．３％
香料 適量
本発明の粉末状化粧料は、単なる混合品に比べて、化粧
水に溶解した時に粘度の低下が非常に小さい。(Composition of lotion) Glycerin 3.0% Propylene glycol 4.0% Dipropylene glycol 4.0% Oleyl alcohol 0.1% Polyoxyethylene sorbitan monolaurate 165% Ethyl alcohol 5.0% Methyl hydroxybenzoate Ester 0.1% Purified water 82.3% Perfume Appropriate amount The powdered cosmetic of the present invention has a very small decrease in viscosity when dissolved in lotion compared to a simple mixture.
Claims (6)
ン酸−Ｌ−アスコルビルマグネシウムとの複合体を含有
することを特徴とする粉末状化粧料。(1) A powdered cosmetic containing a complex of hyaluronic acid or sodium hyaluronate and magnesium L-ascorbyl phosphate.
−アスコルビルマグネシウムとの混合溶液から、溶媒沈
澱によって得られたものである請求項１記載の粉末状化
粧料。(2) The complex is sodium hyaluronate and phosphoric acid-L
- The powdered cosmetic according to claim 1, which is obtained by solvent precipitation from a mixed solution with magnesium ascorbyl.
ある請求項１記載の粉末状化粧料。(3) The powdered cosmetic according to claim 1, wherein the composite is a fine powder having a particle size of 0.5 to 40μ.
によって得られた微粉末である請求項３記載の粉末状化
粧料。(4) The powdered cosmetic according to claim 3, wherein the composite having a particle size of 0.5 to 40 μ is a fine powder obtained by wet grinding.
転ミル式粉砕法である請求項４記載の粉末状化粧料。(5) The powdered cosmetic according to claim 4, wherein the wet pulverization is a medium agitation pulverization method or a wet high speed rotation mill pulverization method.
ン酸−Ｌ−アスコルビルマグネシウムとの複合体粉末を
用いた二剤タイプの粉末状化粧料。(6) A two-drug type powdered cosmetic using a composite powder of hyaluronic acid or sodium hyaluronate and magnesium L-ascorbyl phosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21259488A JPH0262814A (en) | 1988-08-29 | 1988-08-29 | Powdery cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21259488A JPH0262814A (en) | 1988-08-29 | 1988-08-29 | Powdery cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0262814A true JPH0262814A (en) | 1990-03-02 |
Family
ID=16625281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21259488A Pending JPH0262814A (en) | 1988-08-29 | 1988-08-29 | Powdery cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0262814A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000029030A1 (en) * | 1998-11-13 | 2000-05-25 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
-
1988
- 1988-08-29 JP JP21259488A patent/JPH0262814A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000029030A1 (en) * | 1998-11-13 | 2000-05-25 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
| US6585987B1 (en) | 1998-11-13 | 2003-07-01 | Continental Projects Limited | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions |
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