JPH02188531A - Composition having remedying effect on dermatopathy - Google Patents
Composition having remedying effect on dermatopathyInfo
- Publication number
- JPH02188531A JPH02188531A JP1005399A JP539989A JPH02188531A JP H02188531 A JPH02188531 A JP H02188531A JP 1005399 A JP1005399 A JP 1005399A JP 539989 A JP539989 A JP 539989A JP H02188531 A JPH02188531 A JP H02188531A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- citric acid
- present
- papain
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 230000000694 effects Effects 0.000 title abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 108090000526 Papain Proteins 0.000 claims abstract description 8
- 239000004365 Protease Substances 0.000 claims abstract description 8
- 229940055729 papain Drugs 0.000 claims abstract description 8
- 235000019834 papain Nutrition 0.000 claims abstract description 8
- 208000017520 skin disease Diseases 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 238000004061 bleaching Methods 0.000 abstract description 9
- 230000037303 wrinkles Effects 0.000 abstract description 3
- 241000219173 Carica Species 0.000 abstract description 2
- 235000009467 Carica papaya Nutrition 0.000 abstract description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 2
- 102000004190 Enzymes Human genes 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 229940088598 enzyme Drugs 0.000 abstract description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 abstract description 2
- 201000004647 tinea pedis Diseases 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000010201 Exanthema Diseases 0.000 abstract 1
- 201000005884 exanthem Diseases 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 206010037844 rash Diseases 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 206010014970 Ephelides Diseases 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010039580 Scar Diseases 0.000 description 1
- 206010040954 Skin wrinkling Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010044625 Trichorrhexis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】 （産業上の利用分野） 本発明は皮膚病治療効果を有する組成物に関する。[Detailed description of the invention] (Industrial application field) The present invention relates to a composition having therapeutic effects on skin diseases.
（従来の技術）
皮膚のシミ、シワ、ソバカス、日焼けの防止などに用い
る薬剤や組成物は従来から種々知られている。例えば、
シミ、ソバカス、日焼けの防止にはハイドロキノンなど
の皮膚漂白剤、ビタミンＣやビタミンＣ誘導体、生薬抽
出物等を含む組成物が知られている。しかし、これらの
薬剤や組成物は皮膚に対する刺激が強いとか、逆に、刺
激が少ないものは効力の発現に長時間を要したり、効果
が不十分であるなどの欠点を有している。(Prior Art) Various drugs and compositions used for preventing skin spots, wrinkles, freckles, sunburn, etc. have been known. for example,
Compositions containing skin bleaching agents such as hydroquinone, vitamin C, vitamin C derivatives, crude drug extracts, etc. are known for preventing age spots, freckles, and sunburn. However, these drugs and compositions have the disadvantage that they are highly irritating to the skin, and conversely, those that are less irritating take a long time to develop their efficacy or are insufficiently effective.
（発明が解決しようとする課題）
本発明の目的は皮膚に刺激を与えずに短期間で優れた効
果の発現する皮膚病治療効果を有する組成物を提供する
ことにある。(Problems to be Solved by the Invention) An object of the present invention is to provide a composition that has a therapeutic effect on skin diseases and exhibits excellent effects in a short period of time without irritating the skin.
（課題を解決するための手段）
本発明はパパイン及びクエン酸を含有することを特徴と
する皮膚病治療効果を有する組成物に係る。(Means for Solving the Problems) The present invention relates to a composition that contains papain and citric acid and has a therapeutic effect on skin diseases.
本発明で使用されるパパインはパパヤの果実から採取さ
れる酵素で、通常粒末状または顆粒状のものが有利に使
用される。クエン酸も通常市販のものを使用することが
できる。The papain used in the present invention is an enzyme collected from papaya fruit, and is usually advantageously used in the form of powder or granules. Commercially available citric acid can also be used.
本発明の組成物は種々の形態で用いることができ、例え
ば水溶液として塗布する方法、浴用剤として用いる方法
等を挙げることができる。The composition of the present invention can be used in various forms, such as applying it as an aqueous solution and using it as a bath additive.
本発明の組成物にはビタミンＣ等の各種のビタミン類を
添加することも有効である。It is also effective to add various vitamins such as vitamin C to the composition of the present invention.
本発明の組成物に含有される有効成分化合物であるパパ
インとクエン酸の割合は広い範囲から選定可能であるが
、特に前者の１重ｆｆｉ部に対して後者を０．０５〜２
０重量部、更には前者の１重量部に対して後者を０．５
〜５重量部使用するのが好ましい。The ratio of papain and citric acid, which are active ingredient compounds contained in the composition of the present invention, can be selected from a wide range, but in particular, the ratio of the latter to 1 part ffi of the former is 0.05 to 2 parts.
0 parts by weight, or even 0.5 parts by weight of the latter for 1 part by weight of the former.
It is preferred to use ~5 parts by weight.
本発明において組成物中の有効成分の合計量は特に限定
されず広範囲に選定可能であるが、通常は全組成物中約
１〜１００重１％、好ましくは約２０〜１００重量％で
ある。In the present invention, the total amount of active ingredients in the composition is not particularly limited and can be selected over a wide range, but is usually about 1 to 100% by weight, preferably about 20 to 100% by weight of the total composition.
本発明の組成物は例えば皮膚のシミ、シワ、角質の漂白
、防止、除去、或いは吹出物、水虫、皮膚炎等の予防、
治療に有用である。又、本発明の組成物をシャンプーや
育毛剤等に添加して用いたり、或いはシャンプーや育毛
剤の使用の前又は後に、手または〃−ゼ等につけて地風
に塗布することもでき、更にはパーマ処理の前又は後に
使用することもできる。The composition of the present invention can be used, for example, to bleach, prevent, or remove skin spots, wrinkles, and dead skin, or to prevent pimples, athlete's foot, dermatitis, etc.
Useful for treatment. In addition, the composition of the present invention can be used by adding it to shampoos, hair restorers, etc., or it can be applied to the hands or hair dryer before or after using the shampoo or hair restorer. can also be used before or after perming.
（実 施 例） 以下に本発明の組成物の製造例及び試験例を示す。(Example) Production examples and test examples of the composition of the present invention are shown below.
製造例１
パパイン０．５ｇ及びクエン酸１．５ｇを水１１に溶解
して本発明の組成物（水溶液）を得る。Production Example 1 A composition (aqueous solution) of the present invention is obtained by dissolving 0.5 g of papain and 1.5 g of citric acid in 11 parts of water.
製造例２
パパイン１ｇ及びクエン酸０．５ｇを水１１に溶解して
本発明の組成物（水溶液）を得る。Production Example 2 A composition (aqueous solution) of the present invention is obtained by dissolving 1 g of papain and 0.5 g of citric acid in 11 parts of water.
試験例１
シミ、ソバカスを有する１０名に製造例１の水溶液で３
日に１回の割合で１日１回洗顔してもらい、次の評価に
従って脱色効果を判定した。Test Example 1 Ten people with spots and freckles were treated with the aqueous solution of Production Example 1.
The subjects were asked to wash their faces once a day, and the bleaching effect was evaluated according to the following evaluation.
脱色効果非常に良好：脱色部８０〜１００％脱色効果良
好：脱色１！Ｓ５０〜８０％脱色効果あり ：脱色部２
０〜５０％
脱色効果不良：脱色部２０％以下
次の第１表に判定結果を示す。表中の数字は対応する脱
色効果を示した人数を意味する。Very good bleaching effect: bleaching area 80-100% Good bleaching effect: bleaching 1! S50-80% bleaching effect: Decolorizing part 2
0 to 50% Poor bleaching effect: Less than 20% bleached area Judgment results are shown in Table 1 below. The numbers in the table mean the number of people who showed the corresponding bleaching effect.
第１表
試験例２
年令３４才の女性の顔に発生したニキビに対して製造例
２の組成物を用いて治療したところ、表面の化膿がなく
なり、更に第２回目の処理を行うと内部のしこりが消え
た。第３回目の治療によりニキビはほぼ完全に治ｆａさ
れ、第４回目からはニキビ跡のシミの除去が行われた。Table 1 Test Example 2 When the composition of Production Example 2 was used to treat acne that appeared on the face of a 34-year-old woman, the surface suppuration disappeared, and after a second treatment, the internal The lump disappeared. After the third treatment, the acne was almost completely cured, and from the fourth treatment, the acne scars were removed.
試験例３
製造例２の水溶液を１０重量％添加した市販のシャンプ
ーにより２日に１回の割合で２週間洗髪をしたところ次
のような結果が得られた。Test Example 3 When hair was washed once every two weeks for two weeks using a commercially available shampoo containing 10% by weight of the aqueous solution of Production Example 2, the following results were obtained.
（１）７ケが出なくなった。１０人中、８人（２）毛に
ツヤが出た。 〃 ８人（３）枝毛が少な
くなった。 〃 ７人（４）パサパサしなくなっ
た。 〃 ６人（以 上）(1) 7 pieces no longer appear. 8 out of 10 people (2) had shiny hair. 〃 8 people (3) There were fewer split ends. 〃 7 people (4) It's no longer dry. 〃 6 people (or more)
Claims (1)
る皮膚病治療効果を有する組成物。(1) A composition having a therapeutic effect on skin diseases characterized by containing papain and citric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1005399A JPH0615462B2 (en) | 1989-01-12 | 1989-01-12 | Hair composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1005399A JPH0615462B2 (en) | 1989-01-12 | 1989-01-12 | Hair composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02188531A true JPH02188531A (en) | 1990-07-24 |
| JPH0615462B2 JPH0615462B2 (en) | 1994-03-02 |
Family
ID=11610071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1005399A Expired - Fee Related JPH0615462B2 (en) | 1989-01-12 | 1989-01-12 | Hair composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0615462B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06172209A (en) * | 1992-12-10 | 1994-06-21 | Reiko Kosaka | Composition for health of animal |
| WO1994019005A1 (en) * | 1993-02-23 | 1994-09-01 | Albert Scheller | Enzyme-containing pharmaceutical or cosmetic composition, process for preparing the same and its use |
| WO1995007686A1 (en) * | 1993-09-15 | 1995-03-23 | Unilever Plc | Skin care composition comprising thiol proteases from the stratum corneum |
| WO1996008233A1 (en) * | 1994-09-14 | 1996-03-21 | Kuyus-Stiftung | Cosmetic process |
| WO2001019324A1 (en) * | 1999-09-14 | 2001-03-22 | Isao Horiuchi | Cosmetics |
| JP2002284665A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| JP2006522807A (en) * | 2003-03-28 | 2006-10-05 | ロンザ インコーポレイテッド | Topical L-carnitine composition |
-
1989
- 1989-01-12 JP JP1005399A patent/JPH0615462B2/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06172209A (en) * | 1992-12-10 | 1994-06-21 | Reiko Kosaka | Composition for health of animal |
| WO1994019005A1 (en) * | 1993-02-23 | 1994-09-01 | Albert Scheller | Enzyme-containing pharmaceutical or cosmetic composition, process for preparing the same and its use |
| WO1995007686A1 (en) * | 1993-09-15 | 1995-03-23 | Unilever Plc | Skin care composition comprising thiol proteases from the stratum corneum |
| WO1996008233A1 (en) * | 1994-09-14 | 1996-03-21 | Kuyus-Stiftung | Cosmetic process |
| WO2001019324A1 (en) * | 1999-09-14 | 2001-03-22 | Isao Horiuchi | Cosmetics |
| JP2002284665A (en) * | 2001-03-23 | 2002-10-03 | Nippon Hypox Lab Inc | Cosmetics |
| JP2006522807A (en) * | 2003-03-28 | 2006-10-05 | ロンザ インコーポレイテッド | Topical L-carnitine composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0615462B2 (en) | 1994-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |