JPH01300961A - Preparation of membrane type filter apparatus - Google Patents

Abstract

PURPOSE:To obtain the title apparatus capable of being used simply and safely and excellent in water permeability and filterability, by allowing hot water at predetermined temp. or more to fill and applying pressure through hot water to allow water to penetrate in the pores of a porous membrane. CONSTITUTION:A membrane type filter apparatus having a porous membrane, which is composed of a hydrophobic polymer and provided with pores having an average pore size of 0.01-10mum, mounted therein and also having the introducing and lead-out ports of an aqueous solution and a filtrate lead-out port is prepared. Each of the spaces partitioned by said porous membrane of this apparatus if filled with hot water of 60 deg.C or more and pressure is applied through hot water to allow water to penetrate in the pores of the porous membrane.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a method for manufacturing a membrane filtration device,
More specifically, the present invention relates to a method for manufacturing a filtration device incorporating a porous membrane made of a hydrophobic polymer, which is simple and safe to use.

Note that the filtration device here refers to a filtration device used for medical, industrial, and general purposes.

For medical use, there are plasma separators that separate blood cells and plasma components from blood, plasma component separators that further fractionate plasma components by molecules, blood thinners that separate only water from blood, and Examples include plasma component collectors for donating and collecting plasma components from blood from people. Examples of industrial use include a precision wave filter car 1 hedge, a filter shade made of wood or a filtration device for aqueous solutions, and general use such as household water purifiers and portable water purifiers.

[Prior art] In porous membranes made of hydrophobic polymers, aqueous liquids such as blood do not wet the hydrophobic polymers, so it is difficult for aqueous liquids to penetrate into the micropores of the porous membrane. Medical filtration devices incorporating porous membranes made of hydrophobic polymers cannot be used as is. For this reason, it has been proposed to preliminarily treat porous membranes made of hydrophobic polymers to make them lignophilic, and in these lignophilic treatment methods, (1) using a low interfacial tension organic solvent that is soluble in water; Method of infiltrating into micropores and then replacing with water, ■ Method of treating porous membrane with surfactant, ■ Method of chemically introducing wood-philic groups onto the surface of porous membrane, ■ Wood-philicity A method of coating the surface of a porous membrane with a polymer, and a method of infiltrating water into micropores at a pressure of 5 kg/cm2 or more (JP-A-61-92675, JP-A-61-946).
No. 62 and No. 61-109573) are known.

[Problems to be Solved by the Invention] However, there is no method for replacing water with a low interfacial tension organic solvent infiltrated into micropores as described in (2) above.

One drawback is that a large amount of water is required to wash and remove the low interfacial tension organic solvent. In addition, in the method (2) of treating with a surfactant, the surfactant is eluted into the introduced water and the filtrate, resulting in the problem of contamination of various liquids during use.

In addition, the method of chemically introducing wood-loving groups onto the surface of the porous membrane in (2) also has the same problems in use as in (2) above, as reaction residues, solvents, etc. tend to remain. The method of coating polymers not only causes problems in use, as the solvent used for coating tends to remain, but especially when used for medical purposes, the hydrophobic porous membrane has biocompatibility, complement and platelet activities, etc. Good compatibility with blood, such as low
One drawback is that the hydrophobic surface is lost by coating it with another polymer.

Furthermore, with the above method of injecting water into the micropores at a pressure of 5 kg/cm2 or more, is there a possibility that the membrane or container will be damaged if a high pressure of 5 kg/c+s2 or more is applied? However, even if the membrane does not break, the pore diameter of the porous membrane changes due to the high pressure.

[Means for Solving the Problems] Therefore, the present inventors conducted extensive studies to solve the drawbacks of medical filtration devices incorporating porous membranes made of these hydrophobic polymers, and as a result, they arrived at the present invention.

That is, the present invention provides a membrane-type membrane that is made of a hydrophobic polymer, has a built-in porous membrane with an average pore size of 0.01 to 10 microns, and has an inlet and an outlet for an aqueous solution and an outlet for a filtrate. Prepare a filtration device, fill each space separated by the porous membrane with hot water of 60°C or higher, and apply pressure through the hot water to cause water to infiltrate into the micropores of the porous membrane. The present invention provides a method for manufacturing a characteristic membrane-type overloaded stirrup.

The membrane-type filtration device manufactured according to the present invention does not use an organic solvent or a surfactant as a wood-loving treatment agent, and the micropores of the porous membrane are filled with water, so that the inside of the filtration device 4 does not contain water. It is safe for medical use because no lignifying agent remains, and there is no problem of filtrate contamination for industrial or general use.

The porous membrane made of a hydrophobic polymer used in the present invention is not particularly limited in its type;
For example, materials such as polyethylene, polypropylene, poly4-methylpentene-1, polysulfone, polyether J resulfone, polyhynylidene fluoride, polymer 1-lafluoroethylene, polydimethylsiloxane, polyethylene terephthalate, and nylon can be used.

The form of the porous membrane used in the present invention is not particularly limited, and for example, a hollow fiber or flat membrane may be used.

Further, there are no particular limitations on the method for producing the porous membrane, and known production methods such as a stretching method, a wet phase separation method, a melt phase separation method, and a solvent extraction method can be employed.

In addition to wood, the aqueous solution used in the present invention may also be one that has water as its main component and contains non-toxic solutes other than substances that reduce interfacial tension. This includes pure water, distilled water, distilled water for injection, pyrogen-free water,
Examples include physiological saline.

In addition, the present invention targets porous membranes having an average pore diameter of 0.01 to 10 microns (pm) (measured by bubble point method). In porous membranes with an average pore diameter smaller than 0.01 micron, hot water is difficult to penetrate into the micropores;
This is because, in a porous membrane having an average pore diameter larger than 0 microns, water can be caused to flow into the fine pores of the porous membrane using a conventional method.

In the method of the present invention, the conventionally known
Comparing this with the method of infiltrating wood into the fine pores of a porous material using a pressure of By using
For example, JP-A-61-92675, JP-A No. 61-94662
No. 61-109573 - Water can penetrate into the micropores of a porous membrane at a lower pressure than the known methods disclosed in various publications.

In the case of filtration devices using porous membranes, especially those used for medical purposes, polyurethane resin is used as the adhesive to fix the membrane, and polymer is used as the container of the filtration device, and in actual use, filtration at a fairly low pressure is used. It is often used under high pressure, and it is not economically advisable to provide adhesives and containers with pressure resistance that is outside the pressure range of I- (J).Also, high pressure may change the membrane pore diameter. Therefore, it is preferable to infiltrate the wood into the micropores of the porous membrane at as low a pressure as possible.
-Heat to 1. Since it is used in a vacuum, the growth of bacteria can be reduced and the problem of contamination can also be reduced.

Note that it is preferable to seal the filtration device in a high-temperature state and sterilize it with high-pressure steam, since it is possible to provide a completely sterile, Byron-free filtration device.

The temperature of the hot water used is 60°C or higher, preferably 80 to -97°C, and if pressurized water is used, hot water at a temperature of 100°C or higher can also be used. . If the temperature of the hot water is lower than 60°C, even if pressure is applied through the hot water, the wood will be difficult to penetrate into the fine pores of II at low pressure, and the effect will be low.

Further, the pressure applied to the hot water may be lower than the pressure used in conventionally known methods, preferably in the pressure range of 2 to 5 kg/cl112, and 2.5 to 4.5 kg/cm2.
Particularly preferred is the pressure range.

In addition, in the present invention, C is a space between the names separated by a porous membrane in a membrane-type filtration device under reduced pressure (1), and then the space is filled with hot water of 60°C or higher -1-, It is preferable to apply pressure through hot water.

[Examples] Hereinafter, the present invention will be explained in more detail based on Examples.
The present invention is not limited to these examples.

(Example) Polypropylene (UBE-PP-F l 09K, trade name: manufactured by Ube Industries, Ltd., M FI = 9 g/10 minutes) was spun at a spinning temperature of 210'C using a nozzle for manufacturing hollow fibers. . The obtained polypropylene hollow fibers were heat-treated in a heated air bath at 145°C for 30 minutes, and then stretched at a temperature of 135°C to 400% of the initial length and at a strain rate of 8.33%/min, and the stretched state was maintained. Heat treatment was performed for 15 minutes in a heated air bath at 145° C. to produce porous polypropylene hollow fibers. The obtained porous polypropylene had an inner diameter of 32
The film thickness was 55 pm. Further, the membrane pore diameter was 0.48 lm, and the porosity was 75%, as measured by Hatsuruboint υ (using ethanol).

This porous membrane was housed in a polycarbonate housing, and both ends were fixed with polyurethane adhesive.
A porous polypropylene membrane having a membrane area of t! This is the first step in making a transceiver device. After reducing the pressure in the internal space of this filtration device for 1 time using a vacuum pump, warm water at 94°C is filled into each space of the filtration device for 1 time, and hot water is passed through each space separated by a porous membrane for 3 times.
Pressure was applied at a pressure of kg/cm2.

When we measured the water permeability of wood using this filtration device, we found that
301/Ilin-m"kg/cm' high water permeability-7
i was shown.

(Comparative example) After reducing the pressure in the internal space of a filtration device produced in the same manner as in the example, using a vacuum pump, sterile water at 25°C was filled into each space of the filtration device for 1 hour, and each space of the filtration device was heated at room temperature using water pressure. 4
Pressure was applied at J/cm2. When the water permeability was measured using this filtration device, it was found to be 2.2 x 10-'4/
The water permeability amount was min-m2·kg/cIl12, and a practically usable water permeation amount was not obtained.

[Effects of the Invention] As explained below, according to the present invention, the porous membrane is filled with hot water of 60'C or more, and pressure is applied through the hot water so that the water infiltrates into the micropores of the porous membrane. Since the filtration device is manufactured using the same method, it is easy and safe to use, and has high water permeability and
A membrane type filtration device with excellent filtration performance can be obtained.

Claims (1)

[Claims] (1) Made of hydrophobic polymer, the average pore diameter of micropores is 0.
．． A membrane-type filtration device is prepared which incorporates a porous membrane having a diameter of 01 to 10 microns and has an inlet and an outlet for an aqueous solution and an outlet for a filtrate. A method for manufacturing a membrane filtration device, characterized in that the porous membrane is filled with hot water and pressure is applied through the hot water to allow water to enter the micropores of the porous membrane.