JP2001048781A - Composition for external use - Google Patents
Composition for external useInfo
- Publication number
- JP2001048781A JP2001048781A JP11225497A JP22549799A JP2001048781A JP 2001048781 A JP2001048781 A JP 2001048781A JP 11225497 A JP11225497 A JP 11225497A JP 22549799 A JP22549799 A JP 22549799A JP 2001048781 A JP2001048781 A JP 2001048781A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hinokitiol
- alkanediol
- external
- feeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims abstract description 36
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229930007845 β-thujaplicin Natural products 0.000 claims abstract description 18
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 14
- DQYSALLXMHVJAV-UHFFFAOYSA-M 3-heptyl-2-[(3-heptyl-4-methyl-1,3-thiazol-3-ium-2-yl)methylidene]-4-methyl-1,3-thiazole;iodide Chemical compound [I-].CCCCCCCN1C(C)=CS\C1=C\C1=[N+](CCCCCCC)C(C)=CS1 DQYSALLXMHVJAV-UHFFFAOYSA-M 0.000 claims description 3
- 238000013329 compounding Methods 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000007794 irritation Effects 0.000 abstract description 7
- 230000037307 sensitive skin Effects 0.000 abstract description 5
- 206010003645 Atopy Diseases 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 230000002335 preservative effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- PFURGBBHAOXLIO-UHFFFAOYSA-N cyclohexane-1,2-diol Chemical compound OC1CCCCC1O PFURGBBHAOXLIO-UHFFFAOYSA-N 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- ICLZNGAELWYHKL-CAPFRKAQSA-N (E)-3-[5-[5-[4-(N-phenylanilino)phenyl]thiophen-2-yl]thiophen-2-yl]prop-2-enoic acid Chemical compound OC(=O)\C=C\c1ccc(s1)-c1ccc(s1)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 ICLZNGAELWYHKL-CAPFRKAQSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 102100032566 Carbonic anhydrase-related protein 10 Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 101000867836 Homo sapiens Carbonic anhydrase-related protein 10 Proteins 0.000 description 1
- 208000033830 Hot Flashes Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は外用組成物に関し、
さらに詳しくは、十分な防腐性を持ちながら刺激が少な
い特徴を持つ外用組成物に関する。The present invention relates to a composition for external use,
More specifically, the present invention relates to a composition for external use which has sufficient preservative properties and is less irritating.
【０００２】[0002]
【従来の技術】外用剤は、薬物を直接患部に作用させる
ことができる優れた剤型であり、広く使われている。そ
のような外用剤には、製品性を維持するために防腐剤を
配合するのが一般的である。従来、防腐剤としてはパラ
ベン類が最も一般的なものとして広く使われている。し
かし近年、一般消費者の間で自然志向が高まったことか
ら、天然物が好まれる傾向があり、特に敏感肌の人、ア
トピー患者などは外用剤については特に低刺激のものを
好む傾向にある。2. Description of the Related Art External preparations are excellent dosage forms capable of causing a drug to act directly on an affected area, and are widely used. Such external preparations generally contain a preservative in order to maintain product properties. Heretofore, parabens have been widely used as the most common preservatives. However, in recent years, natural products have tended to be preferred due to an increase in nature-consciousness among general consumers. Particularly, people with sensitive skin and atopic patients tend to prefer external preparations, especially those with low irritation. .
【０００３】[0003]
【発明が解決しようとする課題】本発明者らは、刺激が
少なく、肌が弱い人でも安心して使用することができ、
かつ、十分な防腐性を持つ外用剤を得るために、パラベ
ン類に替えて、天然物由来の成分であるヒノキチオール
を防腐剤として使用することを試みた。しかし、防腐効
果を十分に持たせるにはヒノキチオールを高濃度で配合
せねばならず、香料でもあるヒノキチオールの匂いが強
くなりすぎ、使用感の点から製品として使用することは
困難であった。一方、ヒノキチオールを減量すると、防
腐性が不十分であることから、やはり製品としての使用
は困難であった。DISCLOSURE OF THE INVENTION The present inventors have found that a person with little irritation and who has weak skin can use it with peace of mind.
In addition, in order to obtain an external preparation having sufficient preservative properties, an attempt was made to use hinokitiol, which is a component derived from a natural product, as a preservative instead of parabens. However, hinokitiol must be incorporated at a high concentration in order to have a sufficient antiseptic effect, and the odor of hinokitiol, which is also a fragrance, becomes too strong, and it has been difficult to use it as a product from the viewpoint of usability. On the other hand, when hinokitiol was reduced in weight, it was difficult to use it as a product because the preservability was insufficient.
【０００４】本発明の目的は、十分な防腐性を持ちなが
ら刺激が少なく、使用感も良好な外用組成物を得ること
にある。[0004] An object of the present invention is to obtain an external composition which has sufficient preservative properties, is less irritating and has a good feeling upon use.
【０００５】[0005]
【課題を解決するための手段】本発明者らは種々検討し
た結果、使用感を損なわない程度のヒノキチオール配合
量であっても、同時に１，２−アルカンジオールを配合
すると、十分な防腐性を持ち、使用感、刺激性の点から
も問題がないことを見出し本発明を完成した。As a result of various studies, the present inventors have found that even if the amount of hinokitiol is such that the feeling of use is not impaired, if 1,2-alkanediol is simultaneously added, sufficient antiseptic properties can be obtained. They found that there was no problem in terms of holding, feeling of use, and irritation, and completed the present invention.
【０００６】すなわち本発明は、ヒノキチオールおよび
１，２−アルカンジオールを配合したことを特徴とする
外用組成物である。[0006] That is, the present invention is an external composition comprising hinokitiol and 1,2-alkanediol.
【０００７】[0007]
【発明の実施の形態】本発明においてヒノキチオールの
配合量は製剤全体の０．００１〜０．０５重量％が好ま
しく、０．００５重量％以下が特に好ましい。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the amount of hinokitiol is preferably 0.001 to 0.05% by weight, more preferably 0.005% by weight or less of the whole preparation.
【０００８】０．００１重量％未満であると防腐効果が
不十分になり、０．０５重量％を越えて配合すると匂い
などが感じられ使用感が悪くなるからである。その範囲
内でも、特に顔面に塗布するものについては、臭いの点
から０．００５重量％以下がより好ましい。[0008] If the amount is less than 0.001% by weight, the preservative effect becomes insufficient, and if the amount exceeds 0.05% by weight, smell and the like are felt and the feeling of use is deteriorated. Even within this range, it is more preferably 0.005% by weight or less from the viewpoint of odor, especially for those applied to the face.
【０００９】本発明で１，２−アルカンジオールとは、
直鎖状、分岐鎖状、環状のいずれも使用可能である。具
体的には、１，２−ブチレングリコール、１，２−ペン
タンジオール、１，２−ヘキサンジオール、１，２−シ
クロヘキサンジオールなどをあげることができるが、防
腐性、使用感などの点から１，２−ペンタンジオールが
好ましい。配合量は、製剤全体の０．５〜２０重量％が
好ましく、１重量％以上がさらに好ましく、３重量％以
上がよりさらに好ましい。In the present invention, 1,2-alkanediol is
Any of a straight chain, a branched chain, and a ring can be used. Specific examples include 1,2-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, and 1,2-cyclohexanediol. , 2-pentanediol is preferred. The compounding amount is preferably 0.5 to 20% by weight of the whole preparation, more preferably 1% by weight or more, still more preferably 3% by weight or more.
【００１０】本発明では、１，２−アルカンジオールお
よびヒノキチオールの必須成分に、さらにピオニン（商
品名）を配合するのが好ましい。ピオニンとは感光素２
０１号として化粧品原料基準に収載されている化合物で
あり、抗菌剤として使用されている成分であるが、本発
明に用いることで、相乗的に防腐効果が向上するからで
ある。In the present invention, it is preferable that pionin (trade name) is further added to the essential components of 1,2-alkanediol and hinokitiol. Pionin is Photosensitizer 2
It is a compound listed in the standard of cosmetic raw materials as No. 01 and is a component used as an antibacterial agent, but when used in the present invention, the antiseptic effect is synergistically improved.
【００１１】本発明の外用組成物は、有効成分、吸収促
進剤などの外用剤に通常使用される成分を配合すること
ができ、外用剤製造の一般的な方法で、液剤、ローショ
ン剤、クリーム剤、軟膏剤、ゼリー剤、ゲル剤などの製
剤を製造することができる。[0011] The composition for external use of the present invention can contain components usually used for external preparations such as an active ingredient and an absorption enhancer, and can be prepared by a general method for the preparation of external preparations. Preparations such as salves, ointments, jellies and gels.
【００１２】[0012]
【発明の効果】本発明により十分な防腐性を持ち、使用
感、刺激性の点からも問題がない外用組成物を得ること
ができた。これにより、アトピー、敏感肌などの患者で
も安心して使える外用剤を提供することが可能になっ
た。According to the present invention, an external composition having sufficient preservative properties and having no problem in terms of feeling of use and irritation could be obtained. As a result, it has become possible to provide an external preparation that can be used safely by patients with atopic or sensitive skin.
【００１３】[0013]
【実施例】以下、実施例および試験例により本発明をさ
らに詳細に説明する。The present invention will be described in more detail with reference to the following Examples and Test Examples.
【００１４】実施例 表１に示した処方で常法により実施例１〜１０および比
較例１〜４の乳液剤を得た。Examples The emulsions of Examples 1 to 10 and Comparative Examples 1 to 4 were obtained in the usual manner using the formulations shown in Table 1.
【００１５】[0015]
【表１】 [Table 1]
【００１６】試験例１ 実施例１〜１０および比較例１〜４の乳液を被検サンプ
ルとし、被検サンプル１０ｇに対して混合菌液（Staphy
lococcus aureus IFO 13276,Bacillus subtilis IFO 12
210,Escherichia coli IFO 3972）を菌体濃度が１０6/g
になるように、菌体懸濁液を０．１mlの比率で接種し
た。これを３５℃で培養し、１、３、７、１４日目の生
菌数を測定した。[0016] The milky lotion of Test Example 1 Examples 1 to 10 and Comparative Examples 1 to 4 and the test sample, mixed bacterial liquid to the test sample 10g (Staphy
lococcus aureus IFO 13276, Bacillus subtilis IFO 12
210, Escherichia coli IFO 3972) at a cell concentration of 10 6 / g.
The cell suspension was inoculated at a ratio of 0.1 ml so that This was cultured at 35 ° C., and the number of viable bacteria on days 1, 3, 7, and 14 was measured.
【００１７】同様に被検サンプル１０ｇに対して酵母
（Saccharomyces cerevisiae IFO 0234）を菌体濃度１
０5/gになるように、菌体懸濁液を０．１mlの比率で接
種した。これを２５℃で培養し、１、３、７、１４日目
の生菌数を測定した。Similarly, yeast ( Saccharomyces cerevisiae IFO 0234) was added to a test sample (10 g) at a cell concentration of 1%.
0 As 5 / becomes g, it was inoculated with cell suspension in a ratio of 0.1 ml. This was cultured at 25 ° C., and the number of viable bacteria on days 1, 3, 7, and 14 was measured.
【００１８】同様に被検サンプル１０ｇに対してカビ
（Aspergillus niger IFO 9455）を菌体濃度１０4/gに
なるように、生理食塩水に胞子を２白金耳懸濁した胞子
懸濁液を０．１ml接種した。これを２５℃で培養し、
７、１４、２１日目の生菌数を測定した。それぞれの結
果を表２〜４に示した。Similarly, a spore suspension obtained by suspending two platinum loops of spores in physiological saline is added to 10 g of a test sample so that mold ( Aspergillus niger IFO 9455) has a bacterial cell concentration of 10 4 / g. 1 ml was inoculated. This is cultured at 25 ° C,
The viable cell count was measured on days 7, 14, and 21. The results are shown in Tables 2 to 4.
【００１９】数値の違いを解りやすくするため、混合
菌、酵母の生菌数が３日後に１０1オーダーまで減少し
ている場合は：二重丸、１４日後に１０1オーダーまで
減少している場合は：○、１４日後に１０1オーダーま
で減少していない場合は：×と判定し、カビの生菌数が
７日後に１０1オーダーまで減少している場合は：二重
丸、２１日後に１０1オーダーまで減少している場合
は：○、２１日後に１０2オーダーまで減少している場
合は：△、２１日後に１０2オーダーまで減少していな
い場合は：×と判定し、表５に示した。In order to make it easy to understand the difference in the numerical values, when the viable cell counts of the mixed bacteria and yeast are reduced to the order of 10 1 after 3 days: double circle, reduced to the order of 10 1 after 14 days In the case: ○, when the number has not decreased to the order of 10 1 after 14 days, it is judged as ×. When the number of viable fungi has decreased to the order of 10 1 after 7 days: double circle, 21 days If it has been reduced to the order 10 1 later: ○, if it has been reduced to the order 10 2 after 21 days: Δ, if it has not decreased to the order 10 2 after 21 days: × 5 is shown.
【００２０】[0020]
【表２】 [Table 2]
【００２１】[0021]
【表３】 [Table 3]
【００２２】[0022]
【表４】 [Table 4]
【００２３】[0023]
【表５】 [Table 5]
【００２４】表５から明らかなように、ヒノキチオール
の配合量を少なくした場合は1,2-ペンタンジオールを配
合することによって製剤として防腐効果を満足できるよ
うになった。As is clear from Table 5, when the amount of hinokitiol was reduced, the preservative effect of the preparation became satisfactory by adding 1,2-pentanediol.
【００２５】試験例２ 実施例および比較例の乳液について、におい，べたつ
き，しっとり感などの使用感を総合的に５段階（良い：
５、やや良い：４、普通：３、やや悪い：２、悪い：
１）で評価した。１７名の平均の結果を表６に示した。Test Example 2 The emulsions of the Examples and Comparative Examples were evaluated for a total of five levels of feeling of use such as smell, stickiness and moist feeling (good:
5, Moderately good: 4, Normal: 3, Moderately bad: 2, Bad:
1) was evaluated. Table 6 shows the average results of the 17 subjects.
【００２６】[0026]
【表６】 [Table 6]
【００２７】表６から明らかなように、ヒノキチオール
の配合量を増やすことにより、使用感は悪くなり、1,2-
ペンタンジオールを適量配合することによって使用感が
改善された。As is clear from Table 6, increasing the amount of hinokitiol deteriorates the feeling of use and increases 1,2-
The use feeling was improved by blending an appropriate amount of pentanediol.
【００２８】試験例３ 外用製剤の塗布により過去にほてりやヒリヒリ感などの
刺激を感じたことがあるパネラー（敏感肌パネラー）に
対して、実施例および比較例の乳液を上腕内側に使用さ
せ、刺激感の有無について評価した。結果を表７に示し
た。Test Example 3 The emulsions of Examples and Comparative Examples were applied to the inner side of the upper arm of a paneler (sensitive skin paneler) who had previously felt irritation such as hot flashes and burning due to application of an external preparation. The presence or absence of irritation was evaluated. The results are shown in Table 7.
【００２９】[0029]
【表７】 [Table 7]
【００３０】表７から明らかなように、敏感肌パネラー
による刺激感の評価では、ヒノキチオール、1,2-ペンタ
ンジオールの配合処方による刺激感は、ヒノキチオー
ル、1,2-ペンタンジオールの無配合の処方と同様であ
り、ヒノキチオール、1,2-ペンタンジオールの配合が原
因で刺激感を感じると判断した人は認められなかった。As is clear from Table 7, in the evaluation of the irritant feeling by the sensitive skin panelists, the irritant feeling due to the formulation of hinokitiol and 1,2-pentanediol was the same as that of the formulation without hinokitiol and 1,2-pentanediol. The results were the same as in the above, and no person was judged to feel irritating due to the combination of hinokitiol and 1,2-pentanediol.
フロントページの続き (72)発明者 堀 ひとみ 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 長嶋 新一 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 小林 亜紀 大阪府大阪市中央区十二軒町５番12号 株 式会社マンダム中央研究所内 (72)発明者 松浦 由佳 大阪府大阪市中央区十二軒町５番12号 株 式会社マンダム中央研究所内 (72)発明者 岡田 文裕 大阪府大阪市中央区十二軒町５番12号 株 式会社マンダム中央研究所内 (72)発明者 清水 秀雄 大阪府大阪市中央区島之内１丁目３番34号 株式会社感光社内 (72)発明者 岩ヶ瀬 準 大阪府大阪市中央区島之内１丁目３番34号 株式会社感光社内 Ｆターム(参考） 4C076 AA16 BB31 CC31 DD09 DD34 DD38 DD46 DD50 DD57 EE09 EE27 EE53 FF56 4C206 AA01 AA02 CA10 MA02 MA03 MA06 MA52 MA83 ZB35 Continuation of the front page (72) Inventor Hitomi Hori 3- 24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Shinichi Nagashima 3- 24-1, Takada, Toshima-ku, Tokyo Taisho Seiyaku Inside the Company (72) Inventor Aki Kobayashi 5-12, 12 Kengencho, Chuo-ku, Osaka-shi, Osaka Inside Mandom Central Research Laboratories Co., Ltd. No. 12 Inside Mandom Central Research Institute Co., Ltd. (72) Inventor Fumihiro Okada 5-12, Jungen-cho, Chuo-ku, Osaka-shi, Osaka Prefecture Inside (72) Inventor Hideo Shimizu Chuo-ku, Osaka-shi, Osaka 1-33-34, Shimanouchi In-house Co., Ltd. (72) Jun Iwagase Inventor 1-3-34, Shimanouchi, Chuo-ku, Osaka-shi, Osaka F-term (reference) 4C076 AA16 BB31 CC31 DD09 DD34 DD38 DD46 DD50 DD57 EE09 EE27 EE53 FF56 4C206 AA01 AA02 CA10 MA02 MA03 MA06 MA52 MA83 ZB35
Claims (6)
オールを配合したことを特徴とする外用組成物。An external composition comprising hinokitiol and 1,2-alkanediol.
タンジオールである請求項１記載の外用組成物。2. The composition for external use according to claim 1, wherein the 1,2-alkanediol is 1,2-pentanediol.
０．０５重量％である、請求項１または２に記載の外用
組成物。3. The compounding amount of hinokitiol is 0.001 to 0.001.
The composition for external use according to claim 1 or 2, which is 0.05% by weight.
５〜２０重量％である請求項１記載の外用組成物。4. The compounding amount of 1,2-alkanediol is 0.1.
The composition for external use according to claim 1, wherein the content is 5 to 20% by weight.
を配合した外用組成物。5. A composition for external use, wherein the composition according to claim 1 is further blended with pionin.
オールを有効成分とする外用剤用防腐剤。6. An antiseptic for external preparations comprising hinokitiol and 1,2-alkanediol as active ingredients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11225497A JP2001048781A (en) | 1999-08-09 | 1999-08-09 | Composition for external use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11225497A JP2001048781A (en) | 1999-08-09 | 1999-08-09 | Composition for external use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001048781A true JP2001048781A (en) | 2001-02-20 |
Family
ID=16830256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11225497A Pending JP2001048781A (en) | 1999-08-09 | 1999-08-09 | Composition for external use |
Country Status (1)
| Country | Link |
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| JP (1) | JP2001048781A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004028519A1 (en) * | 2002-09-26 | 2004-04-08 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| WO2004028520A1 (en) * | 2002-09-26 | 2004-04-08 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| JP2005232013A (en) * | 2004-02-17 | 2005-09-02 | Mandom Corp | Antiseptic sterilizer, and cosmetic, medicine and food compounded with the antiseptic sterilizer |
| JP2006193493A (en) * | 2005-01-17 | 2006-07-27 | Adeka Corp | Antiseptic agent composition |
| WO2006082151A3 (en) * | 2005-02-02 | 2006-12-14 | Symrise Gmbh & Co Kg | Synergistic mixtures of c6- to c12-alkanediols and tropolone (derivatives) |
| WO2009001938A1 (en) * | 2007-06-27 | 2008-12-31 | Kobayashi Pharmaceutical Co., Ltd. | Hydrophilic composition containing hinokitiol |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7384646B2 (en) | 2002-09-26 | 2008-06-10 | Mandom Corporation | Antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same |
| WO2004028520A1 (en) * | 2002-09-26 | 2004-04-08 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| JPWO2004028520A1 (en) * | 2002-09-26 | 2006-01-19 | 株式会社マンダム | Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant |
| WO2004028519A1 (en) * | 2002-09-26 | 2004-04-08 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| US7632871B2 (en) | 2002-09-26 | 2009-12-15 | Mandom Corporation | Methods of making and methods of using antiseptic disinfectant, cosmetic and toiletries, medicine or food containing the same |
| US7754774B2 (en) | 2002-09-26 | 2010-07-13 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
| JP2005232013A (en) * | 2004-02-17 | 2005-09-02 | Mandom Corp | Antiseptic sterilizer, and cosmetic, medicine and food compounded with the antiseptic sterilizer |
| JP4535744B2 (en) * | 2004-02-17 | 2010-09-01 | 株式会社マンダム | Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant |
| JP2006193493A (en) * | 2005-01-17 | 2006-07-27 | Adeka Corp | Antiseptic agent composition |
| WO2006082151A3 (en) * | 2005-02-02 | 2006-12-14 | Symrise Gmbh & Co Kg | Synergistic mixtures of c6- to c12-alkanediols and tropolone (derivatives) |
| US8647651B2 (en) | 2005-02-02 | 2014-02-11 | Symrise Ag | Synergistic mixtures of C6- to C12-alkanediols and tropolone (derivatives) |
| WO2009001938A1 (en) * | 2007-06-27 | 2008-12-31 | Kobayashi Pharmaceutical Co., Ltd. | Hydrophilic composition containing hinokitiol |
| JP2009007286A (en) * | 2007-06-27 | 2009-01-15 | Kobayashi Pharmaceut Co Ltd | Hinokitiol-containing hydrophilic composition |
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