JPH0193510A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a locally effective hair tonic, containing a diglyceride constituted of a fatty acid having an even number of chain length and phospholipid as an active ingredient and having excellent hair tonic effect and high safety with hardly any skin irritancy without systemic side effects. CONSTITUTION:A hair tonic, containing (A) 0.5-30wt.% diglyceride constituted of a 2-24C fatty acid having an even number of chain length and (B) 0.05-10wt.% phospholipid at 10:1-1:1 weight ratio of the ingredients (A):(B). The ingredient (A) is a diester of a 2-24C fatty acid having the even number of chain length with glycerol and any of saturated fatty acid, such as acetic acid or stearic acid, unsaturated fatty acids, such as oleic acid, and branched fatty acids, such as 2-ethylbutyric acid or isostearic acid, may be used as the fatty acid. 1-Oleyl-2-acetyl diglyceride, etc., however, are preferred as the ingredient (A). Any of natural or synthetic phospholipid may be used as the ingredient (B) and lecithin, etc., are exemplified.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention provides a hair nourishment characterized by containing diglycerides and phospholipids consisting of fatty acids having an even carbon chain length of 2 to 24 carbon atoms as active ingredients. Yes, and used in the pharmaceutical and cosmetic fields.

[Prior Art] Hair nourishing products containing various drugs have been known. For example, it contains vitamins such as vitamin E, amino acids such as serine and methionine, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin function enhancers such as cephalanthine. It is used in the prevention and treatment of alopecia. Fatty acids or their derivatives have also been used in hair cosmetics,
It is included in hair nourishing products, such as fatty acids such as stearic acid, natural vegetable oils such as olive oil and castor oil, and
Fatty acid derivatives having odd-numbered carbon chains are also disclosed in JP-A-59-278.
It was fully disclosed in Publication No. 09.

However, these conventional hair nourishing products are effective against dandruff, itching, and
It is said to be effective in preventing and improving hair loss, etc., and to promote hair growth and growth. The development of highly effective hair nourishing agents is desired.

[Problems to be Solved by the Invention] Alopecia can occur due to various causes, but as a result, hair enters the resting phase (Teloge phase) without normal hair growth.
It is thought that in order to reach the state n), the terminal hair becomes soft and eventually progresses to alopecia.

Therefore, the present inventors developed a substance that promotes hair growth using C3H.
/HeNCrJ As a result of various studies using mice, the hair-nourishing effect was dramatically increased by using diglycerides consisting of even chain length fatty acids with 2 to 24 carbon atoms and natural or synthetic phospholipids as active ingredients. They discovered this and completed the present invention.

[Means for Solving the Problem] That is, the present invention provides one or more diglycerides composed of fatty acids of even chain length having 2 to 24 carbon atoms;
This hair nourishing material is characterized by containing one or more types of phospholipids as an active ingredient.

The configuration of the present invention will be explained in detail below.

The diglyceride used in the present invention has 2 to 24 carbon atoms.
It is a diester of an even number chain length fatty acid and glycerol, and the fatty acid may be any even number chain length fatty acid having 2 to 24 carbon atoms, regardless of whether it is saturated, unsaturated, or branched. In particular, saturated and unsaturated fatty acids with even carbon chain lengths exist in large quantities in the natural world, and many of them are edible, so they pose no safety problems. Branched fatty acids are synthesized in large quantities from petroleum-based raw materials and are easily available at low cost and in large quantities. Examples of these fatty acids include acetic acid,
From lower fatty acids such as butyric acid to saturated fatty acids such as palmitic acid, stearic acid, and lignoceric acid, and unsaturated fatty acids such as oleic acid, linoleic acid, lylunic acid, and arachidonic acid, 2
- Branched fatty acids such as ethylbutyric acid, 2-ethylhexanoic acid, and isostearic acid.

The diglycerides of the present invention include those in which these fatty acids have an ester bond at the 1.2-position with respect to glycerol;
Alternatively, it may be one with an ester bond at the 1.3-position, or it may be a mixed ester diglyceride as long as it is the above fatty acid. These diglycerides may be obtained by synthesis or may be extracted and separated from natural oils. In addition, among the two types of fatty acids constituting diglyceride,
One type of fatty acid is preferably an unsaturated fatty acid.

Among the diglycerides used in the present invention, 1-oleoyl-2-acetyl diglyceride, dioleoyl glyceride, silyl oil glyceride, stearoyl-oleoyl diglyceride, and dipalmitoyl glyceride are particularly preferred.

The amount of diglyceride used in the present invention is 0.1 to 60% by weight, preferably 0.5% by weight based on the amount of hair growth fee.
~30% by weight.

The phospholipids used in the present invention may be naturally obtained or synthesized, and are preferably lecithin, phosphatidylinositol, phosphatidylserine, phosphatidic acid, diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, or sphingolipids. Myelin, etc., and may be a single substance or a mixture.

The amount of phospholipid used in the present invention is 0.01 to 20% by weight, preferably 0.05 to 1% by weight, based on the amount of hair nourishment.
The weight ratio of diglyceride to phospholipid is preferably 10:1 to 1:1.

In addition to diglycerides and phospholipids, the hair nourishing material of the present invention contains vitamins such as vitamin B6, vitamin E and its derivatives, biotin, pantothenic acid and its derivatives, glycyrrhetinic acid and its derivatives, and nicotine. Nicotinic acid esters such as benzyl acid, cyclosporin, carpronium chloride, cephalanthine, oxendrone, ethinyl estradiol, etc. may be combined at the same time. Furthermore, antibacterial agents such as hinokitiol, hexacchlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undeccitric acid, trichlororubanilide and bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives,
Drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil,
Squalane, liquid paraffin, isopropyl myristate, higher fatty acids, oils such as higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water, humectants , a thickener, etc. can be appropriately added within a range that does not impair the effects of the present invention.

The hair tonic of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, milky lotion, or ointment.

[Effects of the Invention] The hair nourishing agent of the present invention has an extremely excellent hair nourishing effect, has no side effects, and is highly safe.

[Example] Next, the present invention will be explained in detail by giving examples. The present invention is not limited thereby. The blending amount is shown in weight%.

Prior to Examples, the results of testing the hair growth effect of the mixture of diglyceride and phospholipid according to the present invention will be shown. The tested substances were mixtures of diglycerides made of fatty acids with various even carbon chain lengths and phospholipids, and as comparison substances, various monoglycerides, diglycerides, triglycerides, and phospholipids each alone, as well as mixtures of monoglycerides, triglycerides, and phospholipids. It is a mixture. Soybean lecithin (manufactured by Nikko Chemical Co., Ltd.:
The product name Resinol S-5-1O was used. The concentrations of these test properties were 5% by weight for glyceride and 1% by weight for soybean lecithin (the remainder was ethanol).

Ethanol containing no test substance was also tested as a control.

1. The hair growth test uses C3H/HeNCr in the resting phase of the hair cycle.
Using the J mouse, Ogawa et al.'s method (Normal and Abnormal Epidemiology)
[Ermal Differentiation], M.
5eiji and 1. A.BernsteinfJW collection,
159-170, 1982, University of Tokyo Publishing). That is, a group of 10 mice was used, the backs of the mice were pricked with hair clippers and a shaver, and 0 and 1 mfL of each sample was applied once a day. The hair growth effect of each sample was determined by measuring the hair growth area on the back of the mouse, comparing the hair growth ratio, and expressing the number of days required for 50% hair growth rate. In addition, the number of days for promoting hair growth indicates the difference from the number of days for 50% hair growth when ethanol, which is a control substance, is used.

(See the margins below) Table 1 As is clear from Table 1, the effect on hair growth was found to be dramatically increased by using diglyceride or phosphorus in combination, compared to using either diglyceride or phosphorus alone. Ta. No hair growth effect was observed with either monoglyceride or triglyceride, nor was it observed with the phospholipid mixed system. As mentioned above,
The substance according to the present invention was found to have an excellent hair-nourishing effect.

Example 1 1-oleoyl-2-acetyl diglyceride 2.0 soybean lecithin
1.095% ethanol
58.0 ion exchange water
37.0 Polyoxyethylene (40 mol addition) Hydrogenated castor oil 2.0 (Production method) 1-oleoyl-2-acetyl diglyceride, soybean lecithin and polyoxyethylene (4
(0 mol addition) Hydrogenated castor oil was added, heated and stirred to dissolve, and then ion-exchanged water was added and mixed to obtain a transparent liquid hair nourishing agent.

Example 2 (Phase A) Soy lecithin 0.5 polyoxyethylene ((50 mol addition) hydrogenated castor oil
2.0 Glycerin 10.0 Dipropylene glycol 9.0 1.3 Butylene gelicol 4.0 Polyethylene glycol 1500 5.0 (B phase) Cetyl isooctanate 9.0 Dioleoyl glyceride 5.0 Squalane 5.0 Vaseline
2.0 Propyl paraben 2.0 (C phase) Carboxyvinyl polymer 1% aqueous solution 30.0 Sodium hexametaphosphate 0.03 Ion exchanged water 8.35 (D phase) Ion exchange water 4.0 (E phase) Flatfish 0 .12 Ion-exchanged water 4.0 (Production method) Phase A and phase B are dissolved by heating at 60°C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed using a homomixer. Next, the dissolved phase C was added thereto, and finally the dissolved phase E was added and emulsified with a homomixer to obtain a 0/ν emulsion type moli.

Example 3 (Phase A) Silyl oil glyceride 10.0 Cetostearyl alcohol 5.5 Glyceryl monostearate 3.0 Polyoxyethylene (20 mole addition) -2-octyl dodecyl ether 3.0 Vitamin E
Acetate 0.05 Propyl paraben 0.3 Fragrance 0.05 (B phase) Phosphatidylinositol 1.0 Glycerin 7.0 Dipropylene glycol 17.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion exchange water
48.095 (Manufacturing method) Phase A and phase B were respectively heated and dissolved and mixed, and emulsified with a homomixer to obtain an ointment-like hair nourishing agent.

Example 4 Stearoyl-oleoyl diglyceride 0.1 Phosphatidylserine 0.05 Ethanol 55.0 Polyoxyethylene (8 mole addition) Oleyl alcohol ether 2.0 Hinokitiol 0.05 F'1
appropriate amount of dye
Appropriate amount of ion exchange water
Residue (manufacturing method) Add polyoxyethylene (8 moles added) oleyl alcohol ether, nutaroyl-oleoyl diglyceride, phosphatidylserine, and hinokitiol to ethanol, add fragrance and dye and dissolve, then add ion-exchanged water. The mixture was solubilized to obtain hair growth tI.

Example 5 (A) Liquid paraffin 5.0 dipalmitoylglyceride 2.5 dioleoylglyceride 2.5 soybean lecithin
2.5 Phosphatidylserine 2.5 Vaseline
5.5EO (20 mol)-2-oketyldopsyl ether
3.0 Vitamin E acetate) 0
．． 05 Propylparaben 0.
3 incense F4 0.05
(Phase B) Glycerin 7.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.05 Ion-exchanged water 44.05 (Production method) Phase A is heated and dissolved, and the mixture of heated and dissolved phase B is dissolved. was added and emulsified using a homomixer to obtain a cream-like hair growth product of ¥31.

The hair growth agent of this invention has an excellent hair growth effect on alopecia patients, is locally effective, has no systemic side effects, is less irritating to the skin, and is a highly safe hair growth product. be.

Claims (1)

[Claims] 1. A hair nourishing agent comprising, as active ingredients, one or more diglycerides composed of even chain length fatty acids having 2 to 24 carbon atoms and one or more phospholipids.