JPH01151461A - Prosthesis material for organism - Google Patents

Abstract

PURPOSE:To provide a novel prosthesis material for an organism in which a bone- inducing element is compounded, by making a part adjacent to osseous tissues porous and by impregnating the porous part with the bone-inducing element. CONSTITUTION:A metal or ceramic material is prepared, which has a porous part adjacent to osseous tissues. The part is made porous by, for example, adding a blowing agent during the preparation of the material or by mixing an organic substance and then decomposing or subliminating the organic substance by heat treatment. A bone- inducing element may be dissolved in a collagen or another solution, or may be dispersed in a physiological salt solution or another. The metal or ceramic prosthesis material is soaked in the solution, and the porous part thereof is sufficiently impregnated with the element. The deaeration by evacuation will help the impregnation complete. The material is then freeze-dried; thereby the solvent of the solution is removed and the bone-inducing element is fixed in the porous part. For example, a porous layer 2 of apatite in the thickness of about 50mum is deposited on the surface of a core 1 of zirconia ceramics, and the porous layer 2 is impregnated with a bone-inducing element (a basic peptide, MW: about 22,000), which is extracted from Dunn osteosarcoma.

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a bioprosthetic material with high osteoinductivity.

<Conventional technology> In recent years, alumina, zirconia,
Hiramix such as apatite or metals such as titanium have come to be used.

Each of these has advantages and disadvantages in terms of strength, toughness, or compatibility with living tissue, but neither of them is satisfactory in terms of bone tissue inductivity.

If the prosthetic material has bone tissue inductivity, tissue attachment will occur in a short period of time, resulting in faster healing.

<Problems to be Solved by the Invention> The present invention has been made in view of the above situation, and its purpose is to develop a new type of prosthetic material in which a so-called umami-inducing prisoner that promotes umami induction is combined into a prosthetic material. To provide bioprosthetic materials.

〈Means for solving problems〉 As a result of intensive research, the present inventors obtained the following knowledge.

When forming a bioprosthetic material using Hiramix such as alumina, zirconia, Avatai 1~, or metal materials such as titanium, at least the part that comes into contact with bone tissue is made into a porous structure, and this porous layer contains osteoinductive factors. It has been found that when a prosthesis impregnated with this material is applied to a defective site in a living body, bone induction occurs in a short period of time, resulting in faster healing of the prosthesis.

The present invention is based on this new knowledge.

<For production> Saitama-induced convicts mainly refer to the following groups of substances.

■Basic peptide ■Proteoblycan (polysaccharide) ■Fibronectin, osteonectin (non-collagen protein) ■Osteocalcin (graprotein) ■Laminin The material of the present invention forms a porous layer on the surface in contact with bone tissue. However, in order to quickly restore the defective region with the prosthesis, the depth of the porous layer is required to be at least 50 μm or more.

If the depth is less than this, sufficient holding force to support the prosthetic material will not be formed even if bone tissue is induced around it. It takes a considerable number of days to recover the holding power.

The bioprosthetic material of the present invention can use all commonly used materials, from metal materials such as titanium to ceramic materials such as alumina, zirconia, and apatite.

The following method is used to impregnate the porous layer with the osteoinductive factor described above.

First, a metal material or a ceramic material is prepared in which the portion that contacts the bone is made porous.

The formation of porosity may be carried out by a commonly used method, such as adding a foaming agent during formation, mixing organic materials, and decomposing and sublimating the organic materials by heat treatment.

Next, the osteoinductive factor is dissolved in a co II agen solution or the like to form a solution, or a suspension is prepared by dispersing it in physiological saline or the like.

The prosthetic material is immersed in the liquid, and is thoroughly impregnated into the pores.

In this case, when vacuum degassing is used in combination, the liquid can be sufficiently impregnated into the porous material.

After impregnation, the liquid components are diffused by freeze-drying or the like, and the osteoinductive factors are fixed within the pores.

<Example> The structure of the bioprosthetic material of the present invention will be explained with reference to the drawings, taking a tooth root as an example.

Fig. 1 shows a case in which the entire tooth root has a porous structure, and Fig. 2 shows a case in which only the surface in contact with bone tissue has a porous structure.

In FIG. 1, (1) is the root of the tooth, and the entire tooth has a porous structure.

In this case, the material (1) is a material with strength and toughness, such as titanium.

When ceramics are used as the tooth root material, the core (1) is made into a dense structure to provide strength and toughness, as shown in Figure 2.

A porous layer (2) is formed on the core (1).

The core (1) and the porous layer (2) do not necessarily have to be made of the same material.

For example, the core may be made of zirconia or alumina, and (2) may be made of apatite.

In addition to the structures shown in Figures 1 and 2 above, osteoinductive prisoners,
For example, by being impregnated with a basic peptide, the pore surface of the porous layer becomes a kind of covered state with these ion-induced particles.

Thus, when this prosthesis is applied to the defect 14, the bone is guided by the osteoinductive factors and is guided throughout the porosity.

This will be illustrated with an example.

Example 1 The core part (1) of the structure shown in Fig. 2 is formed of zirconia ceramics, and a porous layer of about 50 μm thick for the abutment 1 is formed on this.
Formed.

Next, this porous layer was impregnated with an osteoinductive prisoner (basic peptide) having about 22,000 intermolecular molecules extracted from [)unn osteosarcoma.

This was implanted into the dog's mandible, and the state in which new bone was induced was observed.

When the osteoinductive factor was not impregnated, it took about 3 months for bone to be induced into the porous layer, but when it was impregnated, it took about 1 month.

<Effects of the Invention> As described in detail above, the present invention is characterized in that new bone is quickly guided to the prosthetic material, and damage to the prosthetic portion is quickly healed. Therefore, it can be widely used not only in dentistry but also in the orthopedic field.

[Brief explanation of the drawing]

Figure 1 shows a tooth with a porous structure in which the entire root is porous, and Figure 2 shows a tooth with a porous structure only on the surface that contacts the bone tissue. In Figure 1, (1)...Tooth root In Figure 2, (1)...Core (2)...Porous layer Patent applicant Koransha Co., Ltd. Ivy Figure 1 Figure 2

Claims (1)

[Claims] 1. A bioprosthetic material, characterized in that at least a portion in contact with bone tissue is porous, and the porous portion is impregnated with an osteoinductive factor.