JPH01216916A - Method for preventing armpit odor - Google Patents

Abstract

PURPOSE:To absorb perspiration and eliminate the odor emitted from armpit, by preparing a composition containing a reaction product of a (meth)acrylic acid (co)polymer with a quaternary ammonium salt as an active component and spraying or applying the composition to the armpit. CONSTITUTION:The armpit is sprayed or coated with a composition containing a polymeric quaternary ammonium salt which is a reaction product of (A) a homopolymer of acrylic acid or methacrylic acid or a copolymer of the above monomer and other monomer copolymerizable therewith and (B) a compound of formula [R1-R4 are 1-20C aliphatic hydrocarbon group, or three of the above groups are said hydrocarbon groups and the other one is aralkyl or trialkylammonium-alkyl, or two of the above groups are said hydrocarbon groups and the other two are aralkyl or dialkylphenoxy(or alkylphenoxy) alkylenoxyalkyl, or one or two of the above groups are said hydrocarbon groups and the others form a ring together with N; X is halogen].

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a method for preventing armpit odor, which absorbs perspiration from the armpits and deodorizes odors emitted from the armpits.

[Prior art and its problems] Conventionally, various products have been commercially available for the purpose of preventing armpit odor, but many of these products are antiperspirants containing astringent aluminum compounds as active ingredients, or eugenol, etc. It is a masking agent used alone or appropriately blended as an active ingredient. These products are applied to the armpits by spraying or coating.

Incidentally, although antiperspirants have the effect of reducing sweat, which is a source of underarm odor, it is impossible to completely control sweat from a physiological perspective. On the other hand, masking agents have the disadvantage that their fragrance components mix with armpit odor, resulting in an unpleasant odor.

Therefore, the above-mentioned conventional anti-armpit odor agents including antiperspirants and masking agents have had the problem of not being fully satisfactory in terms of effectiveness and usability.

Also, the odor in the armpits is noticeable when you sweat a lot, but when sweat is collected aseptically directly from the sweat pores, it remains odorless even after 2 hours, but when this sweat comes into contact with bacteria on the skin, it remains odorless. It is said that if collected in this state, it will emit an odor.

The armpits have a suitable temperature and humidity, which is favorable for the presence of bacteria, and there are reports that Staphylococcus, Proteus bacteria, etc. can be found there.

Certain quaternary ammonium salts are known to have antibacterial effects and are also effective against the aforementioned bacteria, so spraying or applying an aqueous solution of these quaternary ammonium salts to the armpits will also prevent armpit odor. Although it is thought to be effective, it has problems such as a poor feeling of use, lack of long-lasting efficacy as it washes off due to sweating, and the effect on the skin is not necessarily good, making continued use impossible. Was.

[Means for Solving the Problems] The present inventors have discovered that the antibacterial effect of a high-molecular quaternary ammonium salt is comparable to that of a low-molecular corresponding quaternary ammonium salt, such as a chlorine salt. The present invention was completed based on the discovery that an antibacterial deodorizing effect can be obtained by using the compound.

The present invention relates to a homopolymer of acrylic acid or methacrylic acid, or a copolymer with other monomers copolymerizable with them, and a quaternary ammonium salt represented by the following formula.
R1 R4-N"-R2X- R5 In formula 1, Rt to R4 are each a C heavy to Coo linear or branched saturated or unsaturated aliphatic hydrocarbon group, or RI""R4's 3 is the hydrocarbon group and 1
is an aralkyl group or a trialkylammonium alkyl group, or two of R+ to R4 are the above hydrocarbon groups and the remaining two are aralkyl and dialkylphenoxy (
or alkylphenoxy)alkyleneoxyalkyl group, or one or two of R3-R4 are the above-mentioned hydrocarbon groups and the remaining two or three form a ring together with a nitrogen atom, and X is a halogen atom. be. It is characterized by spraying or applying a composition containing a polymeric quaternary ammonium salt, which is a reaction product of ], as an active ingredient to the armpits.

The polymeric quaternary ammonium salt used in the present invention is an organic polymer having a carboxyl group, that is, polyacrylic acid, a copolymer of acrylic acid and acrylic ester, polymethacrylic acid, a copolymer of methacrylic acid and methacrylic ester. Synthesis is carried out by reacting the combined substance with a quaternary ammonium halide salt. This reaction occurs quantitatively, so the carboxyl group of the organic polymer.

A slightly excess amount of quaternary ammonium halogen salt is applied to the mixture, and the unreacted quaternary ammonium halogen salt and the generated sodium halide salt are washed with water to obtain a completely substituted polymeric quaternary ammonium salt. be able to. As the quaternary ammonium halogen salt used at this time, cetylpyridinium salt, benzethonium salt, dodecyldimethylbenzylammonium salt, tetradecyldimethylbenzylammonium salt, etc. described by the Japanese Pharmacopoeia are suitable.

This polymeric quaternary ammonium salt is a slightly hygroscopic paste-like substance that is sparingly soluble in water.

As a composition containing a polymeric quaternary ammonium salt,
It can be used as a composition for ordinary cosmetics or external medicines, and the polymeric quaternary ammonium salt in this composition is 0.05 to 1
It is preferable to mix it by weight%. As the ingredients in the composition at this time, any ingredients conventionally known as cosmetics or external medicines can be included. Examples of such ingredients include alcohols such as ethanol and isopropanol, waxes such as beeswax, lanolin, and liquid lanolin, natural water-soluble polymer compounds such as gelatin, agar, starch, tragacanth, and pectin, and methylcellulose. , semi-synthetic polymer compounds such as ethyl cellulose and crystalline cellulose, surfactants such as dialkyl sulfosuccinates, alkylaryl sulfonates, and phosphate esters, preservatives such as methyl paraoxybenzoate and ethyl paraoxybenzoate,
Organic pigments such as Red No. 2, Blue No. 1, and Yellow No. 201, inorganic pigments such as aluminum powder, talc, kaolin, and bentonite, antiperspirants such as aluminum sulfate and aluminum hydroxychloride, masking materials such as skatole, lavender oil, and jasmine. agent, Freon 11. Examples include chlorofluorocarbon 12, propellants such as carbon dioxide, and purified water.

The polymeric quaternary ammonium salt in the composition may be mixed as it is, or if it is soluble in a solvent, for example methanol, it may be impregnated into another powder carrier from a methanol solution and dried. It can also be blended after being supported.

Next, polyacrylic acid tetradecyldimethylbenzyl ammonium salt was selected from among the polymeric quaternary ammonium salts, and an antibacterial test was conducted, and the results shown in Table 1 were obtained.

(The following is a blank space) Table 1 As is clear from the results, it is recognized that the polymeric quaternary ammonium salt is effective against bacteria.

The antibacterial activity test was conducted under the following conditions.

Bacterial strain used: Staphylococcus au
reus FDA209P) Bacillus subtilis
IFO Escherichia coli (Escherichia c.
alf IFO Pseudomonas aeruginosa
s aeruginosaIFO3445) Test outline: Dispense 0.5ml of the test substance ethanol solution and 9.5n+1 agar medium into a sterilized petri dish, mix uniformly, solidify, and dilute in a 2-fold dilution series starting from the test substance concentration of 1500μs/ml. Test plates were made up to 23.4 μg/ml.

A test plate made of Nitributo Sawyer agar medium (Hinaga Pharmaceutical Co., Ltd.) was inoculated with test solution I prepared to have a bacterial count of approximately 10 cells/ml using a platinum loop. The plate inoculated with the test bacteria was heated to 37°C.
After culturing for 48 hours, the presence or absence of bacterial growth was observed, and the lowest concentration at which no growth was observed was defined as the minimum growth-inhibiting concentration.

In addition, in order to investigate the effect of ethanol, test bacteria were inoculated into a medium containing only ethanol and the growth status was observed.

As a result, the concentration of ethanol in the medium had no effect on the test bacteria.

[Function] According to the method for preventing armpit odor according to the present invention, armpit odor is suppressed by the antibacterial action of the polymeric quaternary ammonium salt.

[Example] Compositions 1 to 1 containing a polymeric quaternary ammonium salt as an active ingredient
3 was adjusted as follows.

Composition 1: Dissolve 0.5 g of deodorant powder polyacrylic acid tetradecyldimethylbenzyl ammonium salt in 100 ml of ethanol, and add 100 g of Avicel P) I-MOS (manufactured by Asahi Kasei Co., Ltd., cosmetic microcrystals with an average particle size of 6 μm) to 100 ml of ethanol. cellulose) and stir well. Thereafter, ethanol was evaporated in a vacuum dryer to obtain Avicel carrying active ingredients.Next, talc and magnesium stearate were mixed with this Avicel to obtain a deodorizing powder having the composition shown in Table 2.

Table 2 Composition 2: Deodorant spray 0.5 g of benzethonium polyacrylate salt was dissolved in 100 n+1 ethanol, and this was added to 1 00 g of Avicel RC-591NF (manufactured by Asahi Kasei, colloidal grade cosmetic grade microcrystalline cellulose). Stir well.

Thereafter, ethanol is evaporated in a vacuum dryer to obtain Avicel carrying the active ingredient.Next, this Avicel and talc are mixed, and the mixed system is sealed together with propellants of Freon 11 and Freon 12. A deodorizing spray having the composition shown in Table 3 was obtained.

Table 3 Composition 3: Deodorizing Cream Cetylpyridinium polyacrylate (passed through 60 meshes), zinc white, and vaseline were kneaded to obtain a deodorizing cream having the composition shown in Table 4.

(The following is a blank space.) 4th After determining the results, Compositions 1 to 3 were sprayed or applied to the armpits of healthy people (5 men and 5 men) who were aware of having armpit odor to conduct an efficacy test for preventing armpit odor.

Effective: No armpit odor Slightly effective: armpit odor has become slightly weaker No effect; no change in the strength of armpit odor The test results for this test were as shown in Table 5.

Note that the numbers in Table 5 indicate the number of people for the judgment item.

(Hereinafter, blank spaces) Table 5 From the results shown above, it can be seen that all the methods for preventing armpit odor using Compositions 1 to 3 are effective.

Incidentally, compositions containing other compounds among the polymeric quaternary ammonium salts as active ingredients were prepared, and similar efficacy tests were attempted, but almost the same results as above were obtained.

In addition, the feeling of use was good with all the methods using compositions, but especially with the method using composition 1.2, the comfort of use was poor because a lubricant such as talc was mixed in the composition. Even better.

[Effects of the Invention] As described above, according to the method of the present invention, the activity of bacteria that decomposes sweat and generates bad odor is stopped by the antibacterial action of the polymeric quaternary ammonium salt, thereby effectively preventing armpit odor. be able to. Furthermore, since the antibacterial action is relatively mild, no side effects occur even if the product is used continuously, and it also has good adhesion to the skin.

Further, by incorporating a suitable sweat absorbent and lubricant into a composition containing the polymeric quaternary ammonium salt of the present invention as an active ingredient, the comfort of use can be further improved.

Patent applicant Daicel Chemical Industries, Ltd. Agent Patent attorney Hideaki Sato

Claims (1)

[Claims] A homopolymer of acrylic acid or methacrylic acid, or
Copolymers with other monomers that can be copolymerized with them and quaternary ammonium salts represented by the formula below ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ [In the formula, R_1 to R_4 are C_1 to C_2_, respectively]
0 linear or branched saturated or unsaturated aliphatic hydrocarbon groups, or three of R_1 to R_4 are the above hydrocarbon groups and one is an aralkyl group or a trialkylammonium alkyl group, or R_1 to R_4 two of the above hydrocarbon groups and the remaining two are aralkyl and dialkylphenoxy (or alkylphenoxy) alkyleneoxyalkyl groups, or one of R_1 to R_4
One or two of the above hydrocarbon groups and the remaining two or three form a ring together with the nitrogen atom, and X is a halogen atom. ] Polymer No. 4 which is the reaction product of
A method for preventing armpit odor, which comprises spraying or applying a composition containing an ammonium salt as an active ingredient to the armpits.