JPH02292212A - Bactericide gel - Google Patents

Abstract

PURPOSE: To obtain a water substrate sterilizable gel comprising a carboxypolymethylene polymer (carboma) and a polyhydric alcohol and enabling sterilization of gel by gamma irradiation. CONSTITUTION: This sterilizing gel comprises a carboxypolymethylene polymer (carboma) and 1-90% polyhydric alcohol for stabilization (e.g. ethylene glycol). The carboma (carboxymethylene) can be sterilized by assistance of the polyhydric alcohol and avoids deterioration of gel when the gel is sterilized by γ-radiation derived from cobalt 60. The gel can be used for medical use as a lubricant.

Description

[Detailed Description of the Invention] Summary of the Invention] Water-based sterilizing gel primarily for medical purposes. This gel contains carboxyborimethylene, which allows the gel to be sterilized by gamma radiation. [Industrial Field of Application] The present invention relates to a water-based germicidal gel primarily for medical purposes. [Prior Art and Problems] Gels and ointments are used for medical purposes as lubricants, and
It is widely used as a medicinal active substance and vehicle for various purposes. Products of this type must be sterilized. Sterilizing properties are imparted via steam heating, for example by autoclaving. On the other hand, packaging gels exist, which are usually combined with preservatives such as benzoic acid, parabenzene, and parachloric methacresate. However, the use of preservatives is often inappropriate, since these types of drugs affect the active substance and can induce allergies in susceptible people. Many modern packages made of plastic deteriorate when exposed to the heat commonly applied by autoclaving. For this reason, and because of the negative aspects of using preservatives as mentioned above, it has been suggested that sterilization be carried out by ionizing radiation. Unfortunately, however, water-based gels based on Gum Arabic, Tragacanth Carboma, carboxymethylene cellulose, and other gel reagents lose their gel structure when exposed to ionizing radiation; Forms a low viscosity aqueous solution. [Means for Solving the Problem] However, carboma (carboxymethylene) can be sterilized with the aid of polyhydric alcohols such as ethylene glycol, glycerin, propylene glycol, thereby allowing for example Degradation of the gel is avoided when exposed to gamma radiation for sterilization. According to the invention, a water-based germicidal gel, primarily for medical purposes, containing carboxyborimethylene borimer (carboma) and polyhydric alcohol as a stabilizer, is sterilized by ionizing radiation. A filtered water-based sterilizing gel is provided.

Further, according to the present invention, there is provided the gel, characterized in that it contains 1 to 90% of a stabilizing polyhydric alcohol. [Example] See Table 1.

Anus 1 Carbopol 940 1% 250c+ 20
0(J 200(1 200(1 hydrate sodium sharkide 0.04g O.03(1 0
．． 1! ;I 0.1g 2-methylenehentadiol 150g 7-mouth bilene glycol - 50g Glyneptadiol 2
0(1(1) Viscosity at cp before injection 70,000 48,00
Viscosity of 0 70,000 90,000Ill
60,000 49,000 65,00
The effect on stability has not been discussed in great detail for glycerin, a substance with well-described cosmetic properties. This effect is shown in Table 2. Glycerin content in % 2% Carbopol 934 g 200 99% glycerol g i Retained water 9 200 Sodium axillate g o. 1 Viscosity at CP before γ Viscosity at CP after γ Glycerin content in % 2% Carpobol 99% Glycerol g 40 1 standing water g 160 Sodium axillary water g o, 1 At CP before γ Viscosity 41,000 42,000 43,000 5
5,000O 3,400 29,000 37,000 50,0
0054,000 78,000 72,000 Table 2 0.1 0.1 2.5 0.1 0.1 0.1 Viscosity at cp after γ 45,000 60,00
0 65,000 As is clear from Table 2, even a low content of several percent has a stabilizing effect on carboxyborimethylene gel.

Claims (2)

[Claims] (1) A water-based sterilizing gel primarily for medical purposes that contains carboxypolymethylene polymer (carboma) and polyhydric alcohol as a stabilizer, and is sterilized by ionizing radiation. Characteristic water-based sterilizing gel. (2) The gel according to claim 1, characterized in that it contains 1 to 90% of a stabilizing polyhydric alcohol.