JPH02152910A - Control agent against indoor acaridae and control method against indoor acaridae - Google Patents

Abstract

PURPOSE:To obtain a control agent against indoor acaridae exhibiting excellent effect against indoor acaridae, especially against Sarcoptes scabieis containing polynectin complex and/or rothenone as active ingredient. CONSTITUTION:The aimed excellent control agent against indoor acaridae exhibiting control effect against indoor acaridae is obtained by containing 0.2-25wt.%, preferably 0.4-20wt.% active ingredient composed of at least one compound selected from polynectin complex which is antibiotic produced by Streptomyces aureus and well-known as acaricide for agriculture but is not known about effect against indoor acaridae and rothenone expressed by the formula produced by extraction of derris root with carbon tetrachloride, etc., and well-known as effective against plant louses or Dermanysus gallinae but is not known about effect against indoor acaridae.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a pesticidal agent and a pesticidal method that are highly effective against indoor dust mites that occur inside houses, particularly against Dermatophagoides mites.

Indoor dust mites that occur inside homes are rapidly increasing due to recent changes in the indoor environment, such as the recent spread of near conditioners, aluminum window frames, and the disappearance of the habit of drying tatami mats in the sun. The number has increased. There are various types of dust mites, such as mites, mites, and mites. I'm especially concerned about Dermatophagoides mites.

It is thought to be a cause of osteocutaneous asthma and atopic dermatitis.
This has become a serious problem. Furthermore, the Dermatophagoides mites account for the majority of indoor dust mites; Wharton, G.J.
,(1976): J,Med,Er+L,, 12(6).
, 577-621; Inuko Miyamoto et al. (1976): Impulse,
27(3), 251-259: Masatoshi Takaoka et al. (1977)
: Impulse, 28 (4), 355-361]
.

Drying tatami mats and shutan is said to be an effective means of controlling indoor dust mites. However, these methods are very difficult to implement in modern living environments due to space and labor requirements, so chemical control using drugs is common.

Traditionally used drugs include fenthion,
fenitrothion, diazinon, oovp.

Examples include organophosphorus drugs such as trichlorfon, and pyrethroid drugs such as cryslon and permethrin.

Organophosphorus-based drugs are effective against mites, but have poor control activity against mites, which are said to make up the majority of indoor dust mites, and have poor control activities such as moisture stability, residual effectiveness, toxicity, etc. There are also problems. Furthermore, pyrethroid drugs are said to be more effective against Dermatophagoides mites than organophosphorus drugs. However, although it has pesticidal activity, it has insufficient acaricidal power and is expensive, making it not very practical as an indoor dust mite control agent.

Therefore, at present, there is no practical and highly effective control agent against indoor dust mites.

As mentioned above, conventional drugs lack essential pesticidal activity, and therefore require high dosages for actual use.

This applies to human residences, so
There were problems in terms of toxicity, etc.

Furthermore, even when a high dose was used, the control effect against Dermatophagoides was not sufficient. Therefore, there has been a desire for an excellent control agent and control method that is highly effective against Dermatophagoides mites at a low dose.

In view of these circumstances, the inventors of the present invention have conducted intensive research and have found that polynactin complex and rotenone have solved these problems and have low resistance to indoor dust mites, especially Dermatophagoides. It was discovered that the drug showed extremely excellent effects at different dosages.
This led to the present invention.

The polynactin complex used in the present invention is an antibiotic produced by Strobutomyces aureus and is also known as an agricultural acaricide (see Japanese Patent Publication No. 46-28100 and Japanese Patent Publication No. 49-1842). The effect on indoor dust mites is unknown. The vorinactin complex is
It is a complex of dinactin, trinactin and tetranactin. Each component is listed in Japanese Patent Publication No. 46-28100, No. 49
-1842, and can be used regardless of the component ratio.

Rotenone is a natural product found in Delis root and is represented by the formula: It can be produced from Delis root by extracting it with carbon tetrachloride or the like. Rotenone is known to be effective against aphids and spider mites, but its effect on indoor dust mites has not been known so far.

Note that rotenone is available on the market.

When these compounds are actually used as indoor dust mite control agents, the polynactin complex and rotenone may be used alone or in combination.
The pesticidal agent of the present invention can be in various dosage forms. In formulating the formulation, a pharmaceutically acceptable carrier may be used in addition to the active ingredient. It can be manufactured into wettable powders, emulsions, oils, powders, granules, etc. Furthermore, auxiliary agents such as dispersants, diluents, emulsifiers, spreading agents, wetting agents, adsorbents, thickeners, and antifoaming agents can be added to the drug.

The carrier herein may be either solid or liquid, or a combination thereof. For example, talc, clay, hentonite, kaolin, diatomaceous earth, calcium carbonate, white carbon, silicic acid, activated carbon, wood flour, starch, gum arabic, water, alcohol, isopropanol, kerosene, naphtha, xylene, cyclohexanone, methylnaphthalene. , benzene, acetone, tetrahydrofuran, dioxane, toluene, dimethylformamide, glycol ether, N-methylpyrrolidone, etc.

Examples of adjuvants include polyoxyethylene alkylphenyl ether, polyoxyethylene sorbitan monooleate, ethylene oxide propylene oxide copolymer, lignin sulfonate, sorbitan ester, soaps, sulfated oils, alkyl sulfate ester salts, Petroleum sulfone-11, dioctyl sulfosuccinate salts,
Alkylbenzene sulfonate, aliphatic amine salts, quaternary ammonium salts, alkylpyridinium salts, alkylaminoethylglycine, alkyldimethylbetaine, polyglycol sulfate, alkylamine sulfonic acid, isopropyl phosphate, carboxymethyl cellulose, polyvinyl alcohol , hydroxypropyl cellulose, ethylene glycol, xanthan gum, etc. It can also be used as an aerosol agent by mixing with a propellant such as fluorotrichloromethane or dichlorodifluoromethane, or as a fumigant or smoke agent by mixing with an appropriate blowing agent or combustion agent.

In formulating the formulation, the mixing ratio is generally 0.2 to 25% (by weight, same hereinafter) of the polynactin complex and/or rotenone, preferably 0.4 to 20%, and 75 to 99% of the carrier.
．． 8%, adjuvant 0-15% is optimal.

Further, by mixing with other bactericides, insecticides, acaricides, pest repellents, fungicides, fragrances, colorants, etc., a wider range of effects can be expected. When actually using the pesticidal agent of the present invention, the amount to be used is desirably selected depending on the method of use, dosage form, place of use, etc., but preferably 0.1 to 5 g per 1M.
It is a 5-2g treatment.

The polynactin complex and rotenone, when used alone or in combination, are effective in controlling indoor dust mites, especially Dermatophagoides nigricans, at a low dose. It is effective at an extremely low dose compared to conventionally used drugs, so only a small amount is required and toxicity is not an issue.For example,
Compared to the conventional organophosphorus drug fenitrothion, it has a controlling effect on 50% of Dermatophagoides mites at a dosage of 1710 or less. In other words, even if the active ingredients have the same level of toxicity, the toxicity during use will be lower due to the lower dose. In particular, since the polynactin complex has low toxicity, a control agent containing the polynactin complex as an active ingredient or a control method using the polynactin complex is an excellent control agent and control method that can solve the problem of toxicity.

Table 1 Polynactin complex and rotenone were diluted with acetone and adjusted to a predetermined concentration. 5 ml of the diluted 'jPlO was dropped into a glass petri dish with a diameter of 4.5 cm to prepare a dry film, and then 30 adults of Dermatophagoides chinensis were inoculated each. In addition, a strip of insect repellent adhesive was applied around the bottom of the petri dish, and repellent solids were also evaluated.

The test insects were classified into normal solids (hereinafter referred to as "N"), repellent solids (hereinafter referred to as rRJ), reactive (unable to walk), and dead specimens (hereinafter referred to as rM and DJ) for 24 hours. did. Fenitrothion, an organophosphorus drug, was used as a control drug. The results are shown in Table 1. Numerical values in the table indicate percentages.

As described above, both the polynactin complex and rotenone were effective at lower doses than the conventional organophosphorus drug fenitrothion. The effective dose for 50% or more of the test insects was 1 ml of fenitrothion for both polynactin complex and rotenone. It was below.

1LfL2 Among the oils prepared in Example 3 described later, two types of oils each containing a polynactin complex or rotenone as an active ingredient were subjected to a test. Five portions of 5 cm tatami mats were treated with the above oil agent using a small sprayer so that the active ingredients were Ig and 2 g per rrr, respectively. On this tatami surface, 30 adults of Dermatophagoides nigricans were inoculated, and 24 hours later, whether they were alive or dead was determined. Note that Nicetack 0) manufactured by Chiban was pasted on double-sided tape around the tatami surface to prevent the test insects from escaping, and the tatami surface was fixed on a glass petri dish using this tape. As a result, both oils were found to be 1 g/bo and 2 g/bo.
In all cases of the g/d treatment, the mortality rate of mites was 100% (including those that died by escaping onto the tape), indicating an excellent control effect.

The sample was cut into pieces, double-sided tape was pasted around it, and it was fixed on a glass petri dish. Thirty adults of Dermatophagoides nigricans were inoculated onto the sheet, and 24 hours later, whether they were alive or dead was determined.

As a result, in both polynactin complex and rotenone treatment sheets, Ig/% treatment and 2 g/r
The mortality rate of mites in all rT treatments was 100% (including those that died by escaping onto the tape), demonstrating excellent control effects.

One or two of the polynactin complex and rotenone were mixed with white carbon, clay, and talc in the proportions shown in Table 2, and the mixture was pulverized to obtain powders A to C. The following parts indicate parts by weight.

5 parts of the insect repellent sheet prepared in Example 4 (Table 2) and rotenone were added to a non-woven fabric (made of polyethylene-pulv, thickness 30 μm) per 1 mr.
After impregnation, the insect repellent sheet was dried to obtain an insect repellent sheet having a weight of 2 g.

For each 20 parts of vorinactin complex and rotenone,
Tsurupol 02680 (surfactant made by Toho Chemical) 10
1 part, 60 parts of Kijirole, and 10 parts of isopropanol were uniformly stirred and mixed to obtain two types of emulsions.

Claims (1)

[Scope of Claims] 1. An indoor dust mite control agent characterized by containing at least one of a polynactin complex and rotenone as an active ingredient. 2. A method for controlling indoor dust mites using at least one of polynactin complex and rotenone.