JPH02209674A - Rod seal in sealing treatment device - Google Patents
Rod seal in sealing treatment deviceInfo
- Publication number
- JPH02209674A JPH02209674A JP1028928A JP2892889A JPH02209674A JP H02209674 A JPH02209674 A JP H02209674A JP 1028928 A JP1028928 A JP 1028928A JP 2892889 A JP2892889 A JP 2892889A JP H02209674 A JPH02209674 A JP H02209674A
- Authority
- JP
- Japan
- Prior art keywords
- bellows
- pressure
- space
- airtight chamber
- rod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000007789 sealing Methods 0.000 title claims description 9
- 238000011282 treatment Methods 0.000 title description 3
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 4
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Landscapes
- Sealing With Elastic Sealing Lips (AREA)
- Sealing Devices (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は気密室内の雰囲気の汚染防止を完全に行える構
造のロッドシールに関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a rod seal having a structure that completely prevents contamination of the atmosphere within an airtight chamber.
近年、気密室内で行う処理１例λば凍結真空乾燥などが
種々の分野で使われるようになり４各々の分野によって
要求される条件も多様化している。特に凍結真空乾燥の
対象が六晶や医薬品、生体試料などである場合には、雑
菌や異物などの侵入を防ぎ、無菌化を完全に行う必要が
ある。In recent years, treatments performed in airtight chambers, such as freeze-vacuum drying, have come to be used in a variety of fields, and the conditions required by each field are also diversifying. Particularly when the target of freeze-vacuum drying is hexagonal crystals, pharmaceuticals, biological samples, etc., it is necessary to completely sterilize the material by preventing the invasion of bacteria and foreign substances.
しかし、従来の凍結真空乾燥装置では第３図に示すよう
に、乾燥庫（２１）内の棚板（２４）を昇降させるため
のシリンダロッド（２２）が外部のシリンダ（２３）か
ら真空シール（２９）を経由して直接乾燥庫（２１）内
部に導入されている。そして、このシリンダロツド（２
２）は特に除菌されている訳ではないので、その表面に
付着した雑菌等が乾燥庫（２１）内に侵入する可能性が
あり、そのような場合には、いくら乾燥庫（２１）内を
予め滅菌したり、導入ガスを除菌フィルタに通したりし
ても、乾燥庫（２１）内を完全に無菌化することはでき
なかった。However, in the conventional freeze-vacuum drying apparatus, as shown in FIG. 29) directly into the drying chamber (21). And this cylinder rod (2
2) has not been particularly sterilized, so there is a possibility that bacteria adhering to its surface may enter the drying cabinet (21). Even if the inside of the drying chamber (21) was sterilized in advance or the introduced gas was passed through a sterilization filter, it was not possible to completely sterilize the interior of the drying chamber (21).
本発明は以上のような問題に鑑みてなされ、気密室の無
菌操作を完全に行える構造のロッドシールに関する。The present invention was made in view of the above problems, and relates to a rod seal having a structure that allows complete aseptic operation of an airtight chamber.
〔課題を解決するための手段］
上記目的は、気密室の外部から出入するロッドに、該ロ
ッドを包囲するようなベローズを取り付け、該ベローズ
で包囲した内部を排気する排気装置を取り付け、前記ベ
ローズの内部空間と前記気密室内の空間、及び前記ベロ
ーズの内部空間と前記気密室の外部空間とを各々遮断す
るようにしたことを特徴とする密封処理装置におけるロ
ッドシールによって達成される。[Means for Solving the Problems] The above object is to attach a bellows to surround the rod that goes in and out of the airtight chamber from the outside, and to attach an exhaust device to exhaust the inside surrounded by the bellows. This is achieved by a rod seal in a sealing processing apparatus characterized in that the internal space of the bellows is isolated from the space inside the airtight chamber, and the internal space of the bellows is isolated from the external space of the airtight chamber.
以上のように構成される密封処理装置におけるロッドシ
ールによれば、気密室内の空間、ベローズの内部空間お
よび気密室の外部空間とがそれぞれ完全に遮断されるた
め、予め滅菌した気密室に雑菌等が侵入するのを完全に
防止することができるとともに、ベローズ内外の差圧を
小さ（することにより、ベローズの寿命を延ばすことも
できる。According to the rod seal in the sealed processing device configured as described above, the space inside the airtight chamber, the internal space of the bellows, and the external space of the airtight chamber are completely isolated from each other. It is possible to completely prevent the intrusion of the bellows, and by reducing the differential pressure between the inside and outside of the bellows, the life of the bellows can be extended.
次に実施例について図面を参照して説明する。 Next, embodiments will be described with reference to the drawings.
第１図に示される装置は本発明に係るロッドシールを備
えた密封処理装置の１例としての凍結真空乾燥装置であ
る。乾燥庫（１１の内部に複数の棚板（４）が設けられ
、該棚板（４）を昇降させるためのシリンダロッド（２
）が外部のシリンダ（３）から乾燥１！［１１内部に導
入されている。シリンダロッド（２）の周りにこれを包
囲するような形でベローズ（７）を取り付けた。ベロー
ズ取り付は部分を第２図に詳細に示すが、公知の方法に
よってベローズ（７）と装置外壁（１９）およびシリン
ダロッド（２）あるいは棚板（４）との接続部分を各々
シールリングｆ９ａ） 、 ｆ９ｂ） 、 ｆ９ｃ）で
シールし、かつ要所を気密に溶接して、ベローズ（７）
内部の空間旦を、乾燥庫ｉｌ＋内部の空間Δ及び外部と
から各々遮断した。The apparatus shown in FIG. 1 is a freeze-vacuum drying apparatus as an example of a sealing apparatus equipped with a rod seal according to the present invention. A plurality of shelf boards (4) are provided inside the drying chamber (11), and a cylinder rod (2) is provided for raising and lowering the shelf boards (4).
) is dried from the external cylinder (3) 1! [Introduced inside 11. A bellows (7) was attached around the cylinder rod (2) so as to surround it. The bellows installation portion is shown in detail in FIG. 2, and the connection portions between the bellows (7), the device outer wall (19), the cylinder rod (2), or the shelf plate (4) are each connected to the seal ring f9a by a known method. ), f9b), f9c) and welded airtightly at key points, then attach the bellows (7).
The internal space DA was isolated from the drying chamber il+internal space Δ and the outside, respectively.
すなわち、ベローズ（７）の上端部はベローズ支持板（
９ｄ）に気密に溶接され、ベローズ支持板（９ｄ）はシ
ールリング（９ａ）、シールリング部材（９ｅ）を介し
て、シール基板（９ｆ）に固定される。シール基板（９
ｆ）と装置の外壁（１９）とが接する所は気密に溶接さ
れており、シリンダ支持部材（２ｏ）がシール基板（９
ｆ）にン容接により固設されている。同様にベローズ（
７）の下端部は他方のベローズ支持板（９ｄ）に溶接さ
れ、ベローズ支持板（９ｄ）はシールリング（９ｃ）、
シールリング部材（９ｅ）を介して棚板（４）に接続さ
れている。又、シリンダロッド（２）との間は、ベロー
ズ上部のシールリング部材（９ｅ）と気密に接続するガ
イド部材（９ｇ）と、シールリング（９ｂ）とによって
シールされると同時に摺動自在となっている。That is, the upper end of the bellows (7) is connected to the bellows support plate (
9d), and the bellows support plate (9d) is fixed to the seal base plate (9f) via the seal ring (9a) and the seal ring member (9e). Seal board (9
f) and the outer wall (19) of the device are welded airtightly, and the cylinder support member (2o) is connected to the sealing substrate (9).
f) It is fixedly installed by a receptacle. Similarly, bellows (
7) The lower end part is welded to the other bellows support plate (9d), and the bellows support plate (9d) has a seal ring (9c),
It is connected to the shelf board (4) via a seal ring member (9e). Moreover, the guide member (9g), which is airtightly connected to the seal ring member (9e) on the upper part of the bellows, and the seal ring (9b) provide a seal between the cylinder rod (2) and the cylinder rod (2), and are slidable at the same time. ing.
ベローズ（７）の内部空間旦を排気するように、メカニ
カルブースタ（８ａ）、油回転真空ポンプ（８ｂ）とか
ら成る真空ポンプ（８）を設け、配管途中に圧力ゲージ
Ｇ＊［１３１を取り付けた。別に乾燥１１！（１１内部
の圧力を測定する圧力ゲージＧ、ｆ１２）を取り付け、
両正力ゲージの検知量、すなわち表示を比較するように
、配管を圧力比較器（１４）に接続した。乾燥庫（１１
の内部を予め洗浄、滅菌しておき、薬液（１８）を入れ
たバイアル瓶（５）にゴム栓（６）を半打栓した状態で
棚板（４）の上に並べた。A vacuum pump (8) consisting of a mechanical booster (8a) and an oil rotary vacuum pump (8b) was installed to exhaust the internal space of the bellows (7), and a pressure gauge G* [131 was installed in the middle of the piping. . Especially dry 11! (Attach pressure gauge G, f12 to measure the pressure inside 11),
The piping was connected to a pressure comparator (14) so as to compare the detected amounts, ie, the displays, of both positive force gauges. Drying warehouse (11
The inside of the bottle was previously cleaned and sterilized, and the vial bottle (5) containing the drug solution (18) was placed on the shelf board (4) with the rubber stopper (6) partially plugged.
冷却、加熱用媒体を媒体入口（１６）から媒体出口（１
７）へと通して薬液の温度を制御した。排気口（１５）
に接続した真空ポンプ（図示せず）によって乾燥庫ｉｌ
＋ の内部を真空にすると同時に、真空ポンプ（８）に
よってベローズ（７）の内部をも真空にした。この時、
圧力ゲージＧｘｆ１３）の表示の方が圧力ゲージＧｌ（
１２１の表示よりも低くなるように、すなわち、ベロー
ズ（７）内の空間旦の圧力の方が乾燥庫＋１１内の空間
Δの圧力よりも低くなるようにした。凍結真空乾燥の処
理が終了した後、油圧ポンプ（ｌＯ）の操作によって外
部のシリンダ（３）からシリンダロッド（２）を導入し
、棚板（４）を降下させてバイアル瓶（５）のゴム栓（
６）を打栓し完全に密封した。以後、公知の方法によっ
てバイアル瓶を取り出した。The cooling and heating medium is passed from the medium inlet (16) to the medium outlet (1
7) to control the temperature of the chemical solution. Exhaust port (15)
A vacuum pump (not shown) connected to the drying cabinet
At the same time as the inside of the bellows (7) was evacuated using the vacuum pump (8). At this time,
The display on the pressure gauge Gxf13) is better than the display on the pressure gauge Gl(
In other words, the pressure in the space Δ in the bellows (7) was made to be lower than the pressure in the space Δ in the drying chamber +11. After the freeze-vacuum drying process is completed, the cylinder rod (2) is introduced from the external cylinder (3) by operating the hydraulic pump (lO), the shelf board (4) is lowered, and the rubber of the vial (5) is removed. plug(
6) was capped and completely sealed. Thereafter, the vial was taken out by a known method.
上記実施例においてベローズ（７）が、シリンダロッド
（２）の昇降、及び乾燥庫ｆｉｌ内の真空に耐λるのに
充分な強度を有する場合には何も問題はないので、真空
ポンプ（８）の設置を省くことができる。しかし、ベロ
ーズ（７）内が大気圧であれば、真空の乾燥庫（１１内
との差圧が大きいのでベローズは破損し易く、もし万一
ベローズ（７）が破損すると、折角、予め滅菌しておい
た乾燥庫（１１内に雑菌等が侵入してしまうことになる
。従って実施例のように真空ポンプ（８）を設け、ベロ
ーズ（７）内の空間旦の方を乾燥庫（１）内の空間Δよ
りも低圧に保ち、かつ両者の差圧を小さくすることによ
って、予め空間川内を滅菌することができ、かつベロー
ズ（７）が破損する可能性を少な（し、しかも、万一ベ
ローズ（７）が破損しても空間川内に残っている雑菌等
が空間Δに侵入することが防がれる。この際に、圧力ゲ
ージＧ、（１３）と圧力ゲージＧｌ（１２１とが圧力比
較器（１４）に接続されているので１通常はＧ２の表示
＜ Ｇ ＋の表示であるのが、ベローズ（７）が破損す
ると（Ｇ、−Ｇ、）が所定値以下となって圧力比較器（
１４）が７告を発し、即刻、対処することができる。以
上のようにして、万一の場合にも雑菌等の侵入が防がれ
る。In the above embodiment, if the bellows (7) has sufficient strength to withstand the lifting and lowering of the cylinder rod (2) and the vacuum in the drying chamber fil, there is no problem. ) can be omitted. However, if the inside of the bellows (7) is at atmospheric pressure, the difference in pressure between it and the inside of the vacuum drying chamber (11) is large, so the bellows is easily damaged. Therefore, as in the embodiment, a vacuum pump (8) is installed to move the space inside the bellows (7) into the drying cabinet (11). By keeping the pressure lower than the internal space Δ and reducing the differential pressure between the two, it is possible to sterilize the internal space in advance, and to reduce the possibility that the bellows (7) will be damaged (in addition, if Even if the bellows (7) is damaged, bacteria remaining in the space can be prevented from entering the space Δ. At this time, the pressure gauge G, (13) and the pressure gauge Gl (121) are compared with each other for pressure comparison. Since the bellows (7) is connected to the pressure comparator (14), the display normally shows G2 < G +, but if the bellows (7) is damaged, (G, -G,) becomes less than the predetermined value and the pressure comparator (
14) issues 7 complaints and can be dealt with immediately. In the above manner, invasion of various germs and the like can be prevented even in the unlikely event of an accident.
以上、本発明の実施例について説明したが、勿論、本発
明はこれに限定されることなく、本発明の技術的思想に
基づき、種々の変形が可能である。The embodiments of the present invention have been described above, but of course the present invention is not limited thereto, and various modifications can be made based on the technical idea of the present invention.
例λば本実施例では棚板昇降用のシリンダロッド（２）
にベローズ及び真空ポンプが設けられたが、それだけで
なく他の、外部から乾燥庫内に出入するロッド、例えば
棚板落下防止用ロッド等があれば全てに適用され得る。For example, in this example, the cylinder rod (2) for raising and lowering the shelf
Although a bellows and a vacuum pump are provided, the present invention may be applied to any other rod that enters and exits the drying chamber from the outside, such as a rod for preventing shelves from falling.
この場合には複数のベローズの内部の排気を１つの真空
ポンプで行うことができる。In this case, the interiors of the plurality of bellows can be evacuated using one vacuum pump.
又、本実施例では凍結真空乾燥装置に使用したロッドシ
ールについて説明したが、本発明は他のと封処理装匠に
も通用し得る。Further, in this embodiment, a rod seal used in a freeze-vacuum drying apparatus has been described, but the present invention can also be applied to other sealing treatments.
例えば無菌操作が不可欠な錠剤製３ａ器において、容器
に入った薬扮を圧縮成形するための杵を昇降させるシリ
ンダロッドに、ベローズ及び真空ポンプを取り付けて使
用しても良いし、気密室に接続させる配管中のバルブの
ロッドに適用しても良い。For example, in a 3A tablet making machine where aseptic operation is essential, a bellows and a vacuum pump may be attached to the cylinder rod that raises and lowers the pestle used to compress and mold the medicinal preparation in the container, or it may be connected to an airtight chamber. It may also be applied to valve rods in piping.
又、ベローズの強度が充分であればベローズ内を′排気
する真空ポンプを省略することもできる。Furthermore, if the bellows has sufficient strength, a vacuum pump for evacuating the inside of the bellows can be omitted.
さらに又、気密室内の減圧の程度は広い範囲で選択しつ
る。Furthermore, the degree of vacuum in the airtight chamber can be selected within a wide range.
本発明は以上のような構成になっているので、無菌操作
が要求される気密室において雑菌等の侵入が完全に防止
される。Since the present invention is configured as described above, the intrusion of various germs and the like is completely prevented in an airtight room where aseptic operation is required.
第１図は凍結真空乾燥装置に本発明の実施例が取り付け
られた状態の部分断面模式図であり、第２図は、第１図
に示される装置のベローズ取り付は部分を詳細に示した
断面図であり、第３図は従来技術の真空シールを取り付
けた凍結真空乾燥装置の部分断面模式図である。
なお、図において。
ｌ）・・・・・・・・・・・・・乾 燥 庫２）・
・・・・・・・・・・・・シリンダロッド７ ・・・・
・・・・・・・・・ベ ロ − ズ８）・・・・・・・
・・・・・・真空ポンプ９ａｌ （９ｂｌ （９ｃ）
−・シールリング９ｇｌ・・・・・・・・・・・・ガ
イ ド 部 材１２）・・・・・・・・・・・・圧力ゲ
ージＧ＋１３１・・・・・・・・・・・・圧力ゲージＧ
２１４）・・・・・・・・・・・・圧力比較器Ａ・・・
・・・・・・・・・・・乾燥庫内の空間Ｂ・・・・・・
・・・・・・・・ベローズ内の空間代 理 人
飯 阪 泰 雄
第１
回
８・・・・・・・真空ボンフ。
旦・・・・・・ベローズ内の空間
第２図FIG. 1 is a schematic partial cross-sectional view of the embodiment of the present invention attached to a freeze-vacuum drying device, and FIG. 2 is a detailed view of the bellows attachment portion of the device shown in FIG. 1. FIG. 3 is a schematic partial cross-sectional view of a freeze-vacuum drying apparatus equipped with a prior art vacuum seal. In addition, in the figure. l)・・・・・・・・・Drying cabinet 2)・
・・・・・・・・・・・・Cylinder rod 7 ・・・・・・
・・・・・・・・・Bellow 8）・・・・・・・・・
・・・・・・Vacuum pump 9al (9bl (9c)
-・Seal ring 9gl・・・・・・・・・・・・ga
I Do member 12)・・・・・・・・・Pressure gauge G+131・・・・・・・・・・・・Pressure gauge G
214)・・・・・・・・・Pressure comparator A...
・・・・・・・・・・・・Space B in the drying chamber・・・・・・
・・・・・・・・・Space agent inside the bellows Human food Yasuo Saka 1st episode 8・・・・・・Vacuum bonfu. Dan... Space inside the bellows Diagram 2
Claims (4)
包囲するようなベローズを取り付け、該ベローズで包囲
した内部を排気する排気装置を取り付け、前記ベローズ
の内部空間と前記気密室内の空間、及び前記ベローズの
内部空間と前記気密室の外部空間とを各々遮断するよう
にしたことを特徴とする密封処理装置におけるロッドシ
ール。(1) A bellows that surrounds the rod is attached to a rod that enters and exits from the outside of the airtight chamber, and an exhaust device that exhausts the interior surrounded by the bellows is attached, and the internal space of the bellows and the space inside the airtight chamber are and a rod seal in a sealing processing apparatus, characterized in that the internal space of the bellows and the external space of the airtight chamber are each isolated from each other.
と、前記ベローズ内の圧力を測定する第２の圧力測定器
とを備え、前記第１の圧力測定器の圧力と前記第２の圧
力測定器の圧力との比較によって、前記ベローズが破損
したことを知らせる手段を備えたことを特徴とする第１
項記載の密封処理装置におけるロッドシール。(2) A first pressure measuring device that measures the pressure inside the airtight chamber, and a second pressure measuring device that measures the pressure inside the bellows, and the pressure of the first pressure measuring device and the second pressure measuring device are provided. A first method characterized by comprising means for notifying that the bellows is damaged by comparing the pressure with the pressure of the pressure measuring device.
Rod seal in the sealing processing device described in Section 1.
１項又は第２項記載の密封処理装置におけるロッドシー
ル。(3) The rod seal in the sealing device according to item 1 or 2, wherein the airtight chamber is sterilized.
徴とする第１項、第２項又は第３項記載の密封処理装置
におけるロッドシール。(4) The rod seal in the sealing processing apparatus according to item 1, item 2, or item 3, wherein freeze-vacuum drying is performed in the airtight chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1028928A JP2733780B2 (en) | 1989-02-08 | 1989-02-08 | Rod seal in sealing processing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1028928A JP2733780B2 (en) | 1989-02-08 | 1989-02-08 | Rod seal in sealing processing equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02209674A true JPH02209674A (en) | 1990-08-21 |
| JP2733780B2 JP2733780B2 (en) | 1998-03-30 |
Family
ID=12262063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1028928A Expired - Fee Related JP2733780B2 (en) | 1989-02-08 | 1989-02-08 | Rod seal in sealing processing equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2733780B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109751277A (en) * | 2019-02-27 | 2019-05-14 | 沈阳北碳密封有限公司 | Self priming pump positive/negative-pressure operating condition mechanical seal |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55113873A (en) * | 1979-02-23 | 1980-09-02 | Hitachi Ltd | Low pressure device |
| JPS62163369U (en) * | 1986-03-31 | 1987-10-17 |
-
1989
- 1989-02-08 JP JP1028928A patent/JP2733780B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55113873A (en) * | 1979-02-23 | 1980-09-02 | Hitachi Ltd | Low pressure device |
| JPS62163369U (en) * | 1986-03-31 | 1987-10-17 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109751277A (en) * | 2019-02-27 | 2019-05-14 | 沈阳北碳密封有限公司 | Self priming pump positive/negative-pressure operating condition mechanical seal |
| CN109751277B (en) * | 2019-02-27 | 2024-02-13 | 沈阳北碳密封有限公司 | Positive and negative pressure working condition mechanical seal for self-priming pump |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2733780B2 (en) | 1998-03-30 |
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