JPH02162258A - Liquid collecting tube - Google Patents
Liquid collecting tubeInfo
- Publication number
- JPH02162258A JPH02162258A JP31775588A JP31775588A JPH02162258A JP H02162258 A JPH02162258 A JP H02162258A JP 31775588 A JP31775588 A JP 31775588A JP 31775588 A JP31775588 A JP 31775588A JP H02162258 A JPH02162258 A JP H02162258A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- tube body
- tube
- anticoagulant
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims description 22
- 239000008280 blood Substances 0.000 claims abstract description 55
- 210000004369 blood Anatomy 0.000 claims abstract description 55
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 20
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 20
- 238000007789 sealing Methods 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 12
- 229920003169 water-soluble polymer Polymers 0.000 claims description 7
- 239000002274 desiccant Substances 0.000 abstract description 5
- 238000001035 drying Methods 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 description 14
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 7
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 7
- 229960002897 heparin Drugs 0.000 description 7
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 7
- 229960001008 heparin sodium Drugs 0.000 description 7
- 239000011521 glass Substances 0.000 description 6
- 229910052744 lithium Inorganic materials 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920001225 polyester resin Polymers 0.000 description 3
- 239000004645 polyester resin Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000010842 industrial wastewater Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Inorganic materials [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003763 resistance to breakage Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野１
本発明は、例えば採血管として血液の採取に用いられる
採液管に関し、特にヘパリンナトリウムやヘパリンリチ
ウム等の凍結乾燥剤を封入した採液管に関する。Detailed Description of the Invention [Industrial Application Field 1] The present invention relates to a liquid collection tube used for collecting blood, for example, as a blood collection tube, and in particular to a liquid collection tube filled with a freeze-drying agent such as heparin sodium or heparin lithium. Regarding.
［従来の技術］
一般に、臨床検査において、血漿検査及び血糖検査を行
う場合には、採血管としてヘパリンナトリウム、ヘパリ
ンリチウム等の抗凝固剤を封入した管が使用されている
。そして、このヘパリンナトリウム等は採取された血液
に直ちに溶けるように凍結乾燥したものが用いられてい
る。[Prior Art] Generally, when performing plasma tests and blood sugar tests in clinical tests, tubes filled with anticoagulants such as heparin sodium and heparin lithium are used as blood collection tubes. The heparin sodium and the like are freeze-dried so that they immediately dissolve in the collected blood.
一方、この種の採血管の材質としては、従来はガラス製
の有底管とゴム製の封止部材とからなるものが使用され
ていたが、最近、軽量で破損しにくい等の理由からプラ
スチック製の採血管が使用されている。On the other hand, the material used for this type of blood collection tube used to be made of a glass bottomed tube and a rubber sealing member, but recently plastic tubes have been made of plastic because of its light weight and resistance to breakage. blood collection tubes made by the manufacturer are used.
ところで、このような採血管は、工場での製造時におい
て、管体内部の採血量に応じて適度の減圧値に設定する
こととしており、この製造された採血管は、病院等にお
いて使用されるまでの間、ユーザーの元で長い場合は２
〜３年の間保存される。By the way, when such blood collection tubes are manufactured at a factory, the pressure is set to an appropriate depressurization value depending on the amount of blood to be collected inside the tube, and these manufactured blood collection tubes are used in hospitals, etc. If it is long for the user, 2
Stored for ~3 years.
［発明が解決しようとする課題］
しかしながら、従来のプラスチックにより形成された減
圧採血管にあっては、ガラス管によるものに比べて、水
分を透過しゃすい、そのため、ヘパリンナトリウム等の
凍結乾燥剤を封入した採血管を高湿度下（湿度７０％以
上）において保存すると、ヘパリンナトリウム等が潮解
してしまい、そのため採取された血液と混合しにくくな
り、検査精度に影響を与えるという問題があった。[Problems to be Solved by the Invention] However, conventional vacuum blood collection tubes made of plastic are more permeable to water than those made of glass tubes. If the enclosed blood collection tube is stored under high humidity (humidity of 70% or higher), heparin sodium etc. will deliquesce, making it difficult to mix with the collected blood and affecting test accuracy.
また、ガラス管にゴム製封止部材を用いた採血管でも、
ヘパリンナトリウム等の分量が微量の場合には、ゴム製
封止部材に吸収あるいは吸着した極く少量の水分の影響
で潮解し、その形状が変ることがあった。In addition, blood collection tubes that use rubber sealing members on glass tubes also
When the amount of heparin sodium or the like is small, the rubber sealing member may deliquesce and change its shape due to the influence of the very small amount of water absorbed or adsorbed.
本発明はかかる問題点に鑑みてなされたものであって、
高湿度下に保存され水分が侵入しても、抗凝固剤等の乾
燥剤が潮解しにくく、元の形状を長期間維持することが
できる採液管を提供することを目的とする。The present invention has been made in view of such problems, and includes:
To provide a liquid collection tube in which a desiccant such as an anticoagulant hardly deliquesces even if it is stored under high humidity and moisture enters, and can maintain its original shape for a long period of time.
［課題を解決するための手段］
上記課題を解決するために、本発明に係る採液管は、内
部に液体が採取される採液管であって、一端が開口する
とともに他端が閉塞してなる有底管体と、該有底管体の
開口部を封止する封止部材とを備え、前記有底管体の内
部に水溶性の第１の物質と該物質より水溶性の低い第２
の物質とを混合してなる乾燥混合剤を封入したことを特
徴とする。ここで、前記液体は、特に血液であるととも
に、前記第１の物質はこの血液に対する抗凝固剤であり
、また、前記第２の物質は水溶性高分子物質であること
が好ましい、さらに、前記水溶性高分子物質と抗凝固剤
との重量比はｌ：１０〜５：ｌの範囲であることが好ま
しい。[Means for Solving the Problems] In order to solve the above problems, a liquid collection tube according to the present invention is a liquid collection tube into which a liquid is collected, and has one end open and the other end closed. a bottomed tube, and a sealing member for sealing an opening of the bottomed tube, and a water-soluble first substance and a water-soluble first substance lower in water solubility than the substance are contained inside the bottomed tube. Second
It is characterized by enclosing a dry mixture formed by mixing these substances. Here, the liquid is preferably blood, the first substance is an anticoagulant for this blood, and the second substance is preferably a water-soluble polymer substance. The weight ratio of the water-soluble polymeric substance to the anticoagulant is preferably in the range of 1:10 to 5:1.
［作 用］
上記本発明による採液管にあっては、高湿度下に長期間
保存され内部に水分が侵入した場合、内部の抗凝固剤等
の第１の物質が水分を吸収して潮解しようとするが、当
該乾燥混合剤には第１の物質よりも水溶性の低い第２の
物質が混合されているため、乾燥剤が第１の物質単独か
らなる場合に比べて潮解の度合が低下し、元の形状をほ
ぼ維持することができる。したがって、採液針等を通じ
て内部に血液等が流入すると、抗凝固剤等の第１の物質
が速やかに溶ける。[Function] When the liquid collection tube according to the present invention is stored under high humidity for a long period of time and moisture enters the inside, the first substance such as an anticoagulant inside absorbs the moisture and deliquesces. However, since the dry mixture contains a second substance that is less water-soluble than the first substance, the degree of deliquescence is lower than when the desiccant is composed of the first substance alone. The original shape can be maintained. Therefore, when blood or the like flows into the interior through a liquid sampling needle or the like, the first substance such as an anticoagulant quickly dissolves.
［実施例］
以下、図面を参照して本発明の実施例を具体的に説明す
る。[Example] Hereinafter, an example of the present invention will be specifically described with reference to the drawings.
第１図は本発明の一実施例に係る減圧採血管の縦断面構
造を示すものである。この採血管は、上端が開口すると
ともに下端が閉塞してなり、当該開口部２の周縁にフラ
ンジ部３を有する有底管体ｌと、この有底管体ｌの開口
部２を封止する封止部材４とから構成されている。FIG. 1 shows a longitudinal cross-sectional structure of a reduced pressure blood collection tube according to an embodiment of the present invention. This blood collection tube has an open upper end and a closed lower end, and includes a bottomed tube 1 having a flange 3 around the opening 2, and seals the opening 2 of the bottomed tube 1. It is composed of a sealing member 4.
有底管体ｌとしては、プラスチック又はガラス製のもの
が用いられる。プラスチックとしては、ポリエチレン、
ポリプロピレン、ポリ４−メチルペンテン、ポリスチレ
ン、ポリカーボネート、ポリメチルメタアクリレート、
ポリエチレンテレフタレート、ナイロン、アクリルニト
リル系ポリマー等のある程度透明性を有するものが好ま
しい。The bottomed tube l is made of plastic or glass. Plastics include polyethylene,
Polypropylene, poly4-methylpentene, polystyrene, polycarbonate, polymethyl methacrylate,
Preferably, the material has some degree of transparency, such as polyethylene terephthalate, nylon, or acrylonitrile polymer.
また、封止部材２は、例えばアルミニウムにより形成さ
れ、タブ部５を備えるとともに有底管体１のフランジ部
３に接着されて開口部２を覆うガスバリヤ−性のフィル
ム部材４ａと、このフィルム部材４ａ上で開口部２の中
央部に対向させて接着固定された再シールゴム部材４ｂ
とにより構成されている。そして、血液の採取時には、
これらの再シールゴム部材４ｂ及びフィルム部材４ａに
は、図示しない採血ホルダーに設けられた中空の穿刺針
が穿刺され、有底管体ｌの内部に刺通されることとなる
。すなわち、穿刺針の先端から導入された血液は、有底
管体１の内部の減圧状態により穿刺針の中空部を通って
採血管の内部に流入し、これにより採血が行われるもの
である。The sealing member 2 is made of aluminum, for example, and includes a tab portion 5 and a gas barrier film member 4a that is adhered to the flange portion 3 of the bottomed tube body 1 and covers the opening portion 2, and this film member. A resealing rubber member 4b is adhesively fixed on 4a facing the center of the opening 2.
It is composed of. And when blood is collected,
A hollow puncture needle provided in a blood collection holder (not shown) is inserted into the resealing rubber member 4b and the film member 4a, and the needle is inserted into the bottomed tube l. That is, blood introduced from the tip of the puncture needle flows into the blood collection tube through the hollow part of the puncture needle due to the reduced pressure inside the bottomed tube body 1, and thereby blood is collected.
有底管体ｌの内部には乾燥混合剤６が封入されている、
この乾燥混合剤６は、抗凝固剤であるヘパリンナトリウ
ム、ヘパリンリチウム又はフッ化ナトリウム等に、血液
検査に影響を及ぼさない他の水溶性物質を入れて混合溶
液とし、凍結及び乾燥の工程を経て製造したものであり
、顆粒状、粉末状いずれの状態でもよい、すなわち、こ
のような乾燥混合剤６を用いることにより、減圧採血管
内に水分が侵入し、この水分により抗凝固剤が潮解しよ
うとしても、抗凝固剤よりも水溶性の低い水溶性高分子
物質が含まれているため、抗凝固剤単独の場合よりも抗
凝固剤そのものの潮解の度合が低下し、その結果光の形
状をほぼ維持することができる。A dry mixture 6 is sealed inside the bottomed tube l.
This dry mixture 6 is made by adding other water-soluble substances that do not affect blood tests to anticoagulants such as heparin sodium, heparin lithium, or sodium fluoride to make a mixed solution, and then passing through the freezing and drying process. In other words, by using such a dry mixture 6, moisture will enter the vacuum blood collection tube, and this moisture will cause the anticoagulant to deliquesce. However, since it contains a water-soluble polymer substance that is less water-soluble than the anticoagulant, the degree of deliquescence of the anticoagulant itself is lower than that of the anticoagulant alone, and as a result, the shape of the light is approximately can be maintained.
上記水溶性物質としては、抗凝固剤より水溶性の低い水
溶性高分子が用いられ、例えばポリエチレングリコール
、ポリビニルメチルエーテル、ポリビニルピロリドン、
ポリビニルアルコール、ポリヒドロキシセルロースが用
いられる。As the water-soluble substance, a water-soluble polymer having lower water solubility than an anticoagulant is used, such as polyethylene glycol, polyvinyl methyl ether, polyvinyl pyrrolidone,
Polyvinyl alcohol and polyhydroxycellulose are used.
又、この水溶性高分子物質と抗凝固剤との重量の比は１
：ｌＯ〜５：ｌの範囲が好ましく、より好ましくはｌ：
５〜２：１の範囲である。Also, the weight ratio of this water-soluble polymer substance and anticoagulant is 1.
:lO to 5:l is preferable, more preferably l:
The ratio is in the range of 5 to 2:1.
水溶性高分子物質と抗凝固剤との重量の比が１：１０よ
り小さいと潮解の度合が大きく、また５：ｌより大きい
と血液への影響が大きくなり、またコストも増加してし
まう。If the weight ratio of the water-soluble polymer substance to the anticoagulant is less than 1:10, the degree of deliquescence will be large, and if it is larger than 5:1, the effect on blood will be large and the cost will also increase.
上記本実施例の減圧採血管を用いて、血液採取を行う場
合には、先ず、採血器具に取付けられた採血針を患者の
血管に穿刺させる１次に、減圧採血管を、採血針の後端
に形成されている穿刺針の先端が、当該減圧採血管の再
シールゴム部材４ｂ及びフィルム部材４ａを貫通し、内
部に達するまで採血器具に挿入すると、減圧採血管内に
は、その減圧量に応じた量の血液が流入する。ここで、
乾燥混合剤６は、元の形状を維持しているため、血液の
流入の際、血液中に速やかに溶け、血液の凝固を効果的
に防止することができる。When blood is collected using the vacuum blood collection tube of this embodiment, first, the blood collection needle attached to the blood collection device is punctured into the patient's blood vessel.The vacuum blood collection tube is inserted after the blood collection needle. When the tip of the puncture needle formed at the end penetrates the resealing rubber member 4b and film member 4a of the vacuum blood collection tube and is inserted into the blood collection device until it reaches the inside, the inside of the vacuum blood collection tube will be filled with water depending on the amount of vacuum. A large amount of blood flows in. here,
Since the dry mixture 6 maintains its original shape, it quickly dissolves in blood when blood flows in, and can effectively prevent blood from coagulating.
なお、採血が完了すると、採血器具より採血管を抜去し
た後、検査が行われろ。When the blood collection is completed, the blood collection tube should be removed from the blood collection device before the test is performed.
本発明者は上記本発明の効果を実証するために、以下の
ような実験を行った。The present inventor conducted the following experiment in order to demonstrate the effects of the present invention described above.
（実験例１）
有底管体としては、第１図に示したような形状を有し、
開口部の内径１３．４ｍｍ、肉厚１．０ｇ＋ｎ、テーバ
１５／１０００で、開口部周縁に外径１７．３ｎ＋ｎ、
肉厚２．０ｍｍのフランジ部を有するものを、ポリエス
テル樹脂（三井ペット（株）製、商品名ＪＯ２５／ＢＯ
ＩＯ（重量比７：３１）を射出成形することにより作成
した１次に、上記有底管体にヘパリンリチウム液、ヘパ
リンナトリウム液、ヘパリンリチウムにポリビニールピ
ロリドン（ｐｖｐ、平均分子量４０．０００）を重量比
ｌ：１で混合させた液、及びヘパリンリチウムにポリエ
チレングリコール（ＰＥＧ、分子量１２．０００）を混
合させた液を各１０本ずつ０．５ｍ１２分注して凍結乾
燥を行った。そして、フィルム部材をシールしてタブ部
を折曲げた後、このフィルム部材を有底管体のフランジ
部と熱融着させて固定し、さらに再シール部材をフィル
ム部材の中央部に接着させた。そして、上記採血管を各
１０本ずつ室温で湿度８０％下において保存し、潮解の
度合を調べた。その結果を次表に示す。(Experimental Example 1) The bottomed tube had a shape as shown in Fig. 1,
The inner diameter of the opening is 13.4mm, the wall thickness is 1.0g+n, and the outer diameter is 17.3n+n on the periphery of the opening.
Polyester resin (manufactured by Mitsui Pet Co., Ltd., product name JO25/BO) has a flange portion with a wall thickness of 2.0 mm.
First, a heparin lithium solution, a heparin sodium solution, and a polyvinyl pyrrolidone (pvp, average molecular weight 40.000) were added to the heparin lithium in the bottomed tube made by injection molding IO (weight ratio 7:31). A liquid mixed at a weight ratio of 1:1 and a liquid mixed with lithium heparin and polyethylene glycol (PEG, molecular weight 12.000) were each dispensed into 10 bottles of 0.5 ml and freeze-dried. After sealing the film member and bending the tab portion, this film member was fixed by heat fusion to the flange portion of the bottomed tube body, and a resealing member was further adhered to the center portion of the film member. . Then, 10 of each of the above blood collection tubes were stored at room temperature under 80% humidity, and the degree of deliquescence was examined. The results are shown in the table below.
○・・・変化なし、 △・−・２０％潮解ム・・・
３０％潮解、 ×・・・潮解しているなお、上記潮解
の度合は次式により算出した。○...No change, △...20% deliquescence...
30% deliquescence, ×...deliquescence The degree of deliquescence was calculated using the following formula.
上記結果からも明かなようにポリビニールピロリドン及
びポリエチレングリコールについて、それぞれ抗凝固剤
の潮解の度合を抑える効果が認められ耘
（実験例２）
上記と同様にしてヘパリンリチウムにポリエチレングリ
コール（分子量１２．０００）を混合した液を凍結乾燥
させた。この乾燥混合剤を入れたポリエステル樹脂製の
採血管と、ヘパリンリチウムの凍結乾燥剤を入れたガラ
ス製の採血管を用いて５人から各２本づつ採血した。そ
の結果、両採血管ともに、血液が流入した時に直ちに溶
けた。As is clear from the above results, polyvinyl pyrrolidone and polyethylene glycol were each found to be effective in suppressing the degree of deliquescence of anticoagulants (Experiment Example 2). 000) was freeze-dried. Two blood collection tubes were collected from each of the five people using polyester resin blood collection tubes containing this dry mixture and glass blood collection tubes containing heparin lithium freeze-drying agent. As a result, both blood collection tubes melted immediately when blood entered them.
又、生化学検査（ＧＰＴ、総脂質、総コレステロール、
血清アミラーゼ、カルシウム）を行った結果、両者に差
はなく、ポリエステル樹脂製の採血管もガラス製の採血
管と同様に検査に使用可能であることが明らかとなった
。In addition, biochemical tests (GPT, total lipids, total cholesterol,
As a result, there was no difference between the two (serum amylase, calcium), and it became clear that polyester resin blood collection tubes can be used for testing in the same way as glass blood collection tubes.
尚、上記実施例においては、本発明の採液管を減圧採血
管として用いた例について説明したが、本発明は上記実
施例に限定されるものではなく、その他例えば工業排水
等の分析用採液管として用いることも可能である。In the above example, an example was explained in which the liquid collection tube of the present invention was used as a vacuum blood collection tube, but the present invention is not limited to the above example, and may be used for other purposes such as analysis of industrial wastewater. It can also be used as a liquid pipe.
［発明の効果］
以上のように本発明によれば、内部に水溶性の第１の物
質を封入してなる採液管において、前記第１の物質に該
物質より水溶性の低い第２の物質を混合させて乾燥混合
剤とし、該乾燥混合剤を封入するようにしたので、高湿
度下に保存され内部に水分が侵入しても、乾燥混合剤は
殆ど潮解することがなく元の形状を維持することができ
る。したがって、採取液体が内部に流入すると、乾燥混
合剤が直ちに溶け、このため検査精度が向上するという
効果を奏する。[Effects of the Invention] As described above, according to the present invention, in a liquid collection tube in which a water-soluble first substance is sealed, a second substance having lower water solubility than the first substance is added to the first substance. Since the substances are mixed to form a dry mixture and the dry mixture is sealed, even if it is stored under high humidity and moisture enters inside, the dry mixture hardly deliquesces and retains its original shape. can be maintained. Therefore, when the sampled liquid flows into the interior, the dry mixture immediately dissolves, which has the effect of improving inspection accuracy.
第１図は本発明の一実施例に係る減圧採血管を示す断面
図である。FIG. 1 is a sectional view showing a reduced pressure blood collection tube according to an embodiment of the present invention.
Claims (4)
開口するとともに他端が閉塞してなる有底管体と、該有
底管体の開口部を封止する封止部材とを備え、前記有底
管体の内部に水溶性の第１の物質と該物質より水溶性の
低い第２の物質とを混合してなる乾燥混合剤を封入した
ことを特徴とする採液管。(1) A liquid collection tube into which a liquid is collected, a bottomed tube with one end open and the other end closed, and a sealing member that seals the opening of the bottomed tube. and a dry mixture formed by mixing a water-soluble first substance and a second substance less water-soluble than the substance is sealed inside the bottomed tube. tube.
が血液に対する抗凝固剤である請求項１記載の採液管。(2) The liquid collection tube according to claim 1, wherein the liquid is blood and the first substance is an anticoagulant for blood.
１又は２記載の採液管。(3) The liquid collection tube according to claim 1 or 2, wherein the second substance is a water-soluble polymer substance.
：１０〜５：１の範囲である請求項３記載の採液管。(4) The weight ratio of the water-soluble polymer substance and anticoagulant is 1
4. The liquid collection tube according to claim 3, wherein the ratio is from 10 to 5:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31775588A JPH02162258A (en) | 1988-12-16 | 1988-12-16 | Liquid collecting tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31775588A JPH02162258A (en) | 1988-12-16 | 1988-12-16 | Liquid collecting tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02162258A true JPH02162258A (en) | 1990-06-21 |
Family
ID=18091678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP31775588A Pending JPH02162258A (en) | 1988-12-16 | 1988-12-16 | Liquid collecting tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02162258A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05131026A (en) * | 1990-10-09 | 1993-05-28 | Marquest Medical Prod Inc | Method for preventing coagulation of blood in injector and cotton spreading thread |
| JPH0755800A (en) * | 1993-07-23 | 1995-03-03 | Becton Dickinson & Co | Blood-gathering apparatus |
| CN1308351C (en) * | 2005-11-21 | 2007-04-04 | 武汉理工大学 | Exchange method of ionic equilibriom for heparin lithium |
-
1988
- 1988-12-16 JP JP31775588A patent/JPH02162258A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05131026A (en) * | 1990-10-09 | 1993-05-28 | Marquest Medical Prod Inc | Method for preventing coagulation of blood in injector and cotton spreading thread |
| JPH0755800A (en) * | 1993-07-23 | 1995-03-03 | Becton Dickinson & Co | Blood-gathering apparatus |
| CN1308351C (en) * | 2005-11-21 | 2007-04-04 | 武汉理工大学 | Exchange method of ionic equilibriom for heparin lithium |
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