TW202222292A - Rinsing cleaning composition mild to skin including near saturated, saturated, or supersaturated active ingredients, and the production method for the same - Google Patents

Abstract

The present invention provides a rinsing cleaning composition mild to skin including near saturated, saturated, or supersaturated active ingredients, which comprises at least one surface active agent and at least one active ingredient. The composition simultaneously cleans skin and improves morphology and performance of skin, for example, enhanced gloss and anti-wrinkle.

Description

Mild cleansing compositions containing near-saturated, saturated, or supersaturated active ingredients and methods of making the same

The present invention relates to a mild cleansing composition containing near-saturated, saturated, or supersaturated active ingredients and a method for making the same, and in particular to a mild cleansing composition comprising at least one surfactant and at least one near-saturated, saturated, or supersaturated active Cleansing and maintenance compositions of active ingredients for improving skin texture and methods of making the same.

The skin is the largest natural barrier between the human body and the outside world. In order to keep the skin in a good hygienic state (that is, clean and healthy), the goal of skin cleansing is to remove the foreign matter in the human body's environment and the sebum and sweat produced by the human body itself. Therefore, skin cleansing is the first step in maintaining skin health. Taking facial cleansing as an example, after washing your face with general cleansing products, it is easy to not wash your face, which leads to clogged pores or excessive cleaning, which leads to damage to the natural skin barrier (Indian J Dermatol. 2011 Jan-Feb; 56(1): 2 -6); The water temperature, time, selection of cleaning products, and cleaning methods for washing face again and again affect the maintenance of cleaning efficiency and skin function, how to completely clean and maintain the normal function of the skin at the same time, and even increase the aesthetic level of the skin, That is, it is difficult for relevant researchers to break through.

The cleaning principles of detergents can be roughly divided into two types: dissolving and emulsifying dirt (Physicochemical and Engineering Aspects, 74, 169-215 (1993)). Detergents used to remove dirt using the principle of dissolution cannot avoid excessive cleaning of the skin surface, thereby causing damage to the skin barrier and resulting in rough and dry skin after cleansing (Clinics in Dermatology, Volume 14, Issue 1, January-February 1996, Pages 29 -33), or even lead to excessive secretion of sebum; the cleaning agent and emulsifier used to remove dirt by the principle of emulsification are not easy to completely remove the dirt, so a small amount of tiny emulsion droplets that are not washed off after emulsification are accumulated on the skin surface On pores and sweat glands, leading to unclean feeling, clogged pores, and acne breakouts.

In addition, the timing and method of skin care after cleansing is also a challenge in the life of ordinary people. The timing of personal skin care varies from person to person, but the evaluation of skin care products can be analyzed from two aspects: first, the formula combinations of skin care products mainly include water, oil, emulsifier, stabilizer, various base agents and even solvents, etc. It becomes two immiscible oil and water phases and has the largest composition ratio. Therefore, emulsifiers, stabilizers, etc. are required. The proportion of steroids is usually quite low, and it is difficult to achieve the improvement of aesthetic or clinical effects; secondly, the absorption of external skin preparations is mainly affected by the barrier formed by the stratum corneum, resulting in limited effects. Whether it is a drug or cosmetic transdermal delivery system (TDDS), there are roughly two ways: one, directly penetrate the stratum corneum, or penetrate through the lipid bilayer of the keratinocyte space, which is the penetration of the stratum corneum. The main way to penetrate the skin; Second, through the skin appendages such as hair follicles, sebaceous glands or sweat glands, which only account for 0.1 to 1.0% of the skin, so a very small amount of active ingredients are absorbed through this way). The problems to be overcome in the first absorption method mainly include the acid mantle of the skin (Current Pharmaceutical Design, 2015, Vol. 21, No. 00), and the stratum corneum that causes absorption barriers, both of which are barriers to drugs and cosmetics. The main obstacle to the absorption of active ingredients, which is also the main factor for consumers to use various skin care products to achieve the expected maintenance effect.

In conclusion, the present invention is to provide a mild cleansing composition and method for simultaneously addressing cleaning and maintenance, and all literature and patent documents cited herein are incorporated herein by reference.

In view of the shortcomings of the existing cleaning and maintenance technology, the present invention intends to improve the prior art which is difficult to clean the skin with mild formulations and difficult to maintain the skin in a suitable way, so as to simultaneously clean the skin, prevent excessive cleaning, and achieve preliminary maintenance effects to enhance skin function at the same time. Gentle cleansing composition. In the present invention, the active ingredient is supplemented with a mild surfactant formulation in a nearly saturated, saturated or supersaturated manner, and a simple process is used to prepare a composition that can simultaneously cleanse, avoid excessive cleansing and maintain the skin, wherein the active ingredient comprises Angelica dahurica (J Cosmet Sci. 2006 Jan-Feb;57(1):11-21), Baizhi (Ann Dermatol Vol. 28, No. 3, 2016), Atractylodes (Journal of Ethnopharmacology Volume 226, 15 November 2018, Pages 143 -167), Baiji (Fitoterapia Volume 92, January 2014, Pages 72-78), Poria (Planta Medica 77(7):681-91 February 2011), Fuzi (American Journal of Phytomedicine and Clinical Therapeutics, 2014, Pages 1277 -1286), or comfrey (Experimental Dermatology, 2018 Sep; 27(9):1043-1047) one or more of the above extracts; and the surfactants include long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl A combination of one or more of methyl isethionate, or potassium cocoyl glycinate. The mild cleansing composition containing active ingredients of the present invention can be used on any skin part of the human body to directly clean the skin and achieve maintenance effects at the same time. Protein synthesis, anti-inflammatory, avoid dry and cracked skin, antipruritic, anti-allergic, anti-aging, anti-oxidation, immune regulation, anti-fibrosis, etc.

According to the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients according to the present invention, the individual active ingredients are the iconic and representative ingredients (especially fat-soluble, highly physiologically active ingredients cited in the composition of the present invention) The saturation of its aqueous solution is Angelica Radix ≦0.01%, Atractylodes Rhizoma ≦0.003%, Atractylodes Rhizoma ≦0.004%, Baiji ≦0.006%, Poria ≦0.05%, Fuzi≦0.0002%, Lithospermum ≦0.01%; therefore, its total saturation concentration About not more than 0.1%.

The mild cleaning composition containing nearly saturated, saturated, or super-saturated active ingredients can be prepared by extracting the active ingredients by a general high-temperature aqueous solution extraction method, organic solvent extraction method, ultrasonic extraction method, or supercritical fluid extraction method. One or more of the above extraction combinations.

The mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has the active ingredients according to the description of the US Food and Drug Administration Cosmetics Laws & Regulations: it can meet the definitions of cosmetics and pharmaceuticals at the same time. It means that the present invention according to the scientific journal and the intended purpose of use is any ingredient that has any function that can affect humans or other animals; as well as use in human body cleaning, beauty, etc.

Preferably, the mild cleansing composition containing nearly saturated, saturated, or super-saturated active ingredients has an active ingredient that is intended to be used for rubbing, pouring, spraying or sprinkling, introducing or wiping on the human body for cleaning, beautifying, lifting and tightening. A substance that induces or alters appearance.

More preferably, the active ingredient of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients means that its efficacy on the skin can be one of the following or a combination thereof, such as: whitening, promoting collagen synthesis , Anti-inflammatory, avoid dry and cracked skin, antipruritic, anti-allergic, anti-aging, antioxidant, immune regulation, anti-fibrosis, etc.

The mild cleansing compositions containing near-saturated, saturated, or supersaturated active ingredients have O/W microemulsions (American Journal of Pharmtech Research, 2012), emulsions, or micelles (Cancers, July 2018) and other different dosage forms.

In the field of pharmacology, it is often necessary to maximize the active ingredients in the dosage form design, especially the liquid dosage forms containing fat-soluble and high physiological activity, such as paclitaxel, paclitaxel and other drugs, for such needs to achieve effective treatment The dosage and the active ingredients that reduce the total volume of administration as much as possible are as close as possible to the solubility saturation of the active ingredients in the dosage form design; on the contrary, due to the near-saturated, saturated, and super-saturated characteristics of the active ingredients, it is easy to mix with water. Disadvantages of precipitation. The present invention takes advantage of the near-saturated, saturated and super-saturated characteristics of the active ingredient to convert this shortcoming into the advantage of the external preparation, achieves precipitation and absorption of the active ingredient after mixing with water, avoids being dissolved by the cleaning agent, cleans up, and more Further cooperate with the hydration of the cleanser to the skin to increase the absorption and action of active ingredients.

Skin dirt and acidic barriers can be removed by cleaning agents to increase the absorption of active ingredients, but the penetration of the stratum corneum requires the design of a cosmeceutical delivery system to overcome the direct interaction between keratinocytes and keratinocytes. Barriers to Penetration (Skin Pharmacol Physiol 2006: 19: 106-21). The present invention uses a mild combination of surfactants. The combination of surfactants mainly uses the principle of emulsification method to clean the skin and generate a hydration phenomenon of the stratum corneum. In this state, the stratum corneum not only increases The penetration rate also increases the capacity between the stratum corneum (Capacitance), and the present invention utilizes this hydration phenomenon to increase the attachment of active ingredients and penetrate the stratum corneum at an appropriate time (The Journal of Investigative Dermatology, Vol. 101, No. 3 , September 1993); at the same time, the phenomenon that the concentration of active ingredients is close to saturation, saturation, or supersaturation (Pharmaceutical Research, July 2001, Volume 18, Issue 7, pp 1006–1011) is used to facilitate the deposition of active ingredients and absorption through concentration differences. This results in the protection and maintenance of the skin, and because of this novel design principle, the possibility of over-cleaning the skin can also be eliminated at the same time.

Long-chain betaines (Handbook for Cleaning/Decontamination of Surfaces), sodium lauroyl sarcosinate (Cosmetic Ingredient Review, September 2016), sodium lauroyl methyl isethionate (Cosmetic Ingredient Review, September 2013) and potassium cocoyl glycinate (Cosmetic Ingredient Review, September 2013) In various studies and scientific literature, it is a mild and low-irritant surfactant to the skin or eyes. The invention of the mild cleansing composition containing near-saturated, saturated, or supersaturated active ingredients is the application of this mild cleansing. The combination of surfactants is used to gently wash the skin, and then to dissolve the active ingredients to a concentration close to saturation, saturation, or supersaturation, so as to achieve the effect of cleansing the skin and maintaining the skin at the same time.

In order to achieve the above purpose of simultaneously cleaning, avoiding excessive cleaning and maintaining the skin, the present invention provides a mild cleansing composition containing near-saturated, saturated, or super-saturated active ingredients, which comprises at least one surfactant and at least one near-saturated, A cleansing and maintenance composition of an active ingredient that is saturated or supersaturated and can improve skin texture and its preparation method. The surfactant is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 5.00wt% to 70.00wt% of the inventive composition; the active ingredient is Angelica dahuricae , Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Comfrey in any combination of one or more extracts and accounting for 0.1wt% to 10.00wt% of the composition of the invention; the composition of the invention may further comprise an appropriate amount of water, It accounts for 15.00wt% to 85.00wt% of the inventive composition; the inventive composition may further comprise an appropriate amount of cosmetic excipients, such as diluents, thickeners, stabilizers, fragrances, preservatives, cosurfactants ) etc., the excipients comprise from 0 wt % to 15.00 wt % of the inventive composition.

Preferably, the surfactant long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate of the composition of the invention accounts for 0wt% to 25.00wt% and 0wt% to 20.00wt% of the inventive composition, respectively. %, 0wt% to 25.00wt%, 0wt% to 20.00wt%, and their sum must not be zero.

More preferably, the surfactant of the composition of the invention is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 10.00wt% to 65.00% of the composition of the invention. wt%.

Most preferably, the surfactant of the composition of the invention is any combination of one or more of long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate and accounts for 20.00wt% to 60.00% of the composition of the invention wt%.

Preferably, the active ingredients of the composition of the invention, Angelica dahurica, Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Comfrey account for 0wt% to 8.00wt%, 0wt% to 8.00wt%, 0wt% of the inventive composition, respectively. % to 8.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, 0wt% to 4.00wt%, and their sum must not be zero.

Preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahurica, Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Comfrey and accounts for 0.10wt% to 8.00wt% of the inventive composition.

More preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelica, Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Comfrey and accounts for 0.20wt% to 6.00wt% of the inventive composition.

Most preferably, the active ingredient of the composition of the invention is any combination of one or more of Angelica dahuricae, Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Comfrey and accounts for 0.40wt% to 4.00wt% of the inventive composition.

Preferably, the inventive composition may further comprise an appropriate amount of water, which is 20.00 wt % to 80.00 wt % of the inventive composition. More preferably, it is from 25.00 wt% to 75.00 wt% of the inventive composition. Optimally, it comprises 30.00% to 70.00% by weight of the inventive composition.

Preferably, the composition of the present invention may further comprise an appropriate amount of cosmetic excipients, which may be diluents, thickeners, stabilizers, fragrances, preservatives, or cosurfactants, etc. Excipients range from 0.50 wt% to 10.00 wt% of the inventive composition. Preferably, the excipient accounts for 1.00% to 8.00% by weight of the inventive composition. More preferably, the excipient accounts for 2.00% to 6.00% by weight of the inventive composition. Preferably, the excipients account for 4.00% to 6.00% by weight of the inventive composition.

The present invention provides a mild cleansing composition containing near-saturated, saturated, or super-saturated active ingredients, including at least one surfactant and at least one near-saturated, saturated, or super-saturated active ingredient that can improve skin texture. A composition wherein the mild cleansing composition is prepared by the following preparation method comprising the steps of: (i) adding the at least one active ingredient to a mixing vessel and adding an appropriate amount of water; and (ii) the at least one active ingredient At least one surfactant is added to the mixing container in step (i) and mixed evenly, if necessary, heated to dissolve and mixed evenly; (iii) if necessary, add appropriate excipients, such as diluents, thickeners, stabilizers, Flavors, or preservatives, etc., continue to mix evenly and return to room temperature.

According to the present invention, preferably, the active ingredients of the mild cleaning composition containing nearly saturated, saturated, or supersaturated active ingredients and the preparation method thereof can be extracted by general high-temperature aqueous solution, organic solvent extraction, and ultrasonic extraction. , or any combination of one or more of supercritical fluid extraction methods.

In order to make the above-mentioned features and advantages of the present invention more obvious and easy to understand, the following specific embodiments are given and described in detail with the accompanying drawings as follows.

In order to simultaneously cleanse the skin, prevent over-cleansing, and at the same time achieve a primary maintenance effect to enhance skin function, the present invention provides a mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients, the composition comprising one or more of an active ingredient; and one or more of the above surfactants; the inventive composition may further include an appropriate amount of water; the inventive composition may further include an appropriate amount of cosmetic excipients.

Please refer to FIG. 1 , it is explained that the present invention utilizes surfactant and water to hydrate the stratum corneum, and the active ingredient is implemented in a near-saturated, saturated, or supersaturated form in the combination of the present invention, so that the active ingredient is easy to precipitate on the surface of the stratum corneum. Facilitates the absorption of active ingredients.

The following examples serve to demonstrate the invention. These examples are not intended to limit the scope of the invention in any way, but are intended to be indicative of how to practice the materials and methods of the invention.

In the embodiments of the present invention, the so-called at least one surfactant is selected from long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, or potassium cocoyl glycinate, one or more of which are any combination of the above.

In the embodiment of the present invention, the so-called having at least one active ingredient is selected from the extracts of Angelica dahurica, Atractylodes Rhizoma, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, or Lithospermum, and any combination of one or more of the above.

Example 1: Active ingredient-containing mild cleansing composition formulation 1 and method of manufacture

In this embodiment, every 1000 grams of the final product contains an active ingredient equivalent to 5 grams, and its manufacturing method is as follows: the extraction of each active ingredient is carried out with a mixed extract in an equal weight ratio of alcohol and water, wherein the mixed extract and each active ingredient are extracted. The weight ratio of the raw materials of the ingredients is 10:1 to 50:1, the extraction temperature is 50 to 100°C, and the extraction time is 1 hour to 10 hours. Poria, aconite, and comfrey extract each 500 mg, mixed with 50 g each of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, potassium cocoyl glycinate and appropriate amount of water, if necessary, heat to a homogeneous state and add PEG-7 glyceryl 10 grams of cocoate and PEG-200 hydrogenated glyceryl palmate were mixed uniformly, and then 10 grams of sodium chloride was added, stirred and mixed until uniform, and cooled to room temperature.

Table 1, Example 1 formula composition composition table

Examples 2 to 12: Active ingredient-containing mild cleansing compositions Formulations 2 to 12, the manufacturing method of which is similar to that of Example 1, but different formulation compositions and extraction methods are also shown in Table 2, which is Examples 1 to 12 Formulation composition composition table, table 3 is the extraction method of its active ingredient of embodiment 1 to 12 formula composition, table 4 is the extraction condition of each extraction method.

Table 2, Examples 1 to 12 formula composition table

Table 3, the extraction method of the active ingredients of the formula compositions of Examples 1 to 12

Table 4, the extraction conditions of each extraction method

The present invention provides a mild cleansing composition containing nearly saturated, saturated, or super-saturated active ingredients, the test results of which are as follows:

<Approach saturation, saturation, and supersaturation experiments>

Microscopically observe the composition example 12 of the present invention with a microscope. In addition, water and the composition of the present invention are mixed uniformly in a weight ratio of 1:1, and observed with a microscope at time points 10, 60, 360, and 720 minutes. Its saturated precipitation situation is shown in Figure 2 to Figure 6. The results showed that the composition of the present invention did not produce precipitation (Fig. 2); the water and the composition of the present invention were mixed uniformly in a weight ratio of 1:1, and a trace amount of precipitate visible under the optical microscope was produced within 10 minutes of the time point (Fig. 3). ), a small amount of precipitates were produced in 60 minutes (Figure 4), agglomerated precipitates were produced in 360 minutes (Figure 5), and a large amount of sediments were produced in 720 minutes (Figure 6). The stability test is carried out. Due to the decrease in energy, agglutination will slowly occur after a long period of static storage. This test shows the excellent design of the composition of the present invention near the critical value of saturation (Journal of Pharmaceutical Sciences, January 2012); it proves that the composition of the present invention is practical under the concept of "Quality by Design". When the skin is cleansed, it is enough to protect and maintain the skin.

<Avoid excessive cleaning and protection experiments>

Commercially available cleaning products (Dermisa Brightening Bar) and Example 10 of the composition of the present invention were respectively used for 20 consecutive cleaning procedures of washing, drying and then washing the inner thighs. The results are shown in Table 5 and Figures 7 to 12 to avoid excessive cleaning. shown in the experiment.

The experiment used gloss and microscope inspection as observation tools to simulate general washing methods for cleaning. The results showed that the skin surface was damaged after repeated cleaning with general detergents in a short period of time, and the microscope inspection results also showed that the stratum corneum was damaged and white peeled off Flake or even rolled up, this microscopic result of microscopic examination also showed that the macroscopic glossiness test result showed a decrease; on the contrary, the skin surface was not only free of damage after repeated washing with the composition of the present invention in a short period of time , the difference between before and after cleaning can not be distinguished by observing the results of microscopic examination, but the improvement of skin smoothness can be seen from the glossiness result, so it can be expected that long-term use of the composition of the present invention will make the skin more delicate and smooth, which will further lead to glossiness. Significantly improved to the point where the difference can be discerned by the human eye.

Table 5. Avoid excessive cleaning experiments

To sum up, based on the prior art and general knowledge and cognition, it is easy to damage the stratum corneum by using a cleanser to clean the skin, resulting in rough skin surface, and then based on the use of skin care products such as creams on the damaged skin; relatively, the composition of the present invention utilizes close to Saturated, saturated, or super-saturated, the active ingredients can be extracted, absorbed and protected from damage during skin cleansing.

<Moisturizing degree test>

In Example 11, decontamination and cleaning and maintenance are used as the standard steps each time. After each cleaning, a commercially available skin detector (RUNVE Skin Analyzer) is used for measurement. This detector contains three measurement values: humidity and oil. The oil content and the fine roughness can be measured with the skin gloss; the moisture content is expressed as the average value of the three points of the forehead and left and right cheekbones. After about 3 weeks of washing and testing with a general facial cleansing product (Dermisa Brightening Bar), and then using the composition of the present invention to clean the skin for more than 4 weeks according to the above standard use procedures, it can be seen from the test chart of its moisturizing degree (Fig. 13). Whether it was just after cleansing or 10 minutes after cleansing, the hydration index showed a dramatic improvement after two weeks.

Generally, the moisturizing degree of facial cleansing products after cleaning is between 40 and 42, and the moisturizing degree after drying is between 34 and 38. As shown in Table 6, referring to the classification of moisturizing degree in the instruction manual, it can be seen that it falls in the normal skin range after cleaning, and it takes 10 minutes. The water is lost to the dry skin area; relatively, after using the composition of the present invention for about two weeks, the moisture retention after cleansing is about 43 to 48, and the moisture retention after drying is about 38 to 44, referring to the skin detector According to the classification of its moisturizing degree in the manual, it can be known that after cleansing, it falls in the range suitable for moist skin, and the moisture is lost to the normal skin range within 10 minutes.

Table 6. Description of moisturizing degree

<Gloss test>

General dermatologists' perception of skin gloss is that the oil secreted by sebaceous glands and other substances in the environment adhere to the increase of skin gloss (Biomedical Optics Express). This environment on the skin can easily lead to acne, seborrheic The occurrence of skin diseases such as dermatitis; on the contrary, when the skin is cleaned without the above-mentioned sebum and other interference conditions, the skin still shows obvious gloss due to long-term healthy skin composition, such as reducing skin roughness (Skin Research and Technology), reduction of wrinkles, better moisturization of fine and healthy skin performance, which can be contributed by eg epidermal growth factor or collagen hyperplasia (WO2005037270A1). However, the composition of the present invention is rich in effective ingredients enough to promote healthy skin, thereby reducing wrinkles and the like and increasing the gloss of the skin after cleansing (International Journal of Research in Pharmacy and Chemistry).

Take one decontamination and one cleaning and maintenance as standard steps every time you wash your face. After cleaning every day, use a gloss meter (BYK Micro-Gloss) to measure the skin gloss on the flattest forehead of the face. After about 3 weeks of washing and testing with a general face cleansing product (Dermisa Brightening Bar), and then using the composition of the present invention to clean the skin for more than 4 weeks in accordance with the above-mentioned standard use procedures, it can be seen from the glossiness test chart (Figure 14) after washing. Whether it was just after cleaning or 10 minutes after cleaning, the gloss index showed a dramatic improvement after two weeks.

Generally, the gloss of the face of people with sebum is about 2GU (Gloss unit), and it will decrease to about 1GU after cleaning or the roughness of the skin, and it will also increase to 2.5GU with the increase of skin fineness or the use of maintenance cosmetics. Left and right (Optical Review). However, the composition of the present invention can reach a gloss of about 3GU to 5GU after long-term use and before various skin care products are used, so that the difference in gloss can be discerned by the human eye (the difference can be discerned by the human eye is about 3GU). Users can also clearly feel the skin's fineness and see the increase in gloss. Since the hydrated skin after cleansing is not yet dry and the stratum corneum has not returned to its original state, the gloss level falls around 3GU, and after 10 minutes of recovery, the gloss level can appear normally to around 5GU.

Comparative Example 13: Mild Cleansing Composition Containing Unsaturated Active Ingredient Formulation 13 and Method of Manufacture

In this comparative example, every 1000 grams contains an active ingredient equivalent to 0.83 grams, and its manufacturing method is as follows: extracting the extracts in the proportions of alcohol and water, respectively, containing 100 mg of Angelica Radix, Rhizoma Atractylodes, and Atractylodes Rhizoma, Bletilla striata, Poria cocos , 50 mg each of aconite, comfrey extract, mixed with 50 g each of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroyl methyl isethionate, potassium cocoyl glycinate and appropriate amount of water, if necessary, heat to a uniform state and add PEG-7 glyceryl cocoate 10 grams of PEG-200 hydrogenated glyceryl palmate and 10 grams of each were mixed evenly, then 10 grams of sodium chloride was added, stirred and mixed until uniform, and cooled to room temperature.

Table 7, comparative example 13 formula composition composition table

The present comparative example provides a mild cleansing composition containing unsaturated active ingredients, and the comparative test results thereof are as follows:

<Approach saturation, saturation, and supersaturation experiments>

Microscopically, Comparative Example 13 was mixed with water in equal proportions by weight, and observed with a microscope at time points 10 and 60 minutes to check whether the unsaturation had precipitation, as shown in Figures 15 and 16. The results showed that no precipitation occurred in the present unsaturated comparative example 13.

<Avoid over-cleaning and protection comparison experiment>

In this comparative example 13, the inner thigh was cleaned, wiped dry, and then cleaned for 20 consecutive times. The results are shown in Table 8 and the comparative experiments of avoiding excessive cleaning in FIGS. 17 to 20 .

Table 8. Avoid excessive cleaning experiments

The experiment used gloss and microscope inspection as observation tools to simulate general washing methods for cleaning. The results showed that the skin surface of Comparative Example 13 did not change significantly after repeated washing in a short period of time; 1.4GU and 1.4GU after cleaning), there is no obvious change in the smoothness of the skin, and the observation of the microscopic examination results can not see the significant difference between the cell types before and after cleaning, but the observation under the microscope: the gloss after cleaning is still higher than that before cleaning. reduce.

Based on the comparison between saturated Example 10 and unsaturated Example 13 in the avoidance of excessive cleaning and protection, the saturated Example 10 not only has the function of avoiding excessive skin cleaning and protection, but also can increase the skin smoothness; Saturated Example 13 was insignificant in terms of avoiding over-cleansing and protecting the skin. This experiment shows that the invention of the mild cleansing composition containing nearly saturated, saturated, or supersaturated active ingredients has its special novelty and progress.

Although the present invention has been disclosed above by the embodiments, it is not intended to limit the present invention. Anyone with ordinary knowledge in the technical field can make some changes and modifications without departing from the spirit and scope of the present invention. Therefore, The protection scope of the present invention shall be determined by the scope of the appended patent application.

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FIG. 1 is a schematic diagram illustrating that the present invention utilizes surfactants and water to hydrate the stratum corneum, and the active ingredients are implemented in a near-saturated or saturated or supersaturated form to facilitate skin absorption. FIG. 2 is a series of micrographs magnified at different magnifications, showing the precipitation state of the composition Example 12 of the present invention before mixing with water. 3 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 10 minutes after the composition Example 12 of the present invention and water were mixed uniformly in a weight ratio of 1:1. 4 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 60 minutes after the composition Example 12 of the present invention and water were uniformly mixed at a weight ratio of 1:1. 5 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 360 minutes after the composition of Example 12 of the present invention and water were uniformly mixed at a weight ratio of 1:1. 6 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 720 minutes after the composition Example 12 of the present invention and water were uniformly mixed in a weight ratio of 1:1. FIG. 7 is a micrograph at a magnification of 200 times, showing the state of the skin before being washed with a general cleanser. FIG. 8 is a micrograph at a magnification of 200 times, showing the state of the skin before washing with the composition of Example 10 of the present invention. FIG. 9 is a micrograph at a magnification of 30 times, showing a state where the skin is continuously washed 20 times with a general cleanser. Fig. 10 is a micrograph at a magnification of 30 times, showing the state that the skin is continuously washed 20 times in Example 10 of the composition of the present invention. FIG. 11 is a micrograph at a magnification of 200 times, showing the state of the skin being continuously washed 20 times with a general cleanser. Fig. 12 is a microscope photograph magnified at a magnification of 200 times, showing the state in which the skin is continuously washed 20 times in Example 10 of the composition of the present invention. FIG. 13 is a moisture retention test graph, illustrating the moisture retention of the skin immediately after cleansing and 10 minutes after cleansing in Example 11 of the composition of the present invention. FIG. 14 is a gloss test chart illustrating the gloss of the skin immediately after cleansing and 10 minutes after cleansing in Example 11 of the composition of the present invention. 15 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 10 minutes after the composition of Comparative Example 13 of the present invention was mixed with water at a weight ratio of 1:1. 16 is a series of micrographs magnified at different magnifications, showing the precipitation state at the time point of 60 minutes after the composition of Comparative Example 13 of the present invention was mixed with water at a weight ratio of 1:1. FIG. 17 is a micrograph at a magnification of 30 times, showing the state of the skin before washing with the composition of Comparative Example 13 of the present invention. Fig. 18 is a micrograph at a magnification of 30 times, showing the state where the skin is continuously washed 20 times in Comparative Example 13 of the composition of the present invention. FIG. 19 is a micrograph at a magnification of 200 times, showing the state of the skin before washing with the composition of Comparative Example 13 of the present invention. Fig. 20 is a microscope photograph magnified by a magnification of 200 times, showing the state where the skin is continuously washed 20 times in Comparative Example 13 of the composition of the present invention.

Claims (10)

A mild cleansing composition comprising: at least one surfactant; and At least one active ingredient that is nearly saturated, saturated, or supersaturated and that improves skin texture. The mild cleansing composition of claim 1, wherein the surfactant contains long-chain betaines, sodium lauroyl sarcosinate, sodium lauroyl hydroxymethylethanesulfonate (sodium lauroyl methyl isethionate) and at least one of potassium cocoyl glycinate (potassium cocoyl glycinate), and the surfactant accounts for 5wt% to 70wt% of the mild cleansing composition. The mild cleansing composition of claim 1, wherein the surfactant contains long-chain betaine (long-chain betaines), sodium lauroyl sarcosinate (sodium lauroyl sarcosinate), sodium lauroyl hydroxymethyl ethanesulfonate (sodium lauroyl methyl isethionate) and at least one of potassium cocoyl glycinate (potassium cocoyl glycinate), and the surfactant accounts for 10wt% to 65wt% of the mild cleansing composition. The mild cleansing composition of claim 1, wherein the active ingredient contains at least one extract of Angelica dahurica, Baiji, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, and Comfrey, and the active ingredient accounts for the mild cleansing composition 0.1wt% to 10wt%. The mild cleansing composition of claim 1, wherein the active ingredient contains at least one extract of Angelica dahurica, Baiji, Atractylodes Rhizoma, Bletilla striata, Poria, Aconite, and Comfrey, and the active ingredient accounts for the mild cleansing composition 0.2wt% to 6wt%. The mild cleansing composition of claim 1, further comprising: Moderate amount of water. The mild cleansing composition of claim 1, wherein the appropriate amount of water accounts for 20wt% to 80wt% of the mild cleansing composition. The mild cleansing composition of claim 1, further comprising: Appropriate amount of cosmetic excipients. The mild cleansing composition of claim 8, wherein the appropriate amount of cosmetic excipients accounts for 0.50 wt % to 10.00 wt % of the mild cleansing composition. The mild cleansing composition according to claim 1, wherein the preparation method of the active ingredient extract is general high temperature aqueous solution extraction, organic solvent extraction, ultrasonic extraction, or supercritical fluid extraction.

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