JPH01190608A - Novel germicidal composition - Google Patents

Abstract

PURPOSE:To obtain a germicidal composition, containing a specific thioureido based compound and Prumycin(R) as active ingredients and capable of exhibiting high controlling effects especially by foliar spraying and effective even against chemical-resistant germs and producing high synergistic effects. CONSTITUTION:A composition containing (A) 1,2-bis(3-methoxycarbonyl-2- thioureido)benzene capable of exhibiting controlling effects on various pathogenic germs parasitic on agricultural and horticultural crops but especially resulting in appearance of chemical-resistant germs recognized in various disease injuries including especially gray mold by successive application and (B) Prumycin(R); 4-N-D-alanyl-2,4-diamino-2,4-dideoxyarabinose which is known to be effective against disease injuries of various agricultural and horticultural crops but has not been put into practical use at 40:1-1:2, preferably 16:1-1:1 weight ratio. The amount of the applied composition is preferably 15-300g amount of the active ingredients based on 10 ares.

Description

Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a sterilizing composition containing a thioureide compound and purmycin as active ingredients. It can be used as a drug.

[Conventional technology]

1,2-bis(3), which is one of the active ingredients of the composition of the present invention.
-Methoxycarbonyl-2-thioure shows excellent control effects against various pathogenic bacteria that parasitize, and is currently widely used as a fungicide for agricultural and horticultural purposes. However, due to its continued use, drug-resistant bacteria have appeared for various diseases, especially gray mold, and the control effect has decreased, and in some areas, no control effect has been observed at all. On the other hand, purmycin was published in J. Antibiotics 24:9.
00-901 (1971), manufactured by Japanese Patent Publication No. 57-8718, and known to be effective against various agricultural and horticultural crop diseases (Japanese Patent Publication No. 50-33128). No.), but it has not yet been put into practical use.

[Problem to be solved by the invention]

The emergence of drug-resistant bacteria to conventional fungicides has become a very serious problem in the control of agricultural and horticultural crop diseases, and there is a strong desire to develop drugs that prevent the appearance of these drug-resistant bacteria.

A useful agricultural and horticultural fungicide that uses a bactericidal composition as an active ingredient, makes up for the shortcomings of conventional fungicides, is highly effective against bacteria resistant to existing pesticides, and does not have any negative effects on plants, such as phytotoxicity. This is what we are trying to provide.

When the fungicidal composition of the present invention is used as a fungicide for agriculture and horticulture, depending on the purpose of use, it is generally used in the field of agrochemical manufacturing, either as is or with a mixture of pesticide adjuvants to enhance or stabilize the effect. Depending on the method, it can be used in the form of preparations such as powders, fine granules, granules, aqueous preparations, flowable preparations, and emulsions.

In actual use, these various formulations can be used directly or diluted with water to a desired concentration.

=2, preferably in a ratio of 16:1 to 1:1, 0.1 to
The content is adjusted to 99.9%, preferably 0.2 to 80%, according to a conventional formulation method.

Examples of the agricultural chemical auxiliary agents include carriers (diluents) and other auxiliary agents such as spreading agents, emulsifiers, wetting agents, dispersing agents, fixing agents, and disintegrants.

Liquid carriers include aromatic hydrocarbons such as toluene and xylene, alcohols such as methanol, butanol, and glycol, ketones such as acetone, amides such as dimethylformamide, sulfoxides such as dimethyl sulfoxide, methylnaphthalenecyclohexane, and animal and vegetable oils. , fatty acids, fatty acid esters, etc.

Solid carriers include clay, kaolin, talc, diatomaceous earth,
Examples include silica, calcium carbonate, montmorillonite, bentonite, feldspar, quartz, alumina, and sawdust.

In addition, surfactants are usually used as emulsifiers or dispersants, such as anionic surfactants such as higher alcohol sodium sulfate, stearyltrimethylammonium chloride, polyoxyethylene alkylphenyl ether, lauryl betaine, and cationic surfactants. , nonionic surfactants, and amphoteric surfactants.

Spreading agents include polyoxyethylene noni/L/phenyl ether, polyoxyethylene lauryl ether, etc., and wetting agents include polyoxyethylene nonylphenyl,
Dialkyl sulfosuccinate, etc. are used as fixing agents, carboxymethyl cellulose, polyvinyl alcohol, etc.
Examples of disintegrants include sodium pyrogenin sulfonate and sodium lauryl sulfate.

Any of the preparations can be used not only alone, but also in combination with other agricultural and horticultural fungicides, insecticides, plant growth regulators, and acaricides.

When the fungicidal composition of the present invention is applied as a fungicide for agriculture and horticulture, the amount of application is usually 100% of the active ingredient per 10ares.
~400 g is used, preferably 15-300 g.

When applying diluted with water such as irrigation agents and liquid preparations, the preferred range is o,oot~0.4%℃1°C.In addition, in the case of single powder, fine granules, etc., the dosage The concentration may vary depending on the method of use, timing, and other conditions, and may be increased or decreased to change the concentration without sticking to the above range.

The present invention is effective for controlling the following crop diseases, but is not limited thereto.

Apple powdery mildew (Podosphaera 1euc)
otricha) Apple scab (Venturia)) Apple spot leaf blight (Alternaria)
m<history) Monlinia ma
li) Venturia nashic
ola) Gymnosporangiu
m hara6anam) Pear black spot disease (Altern)
aria kikuchiana) persimmon powdery mildew (
Eridan Sansai Tomoe Tora kakicola) Momo Haiboshi (5c
lerotinia cinerea) peach scab (
Cladosporium carpophilum
) Clerotinia cine
rea ) Ume Haiboshi (5cleroLinia ci)
nerea) grape gray mold (7cinerea)
) Grape powdery mildew (Uncinula necato
r) Cercospora bet
icola) Peanut brown spot disease (Cercospora)
arachidicola ) peanut black astringency (Cerc
ospora personata) Wheat Rust (Puccinia recondita) Wheat Naked Smut (Ustilago nuda) Wheat Fusarium (Gibbellera zeae) Wheat Snow Rot Large Sclerotinia (5clerotinia) borealis
) Cucumber 5 Downy Mildew (Sphaerotheca)
fuliginia) cucumber gray mold (BoLr
ytis cinerea) Cucumber Sclerotinia (5cl
eroLinia sclerotiorum) cucumber scab (Cladosporium cucume)
rinum) tomato gray mold (BoLrytis)
cinerea) tomato sclerotia (5cleroLin)
ia sclerotiorum) tomato leaf mold (
Cladosporium fulium ) Eggplant gray mold ( Dotrytjs cinerea ) Eggplant sclerotia ( 5clerotinia sclerotior )
um ) Bell pepper gray mold (BoLryLis ci
nerea) Strawberry gray mold (BoLrytis)
cinerea) strawberry powdery mildew (5phaero
theca humli) rapeseed sclerotium (5cJer
otinia scleroLiorum)
rum) Lettuce Sclerotinia s
cleroLiorum) Cabbage Sclerotinia (5cle
rotinia sclerotiorum) legume sclerotia (5cleroLinia sclerotiorum)
rum) tobacco sclerotia (5cleroLinia s)
clerotiorum) onion gray rot (Bo
Lrytis alli) [Effects of the Invention] We have discovered that the fungicidal composition of the present invention exhibits a high control effect particularly when sprayed on foliage, is effective against drug-resistant bacteria, and has an unexpectedly high synergistic effect, and has developed this invention. Completed the invention.

Next, examples of the formulation as an agricultural and horticultural fungicide of the present invention will be specifically explained in more detail, but the types and mixing ratios of the pesticide adjuvant are not limited to these, and can be used in a wide range. . Note that "parts" means "parts by weight."

Formulation example 1. Powder 4 parts of compound A, 1 part of purmycin, 46 parts of Merck and 49 parts of clay are mixed and ground to form a powder.

45 parts, 3 parts of sodium higher alcohol sulfate, and 2 parts of sodium ligninsulfonate were mixed and ground to obtain a wettable powder.

part, 23 parts of bentonite, 30 parts of talc and 2 parts of disintegrant.
After mixing 18 parts of water and evenly moistening, extruding through an injection molding machine, granulating it, sizing it with a sizing machine, and drying it to form granules with a particle size of 0.6H to 1B. shall be.

Formulation Example: 4 parts of fine granules, 6 parts of alcohol, and 9 parts of clay were uniformly mixed and ground.
Thick powder and eggplant. Separately, 80 parts of oil well-absorbing mineral coarse powder of 74 to 105 microns is placed in a suitable mixer, and 20 parts of water is added while rotating to moisten it, and the above-mentioned thick powder is added, coated, and dried to form fine granules.

Formulation example 5. Emulsion 15 parts of Compound A and 5 parts of purmycin are dissolved in 63 parts of xylene, and 17 parts of a mixture (8:2) of alkylphenol ethylene oxide condensate and calcium alkylbenzenesulfonate are mixed and dissolved to form an emulsion.

The basic rule is to dilute it with water and use it as an emulsion.

Next, it will be explained using experimental examples that the fungicidal composition of the present invention has excellent control effects against various agricultural and horticultural crop diseases.

Experimental example 1. Common bean gray mold control test (drug-sensitive bacteria) Formulation example 2 The carefully prepared irrigation agent was diluted with water and sprayed on primary leaves of common bean (variety: Shin-Edo), air-dried with a diameter of 5I.
Gray mold fungus punched out with III corkpolar (B
Mycelia pieces of (Oirytis cinerea) were left standing and kept in a greenhouse to allow disease to develop, and 72 hours later, the diseased spot diameter was examined and the control value was calculated.

The results are shown in Table 1. The control value was calculated as follows.

Table 1 Experimental Example 2. Green bean gray mold control test (drug-resistant bacteria) Benzimidazole-resistant bacteria were used as gray mold bacteria.

Other test methods were based on Experimental Example 1. The results are shown in Table 2.

Table 2

Claims (1)

[Claims] It is characterized by containing 1,2-bis(3-methoxycarbonyl-2-thioureido)benzene and 4-N-D-alanyl-2,4-diamino-2,4-dideoxyarabinose (purmycin) as active ingredients. A disinfectant composition containing