WO1994017836B1 - A method of decontaminating a chamber that has movable shelves - Google Patents
A method of decontaminating a chamber that has movable shelvesInfo
- Publication number
- WO1994017836B1 WO1994017836B1 PCT/US1994/000564 US9400564W WO9417836B1 WO 1994017836 B1 WO1994017836 B1 WO 1994017836B1 US 9400564 W US9400564 W US 9400564W WO 9417836 B1 WO9417836 B1 WO 9417836B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chamber
- container
- vacuum
- liquid
- sterilant
- Prior art date
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract 14
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims abstract 4
- 230000001954 sterilising Effects 0.000 claims abstract 4
- 239000007788 liquid Substances 0.000 claims 23
- 238000005202 decontamination Methods 0.000 claims 8
- 230000003588 decontaminative Effects 0.000 claims 8
- FVTRDWMTAVVDCU-UHFFFAOYSA-N acetic acid;hydrogen peroxide Chemical compound OO.CC(O)=O FVTRDWMTAVVDCU-UHFFFAOYSA-N 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
Abstract
A method of decontaminating or sterilizing chamber systems including freeze dryers at low temperature and pressure levels by utilizing vaporized sterilant, preferably hydrogen peroxide, peracetic acid and mixtures thereof is disclosed.
Claims
AMENDED CLAIMS
[received by the International Bureau on 29 July 1994 (29.07.94); original claim 21 cancelled; original claims 1-20 replaced by amended claims 22-42; new claim 43 added (7 pages)]
22. A method for decontaminating a chamber system to a predetermined level, that comprises the steps of: a) providing a chamber system having at least a lower and an upper shelf, at least one of which is vertically movable while maintaining its horizontal position, a condenser, and piping that are fluidly connected to each other and to a vacuum system; b) placing at least one container containing a predetermined amount of liquid sterilant into the chamber on at least one shelf; c) placing a loose fitting cap on said at least one container; d) moving one of the shelves until the adjacent shelf presses against the at least one container cap thereby sealing the container; e) evacuating the chamber, condenser and piping to a vacuum of predetermined subatmospheric absolute pressure, wherein the chamber system is isolated from the vacuum system; f) moving another of said movable shelves until the cap on the at least one container is no longer sealed on the container; g) vaporizing at least a portion of said liquid sterilant by exposing said liquid sterilant to the evacuated chamber environment; and h) maintaining the vacuum and exposing the interior of said chamber to sterilant vapor for a predetermined time until a predetermined level of decontamination is achieved.
23. The method of claim 22, wherein the liquid sterilant in said container is selected from the group consisting essentially of hydrogen peroxide and peracetic acid and mixtures thereof.
24. The method of claim 22, wherein the liquid sterilant in said container is from between about 30% to about 35% by weight concentration of aqueous hydrogen peroxide solution.
25. The method of claim 22, wherein the mass of liquid sterilant is small compared to the mass of the container to prevent freezing.
26. The method of claim 22, wherein the predetermined level of decontamination is sterilization.
27. The method of claim 22, wherein the chamber system is a freeze dryer system.
28. The method of claim 22, wherein the method further comprises repeating steps d) through h) for each additional shelf until a predetermined level of decontamination is achieved.
29. A method for decontaminating a chamber system that comprises the steps of a) providing a chamber system having a bottom, at least one middle and a top shelf, wherein at least two of the shelves are vertically movable while maintaining a horizontal position and which can be stopped in any position, a condenser, and piping that are fluidly connected to each other and to a vacuum system; b) placing multiple containers containing a predetermined amount of liquid sterilant into the chamber on at least two of the shelves each of which is directly below and adjacent to one of the other shelves; c) placing a loose fitting cap on each container;
- 26 - d) selectively moving each movable shelf to press the caps and seal the containers on an adjacent shelf; e) evacuating the chamber, condenser and piping to a vacuum of a first predetermined subatmospheric absolute pressure, wherein the chamber system is isolated from the vacuum system; f) moving at least one of the movable shelves until the cap on each container on a respective adjacent shelf is released and the container is no longer sealed; g) vaporizing the liquid sterilant in each non-sealed container by exposing the liquid to the evacuated chamber; h) maintaining the vacuum and exposing the interior of the chamber to sterilant vapor for a first predetermined time; i) venting air into the chamber, thereby raising the pressure within the chamber to a second predetermined subatmospheric absolute pressure; j) evacuating the chamber, condenser and piping to a vacuum of a third predetermined subatmospheric absolute pressure, wherein the chamber system is isolated from the vacuum system; ) moving at least a second one of the movable shelves until the cap on each container on a respective adjacent shelf is released and the container is no longer sealed; i) vaporizing the liquid sterilant in each non-sealed container by exposing the liquid' to the evacuated chamber environment; and m) maintaining the vacuum and exposing the interior of said chamber to sterilant
- 27 - vapor for a second pre-determined time until a predetermined level of decontamination is achieved.
30. The method of claim 29, wherein the liquid sterilant is selected from the group consisting essentially of hydrogen peroxide and peracetic acid and mixtures thereof.
31. The method of claim 29, wherein the liquid sterilant is from between about 30% to about
35% by weight concentration of aqueous hydrogen peroxide solution.
32. The method of claim 29, wherein the predetermined amount of liquid hydrogen peroxide is distributed among the containers placed on the chamber shelves.
33. The method of claim 29, wherein the predetermined level of decontamination is sterilization.
34. The method of claim 29, wherein the chamber system is a freeze dryer system.
35. A method of decontaminating a chamber system, which comprises the steps of: a) providing a chamber system having a plurality of shelves, at least one of which is vertically movable while maintaining its horizontal position, a condenser, and piping that are fluidly connected to each other and to a vacuum system; b) placing n sets of containers, each set consisting of at least one container, into the chamber on at least one of the shelves, each container containing a pre-determined amount of
- 28 - liquid sterilant, and wherein each container further comprises a cap assembly, a compression spring, a plunger, a sealing device, and a bottom assembly such that each set has a cap assembly of a different length; c) placing the cap assembly loosely on each container; d) moving the movable shelves until the cap assembly on each container is pressed by one of the respective adjacent shelves and seals substantially all of the containers; e) evacuating the chamber, condenser and piping to a vacuum of a predetermined subatmospheric absolute pressure, wherein the chamber system is isolated from the vacuum system; f) moving at least one of the movable shelves to a first predetermined level until the cap assembly is released and the seal on at least one of the containers is broken; g) vaporizing the liquid sterilant by exposing said liquid to the evacuated chamber environment; h) maintaining the vacuum and exposing the interior of the chamber system to sterilant vapor for a first predetermined time; i) injecting air into the chamber; j) re-evacuating the chamber, condenser and piping; k) moving at least another movable shelf to another predetermined level until the cap assembly is released and the seal of at least one additional container is broken;
1) vaporizing the liquid sterilant by exposing said liquid to the evacuated chamber environment;
- 29 - m) maintaining the vacuum and exposing the interior of the chamber system to sterilant vapor for another predetermined time; and n) maintaining the vacuum and exposing the interior of the chamber system to sterilant vapor until a predetermined level of decontamination is achieved.
36. The method of claim 35, wherein the bottom assembly of said containers has raised dimples permitting the area on the shelf below the containers to be sterilized.
37. The method of claim 35, wherein the liquid sterilant is selected from the group consisting of hydrogen peroxide and peracetic acid and mixtures thereof.
38. The method of claim 35, wherein the liquid hydrogen peroxide is from between about 30% to about 35% by weight concentration of aqueous hydrogen peroxide solution.
39. The method of claim 35, wherein the predetermined level of decontamination is sterilization.
40. The method of claim 35, wherein the chamber system is a freeze dryer system.
41. The method of claim 35, wherein the liquid sterilant in each container is about 1 and about 2 grams of liquid hydrogen peroxide.
42. The method of claim 35, wherein the number of sets of containers, n, is any number
- 30 - between 2 and 20 and in which steps (e) through (g) are repeated once for each set of containers.
43. The method of claim 35, wherein the method further comprising repeating steps k) through m) until a predetermined level of decontamination is achieved.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6518046A JPH08509391A (en) | 1993-02-04 | 1994-01-12 | Disinfection method for chambers with movable shelves |
| EP94906654A EP0682532B1 (en) | 1993-02-04 | 1994-01-12 | A method of decontaminating a chamber that has movable shelves |
| DE69412068T DE69412068T2 (en) | 1993-02-04 | 1994-01-12 | METHOD FOR DECONTAMINATING A CHAMBER THAT HAS MOVING SHELVES |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/013,429 US5286448A (en) | 1993-02-04 | 1993-02-04 | Method of decontaminating a chamber that has movable shelves |
| US013,429 | 1993-02-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1994017836A1 WO1994017836A1 (en) | 1994-08-18 |
| WO1994017836B1 true WO1994017836B1 (en) | 1994-09-29 |
Family
ID=21759925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1994/000564 WO1994017836A1 (en) | 1993-02-04 | 1994-01-12 | A method of decontaminating a chamber that has movable shelves |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5286448A (en) |
| EP (1) | EP0682532B1 (en) |
| JP (1) | JPH08509391A (en) |
| CA (1) | CA2155336A1 (en) |
| DE (1) | DE69412068T2 (en) |
| WO (1) | WO1994017836A1 (en) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700426A (en) * | 1991-03-08 | 1997-12-23 | Foundation Nationale De Transfusion Sanguine | Method for decontaminating or sterilizing "in situ" a vacuum sealed container and device for implementing such method |
| EP0668783B1 (en) * | 1992-11-12 | 1999-03-17 | American Sterilizer Company | A method of decontaminating freeze dryers |
| US5286448A (en) * | 1993-02-04 | 1994-02-15 | American Sterilizer Company | Method of decontaminating a chamber that has movable shelves |
| FR2704757B1 (en) * | 1993-05-07 | 1995-08-11 | Framatome Sa | Device for high pressure sterilization of products. |
| US5830409A (en) * | 1996-01-04 | 1998-11-03 | American Sterilizer Company | Method to shorten aeration after a sterilization cycle |
| US5788941A (en) * | 1996-01-31 | 1998-08-04 | Steris Corporation | Method of sterilization of bone tussue |
| US5827542A (en) * | 1996-02-12 | 1998-10-27 | Healthpoint, Ltd. | Quick acting chemical sterilant |
| US6495100B1 (en) * | 1996-04-04 | 2002-12-17 | Ethicon, Inc. | Method for sterilizing devices in a container |
| US6030579A (en) * | 1996-04-04 | 2000-02-29 | Johnson & Johnson Medical, Inc. | Method of sterilization using pretreatment with hydrogen peroxide |
| US6325972B1 (en) * | 1998-12-30 | 2001-12-04 | Ethicon, Inc. | Apparatus and process for concentrating a liquid sterilant and sterilizing articles therewith |
| US5851485A (en) * | 1996-12-20 | 1998-12-22 | Johnson & Johnson Medical, Inc. | Process for sterilization with liquid sterilant using controlled pumpdown rate |
| US6066294A (en) * | 1997-08-21 | 2000-05-23 | Ethicon, Inc. | Multi-compartment sterilization system |
| US6977061B2 (en) * | 1997-04-04 | 2005-12-20 | Ethicon Endo-Surgery, Inc. | Method and apparatus for sterilizing a lumen device |
| US6063631A (en) * | 1997-05-21 | 2000-05-16 | 3M Innovative Properties Company | Sterilization indicator |
| US6287518B1 (en) | 1997-06-25 | 2001-09-11 | 3M Innovative Properties Company | Sterilization monitors |
| US7803316B2 (en) * | 1997-08-21 | 2010-09-28 | Ethicon, Inc. | Method and apparatus for processing a lumen device |
| US6815206B2 (en) * | 1997-09-19 | 2004-11-09 | Ethicon, Inc. | Container monitoring system |
| US6355448B1 (en) * | 1998-06-02 | 2002-03-12 | 3M Innovative Properties Company | Sterilization indicator with chemically stabilized enzyme |
| US7045343B2 (en) * | 1998-06-02 | 2006-05-16 | 3M Innovative Properties Company | Sterilization indicator test packs |
| US6010662A (en) * | 1998-06-18 | 2000-01-04 | Ethicon, Inc. | Two-step sterilization process using liquid sterilant |
| US7252800B2 (en) * | 1998-12-30 | 2007-08-07 | Ethicon, Inc. | Sterilization system and method and inlet control apparatus therefor |
| US6852279B2 (en) * | 2002-06-28 | 2005-02-08 | Ethicon, Inc. | Sterilization with temperature-controlled diffusion path |
| US7670550B2 (en) * | 1998-12-30 | 2010-03-02 | Ethicon, Inc. | Rapid sterilization system |
| US7569180B2 (en) | 2004-10-12 | 2009-08-04 | Ethicon, Inc. | Sterilization system and method and orifice inlet control apparatus therefor |
| ITMI20012488A1 (en) * | 2001-11-26 | 2003-05-26 | I C I Internat Chemical Indus | PROCESS FOR THE STERELIZATION OF A POWDER SUBSTANCE |
| US7807100B2 (en) * | 2002-06-28 | 2010-10-05 | Ethicon, Inc. | Sterilization system and method with temperature-controlled condensing surface |
| US7300637B2 (en) * | 2002-09-30 | 2007-11-27 | Ethicon, Inc. | Sterilization container kit |
| US20050147527A1 (en) * | 2004-01-06 | 2005-07-07 | I. Brown | Microbial destruction using a gas phase decontaminant |
| US7850931B2 (en) * | 2005-08-11 | 2010-12-14 | American Sterilizer Company | Self-contained deactivation device |
| CA2678417C (en) * | 2007-03-06 | 2012-06-05 | Steris Inc. | Decontamination unit and process |
| GB0916016D0 (en) * | 2009-09-14 | 2009-10-28 | Morris Watson Michael | Inactivation of pathogens |
| EP2590684A1 (en) * | 2010-07-09 | 2013-05-15 | SP Industries, Inc. | Vacuum system and methods for sterilization thereof |
| US9459233B2 (en) | 2012-06-25 | 2016-10-04 | Steris Corporation | Amperometric gas sensor |
| US10889848B2 (en) | 2017-07-14 | 2021-01-12 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US10900062B2 (en) | 2017-07-14 | 2021-01-26 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US10876144B2 (en) | 2017-07-14 | 2020-12-29 | American Sterilizer Company | Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same |
| US11536512B1 (en) * | 2021-09-16 | 2022-12-27 | Thomas John Harkins, JR. | Apparatus and method for lyophilization |
| US11957790B1 (en) | 2022-01-31 | 2024-04-16 | Thomas John Harkins, JR. | Combination lyophilization and dispensing syringe assembly and methods of using same |
| US11723870B1 (en) | 2022-01-31 | 2023-08-15 | Thomas John Harkins, JR. | Assembly, apparatus and method for lyophilization |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4169123A (en) * | 1975-12-11 | 1979-09-25 | Moore-Perk Corporation | Hydrogen peroxide vapor sterilization method |
| AT351172B (en) * | 1977-05-17 | 1979-07-10 | Ver Edelstahlwerke Ag | STERILIZATION SYSTEM FOR INFUSION SOLUTIONS FILLED IN CONTAINERS OR DGL. |
| US4230663A (en) * | 1979-07-10 | 1980-10-28 | Moore-Perk Corporation | Cold gas sterilization process using hydrogen peroxide at low concentrations |
| US4406861A (en) * | 1980-02-19 | 1983-09-27 | Beauvais Max P | Microwave canning apparatus |
| US4512951A (en) * | 1980-12-30 | 1985-04-23 | American Sterilizer Company | Hydrogen peroxide liquid film sterilization method |
| EP0109352B1 (en) * | 1982-11-16 | 1987-11-11 | Kantonsspital St. Gallen | Method of sterilizing utensils, particularly those made from thermolabile materials |
| SE8405557D0 (en) * | 1983-11-07 | 1984-11-06 | American Sterilizer Co | SET CONCENTRATE VETEPEROXIDE |
| US4642165A (en) * | 1984-12-21 | 1987-02-10 | American Sterilizer Company | Method of vaporizing multicomponent liquids |
| DE3617153A1 (en) * | 1986-05-22 | 1987-11-26 | Wagner Gmbh | VALVE FOR STERILIZING CONTAINER |
| DE3632675A1 (en) * | 1986-09-26 | 1988-04-07 | Aesculap Ag | STERILIZING DEVICE FOR STERILIZING CONTAINERS |
| US4863688A (en) * | 1986-12-31 | 1989-09-05 | American Sterilizer Company | Method of decontaminating surfaces on or near living cells with vapor hydrogen peroxide |
| US4909999A (en) * | 1987-07-06 | 1990-03-20 | American Sterilizer Company | Flow-through vapor phase sterilization system |
| US4956145A (en) * | 1987-12-30 | 1990-09-11 | American Sterilizer Company | Optimum hydrogen peroxide vapor sterilization method |
| FI880221A (en) * | 1988-01-19 | 1989-07-20 | Santasalo Sohlberg Ab Oy | FOERFARANDE OCH ANORDNING FOER STERILISERING ELLER DESINFEKTERING AV VERKTYG. |
| US4952370A (en) * | 1988-05-06 | 1990-08-28 | American Sterilizer Company | Hydrogen peroxide sterilization method |
| US4941519A (en) * | 1988-08-19 | 1990-07-17 | American Sterilizer Company | Liquid feed system using a non-reusable container |
| US5068087A (en) * | 1988-12-30 | 1991-11-26 | American Sterilizer Company | High capacity multicomponent liquid vaporizer |
| US5044141A (en) * | 1990-07-11 | 1991-09-03 | Franchi Richard M | Method for sterile packaging and wetting of articles |
| FR2673540B1 (en) * | 1991-03-08 | 1993-07-09 | Fondation Nale Transfusion San | "IN SITU" DECONTAMINATION PROCESS FOR A VACUUM SEALED ENCLOSURE. |
| US5286448A (en) * | 1993-02-04 | 1994-02-15 | American Sterilizer Company | Method of decontaminating a chamber that has movable shelves |
-
1993
- 1993-02-04 US US08/013,429 patent/US5286448A/en not_active Expired - Fee Related
-
1994
- 1994-01-12 JP JP6518046A patent/JPH08509391A/en active Pending
- 1994-01-12 DE DE69412068T patent/DE69412068T2/en not_active Expired - Fee Related
- 1994-01-12 CA CA002155336A patent/CA2155336A1/en not_active Abandoned
- 1994-01-12 EP EP94906654A patent/EP0682532B1/en not_active Expired - Lifetime
- 1994-01-12 WO PCT/US1994/000564 patent/WO1994017836A1/en active IP Right Grant
- 1994-01-13 US US08/181,640 patent/US5389336A/en not_active Expired - Fee Related
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