JPH02280771A - Percutaneous medicine gradually-exerting fiber and coated material constituted therefrom - Google Patents
Percutaneous medicine gradually-exerting fiber and coated material constituted therefromInfo
- Publication number
- JPH02280771A JPH02280771A JP1105177A JP10517789A JPH02280771A JP H02280771 A JPH02280771 A JP H02280771A JP 1105177 A JP1105177 A JP 1105177A JP 10517789 A JP10517789 A JP 10517789A JP H02280771 A JPH02280771 A JP H02280771A
- Authority
- JP
- Japan
- Prior art keywords
- transdermal
- drug
- fiber
- transdermal drug
- sustained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 71
- 239000000835 fiber Substances 0.000 title claims abstract description 54
- 239000000463 material Substances 0.000 title claims abstract description 30
- 229920000642 polymer Polymers 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 11
- 239000000057 synthetic resin Substances 0.000 claims abstract description 11
- 239000004744 fabric Substances 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 8
- 239000011248 coating agent Substances 0.000 claims abstract description 7
- 238000000576 coating method Methods 0.000 claims abstract description 7
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 7
- 238000009987 spinning Methods 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 63
- 238000013268 sustained release Methods 0.000 claims description 31
- 239000012730 sustained-release form Substances 0.000 claims description 31
- 238000013269 sustained drug release Methods 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000012790 adhesive layer Substances 0.000 claims description 4
- -1 lactone compound Chemical class 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 229920005594 polymer fiber Polymers 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 abstract description 4
- 238000000859 sublimation Methods 0.000 abstract description 2
- 230000008022 sublimation Effects 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 5
- 239000010419 fine particle Substances 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 150000003976 azacycloalkanes Chemical class 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 229920006237 degradable polymer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000002074 melt spinning Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 201000003152 motion sickness Diseases 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229940024473 salicylic acid emollient and protective preparations Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Artificial Filaments (AREA)
- Multicomponent Fibers (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は経皮薬物投与技術に係る経皮薬物徐放繊維及び
経皮薬物徐放繊維で構成した被服素材に関するものであ
る。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to transdermal drug sustained release fibers and clothing materials made of transdermal drug sustained release fibers related to transdermal drug administration technology.
［従来の技術］
濃度を調整しながら薬物を徐々に放出する材料である薬
物徐放剤としては、従来より湿布薬等としてのものが一
部に応用されている。[Prior Art] As a sustained drug release agent, which is a material that gradually releases a drug while adjusting the concentration, it has been used in some cases as a poultice and the like.
［発明が解決しようとする課題］
しかし、これらの湿布薬等は一般に基布に塗着したペー
スト状の蒸散性添加材と混練した薬剤を皮膚面に接触保
持させて使用するものであり、徐放速度が比較的短く、
また制御することが難しいといった問題を有していた。[Problems to be Solved by the Invention] However, these poultices and the like are generally used by keeping a paste-like evaporative additive applied on a base fabric and a medicine kneaded with the skin surface, and the The release rate is relatively short,
Another problem was that it was difficult to control.
またこれらの湿布薬では皮膚面に密着してしまうため、
皮膚呼吸や発汗を妨げる等の問題から長期間の連続使用
及び広範囲の同時使用ができないものであった。Also, since these poultices adhere closely to the skin surface,
Continuous use over a long period of time or simultaneous use over a wide range of conditions was not possible due to problems such as interfering with skin breathing and perspiration.
本発明は上記問題に鑑みてなされたものであり、「着る
」感覚で投薬することができる経皮薬物徐放繊維及び経
皮薬物徐放繊維で構成した被服素材を提供することを目
的とするものである。The present invention has been made in view of the above-mentioned problems, and aims to provide transdermal drug sustained release fibers and clothing materials made of transdermal drug sustained release fibers that can be administered with the feeling of "wearing them". It is something.
［課題を解決するための手段］
本発明に係る経皮薬物徐放繊維及び経皮薬物徐放繊維で
構成した被服素材は、経皮薬物を繊維中に徐放作用をも
たせるように存在させることを要旨とするものである。[Means for Solving the Problems] The transdermal sustained drug release fibers and the clothing material made of the transdermal sustained drug release fibers according to the present invention have a transdermal drug present in the fibers so as to have a sustained release effect. The main points are as follows.
該経皮薬物徐放繊維は、経皮薬物の微粉を経時的に分解
又は昇華する性質を有する高分子化合物被膜（以下「経
時的分解又は昇華性高分子化合物被膜」と称する）によ
ってコーティングすることが好ましく、該コーティング
した経皮薬物の微粉と合成樹脂重合体との混練組成物を
紡糸することを要旨とする。また該経皮薬物徐放繊維を
織成又は編成した布或は不織布等の被服素材にしてこれ
を下着やサポータとして着用することを要旨とするもの
である。The transdermal drug sustained release fibers are coated with a polymer compound coating that has the property of decomposing or sublimating the fine powder of the transdermal drug over time (hereinafter referred to as "temporal decomposition or sublimation polymer compound coating"). is preferred, and the gist thereof is to spin a kneaded composition of the coated fine powder of the transdermal drug and the synthetic resin polymer. Another object of the present invention is to make a clothing material such as a cloth or nonwoven fabric woven or knitted from the transdermal sustained drug release fiber and wear it as underwear or a supporter.
上記経皮薬物徐放繊維は、経皮薬物を繊維の芯部又は局
部に偏在せしめた芯鞘構造であってもよし１゜
更に経皮薬物徐放繊維を織成又は編成した布或は不織布
等の被服素材の面に粘着層を被設することもできる。The above-mentioned transdermal drug sustained release fiber may have a core-sheath structure in which the transdermal drug is unevenly distributed in the core or locally of the fiber, or may be a cloth or nonwoven fabric woven or knitted with the transdermal drug sustained release fiber. An adhesive layer can also be provided on the surface of the clothing material.
〔作用コ
上記構成の経皮薬物徐放繊維は、経皮薬物と合成樹脂重
合体との混線組成物を紡糸したものであるから、合成樹
脂重合体は極めて細く糸状に引き伸ばされており、糸の
内部方向に延びる微細な多数の孔を構成するようになる
。従って、該系中に存在させた経皮薬物は該微細な孔か
ら徐々に滲出し、結果として経時的に移行してしまう。[Function] The sustained transdermal drug release fiber with the above structure is made by spinning a mixed composition of a transdermal drug and a synthetic resin polymer, so the synthetic resin polymer is stretched into an extremely thin thread. It forms a large number of fine pores extending inward. Therefore, the transdermal drug present in the system gradually oozes out from the fine pores, resulting in migration over time.
経皮薬物徐放繊維で構成した被服素材によって例えばア
ンダーシャツを構成した場合、該繊維に混線紡糸した経
皮薬物が着用時に皮膚を通して体内に投与される。For example, when an undershirt is constructed from a clothing material made of fibers for sustained release of transdermal drugs, the transdermal drugs spun into the fibers are administered into the body through the skin when worn.
また上記経皮薬物を経時分解又は昇華性高分子化合物被
膜でコーティングすることによって、該被膜の解消速度
の調節によって徐放速度が制御される。即ち、該高分子
化合物被膜のコーティングは、オキシ酸とラクトン化合
物からなる化合物の種類を変えることにより解消時間が
変えられ、長時間に亘って経皮薬物の放出速度を制御す
ることができる。Furthermore, by coating the transdermal drug with a film of a polymer compound that decomposes over time or sublimes, the sustained release rate can be controlled by adjusting the rate of dissolution of the film. That is, the resolution time of the polymer compound coating can be changed by changing the type of compound consisting of an oxyacid and a lactone compound, and the release rate of the transdermal drug can be controlled over a long period of time.
また使用に際して皮膚面にアンダーシャツが接触しては
いるものの、皮膚面を密封することがないため皮膚呼吸
や発汗を妨げることがなく、長期間の連続使用及び広範
囲の同時使用を可能にし。Furthermore, although the undershirt comes into contact with the skin surface during use, it does not seal the skin surface, so it does not impede skin breathing or perspiration, making continuous use over a long period of time and simultaneous use over a wide range possible possible.
経皮薬物の投与を行うことができる。Transdermal drug administration can be performed.
［実施例］
以下１本発明に係る被服素材を織成又は編成或は不織布
に構成するための経皮薬物徐放繊維の実施例について説
明する。[Example] Hereinafter, an example of a transdermal sustained drug release fiber for forming a clothing material according to the present invention into a woven, knitted or non-woven fabric will be described.
踊遣Ｊ１１途ＩＩＬ敬
経皮薬物徐放繊維（１）
経皮薬物（後述する）を粒径２μｍ以下に粉砕した後、
該微粉を融解したナイロンからなる繊維基材に１０重量
％の添加率で配合し、充分に混練して均一に分散した混
練組成物を調整すると共に、この混線組成物をスクリュ
ー型溶融紡糸機により７０Ｄの糸として吐出して経皮薬
物徐放繊維とする。Odori J11 IIL Percutaneous drug sustained release fiber (1) After pulverizing a transdermal drug (described later) to a particle size of 2 μm or less,
The fine powder is blended into a fiber base material made of melted nylon at an addition rate of 10% by weight, thoroughly kneaded to prepare a uniformly dispersed kneaded composition, and this mixed wire composition is then mixed using a screw-type melt spinning machine. It is extruded as a 70D thread to make a transdermal drug sustained release fiber.
経皮薬物徐放繊維（２） 経皮薬物を粒径５μｍ以下に粉砕した後。Transdermal drug sustained release fiber (2) After pulverizing the transdermal drug to a particle size of 5 μm or less.
該微粒子を種類を異にする化合物の組合せによってそれ
ぞれ分解解消時間を異にするべく調節したオキシ酸とラ
クトン化合物からなる経時分解性高分子化合物により被
膜コーティングする。該コーティングした経皮薬物の微
粒子を融解したナイロンからなる繊維基材に１０重量％
の添加率で配合し、充分に混練して均一に分散した混練
組成物を調整すると共に、この混練組成物をスクリュー
型溶融紡糸機により７０Ｄの糸として吐出して経皮薬物
徐放繊維とする。The fine particles are coated with a film of a time-degradable polymer compound consisting of an oxyacid and a lactone compound whose decomposition time is adjusted to vary depending on the combination of different types of compounds. 10% by weight of the coated transdermal drug fine particles are added to a fiber base material made of melted nylon.
Mixed at an addition rate of .
他の繊維基材としては、アクリル、ポリエステル等、熱
可塑性合成線状重合体を使用することができる。As other fiber base materials, thermoplastic synthetic linear polymers such as acrylic and polyester can be used.
経皮薬物に代えて、経皮薬物と経皮吸収促進薬物（後述
する）の混成物からなる微粒子を使用することができる
。Instead of a transdermal drug, fine particles made of a mixture of a transdermal drug and a transdermal absorption-enhancing drug (described later) can be used.
穂ｎ曳
経皮薬物として使用可能な薬剤の例
Ａ０局所適応薬剤
（１）消炎鎮痛剤
サリチル酸製剤、ステロイド製剤、非ステロイド製剤
（２）抗腫瘍剤
Ｂ、全身適応薬剤
（１）乗物酔防止剤
（２）循環巻用剤
冠血管拡張剤
（３）ホルモン剤
（４）解熱・鎮痛・消炎・鎮痒剤
ステロイド製剤、非ステロイド製剤、抗ヒスタミン製剤
（５）制吐薬
（６）抗腫傷薬
（７）抗菌薬
（８）ホルモン薬
該経皮薬物としては、粉粒体のほか液体の形態でも利用
することができる。Examples of drugs that can be used as transdermal drugs A0 Locally applicable drugs (1) Anti-inflammatory and analgesic salicylic acid preparations, steroid preparations, nonsteroidal preparations (2) Antitumor agent B, systemically applicable drugs (1) Anti-motion sickness agent (2) Coronary vasodilators (3) Hormonal agents (4) Antipyretic, analgesic, antiinflammatory, and antipruritic agents Steroid preparations, nonsteroidal preparations, antihistamine preparations (5) Antiemetics (6) Antitumor drugs ( 7) Antibacterial drugs (8) Hormonal drugs The transdermal drugs can be used in liquid form as well as powder.
旦羞」」すし１１隻
（１）アザシクロアルカン２オン
１アルキル−２ピロリドン−５カルボン酸の脂肪族炭化
水素エステル
ピロリドン誘導体
（２）その他
Ｄａｒｍｅｉｅｃ、 ５ａｐａｓ
から る
（１）縦横糸が経皮薬物徐放繊維である織成布材。11 pieces of sushi (1) Aliphatic hydrocarbon ester pyrrolidone derivative of azacycloalkane 2-one 1-alkyl-2-pyrrolidone-5-carboxylic acid (2) Others from Darmeiec, 5apas (1) The warp and weft are transdermal drugs A woven fabric material that is a sustained release fiber.
（２）縦横糸の何れかが経皮薬物徐放繊維である織成布
材。(2) A woven cloth material in which any of the warp and weft yarns are transdermal drug sustained release fibers.
（３）織糸の全部が経皮薬物徐放繊維である編成布材。(3) A knitted cloth material in which all of the yarns are transdermal sustained drug release fibers.
（４）織糸の一部が経皮薬物徐放繊維である編成布材。(4) A knitted cloth material in which a portion of the yarn is transdermal drug sustained release fiber.
（５）糸の全部が経皮薬物徐放繊維である不織布材。(5) A nonwoven material in which all of the threads are transdermal drug sustained release fibers.
（６）糸の一部が経皮薬物徐放繊維である不織布材。(6) A nonwoven material in which a portion of the threads are transdermal drug sustained release fibers.
鳳１ｉ佳９Ｊ９［匠
（１）アンダーシャツ、パンツ、ブリーフ、ａ下等の衣
類。Otori 1i Ka9J9 [Takumi (1) Clothing such as undershirts, pants, briefs, and lower a.
（２）サポータ、線帯、マスク等の医療補助用品。(2) Medical auxiliary supplies such as supporters, wire belts, and masks.
（３）シーツ、布団（綿であってもよい）、布団カバー
、枕カバー等の寝具。(3) Bedding such as sheets, futons (which may be made of cotton), duvet covers, and pillowcases.
（４）その他ぬいぐるみ等。(4) Other stuffed animals, etc.
の からなる
前述した経皮薬物徐放繊維の織成布材、編成布材或は不
織布材の一面に皮膚面と密着する粘着層を形成する。An adhesive layer that is in close contact with the skin surface is formed on one side of the woven fabric material, knitted fabric material, or nonwoven fabric material of the above-mentioned transdermal drug sustained release fiber.
粘着層の皮膚に対する粘着力によって論述部に安定保持
することができる。It can be stably held on the essay part by the adhesive force of the adhesive layer to the skin.
ぼす影響は極めて大きい。The impact of this is extremely large.
［発明の効果］
以上述べたように本発明に係る経皮薬物徐放繊維及び経
皮薬物徐放繊維で構成した被服素材によれば、経皮薬物
徐放繊維に混練紡糸した経皮薬物が経時分解又は昇華性
高分子化合物被膜の解消によって予め調整した時間を経
て徐放されるもので。[Effects of the Invention] As described above, according to the transdermal drug sustained release fiber and the clothing material made of the transdermal drug sustained release fiber according to the present invention, the transdermal drug mixed and spun into the transdermal drug sustained release fiber is It is released in a sustained manner over a pre-adjusted period of time due to decomposition over time or dissolution of the sublimable polymer compound coating.
経皮薬物の放出速度を自由に制御することができるため
、安全性の高い投薬を行うことができる。Since the release rate of transdermal drugs can be freely controlled, medication can be administered with high safety.
Claims (9)
してなる経皮薬物徐放繊維。(1) A sustained-release transdermal drug fiber obtained by spinning a kneaded composition of a transdermal drug and a synthetic resin polymer.
成樹脂重合体繊維の芯部に位置するように紡糸してなる
芯鞘構造の経皮薬物徐放繊維。(2) Transdermal sustained drug release fibers with a core-sheath structure, which are obtained by spinning a kneaded composition of a transdermal drug and a synthetic resin polymer so that the composition is located in the core of a synthetic resin polymer fiber.
成樹脂重合体繊維の周部に位置するように紡糸してなる
芯鞘構造の経皮薬物徐放繊維。(3) Transdermal sustained drug release fibers with a core-sheath structure, which are obtained by spinning a kneaded composition of a transdermal drug and a synthetic resin polymer so that the composition is located around the periphery of a synthetic resin polymer fiber.
成または編成した布或は不織布等の被服素材。(4) A clothing material such as cloth or nonwoven fabric woven or knitted with the transdermal sustained drug release fiber according to claim 1, 2 or 3.
４記載の経皮薬物徐放繊維及び経皮薬物徐放繊維で構成
した被服素材。(5) The transdermal sustained drug release fiber and the clothing material comprising the transdermal sustained drug release fiber according to any one of claims 1 to 4, wherein the transdermal drug is in the form of fine powder or liquid.
する性質を有する高分子化合物被膜によってコーティン
グした構造になる請求項１乃至４記載の経皮薬物徐放繊
維及び経皮薬物徐放繊維で構成した被服素材。(6) Transdermal drug sustained release fibers and transdermal drug sustained release fibers and transdermal drug sustained release fibers and transdermal drug sustained release fibers according to claims 1 to 4, wherein the transdermal drug has a structure in which the fine powder particles are coated with a polymeric compound film having a property of decomposing or sublimating over time. A clothing material made of loose fibers.
合物被膜がオキシ酸とラクトン化合物からなる種類を異
にする化合物の組合せである請求項６記載の経皮薬物徐
放繊維及び経皮薬物徐放繊維で構成した被服素材。(7) The transdermal drug sustained release fiber and transdermal drug according to claim 6, wherein the polymeric compound coating having the property of decomposing or sublimating over time is a combination of different types of compounds consisting of an oxyacid and a lactone compound. Clothing material composed of slow-release fibers.
の混成物を紡糸してなる請求項１乃至７記載の経皮薬物
徐放繊維及び経皮薬物徐放繊維で構成した被服素材。(8) Instead of the transdermal drug, the transdermal drug sustained release fibers and transdermal drug sustained release fibers according to claims 1 to 7 are formed by spinning a mixture of a transdermal drug and a transdermal absorption promoting drug. clothing material.
布等の被服素材の面に粘着層を被設した請求項４乃至８
記載の経皮薬物徐放繊維で構成した被服素材。(9) Claims 4 to 8, wherein an adhesive layer is provided on the surface of a clothing material such as cloth or nonwoven fabric woven or knitted with transdermal drug sustained release fibers.
A clothing material composed of the transdermal sustained drug release fiber described above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1105177A JPH02280771A (en) | 1989-04-24 | 1989-04-24 | Percutaneous medicine gradually-exerting fiber and coated material constituted therefrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1105177A JPH02280771A (en) | 1989-04-24 | 1989-04-24 | Percutaneous medicine gradually-exerting fiber and coated material constituted therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02280771A true JPH02280771A (en) | 1990-11-16 |
| JPH0431716B2 JPH0431716B2 (en) | 1992-05-27 |
Family
ID=14400398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1105177A Granted JPH02280771A (en) | 1989-04-24 | 1989-04-24 | Percutaneous medicine gradually-exerting fiber and coated material constituted therefrom |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02280771A (en) |
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1989
- 1989-04-24 JP JP1105177A patent/JPH02280771A/en active Granted
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| US8987340B2 (en) | 2005-12-22 | 2015-03-24 | Oakwood Laboratories, Llc | Sublimable sustained release delivery system and method of making same |
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| US9301919B2 (en) | 2005-12-22 | 2016-04-05 | Oakwood Laboratories, Llc | Sublimable sustained release delivery system and method of making same |
| US11434586B2 (en) | 2010-07-02 | 2022-09-06 | The Procter & Gamble Company | Filaments comprising an active agent nonwoven webs and methods for making same |
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| JP2014055119A (en) * | 2012-09-13 | 2014-03-27 | Teika Seiyaku Kk | Drug-containing ultrafine fiber and utilization thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| JPH0431716B2 (en) | 1992-05-27 |
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