JPH02202581A - Inhibitor of photo-deterioration - Google Patents

Abstract

PURPOSE:To obtain inhibitor of photo-deterioration for foods, cosmetics or pharmaceutical, etc., having actions such as inhibiting of pH decrease of product or generation of oxidized matter, preventing of color change or inhibiting of odor deterioration containing catechins (condensate) as active ingredient. CONSTITUTION:The aimed inhibitor of photo-deterioration contains catechins (preferably catechin, epicatechin, gallocatechin, epigallocatechin, catechin gallate, epicatechin gallate, gallocatechin gallate or epigallocatechin gallate) or condensate of said catechins (preferably extract of rhubarb, Polygoni Multlflori Radix, Sanguisorbae Radix, mimosa, Japanese chestnut, catechu or tea) as active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention provides a novel and safe photodegradation inhibitor, more specifically, a novel and safe photodegradation inhibitor.
・Related to photodegradation inhibitors for foods, cosmetics, pharmaceuticals, etc. that have this as an active ingredient.

[Prior Art] Foods, cosmetics, pharmaceuticals, etc. are often displayed under direct sunlight or under the light of showcases, and especially in the case of cosmetics and pharmaceuticals, skin If! Products that are used by rubbing on skin or hair are exposed to light on the human body. At that time, these lights deteriorate the base ingredients such as oils and fats and active agents, which are compounded ingredients, and change the quality of drugs and pigments, causing deterioration of flavor, generation of strange odors, discoloration, etc., and even reducing effectiveness. This may result in the production of toxic or irritating substances. To prevent these, 3a products are usually mixed with ultraviolet absorbers and antioxidants, or placed in light-shielding containers.

[Problems to be Solved by the Invention] Problems with the Prior Art However, the effect of preventing photodeterioration was not sufficient for bends that are subject to prescription and design constraints.

Therefore, there has been a desire for a highly safe photodegradation inhibitor that can be easily incorporated into various dosage forms and effectively prevents photodegradation.

Purpose of the Invention In view of the above circumstances, the present inventors have made extensive studies and discovered that catechins and their condensates have a strong photodegradation prevention effect, and in addition, by combining them with a chelating agent,
They discovered that the effect was even stronger and completed the present invention.

[Means for Solving the Problems] That is, the present invention is a photodegradation inhibitor containing catechins, condensates thereof, or these and a chelating agent as active ingredients.

Hereinafter, the configuration of the present invention will be explained in detail.

Catechins are monomers of condensed tannins contained in plants, and are a group of substances that have flavan-3-ol as a basic skeleton.In addition to catechin and gallocatechin, catechin gallate, which is an ester of gallic acid, and gallocatechin gallate , these stereoisomers include epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, etc. Although these catechins can be obtained by synthesis, they can also be easily obtained by solvent extraction from plants such as rhubarb, heshuwuru, jiyue, mimosa, millet, Asianyaku, and tea. Although the extraction method is not particularly limited, for example, extraction is performed as follows.

That is, each dried plant is immersed in a single or mixed solvent such as an alcohol such as methanol or ethanol, a polyhydric alcohol such as 1,3-buty-I non-glycol, a polar organic solvent such as acetone, ether, or ethyl acetate, or water. and extract at room temperature or with heat.

The solvent is distilled off from the extract to obtain various catechin-containing extracts. Various catechins can be obtained individually by high-performance liquid chromatography or the like, but they may also be blended as an extract or in the form of an extract.

If the crushed leaves are immersed in chloroform or the like before solvent extraction, unnecessary pigments may be removed and post-processing may be easier.

In this way, the catechins of the present invention are obtained. This thing is
By dissolving in water, alcohol, polyhydric alcohol, or aqueous alcohol solution, it can be freely dissolved in both water and oil, and is more effective than conventionally used ultraviolet absorbers and antioxidants. Wide range of applications.

The condensate used in the present invention is a condensed tannin,
These are oxidized polymers of catechins.

Although these condensates can be obtained by synthesis, they can also be easily obtained by solvent extraction from plants such as rhubarb, heshuwura, jiyue, mimosa, millet, asianyaku, and tea.

Chelating agents used in the present invention include birophosphoric acid,
Tripolyphosphoric acid, metaphosphoric acid, hexametaphosphoric acid, 1-
Phosphoric acids and their salts such as hydroxyethane-1,1-cyphosphonic acid and phytic acid, aminopolyacetic acids and their salts such as iminodiacetic acid, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, glycol etherdiaminetetraacetic acid, tonoethylenetetraminehexaacetic acid, glycolic acid,
Hydroxycarboxylic acids and their salts such as malic acid, tartaric acid, citric acid, lactic acid, gluconic acid, and glucuronic acid, organic acids and their salts such as succinic acid, malonic acid, maleic acid, fumaric acid, and phthalic acid, aspartic acid, and glutamic acid. , amino acids such as glycine, and salts thereof.

Among the above components, particularly preferred are phosphoric acid and its salts.

The amount of the catechins or their condensates of the present invention incorporated into cosmetics, pharmaceuticals, foods, or their raw materials is 0 as a dry residue.
．． 001 to 2% by weight, preferably o, oos to 0
．． It is 2% by weight. If it is less than 0.001% by weight, the photodegradation prevention effect of the present invention cannot be obtained, and if it exceeds 2% by weight, there are problems in terms of formulation, such as significant coloring of the system. Regarding the chelating agent, 0.001 to 5% by weight, preferably 0.0%
It is 1 to 1% by weight. If it is less than 0.001% by weight, no further effect can be obtained by adding the chelating agent in the present invention, and if it exceeds 5% by weight, the pH of the system may drop and there may be problems with the formulation, such as solubility problems. be.

The photodegradation inhibitor of the present invention is a base material such as oils and fats, glycerin, glycerin derivatives, polyglycerin, polyglycerin fatty acid ester, polyglycerin alkyl ether, or polyethylene glycol, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, etc. Substances with oxyalkylene chains such as polyoxyethylene polyoxypropylene alkyl ether, condensates of these with inorganic acids, or their salts, as well as pigments and various chemicals, or when they are water-based or oil-based. It is effective in a variety of cosmetics, pharmaceuticals, foods, etc., regardless of the product. In addition, ultraviolet absorbers such as paraaminobenzoic acid and its derivatives, dibenzoylmethane and its derivatives, cinnamic acid and its derivatives,
Tocopherol, organic acid.

Alternatively, a great effect can be expected by using it in combination with an antioxidant such as BHT or BHA.

In the present invention, in addition to catechins or their condensates as the above-mentioned essential components, and their combination with a chelating agent, common ingredients contained in cosmetics, pharmaceuticals, and foods can be used depending on the purpose. Such ingredients include oils, surfactants, thickeners, neutralizers, preservatives, antioxidants, powder ingredients, pigments, fragrances, ultraviolet absorbers, medicinal agents, etc.
They may be used in appropriate combinations as necessary.

The dosage form of the cosmetics, pharmaceuticals, and foods according to the present invention is arbitrary, and includes, for example, an aqueous solution system, a solubilized system, an emulsion system, a powder dispersion system,
Any base may be used, such as a two-layer water-oil system or a three-layer water-oil/powder system, and can be used for basic cosmetics such as lotions, emulsions, creams, and packs, makeup cosmetics such as lipsticks, foundations, etc. A wide variety of products, including cosmetics such as hair cosmetics such as shampoos, conditioners, and hair tonics, pharmaceuticals, quasi-drugs, dairy products, instant noodles, powdered or liquid soups, fried foods, fruit juice drinks, carbonated drinks, pickles, and sweets. . Furthermore, it can also be directly added to these raw materials, such as animal and vegetable oils, active agents, pigments, fragrances, drugs, animal meat, fish meat, and the like.

[Effects of the Invention] The photodegradation inhibitor of the present invention has the following advantages.

(1) Prevent the pH of the product from decreasing.

(2) Suppress the generation of oxidation products such as peroxides from the product.

(3) Suppress product discoloration.

(4) Suppress product odor deterioration.

(5) Suppress the reduction of various drugs in products.

[Example] Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby.

Preparation Example 1 This example illustrates a method for extracting catechins from tea according to the present invention.

After adding 10 kg of chloroform to 1 kg of dried green tea and washing under reflux, the chloroform is removed. Residue 9508
Add 3 kg of water and stir to infiltrate. To this, add 8 parts to 10 parts of ethyl acetate. The liquid phase and the residue are separated and ethyl acetate is distilled off from the liquid phase. The remaining aqueous phase is powder-dried to obtain green tea tannin 978. The catechin purity of this is 70
% or more, and includes epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, etc.

Production Example 2 This example describes a method for isolating various catechins from the green tea catechin mixture obtained in Production Example 1.

Using a reverse phase distribution column, 12 g of green tea tannin obtained in Production Example 1 was mixed with acetone:tetrahydrofuran:water=12
When separated by high performance liquid chromatography using a developing solvent of : 10 : 78 (volume %), epigallocatechin (1.4 g), epicatechin (0.9 g), catechin (0.78), epigallocatechin gallate (4.9gL
Each catechin can be isolated by elution in the order of epicatechin gallate (1.2 g).

Manufacturing example 3 This example describes a method for obtaining tannins from rhubarb.

2 kg of dried rhubarb root is soaked in 5 kg of water and passed through the mouth to obtain a water layer. Add 3 kg of ether to this and shake well to remove the ether layer. Furthermore, 3 kg of ethyl acetate is added to the aqueous layer for extraction. The solvent is distilled off from the ethyl acetate layer and dried to obtain Rhubarb Tannin 608. This extract contains condensed tannins (oxidized polymers of catechins) with a molecular weight of 1000 to 3000, and the tannin content is about 70%.

Experimental example 1 As an example of the present invention, the following tests were conducted.

In 5 g of ethyl linoleate (manufactured by NOF ■), Production Example 1
Add the green tea-derived catechin mixture obtained above, place it in a Xe fade meter (a machine with a Xe lamp in the center, around which the sample rotates and receives light irradiation), and heat at 25°C.
The degree of photodeterioration over time after storage was evaluated using peroxide value as an index. For comparison, a test was also conducted in which paraaminobenzoic acid (PABA) was added.

The Xe lamp used was chosen because its spectrum is similar to that of sunlight, and the amount of irradiation energy in the ultraviolet region is approximately equal to that of sunlight.

The results are shown in Table-1.

Furthermore, when three expert panelists judged the odor of the oil after 16 hours, no off-odor was observed for Nt12-4, but a clear off-odor was observed for Magnet 5.

As is clear from Table 1 and the odor evaluation, the catechin mixture strongly suppressed photodeterioration.

Experimental Example 2 Using the catechin obtained in Production Example 2, a test similar to Experimental Example 1 was conducted. For comparison, BHT, BHA
, tests were also conducted using tocopherols. Display the results -
Shown in 2.

All of NONO's antioxidants showed stronger inhibitory effects than existing antioxidants.

Experimental Example 3 A test similar to Experimental Example 1 was conducted using a combination of the catechin mixture obtained in Production Example 1 and a chelating agent. Display the results -
Shown in 3.

Moreover, when three expert panelists judged the odor of the oil after 16 hours, no off-odor was observed in Nn2-6, but clear off-odor was observed in Nn7-9.

Furthermore, when three expert panelists judged the smell of the oil after 16 hours, no off-odor was observed on Nα2-6, but a clear off-odor was observed on floors 7-9.

As can be seen from Table 2 and odor evaluation, there are differences in the ability to prevent photodegradation depending on the type of catechin. *N02 in the table
~ 5 contains the catechin mixture obtained in Production Example 1 on the second floor 6.
BHT is added to No. 7, and tocopherol is added to No. 8 and No. 9, each of which has an amount of 1,100 pp.

*The amount of chelating agent added is 200 ppm for Black 2 and 3.
.

Others are 11000pp.

*The values in the table are peroxide (lI (meq/kg)) Experimental Example 4 The base oil was changed from ethyl linoleate of Experimental Examples 1 and 2 to 5 g of a 50% aqueous solution of triethylene glycol (Gyudon Kagaku).
I changed it and tested it. Ascorbic acid for comparison,
Similar tests were conducted with triethylene glycol spiked with tocopherol, 4-tert-butyl-4°-methoxy-dibenzoylmethane (BMDM). However, the rating is 1
The odor was evaluated after a week. Judgment by expert panel 3
By name.

The results are shown in Table 4.

The catechins obtained in Example 2 were added and stored at 25°C in a Xe fade meter, and the degree of discoloration and odor was examined after one week. For comparison, a sample to which 2-ethylhexyl valadimethylaminobenzoate (PDABA) was added was also evaluated. Incidentally, the Kishigishi extract is the dry residue obtained by extracting the dried roots of the Kishigishi with hegosan. This product is used as a yellow coloring agent or a skin roughness preventive agent.

The results are shown in Table-5.

As is clear from Table 4, catechins have a remarkable photodegradation prevention effect compared to ascorbic acid, tocopherol, and 4-t-butyl-4-methoxy-dibenzoylmethane alone. There is.

Experimental Example 5 Examples of formulations of cosmetics, foods, and pharmaceuticals using the photodegradation inhibitor of the present invention are shown below. Naturally, the present invention is not limited to these.

Example 1 Emulsion stearic acid 2.5 cetyl alcohol 1.5 vaseline
5.0 liquid paraffin
10.0 POE (10 mol) Monooleic acid ester 2.0 Polyethylene glycol 1
5003.0 Triethanolamine
1.0 Ascorbic acid 5.0
Chiritekin mixture (Production example 1) 0. IE
D T A O, 0
1 ion exchange water residual fragrance'1
Amount of 1143Ill (manufacturing method) Add polyethylene glycol 1500, triethanolamine, ascorbic acid/catechin mixture/EDTA to ion-exchanged water, dissolve by heating, and keep at 70°C (water phase). Mix other ingredients, heat and melt and keep at 70°C (oil phase). The oil phase is added to the water phase for preliminary emulsification, and the mixture is uniformly emulsified using a homomixer. After emulsification, the mixture is cooled to 30°C while stirring well.

Example 2 Lotion (alcohol phase) 95% ethyl alcohol 25.Osicon extract 0.5POE
(60 mol) Hydrogenated castor oil ether 2.0 Antioxidant/preservative Appropriate amount Fragrance
Appropriate amount (aqueous phase) Catechin mixture (Production example 1) 0.05
Glycerin 5.0 Sodium hexametaphosphate 0.05 Ultraviolet absorber Appropriate amount of ion exchange water
Residue (manufacturing method) Solubilize after adjusting the aqueous and alcohol phases.

Example 3 Cleansing cream (A) Setanol 2.0 piece wax 1.0 solid paraffin 1.0 oleic acid
2.0 Vaseline 1
0.0olive oil 35.0P
OE (20) Sorbitan oleate 2.4 Diglycerin diolate 2.6 Probylbaraben 0.3 (B) Rhubarb tannin 0.1 Polyethylene glycol 5.0 Potassium hydroxide
0.08 1-Hydroxyethane-1,1-cyphosphonic acid aqueous solution 0.8 Purified water
Residue (manufacturing method) The oil phase part of (A) and the aqueous phase part of (B) are separately heated and stirred to dissolve. The oil phase was added to the water phase, emulsified, and cooled to obtain a cream.

Example 4 Nutritional emulsion (A) Peace wax Vaseline deodorizing lanolin evening primrose oil Cetyl isooctanoate POE (2) Oleyl ether Ethylbaraben butylparaben fragrance (B) Carboxyvinyl polymer shrimp gallocatechin gallate Diethylenetriamine-pentaacetic acid aqueous solution dipropylene glycol Shi-Arginine purified water (Manufacturing method) Same as Example 3.

1.0 2.0 1.5 6.0 4.0 2.0 0.2 0.1 0.3 0.2 0.01 0.1 2.0 0.2 Remaining Example 5 Foundation (A) Stearic acid 2.0 Cetyl alcohol 0.3 Liquid paraffin
20.0 Polyoxyethylene (10 mol) Oleic acid ester 1.0 Sorbitan trioleic acid ester 1.0 Fragrance
Appropriate amount of preservative Appropriate amount (B) Titanium dioxide 6.0 Talc 6.0 Kaolin
3.0 pigment
Appropriate amount (C) Catechin mixture (rM, Example 1) 0
．． 0051-Hydroxyethane-1,1-sodium cyphosphonate 0.005 Propylene glycol 5.0 Polyethylene glycol 4000
5.0 triethanolamine i,
.

Veegum 0.5 purified water
Residue (manufacturing method) Add pulverized and mixed (B) to heated and dissolved (C), uniformly disperse with a homomixer, and maintain at 70°C. (A) is mixed, heated and dissolved, and kept at 70°C. The former was added to the latter to perform emulsification, and after emulsification, the mixture was stirred while cooling to obtain a foundation.

Example 6 Eyeliner (A) Light liquid paraffin (B) Peace wax Candelilla wax Preservative Fragrance (C) Dimethyl dialkyl ant-ram hectorite (
D) Ethyl alcohol HEC epicatechin gallate cyclohexane diamine sodium tetraacetate (E) Talc black iron oxide (manufacturing method) After heating and dissolving a part of (A) and (B), 68.47 3.0 3.0 0.1 0.1 4.5 2.8 3.0 0.02 0.01 5.0 10.0 Add (C) and mix with stirring. Next, the remainder of (A) and (D) are dissolved by heating, and added to the mixture and mixed. moreover,(
Disperse E) using a homomixer, cool it, and then fill it into a container.

Example 7 Lipstick (A) Carnauba wax 3°0 beeswax 5.0 (B) Castor oil
residual lanolin
11.0 Isopropyl myristate 10
．． 0(C) Catechin mixture (Production example 1) 0.
04 Ethanol 2.0 (D) Titanium oxide 2.0 Red iron
1.0 Red No. 202
3,0 (E) Fragrance
0.1 (Production method) After heating and melting (A), (B) with (C) added thereto is added and mixed, and (D) f! :Additionally, disperse with a mixer when hot. The remaining (E) is added and dispersed while hot, and after degassing, the product is molded.

Example 8 Lipstick (A) Liquid paraffin Glycerin Tristearate Castor oil Candelilla wax Polyethylene wax Polyoxyethylene (20 mol) Polyoxypropylene (20 mol) 2 Tetradecyl octadecyl ether (B
) Red No. 202 Red No. 204 Blue No. 1 Black iron mica titanium oxide (C) Epicatechin gallate 1-hydroxyethane-1,1-sodium cyphosphonate Polyvinyl alcohol Laponite X L G ''' 20.0 20, O Remaining 8 .0 10.0 4.0 0.5 0.5 1.0 0.5 5.0 0.0Q1 0.001 0.5 1.0 Ion exchange water 10.0* Synthetic bentonite manufactured by Laborte, UK Product name (manufacturing method) After dissolving (A) at 80°C, (B) is mixed and dissolved, and (C), which has also been mixed and dissolved, is added with stirring to emulsify.

Thereafter, it was cooled to room temperature to obtain a lipstick.

Example 9 White powder (A) Zinc white 12.0 Talc 3.0 Pigment
Appropriate amount (B) Glycerin 5.0 Catechin 0.001 Purified water
80.0 (C) Fragrance
Appropriate amount (manufacturing method) While (A) was stirred with a blender, (C) was uniformly sprayed, and (B) uniformly dissolved therein was gradually added and kneaded to obtain a white powder.

Example 10 Nail treatment (A) Propylene glycol 5.0 Triethanolamine 1.0 Asenyaku catechin
0.1 purified water
Remaining (B) Veegum 0.3 (] Stearic acid 2.0 Microcrystalline wax 3.0 Vaseline
7.0 Hydrogenated lanolin 2.0
Liquid paraffin 22.0 polyoxyethylene (57) oleate ester
2.0 Preservatives Appropriate amount Fragrance Appropriate amount (Production method) After dissolving (A), add (B), disperse uniformly, heat, and keep at 70°C. Mix (C) and heat to dissolve
Keep at ℃. Pre-emulsify by adding the oil phase to the water phase, and homogeneously emulsify using a homomixer. After emulsification, the mixture is cooled to 30° C. while stirring to obtain a nail treatment.

Example 11 Shampoo lauryl polyoxyethylene (3 mol) M acid I ster triethanolamine salt (40% aqueous solution)
32.0 Lau'J Iu; fi myrioxyethylene 3f) (i4 acid I duter sodium salt (30% aqueous solution) 21.0 Lauroyl diethanolamide 4.0 Polyoxyethylene glycol 400 1.0 He Jingwu tannin
0.1 Sodium hexametaphosphate
0.1 edetate 3.5 sodium
0.2 Preservatives Appropriate amount UV absorber Appropriate amount dye
Appropriate amount of purified water
41.7 Fragrance Appropriate amount (manufacturing method) Heat purified water to 70°C, add other ingredients and dissolve uniformly, then cool to obtain shampoo.

Example 12 Rinse (A) Glycerin 5.0 Protein derivative 2.0 Gallocatechin
o,ooil-hydroxyethane-1,1
- Sodium diphosphonate 0.1 dye
Appropriate amount of purified water Remainder (B) Stearyltrimethylammonium chloride 2.0 Cetyl alcohol
2.0 silicone oil 3
．． 0 polyoxyethylene (10 mol) oleyl alcohol ether 1.0 preservative
Appropriate amount of UV absorber Appropriate amount (Production method) Heat and dissolve (A) and maintain at 70°C. (B) is melted by heating and kept at 70°C. Add the water phase to the oil phase and stir.

Thereafter, the mixture is further stirred while being cooled to obtain a rinse.

Example 13 Hair tonic (A) Ethanol 55.0 Polyoxyethylene (8 t) Oleyl alcohol ether 2.0 Vitamin E acetate 0.2 Hinokitiol 0.02 Ethinyl estradiol 0.0004 Ultraviolet absorber
0.2(B) Mimosa tannin
0.05 edetate disodium
0.15 Purified water remainder (C)
Appropriate amount of dye (manufacturing method) After dissolving (A), add (B) to solubilize.

After coloring with (C), pass through the mouth to obtain tonic.

Example 14 Hair liquid (A) Polyoxypropylene (40 mol) Phthyl ether Lanolin derivative Ethanol Preservative Ultraviolet absorber Fragrance 20.0 1.0 55.0 Appropriate amount Appropriate amount 1.0 (B) Catechin gallate Edetate acid Diebrentria Mine-pentaacetic acid aqueous solution purified water (C) Dye (manufacturing method) According to Example 13.

0.02 0.005 0.035 Remaining appropriate amount Example 15 Hair cream (A) Beeswax Vaseline Liquid paraffin Polyoxyethylene (5 moles) Stearate polyoxyethylene (6 tons) Oleyl alcohol ether polyoxyethylene (6 moles) Cetyl alcohol ether preservative fragrance (B) catechin mixture (sodium hexametaphosphate obtained in Production Example 1 3.0 15.0 42.0 3.0 2.0 1.0 appropriate amount) 0.005 0.001 Purification Water Residual (manufacturing method) Heat and dissolve (A) and keep at 70°C. To this, (B) heated to 70° C. is gradually added and emulsified. After emulsification, the mixture is cooled to 30° C. while stirring to obtain a hair cream.

Example 16 Set lotion (A) Propylene glycol 2.0 Polyoxyethylene (20 mol) Stair 1 liter Alcohol ether 1.5 Preservative
Appropriate amount of UV absorber Appropriate amount of fragrance
J amount ethanol
10.0(B) Polyvinylpyrrolidone
3.0(C) Millet tannin
0.08 Trisodium edetate 0
．． 02 Purified water remainder (D)
Dye Appropriate amount (!12 method) Dissolve (A), add (B) to it and moisten it, gradually add (C) while stirring and color with (D) to make a setting lotion.

Example 16 Health drink Fructose glucose liquid Honey Citric acid DL - Malic acid L - Aspartic acid L - Arginine Nicotinic acid amide Glutamate Sodium Thiamine NDS Riboflavin Pyridoxine Hydrochloride L - Ascorbic acid Epigallocatechin Purified water Fragrance 17.9 0.1 82m8 % 41m8% 20m8% 20mg% 10mg% 1mg% 0.17mg% 0.25mg% 0.5iBχ 50mg% 0.03 Remaining appropriate amount Example 17 Ointment γ-oryzanol 1.0 Epigallocatechin gallate 0.1 Hydrophilic ointment Residue (Production method) After thoroughly mixing γ-oryzanol and epigallocatechin gallate obtained in Production Example 2 with a small amount of hydrophilic ointment,
The remaining hydrophilic ointment is gradually added to make a total of 1 (100%), and the whole product is made uniform.

However, the formulation of the hydrophilic ointment base is as follows.

- Hydrophilic ointment base - Cetyl 6.0 Polyoxyethylene (30 mol) Cetyl ether 2.0 Glyceryl monostearate (self-emulsifying type) 10.0 Liquid paraffin 10.0 White petrolatum 5.0 Methyl paraben
0.1 butylbaraben propylene glycol purified water

Claims (1)

[Scope of Claims] 1) A photodegradation inhibitor containing catechins or condensates thereof as an active ingredient. 2) The light according to claim 1, wherein the catechins are one or more selected from the group of catechin, epicatechin, gallocatechin, epigallocatechin, catechin gallate, epicatechin gallate/gallocatechin gallate, and epigallocatechin gallate. Anti-deterioration agent. 3) The photodegradation inhibitor according to claim 1, wherein the condensate of catechins is an extract of rhubarb, heshuwura, jiyue, mimosa, millet, asianyaku, or tea. 4) A photodegradation inhibitor comprising a combination of catechins or condensates thereof and a chelating agent.