JPH01145069A - Hollow yarn type blood purifying apparatus and preparation thereof - Google Patents

Abstract

PURPOSE:To prevent the leakage or stagnation of blood by a simple constitution, by using an annular elastic seal member used when a sealant is solidified also as a seal member used when a blood introducing and discharging member is mounted to the main body of a hollow yarn type blood purifying apparatus. CONSTITUTION:A blood purifying apparatus is constituted by fixing sealant solidified parts 3 formed by solidifying both end parts of a hollow fiber bundle 2 by a sealant to both end parts of a cylindrical casing 1 in such a state that the hollow fiber bundle 2 protrudes from the opening parts at both ends of the casing 1 and opens in an aligned state. An annular elastic seal member 4 is mounted to the peripheral surface of each of the sealant solidified parts 3 in the state brought into contact with the peripheral surface of the sealant solidified part 3 and the opening end part of the cylindrical casing 1. When a blood purifying and introducing member is mounted to the main body 5 of this hollow yarn type blood purifying apparatus, the annular seal member 4 is deformed to closely bringing each of the sealant solidified part 3 into contact with the opening end surface of the cylindrical casing 1.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a hollow fiber type blood purification device and a method for manufacturing the hollow fiber type blood purification device.

More specifically, this invention eliminates blood stagnation,
The present invention relates to a hollow fiber blood purification device in which a hollow fiber blood purification device main body and a blood lead-in/out member can be airtightly attached, and a method for manufacturing the same.

[Prior art and its problems] Conventionally, hollow fiber blood purification devices have been manufactured as follows.

That is, a bundle of hollow fibers is inserted into a cylindrical casing from its open end, and the hollow fibers are inserted so that both ends of the bundle of hollow fibers protrude from the open end of the cylindrical casing by a predetermined length. Next, a forming frame is attached to both ends of the cylindrical casing, a liquid sealant is put into the cylindrical casing, and the cylindrical casing is rotated to form a mold from inside the cylindrical casing. The liquid sealant is moved into the mold by centrifugal force, and the liquid sealant is solidified. Thereafter, as shown in FIG. 9, the solidified sealant 52 is cut at a position l slightly forward of the opening end surface 51 of the cylindrical casing 50, and as shown in FIG. A hollow fiber type blood purification device main body U is manufactured by opening the end face of the bundle 53. and,
- As shown in FIGS. 10 and 11, for example, an O-ring 55 is placed on the cut surface of the solidified sealant in a region A outside the circular opening of the hollow fiber bundle, and this is used as a sealing member. A hollow fiber type blood purification device was manufactured by attaching the blood introduction/input member 5B to the end of the hollow fiber type blood purification device main body 54.

As mentioned above, in the hollow fiber type blood purification device, since it is necessary to arrange the O-ring 55 on the cut end surface, as shown in FIG. A region A was provided in which the O-ring 55 was arranged.

However, bond castle A for arranging the 0-ring 55
In order to ensure this on the cut surface, first, as shown in FIG.
must be larger than the inner diameter r2 of the central part of the cylindrical casing 50. As a result, the cylindrical casing 5
When a molding frame (not shown) is attached to the end of the hollow fiber bundle 53 to solidify the sealant, the hollow fiber bundle 53 may be slightly separated. Hollow m! ! If the sealant is allowed to solidify while the bundle 53 is separated, as shown in FIG.
A hollow edge on the cut surface where the ring 55 is placed! The open end of 158 will be located. Therefore, the hollow fiber type blood purification device 57 is equipped with the blood introduction/input member 5B with the O-ring 55 interposed on the cut surface of the solidified sealant 52 in the hollow fiber type blood purification device main body 54. When the purifier 57 is used, the open end of the hollow edge 1158 is closed with the O-ring 55, and the hollow edge is closed! Blood stagnation occurs at 158. Also, the hollow edge that fell apart! If the open end of the sealant 158 is located outside the O-ring 55 at the cut surface of the solidified sealant 52, blood will leak.

There is a very strong demand for the hollow fiber type blood purification device 57 to prevent blood leakage.

In order to meet this demand, the conventional device has the following features:
If the cut surface of the sealant solidified material 52 is rough, which results in a manufacturing constraint that the cut surface of the solidified sealant 52 must be cut smoothly with very high precision, the O-ring 5
5, blood may leak from the gap between the cut surface and the O-ring 55.

Further, even if the cut surface is smooth, when the O-ring 55 is pressed against the cut surface by the blood lead-in/out member 5B, blood may leak from between the cut surface and the O-ring 55. In order to completely prevent this, it is necessary to screw the end of the cylindrical casing 50 and the blood inlet/outlet member 56 so as to maintain an appropriate O-ring tightening level. The protruding length of the solidified sealant 52 that protrudes from the open end of the sealant must be set precisely, which also means that the cutting position of the solidified sealant must be set precisely. Strict setting of the protrusion length and cutting position poses a manufacturing problem in that the manufacturing conditions become even more complicated.

Serious accidents involving blood leakage were caused by this hollow fiber type blood purification device 21.
This can also occur due to loosening of the attachment of the blood introduction/input member 5B in the cylindrical casing 50 at 57. This loosening of the attached state often occurred when the end of the cylindrical casing 50 and the blood introduction/input member 5B were attached by screwing together. Therefore, in order to prevent such a situation, it has been considered to fuse the end of the cylindrical casing 50 and the blood lead-in/out member 56, and this has provided a temporary solution.

However, in attachment by such fusion, if the degree of fusion is large, cracks will occur at the fused part, and if the degree of fusion is small, when the internal pressure of the hollow fiber blood purification device 57 is increased, A new problem arises in that the blood introduction/input member 56 easily falls off.

This is due to the equipment mentioned above. Alternatively, in addition to manufacturing problems, the inner diameter r1 of the openings at both ends of the t3 type casing 50
This is because it has to be larger than the inner diameter r2 of the central portion of the cylindrical casing 50.

The problem is that the amount of sealant used increases, leading to an increase in manufacturing costs, and the shape of the cylindrical casing 50 is an unusual shape that has a large diameter part at both ends and a narrow diameter part with a small diameter in the center. Therefore, there are problems such as the inability to make it compact and the need for a large storage space.

This invention aims to solve the above problems.

That is, an object of the present invention is to provide a hollow fiber type blood purification device that prevents blood leakage and retention.

Another object of the present invention is to provide a hollow fiber type blood purification device in which a blood introduction/input member is not easily loosened and blood leakage is prevented.

Another object of the present invention is to provide a small-sized hollow fiber type blood purification device.

Yet another object of the invention is to reduce the amount of sealant used and to reduce the amount of sealant used. This simplifies the manufacturing process and prevents blood from leaking or stagnation. An object of the present invention is to provide a method for manufacturing a hollow fiber type blood purification device with reduced manufacturing costs.

[Means for Solving the Problems] A configuration of the first invention for solving the problems described above is such that the bundle of hollow fibers loaded in the cylindrical casing has an open end, In a hollow fiber type blood purification device comprising a main body in which a bundle of hollow fibers is fixed with a sealant at both ends of a casing, and blood lead-in/out members are attached to both ends of the main body, the hollow fiber blood purification device protrudes from openings at both ends of a cylindrical casing. , and in a state where the ends of the bundle of hollow fibers are aligned and open, and the bundle of hollow fibers is solidified with a sealant, the peripheral surface of the sealant solidified part and the open end surface of the cylindrical casing are in contact with each other. The blood lead-in/out member is airtightly attached to both ends of the main body by mounting an elastic sealing member on the circumferential surface of the sealant solidifying portion and pressing the annular elastic member with the blood lead-in/out member. This is a hollow fiber type blood purification device, and the configuration of the second invention is such that the ends of the bundle of hollow fibers loaded in the cylindrical casing are open, and the hollow fibers are opened at both ends of the cylindrical casing. In a hollow fiber type blood purification device consisting of a hollow fiber type blood purification device made of a bundle of fibers fixed with a sealant, and blood introduction/input members attached to both ends of the main body, the device protrudes from openings at both ends of a cylindrical casing. , and in a state where the ends of the bundle of hollow fibers are aligned and open, and the hollow fiber bundle is solidified with a sealant, the peripheral surface of the sealant solidified part and the open end surface of the cylindrical casing are in contact with each other. A sealing member is attached to the circumferential surface of the sealant solidifying portion, and a threaded portion is formed on the outer circumferential surface of the end portion of the hollow fiber type blood purification device main body, and a first convex portion or a first A concave portion is provided, and the first convex portion or the first! A second recess or a second recess that corresponds to and is screwed into the recess.
A convex portion is provided on the inner circumferential surface of the end portion of the blood lead-in/out member, and the first convex portion or the first recess and the second concave portion or the second convex portion are screwed together, so that the annular elastic member is connected to the blood conductor. A third aspect of the present invention is a hollow fiber type blood purification device, characterized in that the blood lead-in/out/in/out member is attached airtightly to both ends of the hollow fiber type blood purification device main body by pressing with an input member. , the hollow fiber bundle is loaded into a cylindrical casing, the sealant injected into a form attached to the open end of the cylindrical casing is captured, and the solidified sealant is cut, thereby forming the cylindrical casing. A hollow fiber type blood purification device main body is formed by fixing the bundle of hollow fibers with a sealant at both ends, and a hollow fiber type blood purification device is provided by attaching blood lead-in/out members to both ends of the hollow fiber type blood purification device main body. In the manufacturing method for manufacturing the device, a formwork is attached to the open end of the cylindrical casing with the annular elastic member disposed at the end face of the opening of the cylindrical casing used as a sealing member during sealant injection, and the formwork is After solidifying the sealant within the chamber, the solidified sealant is cut so that the end surface of the hollow fiber is open to produce a hollow fiber type blood purification device body, and the annular elastic sealing member is pressed by the blood lead-in/out member. This method of manufacturing a hollow fiber blood purification device is characterized in that the blood lead-in/out member is airtightly attached to both ends of the hollow fiber blood purification device main body.

According to the above configuration, when the blood introduction/input member is attached to the main body of the hollow fiber blood purification device, the annular elastic seal member is attached to the sealant solidification part while being in contact with the peripheral surface of the sealant solidification part and the open end surface of the cylindrical casing. Since I am wearing
The attached annular elastic seal member is deformed by the pressing force of the blood lead-in/out member, and the annular elastic seal member is brought into close contact with the circumferential surface of the sealant solidification portion and the opening end surface of the cylindrical casing. Moreover, the annular elastic seal member is configured to be attached to the circumferential surface of the sealant solidification portion.

The annular elastic sealing member does not close the open ends of the hollow fibers that open at the end faces of the sealant solidification portions.

Furthermore, in addition to providing the annular elastic seal member, a threaded portion is formed on the outer peripheral surface of the end portion of the hollow fiber type blood purification device main body, and a first protrusion or a first recess is provided at at least one location on the threaded portion. , a second recess or a second convex portion that is threadedly engaged with the first convex portion or the first recess is provided on the inner circumferential surface of the end portion of the blood introduction/input member, and the first convex portion or the first! ! 1
By screwing the part and the second recess or the second convex part,
Since the annular elastic member is pressed by the blood lead-in/out member and the blood lead-in/out member is airtightly attached to both ends of the hollow fiber type blood purification device main body, there is no loosening of the screwed portion.

In addition, in the method of the present invention, the annular elastic sealing member serves as a sealing member between the cylindrical casing and the mold during solidification of the sealant, and a sealing member between the hollow fiber blood purification device main body and the blood introduction/input member attached thereto. This also eliminates the step of removing the seal member attached when solidifying the sealant.

Therefore, this method improves manufacturing workability and productivity. Furthermore, since the blood lead-in/out member is attached to the main body of the hollow fiber type blood purification device with the annular elastic seal member attached to the peripheral surface of the sealant, a hollow fiber type blood purification device without blood retention or leakage is completed.

[Example] Next, the present invention will be described in detail to explain the present invention in further detail.

As shown in FIG. 1, the hollow fiber type blood purification device according to the present invention has a hollow fiber bundle 2 that protrudes from openings at both ends inside a cylindrical casing l, and has the ends of the hollow fiber bundle 2 open at the same time. Sealant solidified parts 3, which are formed by solidifying both ends of the hollow fiber bundle 2 with a sealant, are fixed to both ends of the cylindrical casing l.

Said cylindrical casing! Since this cylindrical casing 1 is placed under pressure or reduced pressure, the material for constructing the casing 1 is appropriately determined in consideration of pressure resistance. Such materials include, for example, polycarbonate,
Polystyrene, a copolymer of acrylonitrile and styrene, polymethyl methacrylate, ABS resin, and AB resin are suitable. Furthermore, it is also possible to appropriately employ other ordinary polymeric materials and metallic materials depending on the purpose of use.

The cylindrical casing l is not particularly limited as long as it has a cylindrical shape with openings at both ends, and may have any suitable shape, such as a cylindrical shape, a rectangular cylindrical shape, or a flat cross-sectional shape. A cylindrical casing 1 shown in FIG. 1 has a cylindrical shape.

Hollow fibers are not limited by their properties such as material and shape, but include, for example, cellulose,
Cellulose derivatives such as cellulose diacetate and cellulose triacetate, cellulose ethers, polyamide derivatives, polyester derivatives, methacrylic or acrylic polymers such as polymethyl methacrylate, polyvinyl polymers such as polyvinyl chloride, polyurethane, and hollow fibers of polyolefins such as polyethylene and polypropylene. The outer diameter of the hollow fibers is usually about 10 to 600 #Lm.

As the sealant it is possible to use, for example, curable polymer compositions for polyurethane resins, silicone resins, epoxy resins.

The length by which the hollow fiber bundle 2 solidified with the sealant protrudes from the open end of the cylindrical casing l is a length that allows the annular elastic seal member 4 to be attached.

The sealant solidified portion 3 can be formed by known methods such as the so-called stationary method and centrifugal molding method described in Japanese Patent Application Laid-Open No. 55-104606.

In the device according to the present invention, the annular elastic seal member 4 is attached to the circumferential surface of the sealant solidifying section 3 in a state in which it contacts the circumferential surface of the sealant solidifying section 3 and the open end surface of the cylindrical casing l.

This annular elastic seal member 4 is not particularly limited as long as it is formed in an annular shape and has elasticity.

For example, it can be made of silicone rubber, butadiene rubber, neoprene rubber, or the like.

The cross-sectional shape of the annular elastic seal member 4 is such that when the blood purification lead-in/out member is attached to the main body of the hollow fiber blood purification device, the annular elastic seal member 4 is deformed by the pressing force of the blood lead-in/out member. There is no particular restriction as long as the solidified sealant portion 3 and the opening end surface of the cylindrical casing l can be closely contacted, and various shapes such as a circular cross section or a rectangular cross section may be adopted. Further, the annular elastic seal member 4 may be solid or tubular.

In this embodiment, the peripheral surface 3a of the sealant solidifying section 3 is formed perpendicular to the end surface of the sealant solidifying section 3, as shown in FIG. In order to facilitate attachment of the member 4, a tapered surface 6 as shown in FIG. 2 may be provided.

As shown in FIG. 1, the annular elastic seal member 4 may be attached to the smooth circumferential surface of the sealant solidified portion 3, but as shown in FIG. By forming an annular recess 7 that goes around the circumferential surface, fitting the annular elastic seal member 4 into the annular recess 7 allows the annular elastic seal member 4 to be attached to the circumferential surface of the sealant solidified portion 3. Not only can this be ensured, but also the annular elastic seal member 4 and the inner concave surface of the annular recess 7 are in surface contact, making it easier to attach the hollow fiber type blood purification device main body 5 and the blood lead-in/out member. It can be made airtight.

In this embodiment, as shown in FIG.

A hollow fiber blood purification device main body 5 has an annular elastic sealing member 4 attached to the circumferential surface of the sealant solidifying portion 3, and blood lead-in/out members 8 are attached to both ends of the hollow fiber blood purification device main body 5. As shown in FIG. 4, in addition to having a normal configuration including a blood inlet 10t through which blood can be introduced into and taken out of the hollow fiber blood purification device main body 5,
It is sufficient that the annular elastic seal member 4 disposed on the circumferential surface of the sealant solidification part 3 can be pressed.
The annular elastic seal member 4 is normally pressed by the inner surface of the blood inlet/outlet member 8, but in order to achieve more reliable pressing, an annular elastic seal attached to the circumferential surface of the sealant solidifying portion 3 is used. A flat suppressing portion 11a as shown in FIG.
Alternatively, it is preferable to form a curved pressing portion ub as shown in FIG.

The hollow fiber type blood purification device main body 5 and the blood introduction/input member 8 are as follows:
By screwing together the outer circumferential surface of the end of the hollow fiber type blood purification device main body 5 and the inner circumferential surface of the end of the blood introduction/input member 8,
Alternatively, it can be attached by ultrasonically fusing the outer circumferential surface of the end of the hollow fiber type blood purification device main body 5 and the inner circumferential surface of the end of the blood introduction/input member 8.

In addition to the above-mentioned screwing and ultrasonic welding, the mounting means may also employ an adhesive method.

When the hollow fiber type blood purification device main body 5 and the blood introduction/input member 8 are attached by screwing, in order to prevent the attached blood introduction/input member 8 from loosening, as shown in Fig. 57, the hollow fiber type At least one convex portion 1 is provided at the tip of a screw portion, for example, a male screw 12, formed on the outer peripheral surface of the end portion of the blood purification device main body 5.
3 is provided, and the convex portion! A female screw 1 having a recess 14 formed in the inner circumferential surface of the end portion of the blood lead-in/out member 8 to be engaged in accordance with the number 3.
5. By doing so, when the hollow fiber blood purification device main body 5 and the blood introduction/input member 8 are attached by screwing, the convex portion 13 and the concave portion 14 will be engaged. This can be used to prevent the screw from loosening.

Note that a concave portion may be formed in place of the convex portion 13, and a convex portion may be formed in place of the concave portion 14.

As explained above, according to the configuration of the embodiment device shown in FIG. Since the annular elastic sealing member 4 is attached to the sealant solidifying portion 3 in a state in contact with the opening end surface of the sealant solidifying portion 3, the attached annular elastic sealing member 4 is deformed by the pressing force of the blood introduction/input member 8. The annular elastic seal member 4 is in close contact with the circumferential surface of the sealant solidifying portion 3 and the open end surface of the cylindrical casing l. Moreover, since the annular elastic seal member 4 is configured to be attached to the circumferential surface of the sealant solidification section 3,
The annular elastic sealing member 4 does not close the open ends of the hollow fibers that open at the end faces of the sealant solidifying portions 3.

This hollow fiber type blood purification device 9 is disclosed in Japanese Patent Application Laid-Open No. 55-1046.
The sealant solidified portion 3 can be manufactured by forming the sealant solidified portion 3 by a known method such as the so-called static molding method and the centrifugal molding method described in Japanese Patent No. 06 and the like.

However, with a more simplified process, the hollow fiber blood purification device main body 5 and the blood introduction/input member 8 can be completely attached, and the hollow fiber blood purification device can prevent blood from accumulating or leaking during use. In order to manufacture this, it is preferable to adopt the manufacturing method according to the second invention of the present application.

An example of a method for manufacturing the embodiment device having the configuration shown in FIG. 1 will be described below.

As shown in FIG. 8(a), first, both ends 2a (only one end is shown in the figure) of the hollow fiber bundle 2 are placed in a cylindrical casing l.
with both ends protruding from the opening.

An annular elastic sealing member 4 is placed on the opening end face of a cylindrical casing l loaded with a hollow fiber bundle 2, and then a mold 15 is placed.
is attached to the opening of this cylindrical casing l. In addition,
At this time, the hollow fiber bundle 2 is attached to the end 2a of the hollow TA fiber bundle 2.
A small amount of sealant may be applied to prevent the parts from coming apart.

Thereafter, sealant is injected into the cylindrical casing 1 from a sealant inlet previously provided, and the sealant is injected into the mold by centrifugal molding, that is, by rotating the hollow fiber bundle 2 with the center of the hollow fiber bundle 2 as the rotation axis. The sealant is injected and cured at room temperature or while heating.

After the sealant has hardened, the mold 15 is removed. At this time, the annular elastic seal member 4 remains attached to the open end surface of the cylindrical casing l. As a result, as shown in FIG. 8(b), a cured body 16 is obtained which protrudes from the opening of the cylindrical casing 1 and has the hollow fiber bundle 2 solidified with the sealant. As shown in FIG. 8(c), by cutting the cured body 15 just before the annular elastic seal member 4, the cured body 15 is brought into contact with the circumferential surface of the sealant solidified portion 3 and the opening end surface of the cylindrical casing 1. Then, a hollow fiber type blood purification device main body 5 is assembled, in which an annular elastic seal member 4 is attached to the circumferential surface of the sealant solidifying portion 3.

Next, as shown in FIG. 1, a hollow fiber blood purification device 9 is obtained by attaching blood lead-in/out members 8 to the openings at both ends of the hollow fiber blood purification device main body 5.

As mentioned above, AI is applied to the outer peripheral surface of the end of the cylindrical casing l.
If a female thread is formed on the inner circumferential surface of the blood lead-in/out member 8, the blood lead-in/out member 8 can be attached to the hollow fiber type blood purification device main body 5 by screwing. .

Usually, the hollow fiber blood purification device 219 is completed by screwing together, but just to be sure, the screwed parts may be fused using ultrasonic waves, or if not by screwing, for example The blood lead-in/out member 8 may be fitted to the outer peripheral surface of the openings at both ends of the hollow fiber type blood purification device main body 5, and then the fitted portion may be irradiated with ultrasonic waves to fuse them. .

[Effects of the Invention] According to the present invention, (1) the annular elastic seal member is attached to the sealant solidifying part in a state where it is in contact with the peripheral surface of the sealant solidifying part and the opening end surface of the cylindrical casing; , the annular elastic seal member is deformed by the pressing force of the blood lead-in/out member;
Since the deformed annular elastic seal member is in close contact with the circumferential surface of the sealant solidification section, the opening end surface of the cylindrical casing, and the inner surface of the blood introduction/input member, a high degree of airtightness can be achieved and blood leakage can be prevented. .

(2) Furthermore, since the annular elastic sole member is not attached to the end face of the sealant solidification section, the i-end between the hollow fibers of the hollow system bundle is not obstructed at all, and as a result, blood flow due to the annular elastic seal member It is possible to eliminate the retention of

(3) In this invention, since the annular elastic sealing member is not arranged on the end face of the sealant solidifying part, there is no space for disposing the annular elastic sealing member on the end face of the sealant solidifying part unlike the conventional device. As a result, the amount of sealant required for the sealant solidification part can be reduced and the volume of the sealant solidification part can be reduced, so it is possible to achieve overall miniaturization and simplification of the device shape, (4) and , When attaching the blood lead-in/out member to the outer periphery of the end of the hollow fiber type blood purification device main body by Is fitting,
Since the screw portion is provided with recesses and protrusions, and the blood lead-in/out member is locked to the main body due to the uneven relationship, the threaded state of the blood lead-in/out member is prevented from loosening over time, and thereby, For example, it is possible to prevent blood leakage due to the blood introduction/intake member coming off during use of the blood purification device.

Further, according to the present invention, (1) the annular elastic seal member used when solidifying the sealant is also used as a seal member when attaching the blood lead-in/out member to the hollow fiber blood purification device main body;
It is possible to eliminate the complexity of removing the seal member when forming the sealant solidified portion.

(2) When solidifying the sealant, the annular elastic sealing member, which is the sealing member used when installing the blood lead-in/output member to the main body of the hollow fiber blood purification device, has already been installed, and in addition, the sealant solidification part Since the annular elastic seal member is not attached to the end face, the length of the protrusion from the open end of the cylindrical casing in the sealant solidifying part must be strictly controlled, and the end face of the sealant solidifying part must be highly smoothed. (3) Since the amount of sealant used can be reduced as mentioned above, manufacturing costs can be reduced. It can produce excellent effects such as .

[Brief explanation of the drawing]

FIG. 1 is a schematic sectional view showing an embodiment of the present invention, FIG. 2 is a schematic sectional view showing a modification of the invention, FIG. 3 is a schematic sectional view showing another modification of the invention, and FIG. The figure is a schematic cross-sectional view showing the state in which the blood lead-in/outlet member is attached to the hollow fiber type blood purification device main body according to the present invention, FIGS. The figures are cross-sectional views showing a state in which a blood lead-in/out member is screwed onto the outer periphery of the end face of a cylindrical casing in a hollow fiber type blood purification device, FIGS. 8(a), 8(b), and 8(C). 9 is a schematic sectional view showing the main body of the hollow fiber type blood purification device in the conventional device, and FIG. 1O is the hollow fiber type blood purification device in the conventional device. FIG. 11 is a front view showing the main body and a schematic sectional view showing a conventional hollow fiber type blood purification device. l...Casing, 2...Hollow fiber bundle, 3...-Sealant solidification part, 4...Annular elastic seal member, 5...
・Hollow fiber type blood purification device body, 6...Tapered surface, 7...
- Annular recess, 8, φ, blood lead-in/out/in/out member, 9...-hollow fiber blood purification device, 13... convex part, 14... concave part.

Claims (1)

[Claims] (1) Hollow fibers formed by fixing the bundle of hollow fibers loaded in a cylindrical casing with a sealant at both ends of the cylindrical casing, with the ends of the bundle open. In a hollow fiber type blood purification device in which blood introduction/input members are attached to both ends of a main body of a hollow fiber type blood purification device, a hollow fiber type blood purification device is provided that protrudes from openings at both ends of a cylindrical casing, and the ends of a bundle of hollow fibers are aligned to form an opening. In this state, an annular elastic seal member is placed on the circumferential surface of the sealant solidified portion in contact with the peripheral surface of the sealant solidified portion formed by solidifying the bundle of hollow fibers with a sealant and the opening end surface of the cylindrical casing. The hollow fiber type blood purification is characterized in that the annular elastic member is pressed by the blood lead-in/out member to airtightly attach the blood lead-in/out member to both ends of the hollow fiber type blood purification device main body. Device. (2) The hollow fiber type blood purification device according to claim 1, wherein the circumferential side of the sealant solidification portion is formed into a tapered shape. (3) The hollow fiber type blood purification device according to claim 1 or 2, wherein the annular elastic body is mounted in an annular recess formed on the peripheral side of the sealant solidification section. (4) Screwing together the outer circumferential surface of the end of the hollow fiber type blood purification device main body and the inner circumferential surface of the end of the blood introduction/input member, so that the blood is introduced into and out of both ends of the hollow fiber blood purification device main body. A hollow fiber blood purification device according to any one of claims 1 to 3, which is equipped with a member. (5) Welding the outer circumferential surface of the end of the hollow fiber type blood purification device main body and the inner circumferential surface of the end of the blood introduction/input member using ultrasound;
Claims 1 to 3, wherein the blood introduction/input member is attached to both ends of the hollow fiber type blood purification device main body.
The hollow fiber blood purification device according to any one of paragraphs. (8) A hollow fiber blood purification device in which the bundle of hollow fibers loaded into a cylindrical casing is fixed with a sealant at both ends of the cylindrical casing, with the ends of the bundle open. In a hollow fiber type blood purification device in which blood lead/in/out members are attached to both ends of the main body, the hollow fiber blood purification device protrudes from openings at both ends of a cylindrical casing, and the ends of the bundle of hollow fibers are aligned and open. An annular elastic seal member is attached to the circumferential surface of the sealant solidified portion in a state in which it is in contact with the peripheral surface of the sealant solidified portion formed by solidifying a hollow fiber bundle with a sealant and the opening end surface of the cylindrical casing, and A threaded portion is formed on the outer circumferential surface of the end of the main body of the thread-type blood purification device, a first protrusion or a first recess is provided at at least one location on the threaded portion, and a first protrusion or a first recess is provided corresponding to the first protrusion or the first recess. The second recess or the second
A convex portion is provided on the inner circumferential surface of the end portion of the blood lead-in/out member, and the first convex portion or the first recess and the second concave portion or the second convex portion are screwed together, so that the annular elastic member is connected to the blood conductor. A hollow fiber blood purification device, characterized in that the blood lead-in/out member is airtightly attached to both ends of the hollow fiber blood purification device main body by pressing with an input member. (7) Load the hollow fiber bundle into a cylindrical casing, solidify the sealant injected into the formwork attached to the open end of the cylindrical casing, and cut the solidified sealant to create a cylindrical shape. A hollow fiber type blood purification device body is formed by fixing the bundle of hollow fibers with a sealant at both ends of the casing, and blood lead-in/output members are attached to both ends of this hollow fiber type blood purification device body, thereby forming a hollow fiber type blood purification device body. In a method for manufacturing a hollow fiber blood purification device, the opening of the cylindrical casing is opened with an annular elastic member disposed at an end face of the opening of the cylindrical casing serving as a sealing member during sealant injection. After attaching a formwork to the end and solidifying the sealant within the formwork, the solidified sealant is cut so that the end face of the hollow fiber is open to produce a hollow fiber type blood purification device main body, and the annular elastic member is A method for manufacturing a hollow fiber blood purification device, characterized in that the blood lead-in/out member is pressed by the blood lead-in/out member to airtightly attach the blood lead-in/out member to both ends of the hollow fiber blood purification device main body.