JPH0159241B2 - - Google Patents
Info
- Publication number
- JPH0159241B2 JPH0159241B2 JP17922085A JP17922085A JPH0159241B2 JP H0159241 B2 JPH0159241 B2 JP H0159241B2 JP 17922085 A JP17922085 A JP 17922085A JP 17922085 A JP17922085 A JP 17922085A JP H0159241 B2 JPH0159241 B2 JP H0159241B2
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- fixation
- dimethyl
- ammonium
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000001519 tissue Anatomy 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 10
- 239000007975 buffered saline Substances 0.000 claims description 9
- 210000003709 heart valve Anatomy 0.000 claims description 9
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 7
- 230000033558 biomineral tissue development Effects 0.000 claims description 7
- 229960003237 betaine Drugs 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 3
- 210000001951 dura mater Anatomy 0.000 claims description 2
- 210000003041 ligament Anatomy 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 210000002435 tendon Anatomy 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 3
- 230000003111 delayed effect Effects 0.000 claims 1
- 210000003516 pericardium Anatomy 0.000 claims 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical class CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 12
- 239000003599 detergent Substances 0.000 description 9
- 239000011575 calcium Substances 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000008351 acetate buffer Substances 0.000 description 3
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- JCGCKSUCGVTMNB-UHFFFAOYSA-N acetic acid;formaldehyde Chemical compound O=C.CC(O)=O JCGCKSUCGVTMNB-UHFFFAOYSA-N 0.000 description 1
- -1 aliphatic alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- ICAKDTKJOYSXGC-UHFFFAOYSA-K lanthanum(iii) chloride Chemical compound Cl[La](Cl)Cl ICAKDTKJOYSXGC-UHFFFAOYSA-K 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000001991 scapula Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64072684A | 1984-08-14 | 1984-08-14 | |
| US640726 | 1984-08-14 | ||
| US674897 | 1984-11-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6156101A JPS6156101A (ja) | 1986-03-20 |
| JPH0159241B2 true JPH0159241B2 (enrdf_load_stackoverflow) | 1989-12-15 |
Family
ID=24569468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17922085A Granted JPS6156101A (ja) | 1984-08-14 | 1985-08-14 | 表面活性ベタインによる移植可能な組織の鉱化を遅延させる方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS6156101A (enrdf_load_stackoverflow) |
| ZA (1) | ZA856103B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0311353A (ja) * | 1989-06-08 | 1991-01-18 | Canon Inc | 電子写真感光体 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69922228T2 (de) * | 1998-09-30 | 2005-12-01 | Medtronic, Inc., Minneapolis | Verfahren zur Reduzierung der Mineralisierung von Gewebe zum Gebrauch bei Transplantationen |
-
1985
- 1985-08-13 ZA ZA856103A patent/ZA856103B/xx unknown
- 1985-08-14 JP JP17922085A patent/JPS6156101A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0311353A (ja) * | 1989-06-08 | 1991-01-18 | Canon Inc | 電子写真感光体 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6156101A (ja) | 1986-03-20 |
| ZA856103B (en) | 1987-03-25 |
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