JPH02284063A - Automatic analyzer - Google Patents

Abstract

PURPOSE:To quickly and easily perform reanalysis by immediately performing interrupt reanalysis when the measured data are rejected. CONSTITUTION:In the optical measurement, at every time when a reaction table 6 performs one rotation and one pitch rotation, absorbency measurement in the wavelength for measuring every item of the whole reaction tube is performed. When the absorbency of measuring beam is too small or too large or when the data are uncreditable, the measuring beam is controlled by the respective controlling parts 22, 24 and indicated on an operation panel 23. Reanalysis is indicated and a correspondent specimen is read out. An output terminal is connected to the connecting part 25 of both a power plant 91 for driving a sample table 4 and a motor for controlling a sampling pipet. In such a way, the sample table 4 is returned to the suction position of a vessel for reanalysis specimen and the sampling pipet 9 is worked by interruption. Reanalysis is enabled and prescribed operation is continued. Abnormality of reanalysis is decided in a reanalysis decision mechanism 24. Thereby reanalysis quickly and easily is performed.

Description

[Detailed Description of the Invention] (1) Field of Industrial Application The present invention relates to an automatic analyzer, and particularly relates to an automatic analyzer capable of multi-purpose and multi-item measurements that can perform biochemical analysis with high precision and high speed. . The present invention also relates to a sampling suction position suitable for reanalysis in an automatic analyzer.

[Conventional technology]

When analyzing samples such as blood and plasma, it is necessary to process many samples and analysis items in a short time.
In order to improve efficiency, the mainstream method was to use standard samples and compare actual measured values with indicated values. Furthermore, in recent years, automated analyzers have systems in which a power unit is connected to enable the sample container transport section to be rotated forward and backward, and a reading device is installed on the conveyor path between the analyzed sample container accommodating section and the sample suction position to provide feedback. (Japanese Unexamined Patent Publication No. 63-85457) was disclosed.

[Problem that the invention seeks to solve]

However, the conventional method of comparing and correcting the analytical value of the actual measured value of the standard sample and the indicated value of the specimen is a method that can be determined and implemented after all lots have been analyzed, so re-analysis is required. In order to do this, it was difficult to extract from analyzed samples, and it required a lot of effort and time. Furthermore, in the reanalysis system applied to recent automatic analyzers, the sampling is transported from the suction position on a conveyor path, stored in the analyzed storage section, and then fed back for reanalysis. However, the disadvantage was that it required some time.

In order to solve such conventional problems, the present invention aims to provide a reanalysis system that can be quickly and easily implemented in an automatic analyzer having a turret-shaped sample table and a reaction table. It is.

[Means for solving problems]

In order to achieve the above object, the present invention provides a turret-shaped sample table that holds a plurality of sample containers for general specimens on the outer periphery and further maintains sample containers for emergency specimens on the inner periphery. Has an identification function,
A number of reaction tables are arranged concentrically on the outer periphery of the sample table so as to be rotatable forward and backward, a first reagent table and a second reagent table are installed near the reaction table, and a sampling pipette device disposed adjacent to the reaction table for selectively dispensing a sample or diluted sample into a reaction tube or a dilution tube;
A first reagent pipette device for dispensing a first reagent disposed between the first reagent table and the reaction table, and the reaction table and the second reagent table for dispensing a second reagent or a third reagent into a reaction tube. It is equipped with a second reagent pipette device placed between the two, and an optical measurement device that colorimetrically measures the reaction solution in the reaction tube. Provided is an automatic analyzer characterized in that it immediately performs an interrupt re-analysis if a problem occurs.

[For production]

The present invention has the following effects due to the above configuration.

That is, the sampling pipette device operates, and the pipette nozzle at one end reads a predetermined amount of the sample from the sample container, uses the function to aspirate the sample stored in the computer, dispenses it into the reaction tube, and at the same time, the pipette nozzle at the other end aspirates the sample stored in the computer. The pipette nozzle is cleaned internally and externally. The sampling operation is then repeated in accordance with the sample measurement items stored in the computer.

In addition, for a certain measurement item, the sample is diluted to a predetermined ratio, and the sampling pipette device is activated to aspirate the required amount of diluted sample from the dilution tube, and then dispensed into the reaction tube. . Depending on the urgency of the clinical test, there are two types of specimens: a reading function for general specimens and emergency specimens, and
Alternatively, the containers are classified using the container identification function, and emergency specimens are sampled with priority over general specimens. Next, when the first reagent bottle and the second reagent bottle table corresponding to the measurement item arrive at a predetermined reagent suction position, the pipette nozzle at one end of the first reagent pipette device and the pipette nozzle at one end of the second reagent pipette device respectively After the first reagent and the second reagent are actuated and measured by suction, they are injected into the reaction tube. At about the same time, the pipette nozzle at each other end is cleaned internally and externally. The reaction liquid dispensed into these reaction tubes generates bubbles due to the introduction of air.
The movement provides stirring, which serves to homogenize and accelerate the reaction. In the optical measurement device, the measurement light enters the light guiding hole of the reaction table and passes through the reaction liquid in the reaction tube, is separated by a concave diffraction grating, is measured using a photodiode element, and the concentration is calculated by a microcomputer. will be held. If the absorbance is below or above a certain value, or if data is lost due to other reasons, reanalysis is performed. At this time, the corresponding sample containers and reaction tubes are immediately read by the reading mechanism with the identification mark and/or the container identification mechanism, and the reading output terminal of the device is connected to the power device for driving the sample table and the motor control device for driving the sampling nozzle. Connected to the input section. In this way, return the sample table to the sample suction position of the reanalysis sample container,
The interrupt allows the sampling pipette to be activated and re-analyzed. Detection of abnormalities in reanalysis is determined by a reexamination mechanism. At this time, arithmetic processing device [Embodiment] Hereinafter, embodiments of the present invention will be described with reference to the drawings.

FIG. 1 shows an automatic analyzer, in which 4 is a turret-shaped sample table, 6 is a reaction table placed on the outer periphery of the sample table 4, 7 is a first reagent table placed near the reaction table 6, and 8 is a reaction table placed on the outer periphery of the sample table 4. Similarly, the second reagent table is shown. In addition, 9 is a sampling pipette device,
Reference numeral 11 indicates a first reagent pipette device, and reference numeral 13 indicates a second reagent pipette device, both of which are arranged adjacent to the reaction table 6. 14 is a first reagent table 7 and a second reagent table 8
This is an optical measurement device placed in the middle of the A plurality of sample containers l for general specimens are placed on the outer periphery of the sample table 4, similar dilution tubes 2 are placed on the middle periphery, and sample containers 3 for emergency specimens are arranged in a circular manner on the inner periphery. A large number of each are held in sequential order. The sample containers 1 and 3 contain the required amount of the specimen (serum, urine, etc.) collected from the whole body to be measured, and the sample container 1, emergency specimen sample container 3, and dilution tube 2 described above contain the required amount of specimen (serum, urine, etc.) to be measured. A barcode is attached to the sample, and the history of the sample can be read using the reader 15. The sample table 4 is rotationally driven by a drive device 91, and when a predetermined sample container l reaches a predetermined sample suction position, the sample history is identified by a reading mechanism 15 and a container recognition device 16, and a computer (not shown) ). A predetermined amount of the specimen in the sample container 1 is aspirated through the pipette nozzle 105 at one end of the sampling pipette device 9, and then dispensed into the corresponding reaction tube 5 at the sample discharge position.
At the same time, it is read by the recognition device @16, and the computer stores which sample has been injected into which reaction tube. Also,
When using an emergency specimen in a predetermined sample container 3, the sample table 4 is rotated and transferred to a predetermined sampling position a, and then the sampling device moves and extracts the emergency specimen from a pipette nozzle 105 at one end. After aspirating the required amount from the sample container 3, the sample is read in the same manner as above, and dispensed into the reaction tube 5 at the discharge position.

Furthermore, when storing a diluted sample obtained by diluting the sample in the sample container 1 or the emergency sample container 3 to a required ratio into the dilution tube 2, the holder 104 of the sample pipette device 9 moves and the pipette nozzle 105 is inserted into the sample container. 1 or the emergency sample container 3, the sample is injected into the dilution tube 2 as a diluted sample, read by the reading mechanism 15, and stored in the computer.

Note that when the diluted sample is dispensed from the dilution tube 2 into the corresponding reaction tube 5, the pipette nozzle 105 at one end of the sampling pipette device 9 is attached to the pipette nozzle 105 in accordance with the above-described operation.

Next, the first reagent table 7 and the second reagent table 8
, a plurality of first reagent bottles IO and second reagent bottles I2 used for the reaction are placed respectively, and when the reaction tube 5 into which the first sample has been dispensed comes to the first reagent discharge position 5, the first reagent bottle IO and the second reagent bottle I2 are placed. The table 7 rotates and rotates and transfers the first reagent bottle IO corresponding to the measurement item to d corresponding to the measurement item, and the required amount of the first reagent is sucked into the pipette nozzle 39 and the stirring nozzle 41 is brought close to the first reagent pipette nozzle 39. stirring pump 20
The reaction solution in the reaction tube 5 is stirred by sending air through the reaction tube 5. Furthermore, the reaction tube 5 is transferred at a required pitch, and when it reaches the second reagent discharge position g, the second reagent table 8 rotates and transfers the reagent bottle 12 corresponding to the measurement item to the second reagent suction position e. A required amount of the second reagent is absorbed into the pipette nozzle 40 from within the second reagent bottle 12 via the second reagent pipette device 13, and the second reagent pipette is transferred to the reagent discharge position 9 to dispense the required amount into the reaction tube 5. be done.

When the reaction table 6 is transferred two pitches, the stirring pump 21 is sent to the stirring nozzle 42 arranged in parallel to the second reagent pipette.
Air is sent to stir the reaction liquid in the reaction tube 5. The pipettes are washed with extruded water.

The optical measurement device I4 uses a multi-wavelength photometer and has a light source lamp 14.
The light from 1 passes through the condenser lens 142, and the measurement light that enters the light guiding hole (not shown) of the reaction table 6 is reflected by the reflecting mirror 143 and passes through the slit 144 to the concave diffraction grating 1.
45, and a plurality of light receiving elements 146 pass through an amplifier, an AD converter, and a microcomputer to calculate the concentration of the current change of each wavelength. During the optical measurement, the absorbance at the measurement wavelength of each item of all the reaction tubes is measured every time the reaction table 6 rotates once and every pitch.

If the absorbance of the measurement light is less or more than the specified value,
In the case of data transmission, it is controlled by the respective control units 22 and 24, displayed on the operation panel 23, and becomes a reanalysis display.
The corresponding sample is read, and the output end is connected to the drive power device 91 of the sample table 4 and the connection part 25 of the sampling pipette control motor.

As described above, the sample table 4 is returned to the suction position of the reanalysis sample container, the sampling pipette 9 is operated as an interrupt, and reanalysis becomes possible, and the predetermined operation continues. The abnormality of the reanalysis is determined by the reanalysis determination mechanism 24 and executed.

〔Effect of the invention〕

The present invention is an automatic analyzer having a turret-shaped sample table and a reaction table that can quickly interrupt and perform re-analysis. It has a reanalysis determination function, and its output end is connected to the sample table drive device and sampling pipette control motor connection.
In the event of data abnormalities, we have a system that allows for immediate re-analysis, without waiting for the entire analysis to be completed.

[Brief explanation of drawings]

FIG. 1 is a plan view of an automatic analyzer according to an embodiment of the present invention. ■, sample container for general laboratory use, dilution tube 3, sample container for emergency specimen 4, sample table 60, reaction table 7, first reagent table 8. Second reagent table 9, sampling pipette device 10, first reagent bottle 11. First reagent pipette device 1
2. Second reagent bottle 13. Second reagent pipette device 14
, optical measuring device 15. Reading mechanism 16, container recognition device 24. Reanalysis determination device patent applicant Nippon Techtron Co., Ltd.

Claims (1)

[Claims] A sample table that holds a plurality of sample containers for general specimens on the outer periphery, and samples for emergency specimens on the inner periphery, and reaction tubes arranged in forward and reverse rotation on the outer periphery of the sample table are held. An automatic analyzer comprising a reaction table, further having an identification function for the sample container and reaction tube, connected to a re-examination determination mechanism, and immediately interrupting and re-analyzing when measured data is rejected. .